Affiliation: Tianjin Medical University
Hong W, Baniahmad A, Li J, Chang C, Gao W, Liu Y. Bag-1M inhibits the transactivation of the glucocorticoid receptor via recruitment of corepressors. FEBS Lett. 2009;583:2451-6 pubmed publisher
..In addition, Bag-1M is not involved in the degradation of the receptor. These findings indicate a novel mechanism by which Bag-1M acts as a corepressor and downregulates the activity of the GR. ..
Hong W, Chen L, Liu Y, Gao W. ATP hydrolysis is essential for Bag-1M-mediated inhibition of the DNA binding by the glucocorticoid receptor. Biochem Biophys Res Commun. 2009;390:77-81 pubmed publisher
..These results indicate that ATP hydrolysis is essential for Bag-1M-mediated inhibition of the DNA binding by the GR and Hsp70 is a mediator for this process. ..
Hong W, Baniahmad A, Liu Y, Li H. Bag-1M is a component of the in vivo DNA-glucocorticoid receptor complex at hormone-regulated promoter. J Mol Biol. 2008;384:22-30 pubmed publisher
..These findings identify a regulatory mechanism, downstream of hormone binding, used by Bag-1M for attenuating GR action in response to its changing cellular levels. ..
Hong W, Li J, Wang B, Chen L, Niu W, Yao Z, et al
. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. Biochem Biophys Res Commun. 2011;415:650-5 pubmed publisher
..Taken together, our data indicate that ESET is involved in TR?1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation. ..
Zhang K, Han X, Zhang Z, Zheng L, Hu Z, Yao Q, et al
. The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGF? and Notch pathways. Nat Commun. 2017;8:144 pubmed publisher
..Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGF? and Notch signaling. ..
Wang C, Luo F, Zhou Y, Du X, Shi J, Zhao X, et al
. The therapeutic effects of docosahexaenoic acid on oestrogen/androgen-induced benign prostatic hyperplasia in rats. Exp Cell Res. 2016;345:125-33 pubmed publisher
..These results indicate that DHA inhibits the multiplication of prostate stromal and epithelial cells through a mechanism that may involve cell cycle arrest and the downregulation of ERÎ± and AR expression. ..
Shi Z, Hong Y, Zhang K, Wang J, Zheng L, Zhang Z, et al
. BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2398-2407 pubmed publisher