Jiuhong Kang


Affiliation: Tongji University
Country: China


  1. Jiapaer Z, Li G, Ye D, Bai M, Li J, Guo X, et al. LincU Preserves Naïve Pluripotency by Restricting ERK Activity in Embryonic Stem Cells. Stem Cell Reports. 2018;11:395-409 pubmed publisher
    ..Therefore, our findings unveil LincU as a conserved lncRNA that intrinsically restricts MAPK/ERK activity and maintains the naïve state of ESCs. ..
  2. Liu Q, Wang G, Lyu Y, Bai M, Jiapaer Z, Jia W, et al. The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs. Stem Cell Reports. 2018;11:88-101 pubmed publisher
    ..This study elucidated the role of the miR-590/Acvr2a/Terf1 signaling pathway in modulating telomere elongation and pluripotency in pre-iPSCs. ..
  3. Li A, Chen P, Leng Y, Kang J. Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3-COX2-dependent pathway. Oncogene. 2018;37:5952-5966 pubmed publisher
    ..Thus, HDAC6 may be a good potential target to improve breast cancer immunotherapy. ..
  4. Wei T, Chen W, Wang X, Zhang M, Chen J, Zhu S, et al. An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells. Nucleic Acids Res. 2015;43:5409-22 pubmed publisher
  5. Liu X, Han S, Yang Y, Kang J, Wu J. Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic β-cell insulin secretion. Biochem Biophys Res Commun. 2015;464:730-6 pubmed publisher
    ..Our results suggest that the glucose-induced glutathione reduction in mitochondria is primarily required for the first phase of GSIS. ..
  6. Wang C, Li G, Wu Y, Xi J, Kang J. LincRNA1230 inhibits the differentiation of mouse ES cells towards neural progenitors. Sci China Life Sci. 2016;59:443-54 pubmed publisher
    ..Collectively, these findings revealed a crucial role for LincRNA1230 in the regulation of the neural differentiation of mouse ES cells. ..
  7. Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, et al. A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis. Cell Stem Cell. 2018;: pubmed publisher
    ..In summary, linc1405 mediates a Eomes/WDR5/GCN5 complex that contributes to cardiogenesis, highlighting the critical roles of lincRNA-based complexes in the epigenetic regulation of cardiogenesis in vitro and in vivo. ..
  8. Xi J, Sun Q, Ma L, Kang J. Long non-coding RNAs in glioma progression. Cancer Lett. 2018;419:203-209 pubmed publisher
  9. Yang D, Wang G, Zhu S, Liu Q, Wei T, Leng Y, et al. MiR-495 suppresses mesendoderm differentiation of mouse embryonic stem cells via the direct targeting of Dnmt3a. Stem Cell Res. 2014;12:550-61 pubmed publisher
    ..Thus, our studies not only uncovered a previously uncharacterized function of miR-495 in mESC differentiation but also generated a new idea to explore the mechanisms governing the functional difference between Dnmt3a and Dnmt3b. ..

More Information


  1. Liu Q, Wang G, Chen Y, Li G, Yang D, Kang J. A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during mESC proliferation. Stem Cell Reports. 2014;3:1103-17 pubmed publisher
    ..Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal. ..
  2. Zhu S, Jing R, Yang Y, Huang Y, Wang X, Leng Y, et al. A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint. J Biol Chem. 2015;290:11282-92 pubmed publisher
    ..Our findings help to dissect the mechanisms of BUB3 in mitotic checkpoint signaling. ..
  3. Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, et al. Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice. Cell Rep. 2017;18:2880-2892 pubmed publisher
    ..Thus, our study suggests a strategy to improve the quality of iPSCs derived from old donors by activating NHEJ and stabilizing the genome. ..
  4. Li G, Jiapaer Z, Weng R, Hui Y, Jia W, Xi J, et al. Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects. Stem Cell Reports. 2017;8:1270-1286 pubmed publisher
    ..Together, our results suggest that early exposure to environmental stresses results in the dysregulation of the SIRT1/OCT6 axis and increases the risk of NTDs. ..
  5. Xi J, Wu Y, Li G, Ma L, Feng K, Guo X, et al. Mir-29b Mediates the Neural Tube versus Neural Crest Fate Decision during Embryonic Stem Cell Neural Differentiation. Stem Cell Reports. 2017;9:571-586 pubmed publisher
    ..Therefore, our study showed that the Pou3f1-miR-29b-Dnmt3a regulatory axis was active at the initial stage of neural differentiation and regulated the determination of cell fate. ..