Hui Guo Liu

Summary

Affiliation: Tongji Medical College
Country: China

Publications

  1. Ren J, Jin M, You Z, Luo M, Han Y, Li G, et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. Sleep Breath. 2018;: pubmed publisher
    ..These results suggest that melatonin could ameliorate FD/CIH-induced hepatocellular damage by activating SIRT1-mediated autophagy signaling. ..
  2. Liu X, Deng Y, Shang J, Yang X, Liu K, Liu H, et al. Effect of NADPH oxidase inhibitor apocynin on the expression of hypoxia-induced factor-1? and endothelin-1 in rat carotid body exposed to chronic intermittent hypoxia. J Huazhong Univ Sci Technolog Med Sci. 2013;33:178-184 pubmed publisher
    ..Inhibition of NADPH oxidase activity may hopefully serve as a useful strategy for prevention and treatment of obstructive sleep apnea hypopnea syndrome-induced hypertension. ..
  3. Guo X, Deng Y, Liu H. Clinical characteristics of hereditary multiple exostoses: a retrospective study of mainland chinese cases in recent 23 years. J Huazhong Univ Sci Technolog Med Sci. 2014;34:42-50 pubmed publisher
    ..This study shows some variance from current literature regarding other ethnic populations and may provide valuable baseline assessment of the natural history of HME in mainland China. ..
  4. Shang J, Guo X, Deng Y, Yuan X, Liu H. Regulatory effects of AT?R-TRAF6-MAPKs signaling on proliferation of intermittent hypoxia-induced human umbilical vein endothelial cells. J Huazhong Univ Sci Technolog Med Sci. 2015;35:495-501 pubmed publisher
    ..Targeting the AT1R-TRAF6-p-ERK1/2 signaling pathway might be helpful in restoring endothelial function. ..
  5. Ren J, Liu W, Li G, Jin M, You Z, Liu H, et al. Atorvastatin Attenuates Myocardial Hypertrophy Induced by Chronic Intermittent Hypoxia In Vitro Partly through miR-31/PKCĪµ Pathway. Curr Med Sci. 2018;38:405-412 pubmed publisher
    ..These results suggest that atorvastatin provides the cardioprotective effects against CIH probably via up-regulating PKCĪµ and down-regulating miR-31. ..
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    Liu H, Zhou Y, Liu K, Xu Y. [Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome]. Zhonghua Jie He He Hu Xi Za Zhi. 2010;33:118-22 pubmed
    ..these findings suggest that there are changes of NADPH oxidase p22phox expression in induced sputum cells of OSAHS patients, and these changes are related to the severity of OSAHS. ..
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    Liu H, Wu H, Xu Y. [Changes of blood pressure and expression of NADPH oxidase in carotid body in rats exposed to intermittent hypoxia]. Zhonghua Jie He He Hu Xi Za Zhi. 2011;34:26-9 pubmed
    ..05). CIH upregulates the expression of NADPH oxidase in rat carotid body and elevates the rat SBP. These results indicate that NADPH oxidase up-expression is closely associated with OSAHS patients with hypertension. ..
  8. Yuan X, Guo X, Deng Y, Zhu D, Shang J, Liu H. Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS/NO and inhibition of lipid peroxidation and inflammatory responses. Brain Res. 2015;1596:48-57 pubmed publisher
    ..In conclusion, Pre-CIH telmisartan administration attenuated CIH-induced hippocampal apoptosis partly by regulating NOS activity, inhibiting excessive NO generation, and reducing lipid peroxidation and inflammatory responses. ..
  9. Xie S, Deng Y, Pan Y, Wang Z, Ren J, Guo X, et al. Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway. Biochem Biophys Res Commun. 2015;464:975-981 pubmed publisher
    ..Our results suggest that melatonin ameliorates cardiac hypertrophy caused by CIH by inducing autophagy via the AMPK pathway and by autophagy-regulated apoptosis. ..

More Information

Publications16

  1. Deng Y, Yuan X, Guo X, Zhu D, Pan Y, Liu H. Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: Involving TLR4 and its downstream signaling pathway. Respir Physiol Neurobiol. 2015;218:57-63 pubmed publisher
    ..Our study suggests that atorvastatin may attenuate CIH induced hippocampal neuronal damage partially via TLR4 and its downstream signaling pathway. ..
  2. Zhu D, Deng Y, Pan Y, Wang Z, Yuan X, Guo X, et al. N-acetylcysteine Ameliorates the Erectile Dysfunction Caused by Chronic Intermittent Hypoxia in Rats: Partly Involvement of Endoplasmic Reticulum Stress. Urology. 2015;86:844.e7-844.e14 pubmed publisher
    ..Our results show that pre-CIH NAC administration ameliorates the ED following CIH partly by alleviating CIH-induced ERS and cell apoptosis via regulating the expressions of BIP, CHOP, caspase12, and Bax. ..
  3. Xie S, Deng Y, Pan Y, Ren J, Jin M, Wang Y, et al. Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5'-monophosphate-activated protein kinase pathway. Arch Biochem Biophys. 2016;606:41-52 pubmed publisher
    ..Collectively, these data demonstrated that impaired autophagy induced by CIH through the AMPK pathway contributed to cardiac hypertrophy. ..
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    Liu H, Liu K, Zhou Y, Xu Y. [Effect of NADPH oxidase activity inhibitor apocynin on blood pressure in rats exposed to chronic intermittent hypoxia and the possible mechanisms]. Zhonghua Jie He He Hu Xi Za Zhi. 2008;31:921-5 pubmed
    ..Inhibition of NADPH oxidase activity may be hopefully served as a useful strategy for prevention and treatment of OSAHS-induced hypertension. ..
  5. request reprint
    Liu H, Liu K, Zhou Y, Xu Y. Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population. Chin Med J (Engl). 2009;122:1369-74 pubmed
    ..45). The NADPH oxidase subunit p22phox gene polymorphism may be associated with susceptibility to OSAHS, and it may be an important candidate gene for OSAHS. ..
  6. Ren J, Liu W, Deng Y, Li G, Pan Y, Xie S, et al. Losartan attenuates aortic endothelial apoptosis induced by chronic intermittent hypoxia partly via the phospholipase C pathway. Sleep Breath. 2017;21:679-689 pubmed publisher
  7. Yuan X, Deng Y, Guo X, Shang J, Zhu D, Liu H. Atorvastatin attenuates myocardial remodeling induced by chronic intermittent hypoxia in rats: partly involvement of TLR-4/MYD88 pathway. Biochem Biophys Res Commun. 2014;446:292-7 pubmed publisher