Affiliation: Tianjin University of Science and Technology
Liu Z, Shi Z, Lin J, Zhao S, Hao M, Xu J, et al
. Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells. Biochem Pharmacol. 2019;163:101-110 pubmed publisher
..These findings uncover a critical mechanism underlying the effects of PL on cancer cells. ..
Li W, Lin J, Shi Z, Wen J, Li Y, Liu Z, et al
. Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization. Biochem Pharmacol. 2019;162:191-201 pubmed publisher
..Altogether, these findings have broad implications for our understanding of TFEB function and provide new insights into CC pharmacological therapy. ..
Ma L, Sun N, Meng Y, Tu C, Cao X, Wei Y, et al
. Harnessing the affinity of magnetic nanoparticles toward dye-labeled DNA and developing it as an universal aptasensor revealed by lipopolysaccharide detection. Anal Chim Acta. 2018;1036:107-114 pubmed publisher
Zhao T, Li Z, Guo Z, Wang A, Liu Z, Zhao Q, et al
. Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors. Protein Expr Purif. 2018;150:12-16 pubmed publisher
..These results indicate that the Pichia pastoris expression system can produce highly active recombinant Legumain protein allowing it to be used for High-throughput screening (HTS) applications. ..
Dang J, Jing L, Shi W, Qin P, Li Y, Diao A. Expression and purification of active recombinant human bone morphogenetic 7-2 dimer fusion protein. Protein Expr Purif. 2015;115:61-8 pubmed publisher
..High level osteogenic activity was found in all the assays tested demonstrating the production of corrected folded and active rhBMP7-2 protein. ..
Li Y, Pan G, Chen Y, Yang Q, Hao T, Zhao L, et al
. Inhibitor of the human telomerase reverse trancriptase (hTERT) gene promoter induces cell apoptosis via a mitochondrial-dependent pathway. Eur J Med Chem. 2018;145:370-378 pubmed publisher
..Taken together, these results suggested that compound 8b down-regulates the expression of hTERT and induces mitochondrial-dependent apoptosis. ..
Luo S, Yang M, Lv D, Jing L, Li Y, Liu Z, et al
. TMEPAI increases lysosome stability and promotes autophagy. Int J Biochem Cell Biol. 2016;76:98-106 pubmed publisher
..Our study reveals the role of TMEPAI in promoting lysosome stability and autophagy, which might be used as a target for cancer chemotherapeutic treatment. ..
Bai X, Jing L, Li Y, Li Y, Luo S, Wang S, et al
. TMEPAI inhibits TGF-? signaling by promoting lysosome degradation of TGF-? receptor and contributes to lung cancer development. Cell Signal. 2014;26:2030-9 pubmed publisher
..These results reveal a novel function for TMEPAI in regulating TGF-? signaling through the modulation of T?RI levels, which has important implications for cancer development in vivo. ..
Li Y, Guo A, Feng Y, Zhang Y, Wang J, Jing L, et al
. Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation. Cell Prolif. 2016;49:710-719 pubmed publisher
..These results indicate that the sequence between -298 and +24 consists of the basal promoter activity for TMEPAI. Sp1 promotes TMEPAI expression and contributes to cell proliferation. ..