Wei min Zhang

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Chinese University of Hong Kong, Hong Kong
    Spine (Phila Pa 1976) 31:2463-8. 2006
  2. doi Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China
    J Cancer Res Clin Oncol 139:419-27. 2013
  3. doi Genetic epidemiology and heritability of AIS: A study of 415 Chinese female patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Orthop Res 30:1464-9. 2012
  4. pmc Type I Gaucher disease with exophthalmos and pulmonary arteriovenous malformation
    Chun An Chen
    Departments of Pediatric, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    BMC Med Genet 6:25. 2005
  5. pmc The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population
    Hui Li
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
    BMC Med Genet 10:134. 2009
  6. pmc Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
    K C Allen Chan
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 5:26. 2005
  7. pmc A hidden two-locus disease association pattern in genome-wide association studies
    Can Yang
    Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong
    BMC Bioinformatics 12:156. 2011
  8. pmc MegaSNPHunter: a learning approach to detect disease predisposition SNPs and high level interactions in genome wide association study
    Xiang Wan
    Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, PR China
    BMC Bioinformatics 10:13. 2009
  9. ncbi Novel mutations in type 2 Gaucher disease in Chinese and their functional characterization by heterologous expression
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, People s Republic of China
    Hum Mutat 26:59-60. 2005
  10. ncbi Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    Clin Chem 51:2333-40. 2005

Detail Information

Publications59

  1. ncbi A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Chinese University of Hong Kong, Hong Kong
    Spine (Phila Pa 1976) 31:2463-8. 2006
    ..A genetic association study of estrogen receptor-[alpha] gene (ESR1) with adolescent idiopathic scoliosis (AIS) in Chinese...
  2. doi Role of pharmacogenetics on adjuvant chemotherapy-induced neutropenia in Chinese breast cancer patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China
    J Cancer Res Clin Oncol 139:419-27. 2013
    ..In this investigation, we examined the effects of four SNPs in NR1I2, CYP3A4 and CYP3A5 genes on chemotherapy-induced severe neutropenia in 311 female Chinese breast cancer patients undergoing a standard adjuvant chemotherapy regimen...
  3. doi Genetic epidemiology and heritability of AIS: A study of 415 Chinese female patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Orthop Res 30:1464-9. 2012
    ..Here we provided a large-scale study for the genetic aggregation estimates in an Asian population for the first time. The finding also positioned AIS among other common disease or complex traits with a high heritability...
  4. pmc Type I Gaucher disease with exophthalmos and pulmonary arteriovenous malformation
    Chun An Chen
    Departments of Pediatric, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    BMC Med Genet 6:25. 2005
    ..Gaucher disease type I, the non-neuropathic type, usually presents in adulthood with hepatosplenomegaly. We report here an adult with type I Gaucher disease presented with unusual and severe clinical manifestations...
  5. pmc The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population
    Hui Li
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
    BMC Med Genet 10:134. 2009
    ..As infection is a major cause of human death and a mechanism of natural selection, we hypothesized that VNTR polymorphism of DC-SIGNR might have an effect on human life span...
  6. pmc Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
    K C Allen Chan
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 5:26. 2005
    ..Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requirement of intensive care in SARS patients...
  7. pmc A hidden two-locus disease association pattern in genome-wide association studies
    Can Yang
    Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong
    BMC Bioinformatics 12:156. 2011
    ..This phenomenon is due to the existence of unfaithfulness: the marginal effects of correlated SNPs do not express their significant joint effects faithfully due to the correlation cancelation...
  8. pmc MegaSNPHunter: a learning approach to detect disease predisposition SNPs and high level interactions in genome wide association study
    Xiang Wan
    Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, PR China
    BMC Bioinformatics 10:13. 2009
    ....
  9. ncbi Novel mutations in type 2 Gaucher disease in Chinese and their functional characterization by heterologous expression
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, People s Republic of China
    Hum Mutat 26:59-60. 2005
    ..Expression of novel mutations revealed that the enzyme defect could arise from one of two mechanisms: loss of catalytic activity (Y363C and M416V) or enzyme instability (P122L and N382K)...
  10. ncbi Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    Clin Chem 51:2333-40. 2005
    ..Previous studies on chemokines have included only small numbers of patients, and the utility of plasma chemokines as prognostic indicators is unclear...
  11. ncbi Evaluation of an algorithm of tagging SNPs selection by linkage disequilibrium
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Biochem 39:240-3. 2006
    ..Currently, a more efficient cluster-based algorithm is proposed which clusters SNPs solely by a LD parameter, such as r(2). Here, we evaluated the sample distribution of r(2) and its effect on the cluster-based tagSNPs selection...
  12. ncbi A novel mutation (G233D) in the glycogen phosphorylase gene in a patient with hepatic glycogen storage disease and residual enzyme activity
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, China
    Mol Genet Metab 79:142-5. 2003
    ..This location forms a hairpin turn secondary structure and the small glycine residue is completely conserved in all the orthologous proteins from Escherichia coli to mammals. This is the sixth reported mutation of this form of GSD...
  13. doi Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Chim Acta 406:98-102. 2009
    ..These chemokines are components of innate immune response to respiratory tract pathogens. We examined the promoter variants of CXCL-10 and their role in predisposition to tuberculosis (TB)...
  14. ncbi The alpha(1S) subunit of the L-type calcium channel is not a predisposition gene for thyrotoxic periodic paralysis
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese Univerisity of Hong Kong SAR, China
    Clin Endocrinol (Oxf) 66:229-34. 2007
    ..In this study we have examined 48 genetic polymorphisms in the CACNA1S gene and genotyped a tagging set of representative polymorphisms to determine the role of this gene in TPP...
  15. doi Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Bone 46:543-50. 2010
    ..This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on BMD and osteoporotic risk...
  16. ncbi No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Kong Kong
    Clin Endocrinol (Oxf) 61:109-12. 2004
    ..We studied 79 Chinese TPP patients by DNA sequencing of the entire coding sequence of KCNE3 to determine if this gene is the cause of TPP in Chinese patients...
  17. ncbi Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency
    N L Tang
    Department of Chemical Pathology and Department of Paediatrics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Hum Mol Genet 8:655-60. 1999
    ..Our data indicate that mutations in OCTN2 are responsible for CDSP. Identification of the underlying gene in this disease will allow rapid detection of carriers and postnatal diagnosis of affected patients...
  18. ncbi Total daily energy expenditure in wasted chronic obstructive pulmonary disease patients
    N L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Eur J Clin Nutr 56:282-7. 2002
    ..To investigate total daily energy expenditure in chronic obstructive pulmonary disease (COPD) patients during a rehabilitation programme...
  19. ncbi Recurrent and novel mutations of GCDH gene in Chinese glutaric acidemia type I families
    N L Tang
    Department of Chemical Pathology, The Chinese University of Hong Kong
    Hum Mutat 16:446. 2000
    ..This is the first report of GCDH mutations describing recurrent mutations in Chinese patients. The carrier rate of IVS10-2A>C may be particularly high in Chinese...
  20. ncbi Prevalence of breast cancer predisposition gene mutations in Chinese women and guidelines for genetic testing
    N L Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, SAR, Hong Kong, China
    Clin Chim Acta 313:179-85. 2001
    ..It is not clear if the differences in cancer incidence between Caucasians and Chinese are due to genetic or environmental factors...
  21. ncbi A founder mutation (R254X) of SLC22A5 (OCTN2) in Chinese primary carnitine deficiency patients
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Hum Mutat 20:232. 2002
    ..Other previously reported mutations found in the Japanese population were also screening in 250 control samples but no carrier was identified, indicating that they were either very rare or not present in Southern Chinese...
  22. ncbi Overview of common inherited metabolic diseases in a Southern Chinese population of Hong Kong
    N L Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, SAR, Hong Kong, People s Republic of China
    Clin Chim Acta 313:195-201. 2001
    ..We also analyzed the mutations in multiple carboxylase deficiency and Niemann-pick type C on four families...
  23. ncbi A genomic approach to mutation analysis of holocarboxylase synthetase gene in three Chinese patients with late-onset holocarboxylase synthetase deficiency
    Nelson L S Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Biochem 36:145-9. 2003
    ..In addition, a fibroblast cell line with MCD from Coriell Cell repositories was also studied...
  24. ncbi Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis
    Xu Sheng Qiu
    Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, China
    Spine (Phila Pa 1976) 32:1748-53. 2007
    ..A genetic association study to comprehensively investigate variations of melatonin receptor 1B gene polymorphism by a set of tagging single nucleotide polymorphisms (tagSNPs) derived from the International Hapmap project...
  25. ncbi Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer's disease
    Suk Ling Ma
    Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, China
    Neurology 62:307-9. 2004
    ..A high-risk TNFalpha haplotype (-1,031C-863C-857C) with an odds ratio of 2.54 (95% CI 1.37 to 4.79) for AD was identified. No interaction effect of APOE and TNFalpha genotypes was found, but both acted as important risk factors for AD...
  26. ncbi A novel functional assay for simultaneous determination of total fatty acid beta-oxidation flux and acylcarnitine profiling in human skin fibroblasts using (2)H(31)-palmitate by isotope ratio mass spectrometry and electrospray tandem mass spectrometry
    Lap Kay Law
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT Hong Kong SAR
    Clin Chim Acta 382:25-30. 2007
    ..We developed a novel functional assay for total FAO rate assay by measurement of deuterated water enrichment and to combine it with the conventional acylcarnitine profiling method into a single tracer incubation experiment...
  27. doi Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimer's disease in a southern Chinese community
    Suk L Ma
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Int Psychogeriatr 21:977-86. 2009
    ..Preliminary associations between two polymorphisms of ESR1 (PvuII and XbaI) gene and AD have been reported...
  28. ncbi ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome
    Rossa W K Chiu
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin
    Clin Chem 50:1683-6. 2004
  29. doi Association of plasma soluble CTLA-4 with lung function and gene polymorphism in Chinese asthmatic children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
    Int Arch Allergy Immunol 152:113-21. 2010
    ..We investigated the effects of single nucleotide polymorphisms (SNPs) of CTLA-4 on asthma traits and plasma sCTLA-4 in 298 Chinese asthmatic children and 175 controls...
  30. doi Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong
    Pediatr Allergy Immunol 20:142-50. 2009
    ..This is the first report to show significant association of Egr-1 polymorphisms with plasma total IgE and atopy in asthmatics. It may help to explore the pharmacogenetics of Egr-1 inhibitors...
  31. doi PHF11 is not a major candidate gene for asthma or eczema in Chinese children
    Hing Y Sy
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 45:890-7. 2010
    ..Our findings do not support PHF11 to be a major candidate gene for asthma, eczema and aeroallergen sensitization in Chinese children...
  32. ncbi Genetic association study of growth hormone receptor and idiopathic scoliosis
    Xu S Qiu
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong
    Clin Orthop Relat Res 462:53-8. 2007
    ..The Cobb angles among patients of different genotypes were similar. The growth hormone receptor did not appear to be a predisposing gene or disease modifier gene of adolescent idiopathic scoliosis...
  33. ncbi Determinants of cervical human papillomavirus infection: differences between high- and low-oncogenic risk types
    Paul K S Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Infect Dis 185:28-35. 2002
    ..Barrier contraception was protective for low-risk HPVs; current vaginal discharge had a negative association with unknown-risk HPVs. The results indicate that different risk profiles exist for infections with different HPV groups...
  34. pmc Older men with higher self-rated socioeconomic status have shorter telomeres
    Jean Woo
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 9 F, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Age Ageing 38:553-8. 2009
    ..previous studies examining the relationship between socioeconomic status and telomere length showed conflicting results, one study finding shorter telomere length in subjects with lower socioeconomic status and one showing no relationship...
  35. doi Association of SRD5A2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in Chinese elderly men
    Jieying Jiang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Chem 56:1742-9. 2010
    ....
  36. ncbi Apolipoprotein epsilon-4 allele and the two-year progression of cognitive function in Chinese subjects with late-onset Alzheimer's disease
    Linda C W Lam
    Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR
    Am J Alzheimers Dis Other Demen 21:92-9. 2006
    ..This study examined the two-year progression of cognitive decline and its association with Apo E4 allelic status in a group of Chinese elderly subjects with AD...
  37. doi Association of genetic variations in aromatase gene with serum estrogen and estrogen/testosterone ratio in Chinese elderly men
    Jieying Jiang
    Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Chim Acta 411:53-8. 2010
    ..We determined whether 2 CYP19A1 SNPs tagging different haploblocks (rs2470152 and rs2899470) are associated with sex steroid levels in Chinese men...
  38. doi Shorter telomere length is associated with greater decrease in ankle-brachial index in elderly Chinese women but not men
    Jean Woo
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Angiology 62:87-91. 2011
    ..No significant association was observed in men. The findings support the association between TL and markers of atherosclerosis in older women but not men...
  39. ncbi Genetic association of complex traits: using idiopathic scoliosis as an example
    Jack C Y Cheng
    Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Orthop Relat Res 462:38-44. 2007
    ..In this commentary, we illustrate what is possible in the genomic era, and indicate what we should expect from genetic studies in adolescent idiopathic scoliosis, a complex trait disease...
  40. ncbi Inhalant allergens as risk factors for the development and severity of mild-to-moderate asthma in Hong Kong Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    J Asthma 39:323-30. 2002
    ..In conclusion, indoor aeroallergens are one of the risk factors for the development and severity of mild-to-moderate asthma in Chinese children in Hong Kong...
  41. ncbi Isolate diffuse thickening of glomerular capillary basement membrane: a renal lesion in prediabetes?
    Fernand Mac-Moune Lai
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Mod Pathol 17:1506-12. 2004
    ..Patients with proteinuria and isolated thick glomerular basement membrane must be differentiated from MCN for therapeutic implications, and specifically managed for its strong association with prediabetes or early diabetes...
  42. ncbi CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergy
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Curr Drug Targets Inflamm Allergy 4:169-75. 2005
    ..Lastly, the prospect of using immunomodulatory agents targeting on the innate immunity to treat or even prevent asthma and other allergic diseases will be discussed...
  43. ncbi Sensitization to common food allergens is a risk factor for asthma in young Chinese children in Hong Kong
    Ting Fan Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Asthma 39:523-9. 2002
    ..In conclusion, a significant association was found between asthma and the presence of food-specific IgE antibodies in young Chinese children. Significant sensitization to common foods is rare in this cohort...
  44. ncbi The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Pediatr Allergy Immunol 14:255-60. 2003
    ..039). This polymorphic marker was not associated with asthma or aeroallergen sensitization in our cohort. Our results suggest that the C-159T of CD14 was associated with serum total IgE concentration in atopic Chinese children...
  45. ncbi Genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinic patients in Hong Kong
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 68:273-7. 2002
    ..This together with previous reports of the high prevalence of HPV58 among Chinese cervical cancer patients accentuate the importance of developing vaccines targeting at this otherwise uncommon genotype...
  46. ncbi Apolipoprotein E epsilon4 allele is associated with vascular dementia
    Larry Baum
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Dement Geriatr Cogn Disord 22:301-5. 2006
    ..The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study...
  47. ncbi Genetic association study between mbl2 and asthma phenotypes in Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese Univesity of Hong Kong, Prince of Wales Hospital, Hong Kong
    Pediatr Allergy Immunol 17:501-7. 2006
    ..047). The latter three associations became insignificant when adjusted for multiple comparisons. Despite the importance of MBL in innate immunity, our mbl2 polymorphisms only show weak association with asthma and atopy in children...
  48. ncbi Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR, China
    Pediatr Allergy Immunol 13:10-7. 2002
    ..This marker is also associated with the extent of allergic sensitization to cat, as well as with reduced FEV1 and FVC values...
  49. doi Dopamine receptor D4 gene -521C/T polymorphism is associated with opioid dependence through cold-pain responses
    Ada M C Ho
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, Hong Kong S A R, China
    Ann N Y Acad Sci 1139:20-6. 2008
    ..TT individuals might have a higher tendency to use opioids because they experience pain less strongly after chronic opioid use...
  50. doi Novel mutations in ETFDH gene in Chinese patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency
    Lap Kay Law
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Clin Chim Acta 404:95-9. 2009
    ..Recently, mutations in ETFDH were found to be responsible for all riboflavin-responsive MADD patients. In this study, we present the clinical features and molecular studies of 2 Chinese families with riboflavin-responsive MADD...
  51. doi High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Chim Acta 411:67-71. 2010
    ..We investigated the effects of Chinese-tagging single nucleotide polymorphism (SNP) of Egr-1 and its mRNA expression on allergic rhinitis (AR) traits...
  52. ncbi How the SARS coronavirus causes disease: host or organism?
    Anthony W I Lo
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, China
    J Pathol 208:142-51. 2006
    ..Continued research is still required to determine the pathogenetic mechanisms involved and to combat this new emerging human infectious disease...
  53. pmc The familial risk and HLA susceptibility among narcolepsy patients in Hong Kong Chinese
    Lei Chen
    Department of Psychiatry, The Chinese University of Hong Kong, Prince of Wales and Shatin Hospitals, Shatin, Hong Kong SAR
    Sleep 30:851-8. 2007
    ..To explore the familial aggregation and HLA susceptibility of narcolepsy in Hong Kong Chinese by objective sleep measurements and HLA typing...
  54. doi Predictive rule inference for epistatic interaction detection in genome-wide association studies
    Xiang Wan
    Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
    Bioinformatics 26:30-7. 2010
    ..In this work, we propose a novel learning approach (SNPRuler) based on the predictive rule inference to find disease-associated epistatic interactions...
  55. ncbi Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Allergy Clin Immunol 117:127-33. 2006
    ..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into asthma pathophysiology...
  56. ncbi Carnitine level in Chinese epileptic patients taking sodium valproate
    Eva L W Fung
    Department of Paediatrics Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Neurol 28:24-7. 2003
    ..We conclude that routine carnitine level checking is not justified in pediatric patients taking valproate...
  57. ncbi Hepatitis C virus genotype distribution among intravenous drug user and the general population in Hong Kong
    Daniel X M Zhou
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Med Virol 78:574-81. 2006
    ..The co-circulation of a common (1b) and a rare (6a) HCV genotype in Hong Kong provides a unique opportunity for future studies to compare their transmission efficiency, clinical course, and response to treatment...
  58. ncbi Re: Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men
    Ying Man Sung
    J Natl Cancer Inst 95:559-60. 2003
  59. ncbi Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
    Nelson Leung Sang Tang
    Nat Genet 39:691-2; author reply 694-6. 2007