Zhen Yuan Zhu


Affiliation: Tianjin University of Science and Technology
Country: China


  1. Zhu Z, Zhang J, Liu F, Chen L, Chen L, Tang Y. Characterization and lymphocyte proliferation activity of an oligosaccharide degraded from Astragalus polysaccharide. Medchemcomm. 2017;8:1521-1530 pubmed publisher
    ..The results indicated that AOS can restore cyclophosphamide-induced immunosuppression by stimulating the secretion of GM-CSF, which promoted the differentiation of progenitor cells after proliferation. ..
  2. Tang Y, Zhu Z, Liu Y, Sun H, Song Q, Zhang Y. The chemical structure and anti-aging bioactivity of an acid polysaccharide obtained from rose buds. Food Funct. 2018;9:2300-2312 pubmed publisher
    ..The results show that R-PL does not have a triple-helical conformation in solution; its shape resembles twisted ribbons. Anti-oxidative and anti-aging analyses show that R-PL has significant antioxidant and anti-aging abilities in vivo. ..
  3. Zhu Z, Meng M, Sun H, Li Y, Yu N, Zhang Y. Structural analysis and immunostimulatory activity of glycopeptides from Paecilomyces sinensis. Food Funct. 2016;7:1593-600 pubmed publisher
    ..Cell proliferation assay and morphological observations indicated that in a certain range of concentrations and time, CPS-II can significantly improve the proliferation activity of RAW264.7 cells. ..
  4. Liu X, Zhu Z, Liu Y, Sun H. Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro. Int J Biol Macromol. 2019;130:307-314 pubmed publisher
    ..Furthermore, CMPS-II is a potentially useful substitution for CBPS-II in the treatment of lung cancer and provides new insights into the mechanism of its anti-tumor activity. ..
  5. Zhu Z, Pang W, Li Y, Ge X, Chen L, Liu X, et al. Effect of ultrasonic treatment on structure and antitumor activity of mycelial polysaccharides from Cordyceps gunnii. Carbohydr Polym. 2014;114:12-20 pubmed publisher
    ..It was possible that ultrasonic treatment is an effective way for enhancing antitumor activity of polysaccharides. ..
  6. Sun H, Zhu Z, Tang Y, Ren Y, Song Q, Tang Y, et al. Structural characterization and antitumor activity of a novel Se-polysaccharide from selenium-enriched Cordyceps gunnii. Food Funct. 2018;9:2744-2754 pubmed publisher
    ..Animal experiments revealed that SeCPS-II inhibits tumors within an ovarian tumor model rat, modeled with SKOV-3 cells. All the results indicated that selenium-enriched C. gunnii can be used to develop new selenium-containing additives. ..
  7. Zhu Z, Pan L, Yun Tang -, Zhang Y. Structural analysis and antioxidant activity of the glycoside from Imperial Chrysanthemum. Bioorg Med Chem Lett. 2018;28:1581-1590 pubmed publisher
    ..This work is of significance to keep the antioxidant activity in the processing and application of Imperial Chrysanthemum. ..
  8. Zhu Z, Guo M, Liu F, Luo Y, Chen L, Meng M, et al. Preparation and inhibition on ?-d-glucosidase of low molecular weight polysaccharide from Cordyceps militaris. Int J Biol Macromol. 2016;93:27-33 pubmed publisher
    ..The results showed that the optical rotation of LCMPs-II was +25° and it was 1,3-branched-rhamnoxyloglucan which had a linear backbone of (1?4)-linked ?-d-glucopyranose (?-d-Glcp units). ..
  9. Wang X, Zhu Z, Zhao L, Sun H, Meng M, Zhang J, et al. Structural characterization and inhibition on ?-d-glucosidase activity of non-starch polysaccharides from Fagopyrum tartaricum. Carbohydr Polym. 2016;153:679-685 pubmed publisher
    ..The ?-d-glucosidase inhibitory activity of TBP-II was determined using acarbose as positive control. The result showed that the inhibition rate depended on the concentration of polysaccharides. ..

More Information


  1. Zhu Z, Liu F, Gao H, Sun H, Meng M, Zhang Y. Synthesis, characterization and antioxidant activity of selenium polysaccharide from Cordyceps militaris. Int J Biol Macromol. 2016;93:1090-1099 pubmed publisher
    ..In addition, the in vitro antioxidant results suggested that selenium-containing polysaccharide should be applied as a novel selenium source in dietary supplements, with potent antioxidant properties. ..
  2. request reprint
    Zhu Z, Chen L, Liu F, Chen L, Meng M, Sun H, et al. Preparation and activity evaluation of chrysin-?-D-galactopyranoside. Arch Pharm Res. 2016;39:1433-1440 pubmed
    ..The anti-tumor, antioxidant and antimicrobial activities of chrysin-?-D-galactopyranoside were proved to be enhanced significantly compared with chrysin. ..
  3. Zhu Z, Meng M, Sun H, Li Y, Ren Y, Zhang Y. Immunostimulatory activity of glycopeptides from Paecilomyces sinensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models. Food Funct. 2016;7:3566-76 pubmed publisher
    ..In conclusion, our results indicated that CPS-II was involved in immunostimulatory actions leading to its modulatory effects on immunosuppression, and one possible mechanism of action was to activate NF-κB. ..
  4. Zhu Z, Liu X, Tang Y, Dong F, Sun H, Chen L, et al. Effects of cultural medium on the formation and antitumor activity of polysaccharides by Cordyceps gunnii. J Biosci Bioeng. 2016;122:494-8 pubmed publisher
    ..5% and the C/N ratio was 10:1.5. Thus, there was a positive correlation between molecular weight distribution and antitumor activity of IPS by C. gunnii. ..
  5. Zhu Z, Luo Y, Dong G, Ren Y, Chen L, Guo M, et al. Effects of the ultra-high pressure on structure and ?-glucosidase inhibition of polysaccharide from Astragalus. Int J Biol Macromol. 2016;87:570-6 pubmed publisher
    ..FT-IR, SEM, CD spectra, atomic force microscope and Congo red test analysis of APS and 400MPa-APS showed ultra-high pressure treatment didn't change the preliminary structure but had an effect on its advanced structure. ..
  6. Zhu Z, Cui D, Gao H, Dong F, Liu X, Liu F, et al. Efficient synthesis and activity of beneficial intestinal flora of two lactulose-derived oligosaccharides. Eur J Med Chem. 2016;114:8-13 pubmed publisher
    ..Among them, 3-O-β-d-galactopyranosyl-d-fructose displayed the most potent activity of proliferation of L. acidophilus. ..
  7. Zhu Z, Liu X, Dong F, Guo M, Wang X, Wang Z, et al. Influence of fermentation conditions on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris. Appl Microbiol Biotechnol. 2016;100:3909-21 pubmed publisher
    ..militaris in a liquid-submerged culture. Our study might be helpful for further research on the pathway of polysaccharide biosynthesis aimed to improve the IPS production of C. militaris. ..
  8. Zhu Z, Liu X, Fang X, Sun H, Yang X, Zhang Y. Structural characterization and anti-tumor activity of polysaccharide produced by Hirsutella sinensis. Int J Biol Macromol. 2016;82:959-66 pubmed publisher
    ..The molar ratio of Rha:Ara:Xyl:Man:Glu:Gal was 1.00:2.44:13.11:74.13:13.80:54.39. The main chain of HSP-III was majorly composed of (1→3) glucose. The tumor inhibition ratio on H22 cell was 79.04% at 100 μg/mL of HSP-III. ..
  9. Liu X, Zhu Z, Tang Y, Wang M, Wang Z, Liu A, et al. Structural properties of polysaccharides from cultivated fruit bodies and mycelium of Cordyceps militaris. Carbohydr Polym. 2016;142:63-72 pubmed publisher
    ..Congo-red test revealed that CMPS-II and CBPS-II existed as triple-helical chains in 0.05-0.15 M NaOH solution. ..
  10. Zhu Z, Dong F, Liu X, Lv Q, YingYang -, Liu F, et al. Effects of extraction methods on the yield, chemical structure and anti-tumor activity of polysaccharides from Cordyceps gunnii mycelia. Carbohydr Polym. 2016;140:461-71 pubmed publisher
  11. Liu W, Xie F, Sun H, Meng M, Zhu Z. Anti-tumor effect of polysaccharide from Hirsutella sinensis on human non-small cell lung cancer and nude mice through intrinsic mitochondrial pathway. Int J Biol Macromol. 2017;99:258-264 pubmed publisher
    ..HSP-III could be a composition for lung cancer treatment. ..
  12. Liu F, Zhu Z, Sun X, Gao H, Zhang Y. The preparation of three selenium-containing Cordyceps militaris polysaccharides: Characterization and anti-tumor activities. Int J Biol Macromol. 2017;99:196-204 pubmed publisher
    ..SeCPS-II showed the strongest anti-tumor effects judging from the result of in vitro anti-tumor assays against two tumor cell lines (hepatocellular carcinoma HepG-2 cells and lung adenocarcinom A549 cells). ..
  13. Ren Y, Zhu Z, Sun H, Chen L. Structural characterization and inhibition on α-glucosidase activity of acidic polysaccharide from Annona squamosa. Carbohydr Polym. 2017;174:1-12 pubmed publisher
    ..The α-glucosidase inhibitory activity assay showed that GASP3-3-I had a certain inhibition on α-glucosidase activity. ..