Liegang Liu


Affiliation: Tongji Medical College
Country: China


  1. Sun T, Rong Y, Hu X, Zhu Y, Huang H, Chen L, et al. Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population. Diabetes Care. 2018;41:440-445 pubmed publisher
    ..These findings suggested that higher plasma DHPPA concentrations were associated with lower odds of T2D and IGR. Further studies are warranted to confirm these findings in prospective cohorts. ..
  2. Shan Z, Ma H, Xie M, Yan P, Guo Y, Bao W, et al. Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2015;38:529-37 pubmed publisher
    ..Both short and long sleep duration are associated with a significantly increased risk of type 2 diabetes, underscoring the importance of appropriate sleep duration in the delay or prevention of type 2 diabetes. ..
  3. Li P, Shan Z, Zhou L, Xie M, Bao W, Zhang Y, et al. MECHANISMS IN ENDOCRINOLOGY: Parity and risk of type 2 diabetes: a systematic review and dose-response meta-analysis. Eur J Endocrinol. 2016;175:R231-45 pubmed publisher
    ..Higher parity is significantly associated with an increased risk of type 2 diabetes. Further studies are warranted to fully adjust for the potential confounders and explore the causality between parity and type 2 diabetes risk. ..
  4. Yin J, Jin X, Shan Z, Li S, Huang H, Li P, et al. Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. J Am Heart Assoc. 2017;6: pubmed publisher
    ..18 (95% CI, 1.14-1.21) per 1-hour increment of sleep duration. Our findings indicate that both short and long sleep duration is associated with an increased risk of all-cause mortality and cardiovascular events. ..
  5. Shan Z, Sun T, Huang H, Chen S, Chen L, Luo C, et al. Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes. Am J Clin Nutr. 2017;106:888-894 pubmed publisher
    ..This study was registered at as NCT03130894. ..
  6. Yin J, Wang X, Li S, Zhu Y, Chen S, Li P, et al. Interactions between plasma copper concentrations and SOD1 gene polymorphism for impaired glucose regulation and type 2 diabetes. Redox Biol. 2019;24:101172 pubmed publisher
    ..Plasma copper concentrations are positively and significantly associated with IGR as well as T2D, and these associations may be modified by SOD1 polymorphism. Further studies are warranted to elucidate the potential mechanisms. ..
  7. Li P, Yin J, Zhu Y, Li S, Chen S, Sun T, et al. Association between plasma concentration of copper and gestational diabetes mellitus. Clin Nutr. 2019;: pubmed publisher
    ..05). The present study indicated a significantly increased odds of GDM in association with higher concentrations of plasma Cu. Prospective cohort studies in other populations are needed to confirm our findings. ..
  8. Li X, Yin J, Zhu Y, Wang X, Hu X, Bao W, et al. Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption. Nutrients. 2018;10: pubmed publisher
    ..When compared with LA, whole milk supplementation could alter the intestinal microbiota composition in LM, without significant changes in fecal SCFAs and cardiometabolic biomarkers. ..
  9. Rong S, Zhao S, Kai X, Zhang L, Zhao Y, Xiao X, et al. Procyanidins extracted from the litchi pericarp attenuate atherosclerosis and hyperlipidemia associated with consumption of a high fat diet in apolipoprotein-E knockout mice. Biomed Pharmacother. 2018;97:1639-1644 pubmed publisher

More Information


  1. Yu M, Wang D, Xu M, Liu Y, Wang X, Liu J, et al. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats. Food Chem Toxicol. 2014;69:210-9 pubmed publisher
    ..Simultaneously, inflammation and apoptosis continues to progress, liver dysfunction and tissue damage will be occurred eventually. ..
  2. Huang H, Yan P, Shan Z, Chen S, Li M, Luo C, et al. Adverse childhood experiences and risk of type 2 diabetes: A systematic review and meta-analysis. Metabolism. 2015;64:1408-18 pubmed publisher
    ..39 with the 95% confidence intervals from 1.28 to 1.52. The results support a significant association of adverse childhood experiences with an elevated risk of type 2 diabetes in adulthood. ..
  3. Gao H, Wang D, Zhang S, Xu M, Yang W, Yan P, et al. Roles of ROS mediated oxidative stress and DNA damage in 3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide-induced immunotoxicity of Sprague-Dawley rats. Regul Toxicol Pharmacol. 2015;73:587-94 pubmed publisher
    ..Thus, the primary finding of this study is that QCT exposure (2400 mg/kg/day) could cause immunotoxicity in SD rats due to ROS mediated oxidative stress and DNA damage. ..
  4. Wang X, Chen H, Liu J, Ouyang Y, Wang D, Bao W, et al. Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population. Int J Mol Sci. 2015;16:16483-96 pubmed publisher
    ..This polymorphism may also contribute to impaired insulin secretory capacity and increased insulin resistance in a Chinese population. ..
  5. Song Y, Shan Z, Luo C, Kang C, Yang Y, He P, et al. Glutathione S-Transferase T1 (GSTT1) Null Polymorphism, Smoking, and Their Interaction in Coronary Heart Disease: A Comprehensive Meta-Analysis. Heart Lung Circ. 2017;26:362-370 pubmed publisher
    ..Future studies with detailed individual information are needed to confirm our findings. ..
  6. Chen S, Jin X, Shan Z, Li S, Yin J, Sun T, et al. Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study. Nutrients. 2017;9: pubmed publisher
    ..70 (0.54-0.91), 0.67 (0.52-0.88), and 0.58 (0.43-0.78), respectively (p for trend < 0.001). Our results indicated that plasma chromium concentrations were inversely associated with T2DM and pre-DM in Chinese adults. ..
  7. Yu M, Chen L, Peng Z, Wang D, Song Y, Wang H, et al. Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway. Toxins (Basel). 2017;9: pubmed publisher
    ..Besides, Nrf2/HO-1 pathway accompanied by the "threshold effect" also plays an important role against DON-induced oxidative damage in this process. ..
  8. Yu X, Xu Y, Zhang S, Sun J, Liu P, Xiao L, et al. Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy. Nutrients. 2016;8: pubmed publisher
    ..Quercetin alleviated ethanol-elicited mitochondrial damage through enhancing mitophagy, highlighting a promising preventive strategy for alcoholic liver disease. ..
  9. Gao H, Yan P, Zhang S, Nie S, Huang F, Han H, et al. Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway. Brain Behav Immun. 2016;57:314-325 pubmed publisher
    ..Taken together, our findings provide new insights into the link between ALA and PERK/eIF2α signaling, which could contribute to a better understanding of an ALA-mediated protective effect in aging-associated neuropathology. ..
  10. Gao H, Yan P, Zhang S, Huang H, Huang F, Sun T, et al. Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats. Mol Neurobiol. 2016;53:4772-86 pubmed publisher
  11. Sun T, Chen S, Huang H, Li T, Yang W, Liu L. Metabolic profile study of 7, 8-dihydroxyflavone in monkey plasma using high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:97-102 pubmed publisher
    ..We further demonstrated that methylated 7, 8-DHF can be also conjugated with glucuronidation/sulfation, and the methylation occurs mainly in the 8 position. ..
  12. Chen S, Jin X, Liu J, Sun T, Xie M, Bao W, et al. Association of Plasma Magnesium with Prediabetes and Type 2 Diabetes Mellitus in Adults. Sci Rep. 2017;7:12763 pubmed publisher
    ..29 (1.06-1.57), 1.16 (0.95-1.41), 1.00 (0.81-1.22), and 0.71 (0.58-0.88) mg/l. Plasma magnesium was independently and inversely associated with prediabetes and T2D in Chinese adults. ..
  13. Rong S, Hu X, Zhao S, Zhao Y, Xiao X, Bao W, et al. Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress. Food Funct. 2017;8:4210-4216 pubmed publisher
    ..These results elucidated that LPPC could ameliorate atherosclerosis in ApoE-KO mice by improving NO bioavailability and reducing oxidative stress through NADPH oxidase-dependent mechanisms. ..
  14. Liu L, Yan H, Yao P, Zhang W, Zou L, Song F, et al. CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes. World J Gastroenterol. 2005;11:4530-5 pubmed
    ..A positive relationship between ethanol-induced oxidative damage in human primary cultured hepatocytes and CYP2E1 activity was exhibited, and the inhibition of CYP2E1 could partly attenuate ethanol-induced oxidative damage. ..