Research Topics

Changlu Wang


Affiliation: Tianjin University of Science and Technology
Country: China


  1. Cui H, Wu S, Sun Y, Wang T, Li Z, Chen M, et al. Polysaccharide from Pleurotus nebrodensis induces apoptosis via a mitochondrial pathway in HepG2 cells. Food Funct. 2016;7:455-63 pubmed publisher
    ..Finally, the results indicated that PNA-2 significantly suppressed tumor growth in HepG2 tumor-bearing mice, indicating that PNA-2 may be developed as a candidate drug or functional food factor to prevent or treat liver cancer. ..
  2. Cui H, Wu S, Shang Y, Li Z, Chen M, Li F, et al. Pleurotus nebrodensis polysaccharide(PN50G) evokes A549 cell apoptosis by the ROS/AMPK/PI3K/AKT/mTOR pathway to suppress tumor growth. Food Funct. 2016;7:1616-27 pubmed publisher
    ..All the results suggested that PN50G-mediated apoptosis and autophagy of A549 tumor cells in vivo mainly involved in the mitochondrial pathway and the AMPK/PI3K/mTOR pathway. ..
  3. Yang M, Lu L, Li S, Zhang J, Li Z, Wu S, et al. Transcriptomic Insights into Benzenamine Effects on the Development, Aflatoxin Biosynthesis, and Virulence of Aspergillus flavus. Toxins (Basel). 2019;11: pubmed publisher
    ..flavus at the level of transcription, and these potential targets may be conducive in developing new strategies for preventing aflatoxin contamination. ..
  4. Cui H, Wang C, Wang Y, Li Z, Zhang Y. The polysaccharide isolated from Pleurotus nebrodensis (PN-S) shows immune-stimulating activity in RAW264.7 macrophages. Chin J Nat Med. 2015;13:355-60 pubmed publisher
    ..In conclusion, these results suggest that the purified PN-S can improve immunity by activating macrophages. ..
  5. Cui H, Wang C, Wang Y, Li Z, Chen M, Li F, et al. Pleurotus nebrodensis polysaccharide (PN-S) enhances the immunity of immunosuppressed mice. Chin J Nat Med. 2015;13:760-6 pubmed publisher
    ..This study may provide a basis for the application of this fungus in adjacent immunopotentiating therapy against cancer and in the treatment of chemotherapy-induced immunosuppression. ..
  6. Wang C, Chen D, Chen M, Wang Y, Li Z, Li F. Stimulatory effects of blue light on the growth, monascin and ankaflavin production in Monascus. Biotechnol Lett. 2015;37:1043-8 pubmed publisher
    ..MS and AK production decreased when exposed to blue light of 300 and 450 lux. The expression of pigment biosynthetic genes were analyzed by real-time quantitative PCR and correlated with phenotypic production of MS and AK. ..
  7. Chen D, Xue C, Chen M, Wu S, Li Z, Wang C. Effects of blue light on pigment biosynthesis of Monascus. J Microbiol. 2016;54:305-10 pubmed publisher
    ..Results indicated that gene MpPKS5, mppR1, mppA, mppB, mmpC, mppD, MpFasA, MpFasB, and mppF were positively correlated with the yields of RUN and MON, whereas mppE and mppR2 were associated with RUM, MOM, MS, and AK production. ..
  8. Zhang X, Liu W, Chen X, Cai J, Wang C, He W. Effects and Mechanism of Blue Light on Monascus in Liquid Fermentation. Molecules. 2017;22: pubmed publisher
  9. Chen D, Chen M, Wu S, Li Z, Yang H, Wang C. The molecular mechanisms of Monascus purpureus M9 responses to blue light based on the transcriptome analysis. Sci Rep. 2017;7:5537 pubmed publisher
    ..Based on this study, we propose a predicted light-stimulated signal transduction pathway in Monascus. Our work is the first comprehensive investigation concerning the mechanism of Monascus responses to blue light. ..