Kwok Yung Yuen

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    BMC Infect Dis 14:470. 2014
  2. pmc Minimal intervention for controlling nosocomial transmission of methicillin-resistant staphylococcus aureus in resource limited setting with high endemicity
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    PLoS ONE 9:e100493. 2014
  3. doi request reprint Immunogenicity of intradermal trivalent influenza vaccine with topical imiquimod: a double blind randomized controlled trial
    Ivan F N Hung
    State Key Laboratory for Emerging Infectious Diseases, Carol Yu s Centre for Infection and Division of Infectious Diseases Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Clin Infect Dis 59:1246-55. 2014
  4. pmc Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor
    Can Li
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    PLoS ONE 9:e107966. 2014
  5. doi request reprint Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection
    Kelvin K W To
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    Arch Virol 160:777-86. 2015
  6. doi request reprint Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis/oralis
    Jonathan H K Chen
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
    J Clin Pathol 68:652-6. 2015
  7. pmc Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Virol 89:3076-92. 2015
  8. doi request reprint Laboratory diagnosis of melioidosis: past, present and future
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Exp Biol Med (Maywood) 240:742-51. 2015
  9. doi request reprint A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East
    Patrick C Y Woo
    2Department of Microbiology, The University of Hong Kong, Hong Kong, PR China 3Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, PR China 1State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, PR China 4Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, PR China
    J Gen Virol 96:1723-31. 2015
  10. pmc Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease
    Jasper F W Chan
    State Key Laboratory of Emerging Infectious Diseases and Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China Carol Yu Centre for Infection, Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Microbiol Rev 28:465-522. 2015

Collaborators

  • Patrick C Y Woo
  • Pak Leung Ho
  • James J Cai
  • Pui Hing Chau
  • Joseph T Wu
  • Xuhua Xia
  • Ka Hing Wong
  • Yi Guan
  • Can Li
  • Susanna K P Lau
  • Kelvin K W To
  • Jasper F W Chan
  • Kwok Hung Chan
  • Vincent C C Cheng
  • Vincent Chi Chung Cheng
  • Honglin Chen
  • Siddharth Sridhar
  • Jasper Fuk Woo Chan
  • Ivan F N Hung
  • Anna J X Zhang
  • Kelvin Kai Wang To
  • Kenneth S M Li
  • Jonathan Hon Kwan Chen
  • Samson S Y Wong
  • Cyril C Y Yip
  • Sally Cheuk Ying Wong
  • Hoi Wah Tsoi
  • Rachel Y Y Fan
  • Herman Tse
  • Yu Lung Lau
  • Alan K L Tsang
  • Jonathan H K Chen
  • Sally C Y Wong
  • Wenjun Song
  • Yi Huang
  • Josepha Wai Ming Tai
  • Rosana W S Poon
  • Jade L L Teng
  • Ming Wang
  • Bo Jian Zheng
  • Iris W S Li
  • Rodney A Lee
  • Ching Wan Lam
  • Kim Chung Lee
  • Akhee S Jahan
  • Lanjuan Li
  • Wai Lan Wu
  • Tak Lun Que
  • Hou Shun Zhu
  • Simon Yung Chun So
  • Siu Ying Lau
  • Tuen Ching Chan
  • Mei Kum Yan
  • Wing Cheong Yam
  • Bone S F Tang
  • Rongtong Guo
  • Iris W Li
  • Sik To Lai
  • Bojian Zheng
  • Huifang Xu
  • Lok Yee So
  • Chee Kin Hui
  • Beatrice H L Wong
  • Wilina W L Lim
  • Samson Wong
  • Kevin K K She
  • Yi Hong Ke
  • Chun Yiu Law
  • Kong Hung Sze
  • Wang Ngai Chow
  • Candy C Y Lau
  • Hayes K H Luk
  • Chi Chun Ho
  • Alan Ka Lun Tsang
  • Andrea L Wu
  • Oi Ying Wong
  • Ka Ching Lo
  • Andy S F Chan
  • Yin Ming Lui
  • Ivan Fan Ngai Hung
  • David Christopher Lung
  • Bobo Wing Yee Mok
  • Kin Land Lo
  • Ivan Fan Ngan Hung
  • Ricky H Y Ng
  • Min Zheng
  • Anna J Zhang
  • Yu Chen
  • Patrick Li
  • Sandy Chau

Detail Information

Publications71

  1. pmc Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    BMC Infect Dis 14:470. 2014
    ..We report a fatal case of anti-aquaporin-4 antibody positive NMO spectrum disorder in a patient who was receiving treatment for pulmonary tuberculosis...
  2. pmc Minimal intervention for controlling nosocomial transmission of methicillin-resistant staphylococcus aureus in resource limited setting with high endemicity
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    PLoS ONE 9:e100493. 2014
    ..To control nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) in resource-limited healthcare setting with high endemicity...
  3. doi request reprint Immunogenicity of intradermal trivalent influenza vaccine with topical imiquimod: a double blind randomized controlled trial
    Ivan F N Hung
    State Key Laboratory for Emerging Infectious Diseases, Carol Yu s Centre for Infection and Division of Infectious Diseases Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Clin Infect Dis 59:1246-55. 2014
    ..Imiquimod, a synthetic Toll-like receptor 7 agonist enhanced immunogenicity of influenza vaccine in a mouse model. We hypothesized that topical imiquimod before intradermal influenza vaccination (TIV) would produce similar effect in human...
  4. pmc Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor
    Can Li
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    PLoS ONE 9:e107966. 2014
    ..Human infection caused by the avian influenza A H7N9 virus has a case-fatality rate of over 30%. Systematic study of the pathogenesis of avian H7N9 isolate and effective therapeutic strategies are needed...
  5. doi request reprint Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection
    Kelvin K W To
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    Arch Virol 160:777-86. 2015
    ..This recombinant A(H7N9)-HA2 vaccine should be investigated as a complement to egg- or cell-based live attenuated or subunit influenza vaccines...
  6. doi request reprint Use of MALDI Biotyper plus ClinProTools mass spectra analysis for correct identification of Streptococcus pneumoniae and Streptococcus mitis/oralis
    Jonathan H K Chen
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
    J Clin Pathol 68:652-6. 2015
    ..However, differentiation of S. pneumoniae from other Streptococcus mitis group organisms was found to be problematic using the Bruker MALDI Biotyper system...
  7. pmc Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Virol 89:3076-92. 2015
    ..ChRCoV HKU24 may represent the murine origin of Betacoronavirus 1, and rodents are likely an important reservoir for ancestors of lineage A ╬▓CoVs...
  8. doi request reprint Laboratory diagnosis of melioidosis: past, present and future
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Exp Biol Med (Maywood) 240:742-51. 2015
    ..thailandensis . Further studies using bacterial cultures and direct patient samples are required to evaluate the potential of metabolomics for improving diagnosis of melioidosis...
  9. doi request reprint A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East
    Patrick C Y Woo
    2Department of Microbiology, The University of Hong Kong, Hong Kong, PR China 3Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, PR China 1State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, PR China 4Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, PR China
    J Gen Virol 96:1723-31. 2015
    ..Further studies are important to understand the pathogenicity, epidemiology and genetic evolution of DcEV in this unique group of animals...
  10. pmc Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease
    Jasper F W Chan
    State Key Laboratory of Emerging Infectious Diseases and Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China Carol Yu Centre for Infection, Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Microbiol Rev 28:465-522. 2015
    ..They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic. ..
  11. pmc High incidence of severe influenza among individuals over 50 years of age
    Anna J X Zhang
    Research Centre of Infection and Immunology, State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China
    Clin Vaccine Immunol 18:1918-24. 2011
    ....
  12. doi request reprint Ebola virus disease: a highly fatal infectious disease reemerging in West Africa
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Microbes Infect 17:84-97. 2015
    ..High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health workers to contain the outbreak. ..
  13. doi request reprint Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Infect 70:433-44. 2015
    ..Rapid diagnostic tests for bacteremia are important for early treatment to improve clinical outcome. We sought to identify plasma biomarkers that can identify patients with bacteremia using an untargeted global metabolomic analysis...
  14. doi request reprint Proactive infection control measures to prevent nosocomial transmission of vancomycin-resistant enterococci in Hong Kong
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    J Formos Med Assoc 113:734-41. 2014
    ....
  15. pmc Decolonization of gastrointestinal carriage of vancomycin-resistant Enterococcus faecium: case series and review of literature
    Vincent C C Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, Hong Kong, China
    BMC Infect Dis 14:514. 2014
    ..Prolonged asymptomatic carriage of vancomycin-resistant enterococci (VRE) in the gastrointestinal tract and the lack of effective decolonization regimen perpetuate the endemicity of VRE in the healthcare settings...
  16. doi request reprint Characterization of the antigenicity of Cpl1, a surface protein of Cryptococcus neoformans var. neoformans
    Jian Piao Cai
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region
    Mycologia 107:39-45. 2015
    ..neoformans var. neoformans and we showed by immunostaining that the Cpl1 protein was located on the surface. The Cpl1 protein is a specific surface protein of C. neoformans var. neoformans. ..
  17. pmc Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong
    Virol J 11:182. 2014
    ..The objective of this study was to investigate the prevalence and genetic diversity of HPeV, AiV and SalV in fecal samples from hospitalized children with gastroenteritis in Hong Kong...
  18. doi request reprint Retracted: outcome and immune reconstitution of HBV-specific immunity in patients with reactivation of occult HBV infection after alemtuzumab-containing chemotherapy regimen
    Chee Kin Hui
    Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong, Special Administrative Region, China
    Hepatology 48:1-10. 2008
    ..Loss of HBsAg occurred after recovery of the CD4+T cell count and increased CD4+T cell reactivity against HBcAg 9 months after the end of chemotherapy...
  19. ncbi request reprint Accelerated evolutionary rate may be responsible for the emergence of lineage-specific genes in ascomycota
    James J Cai
    Department of Microbiology, Faculty of Medicine, University of Hong Kong, University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    J Mol Evol 63:1-11. 2006
    ..These analyses suggest that accelerated rates of gene evolution may be responsible for the emergence of apparently orphan genes...
  20. pmc Logistical feasibility and potential benefits of a population-wide passive-immunotherapy program during an influenza pandemic
    Joseph T Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Proc Natl Acad Sci U S A 107:3269-74. 2010
    ..As such, passive immunotherapy deserves more consideration by clinical researchers regarding its safety and efficacy as a treatment for severe cases of pandemic influenza...
  21. doi request reprint Cross-species transmission and emergence of novel viruses from birds
    Jasper Fuk Woo Chan
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, and Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region
    Curr Opin Virol 10:63-9. 2015
    ..A comprehensive avian virome will improve our understanding of birds' evolutionary dynamics. ..
  22. pmc Fatal systemic necrotizing infections associated with a novel paramyxovirus, anaconda paramyxovirus, in green anaconda juveniles
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong
    J Clin Microbiol 52:3614-23. 2014
    ..Epidemiological and genomic analyses suggested that the anaconda juveniles acquired the virus perinatally from the anaconda mother rather than from other reptiles in the park, with subsequent interanaconda juvenile transmission. ..
  23. pmc The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei
    Patrick C Y Woo
    1 Department of Microbiology, The University of Hong Kong, Hong Kong 2 State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong 3 Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong 4 Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong
    Sci Rep 4:6728. 2014
    ..The present study on elucidation of the biosynthetic pathway of monascorubrin is a proof-of-the-concept study that serves as a cornerstone for future studies on monascorubrin biosynthesis pathway dissection in Monascus species. ..
  24. doi request reprint Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China Department of Microbiology, The University of Hong Kong, Hong Kong, China Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China Electronic address
    Virology 471:117-25. 2014
    ..Further studies comparing the incidence of these viral families in healthy and sick dromedaries will reveal their pathogenic potential. ..
  25. doi request reprint Viral lung infections: epidemiology, virology, clinical features, and management of avian influenza A(H7N9)
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Curr Opin Pulm Med 20:225-32. 2014
    ..Here, we present the virological features relevant to clinical practice, and summarize the epidemiology, clinical findings, diagnosis, treatment, and preventive strategies of A(H7N9) infection...
  26. doi request reprint Emergence in China of human disease due to avian influenza A(H10N8)--cause for concern?
    Kelvin K W To
    State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region
    J Infect 68:205-15. 2014
    ..Vigilant virological and serological surveillance for A(H10N8) in human, poultry and wild bird is important for following the trajectory of this emerging influenza virus. ..
  27. ncbi request reprint Proactive infection control measures to prevent nosocomial transmission of carbapenem-resistant Enterobacteriaceae in a non-endemic area
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong, China Infection Control Team, Queen Mary Hospital, Hong Kong, China
    Chin Med J (Engl) 126:4504-9. 2013
    ....
  28. doi request reprint Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong
    Kelvin Kai Wang To
    State Key Laboratory for Emerging Infectious Diseases, Hong Kong Special Administrative Region Carol Yu Centre for Infection, Hong Kong Special Administrative Region Research Centre of Infection and Immunology, Hong Kong Special Administrative Region Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region
    J Infect 69:60-8. 2014
    ..Human infections caused by avian influenza virus A(H7N9) re-emerged in late 2013. We reported the first Hong Kong patient without risk factors for severe A(H7N9) disease...
  29. doi request reprint Molecular diagnosis in clinical parasitology: when and why?
    Samson S Y Wong
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pok Fu Lam, Hong Kong
    Exp Biol Med (Maywood) 239:1443-60. 2014
    ..Such tests can also be used for monitoring these recipients or highly immunosuppressed patients, so that early preemptive treatment can be given for reactivated parasitic infections while the parasitic burden is still low. ..
  30. doi request reprint Circulating cytomegalic cells in a patient with advanced HIV presenting with cytomegalovirus rhinosinusitis
    Siddharth Sridhar
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR, China
    J Clin Virol 65:87-9. 2015
    ..Furthermore, the detection of circulating cytomegalic cells is described--a rare finding with pathological and clinical significance in immunocompromised patients with CMV disease...
  31. pmc The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
    Wenjun Song
    1 State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, and the Research Center of Infection and Immunology, The University of Hong Kong, Hong Kong SAR, China 2 The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China
    Nat Commun 5:5509. 2014
    ..PB2-K526R interacts with nuclear export protein and our results suggest that it contributes to enhance replication for certain influenza virus subtypes, particularly in combination with 627K. ..
  32. doi request reprint Management of an incident of failed sterilization of surgical instruments in a dental clinic in Hong Kong
    Vincent Chi Chung Cheng
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China Infection Control Team, Queen Mary Hospital, Hong Kong Special Administrative Region, China Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Formos Med Assoc 112:666-75. 2013
    ..We aim to illustrate the principles in performing such investigations and to highlight some of the important checkpoints in sterilization procedures...
  33. doi request reprint Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    J Clin Pathol 67:361-6. 2014
    ..We aim to evaluate the usefulness of MALDI-TOF MS for identification of 'difficult-to-identify' bacterial isolates...
  34. pmc First report of brain abscess caused by a satelliting phenotypic variant of Helcococcus kunzii
    Siddharth Sridhar
    Department of Microbiology, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Microbiol 52:370-3. 2014
    ..This is the first reported case of severe central nervous system infection due to H. kunzii and the first description of a satelliting phenotypic variant of this organism. ..
  35. pmc Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB/c mice
    Anna J X Zhang
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    Clin Vaccine Immunol 21:570-9. 2014
    ..The mechanisms of imiquimod-induced immune protection deserve further study. ..
  36. doi request reprint Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71
    Cyril C Y Yip
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Arch Virol 155:1413-24. 2010
    ..CA16 strains should also be classified into two genotypes. This represents the first evidence for a combination of intratypic and intertypic recombination in EV71 strains...
  37. doi request reprint Antimicrobial resistance among uropathogens that cause acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008
    Pak Leung Ho
    Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 66:87-93. 2010
    ..4-5.7; P = 0.003) and ciprofloxacin resistance (OR, 2.5; 95% CI, 1.1-5.8; P = 0.03). Knowledge of the resistance data and risk factors could inform better use of antibiotics for empiric therapy for acute uncomplicated cystitis...
  38. ncbi request reprint Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscess
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong
    Syst Appl Microbiol 28:316-22. 2005
    ....
  39. pmc Human parainfluenza virus 4 outbreak and the role of diagnostic tests
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital
    J Clin Microbiol 43:4515-21. 2005
    ..To better define the epidemiology and clinical spectrum of disease of HPIV-4 infections, HPIV-4 should be included in the routine panels of respiratory virus detection on respiratory specimens...
  40. pmc Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
    Susanna K P Lau
    Department of Microbiology, Research Centre of Infection and Immunology, State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China
    Proc Natl Acad Sci U S A 102:14040-5. 2005
    ..Neutralizing antibody to human SARS-CoV also was detected in bats with lower viral loads. Precautions should be exercised in the handling of these animals...
  41. ncbi request reprint Seasonal and tissue distribution of Laribacter hongkongensis, a novel bacterium associated with gastroenteritis, in retail freshwater fish in Hong Kong
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong
    Int J Food Microbiol 113:62-6. 2007
    ..Proper handling of freshwater fish for cooking, especially the gills and gut, is recommended to prevent acquisition of L. hongkongensis, and other freshwater fish related infections...
  42. pmc Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 81:1574-85. 2007
    ..Further molecular epidemiological studies on coronaviruses in the bats of other countries, as well as in other animals, and complete genome sequencing will shed more light on coronavirus diversity and their evolutionary histories...
  43. pmc Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 45:395-401. 2007
    ..hongkongensis. Further studies should be performed to ascertain the epidemiology and other disease associations of this bacterium...
  44. pmc Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus
    Patrick C Y Woo
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Virol 83:908-17. 2009
    ..Further studies would be important to delineate whether the Asian leopard cat CoV was a result of interspecies jumping from birds, a situation analogous to that of bat and civet severe acute respiratory syndrome CoVs...
  45. doi request reprint The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
    Iris W Li
    Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, 4 F University Pathology Bldg, 102 Pokfulam Rd, Queen Mary Hospital, Hong Kong
    Chest 137:759-68. 2010
    ..The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain...
  46. doi request reprint Viral load in patients infected with pandemic H1N1 2009 influenza A virus
    Kelvin K W To
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Med Virol 82:1-7. 2010
    ..Younger age was associated with prolonged shedding in the respiratory tract and higher viral load in the stool. Data from this quantitative analysis of viral shedding may have implications for formulating infection control measures...
  47. pmc Leptotrichia hongkongensis sp. nov., a novel Leptotrichia species with the oral cavity as its natural reservoir
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
    J Zhejiang Univ Sci B 11:391-401. 2010
    ..Based on phenotypic and genotypic characteristics, we propose a new species, Leptotrichia hongkongensis sp. nov., to describe this bacterium...
  48. pmc Increased genetic diversity of HIV-1 circulating in Hong Kong
    Jonathan Hon Kwan Chen
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    PLoS ONE 5:e12198. 2010
    ..Our study demonstrated the complex recombination of HIV-1 in Hong Kong and the need in developing surveillance system for tracking the distribution of new HIV-1 genetic variants...
  49. doi request reprint D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice
    Bojian Zheng
    Department of Microbiology, The University of Hong Kong, Pokfulam, China
    Exp Biol Med (Maywood) 235:981-8. 2010
    ..The only consistent mutation in the genomes of viral clones obtained from dying mice was D225G substitution...
  50. pmc MBEToolbox: a MATLAB toolbox for sequence data analysis in molecular biology and evolution
    James J Cai
    Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China
    BMC Bioinformatics 6:64. 2005
    ..However, few functions are freely available in MATLAB to perform the sequence data analyses specifically required for molecular biology and evolution...
  51. ncbi request reprint Anaerospora hongkongensis gen. nov. sp. nov., a novel genus and species with ribosomal DNA operon heterogeneity isolated from an intravenous drug abuser with pseudobacteremia
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital Compound, Hong Kong
    Microbiol Immunol 49:31-9. 2005
    ..hippei and P. vibrioides. The G+C content of the bacterium (mean +/- SD) was 46.8 +/- 3.2%. For these reasons, a new genus and species, Anaerospora hongkongensis gen. nov. sp. nov., is proposed, for which HKU15T is the type strain...
  52. pmc Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 79:884-95. 2005
    ..13 x 10(6) copies per ml, from a 35-year-old woman with pneumonia. Our data support the existence of a novel group 2 coronavirus associated with pneumonia in humans...
  53. ncbi request reprint Laribacter hongkongensis: a potential cause of infectious diarrhea
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, China
    Diagn Microbiol Infect Dis 47:551-6. 2003
    ..More extensive epidemiologic studies should be carried out to ascertain the causative association between L. hongkongensis and diarrhea and to define the reservoir and modes of transmission of L. hongkongensis...
  54. ncbi request reprint The mitochondrial genome of the thermal dimorphic fungus Penicillium marneffei is more closely related to those of molds than yeasts
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong, PR China
    FEBS Lett 555:469-77. 2003
    ..Analysis of gene contents, gene orders, and gene sequences revealed that the mitochondrial genome of P. marneffei is more closely related to those of molds than yeasts...
  55. pmc Clinical and molecular epidemiology of erythromycin-resistant beta-hemolytic lancefield group G streptococci causing bacteremia
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 41:5188-91. 2003
    ..The five isolates resistant to erythromycin but sensitive to clindamycin and one of those resistant to both erythromycin and clindamycin possessed mef genes...
  56. pmc Seronegative bacteremic melioidosis caused by Burkholderia pseudomallei with ambiguous biochemical profile: clinical importance of accurate identification by 16S rRNA gene and groEL gene sequencing
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 41:3973-7. 2003
    ..Sequencing of the groEL gene showed that the isolate was B. pseudomallei. Proper identification of the bacterium in this study is crucial, since there would be a radical difference in the duration of antimicrobial therapy...
  57. ncbi request reprint Single gene target bacterial identification. groEL gene sequencing for discriminating clinical isolates of Burkholderia pseudomallei and Burkholderia thailandensis
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Diagn Microbiol Infect Dis 44:143-9. 2002
    ....
  58. pmc Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Hong Kong, Hong Kong
    J Virol 84:2808-19. 2010
    ..Such frequent recombination, coupled with rapid evolution especially in ORF7b/ORF8 region, in these animals may have accounted for the cross-species transmission and emergence of SARS...
  59. ncbi request reprint Bats as a continuing source of emerging infections in humans
    Samson Wong
    Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, 4 F University Pathology Building, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Rev Med Virol 17:67-91. 2007
    ..A systematic survey of bats is warranted to better understand the ecology of these viruses...
  60. doi request reprint Lactobacillus rhamnosus hepatic abscess associated with Mirizzi syndrome: a case report and review of the literature
    Jasper F W Chan
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Diagn Microbiol Infect Dis 66:94-7. 2010
    ..Literature on sporadic reports of Lactobacillus liver abscess is reviewed...
  61. pmc First report of Tsukamurella keratitis: association between T. tyrosinosolvens and T. pulmonis and ophthalmologic infections
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, and Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 47:1953-6. 2009
    ..One case was associated with trichiasis and the other with contact lens wear. The two isolates were identified as T. tyrosinosolvens and T. pulmonis, respectively, by phenotypic characterization and 16S rRNA sequencing...
  62. pmc Clinical and molecular epidemiology of human parainfluenza virus 4 infections in hong kong: subtype 4B as common as subtype 4A
    Susanna K P Lau
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 47:1549-52. 2009
    ..Patients with HPIV4 infection were mainly young children and immunocompromised adults. In contrast to the reported predominance of HPIV4A infection, molecular subtyping revealed that 15 (44%) cases were caused by HPIV4B...
  63. doi request reprint Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    Virology 404:106-16. 2010
    ..Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes...
  64. doi request reprint Molecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Department of Microbiology and Centre of Infection, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Diagn Microbiol Infect Dis 61:135-42. 2008
    ..In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns...
  65. pmc Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
    Vincent C C Cheng
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Clin Microbiol Rev 20:660-94. 2007
    ....
  66. pmc CoVDB: a comprehensive database for comparative analysis of coronavirus genes and genomes
    Yi Huang
    Department of Microbiology, Research Centre of Infection and Immunology and State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong
    Nucleic Acids Res 36:D504-11. 2008
    ..With the annotated sequences in CoVDB, more specific blast search results can be generated for efficient downstream analysis...
  67. ncbi request reprint Cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape codon usage bias in coronaviruses
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong
    Virology 369:431-42. 2007
    ..The underlying mechanism for the extreme codon usage bias, cytosine deamination and G+C content in CoV-HKU1 warrants further studies...
  68. pmc Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China
    Honglin Chen
    The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Emerg Infect Dis 15:1970-2. 2009
    ..Investigations showed a resistant virus with the neuraminidase (NA) 274Y genotype in quasi-species from a nasopharyngeal aspirate. Monitoring for the naturally occurring NA 274Y mutation in this virus is necessary...
  69. ncbi request reprint Characterization of a novel cryptic plasmid, pHLHK26, in Laribacter hongkongensis
    Patrick C Y Woo
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    New Microbiol 30:139-47. 2007
    ....
  70. ncbi request reprint Characterization of a novel insertion sequence, IS Bp1, in Burkholderia pseudomallei
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    Arch Microbiol 177:267-73. 2002
    ..Using several insertion sequences and a combination of insertion-sequence-based and non-insertion-sequence-based methods such as ribotyping will probably increase the discriminatory power of molecular typing in B. pseudomallei...
  71. pmc Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 45:3655-64. 2007
    ..A newly identified HRV species, HRV-C, is circulating worldwide and is an important cause of febrile wheeze and asthmatic exacerbations in children requiring hospitalization...