Tian J, Liu Y, Liu X, Sun X, Zhang J, Qu L. Feline Herpesvirus 1 US3 Blocks the Type I Interferon Signal Pathway by Targeting Interferon Regulatory Factor 3 Dimerization in a Kinase-Independent Manner. J Virol. 2018;92: pubmed publisher
..We believe that these findings not only will help us to better understand the mechanism of how FHV-1 manipulates the host IFN response but also highlight the potential role of US3 in the establishment of latent infection in vivo. ..
Zhang X, Wu H, Liu C, Tian J, Qu L. PI3K/Akt/p53 pathway inhibits reovirus infection. Infect Genet Evol. 2015;34:415-22 pubmed publisher
..This study demonstrates that PI3K/Akt/p53 activated by mammalian reovirus can serve as a pathway for inhibiting virus replication/infection, yet the precise mechanism of this process remains under further investigation. ..
Wu H, Zhang X, Liu C, Liu D, Liu J, Tian J, et al
. Antiviral effect of lithium chloride on feline calicivirus in vitro. Arch Virol. 2015;160:2935-43 pubmed publisher
..These results demonstrate that LiCl might be an effective anti-FCV drug for controlling FCV disease. Further studies are required to explore the antiviral activity of LiCl against FCV replication in vivo. ..
Wu H, Zhang X, Liu C, Liu D, Liu J, Wang G, et al
. Molecular cloning and functional characterization of feline MAVS. Immunol Res. 2016;64:82-92 pubmed publisher
..The identification of MAVS will promote the understanding and control of feline infectious diseases. ..
Wu H, Liu Y, Zu S, Sun X, Liu C, Liu D, et al
. In vitro antiviral effect of germacrone on feline calicivirus. Arch Virol. 2016;161:1559-67 pubmed publisher
..This is the first report of antiviral effects of germacrone against a calicivirus, and extensive in vivo research is needed to evaluate this drug as an antiviral therapeutic agent for FCV. ..
Tian J, Liu D, Liu Y, Wu H, Jiang Y, Zu S, et al
. Molecular characterization of a feline calicivirus isolated from tiger and its pathogenesis in cats. Vet Microbiol. 2016;192:110-117 pubmed publisher
..The results presented here show that a tiger-origin FCV exhibits high virulence in cats. ..
Tian J, Hu X, Liu D, Wu H, Qu L. Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. Int J Biol Macromol. 2017;95:160-167 pubmed publisher
..These findings suggest that IOP may be a potential broad-spectrum antiviral drug against feline viruses. ..
Wu H, Zu S, Sun X, Liu Y, Tian J, Qu L. N-Terminal Domain of Feline Calicivirus (FCV) Proteinase-Polymerase Contributes to the Inhibition of Host Cell Transcription. Viruses. 2016;8: pubmed publisher
..Finally, we found that 2280 PP and 3CLP significantly repressed reporter gene transcription but did not affect mRNA translation. Our results provide new insight into the mechanism of the FCV-mediated inhibition of host gene expression. ..
Wang L, Fu X, Zheng Y, Zhou P, Fang B, Huang S, et al
. The NS1 protein of H5N6 feline influenza virus inhibits feline beta interferon response by preventing NF-ÎºB and IRF3 activation. Dev Comp Immunol. 2017;74:60-68 pubmed publisher
..Our findings provide an example of an H5N6 influenza virus suppressing IFN production, which might be associated with interspecies transmission of avian influenza viruses to cats. ..