David Tai Wai Yew

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Long term ketamine and ketamine plus alcohol toxicity - what can we learn from animal models?
    M S M Wai
    Brain Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Mini Rev Med Chem 13:273-9. 2013
  2. ncbi request reprint DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment
    Lihong Zhang
    Brain Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Curr Neurovasc Res 9:167-75. 2012
  3. pmc Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    Dietrich E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Box 17666, Al Ain, United Arab Emirates
    BMC Neurosci 7:36. 2006
  4. ncbi request reprint Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison
    D T Yew
    Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories, China
    Exp Gerontol 34:117-33. 1999
  5. doi request reprint 5-HT 1A and 2A receptor positive cells in the cerebella of mice and human and their decline during aging
    David T Yew
    Department of Anatomy, Chinese University of Hong Kong, Shatin, N T, Hong Kong S A R, China
    Microsc Res Tech 72:684-9. 2009
  6. pmc Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke
    Lihong Zhang
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Chin Med 5:35. 2010
  7. ncbi request reprint Serotonin and its receptors in the human CNS with new findings - a mini review
    A S M Hung
    School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Curr Med Chem 18:5281-8. 2011
  8. ncbi request reprint Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains
    David T Yew
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, SAR, China
    Neurosci Lett 367:113-7. 2004
  9. ncbi request reprint Chromatographic identification of a biochemical alteration in the aqueous humour of megalophthalmic Black Moor goldfish
    D T Yew
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories
    J Chromatogr B Biomed Sci Appl 751:349-55. 2001
  10. doi request reprint Mechanism of the specific neuronal toxicity of a type I ribosome-inactivating protein, trichosanthin
    Ou Sha
    Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin NT, Hong Kong, China
    Neurotox Res 18:161-72. 2010

Collaborators

  • Dietrich E Lorke
  • Chun Shi
  • Ge Lin
  • Ping Chung Leung
  • Ou Sha
  • W Y Chan
  • Xin Wang
  • Hua Wang
  • Kwok Pui Fung
  • Chi Kong Yeung
  • Y Jiang
  • L Zhang
  • Kouichi Yamamoto
  • L Zhou
  • W K Liu
  • Yan Zou
  • Francis K H Lee
  • C P Pang
  • David K W Yeung
  • Maria S M Wai
  • Sze Wa Chan
  • Maria Sen Mun Wai
  • Sen Mun Wai
  • Marong Fang
  • Jie Xu
  • Gang Lu
  • Yan Wu
  • Guo Li
  • Hsiang Fu Kung
  • Chu Yan Chan
  • Aiqun Zhang
  • John A Rudd
  • Yonghong Zhu
  • M S M Wai
  • Lanhai Lü
  • Ying T Mak
  • Wai Ping Lam
  • Wing Hang Kwong
  • W H Kwong
  • David Wing Shing Cheung
  • Jicheng Li
  • T Y M Tsui
  • Xiangyang Gong
  • A S M Hung
  • Marie Chia Mi Lin
  • John Anthony Rudd
  • Xiao ai Zhang
  • Ming Liang He
  • W P Lam
  • Wei Zai Shen
  • Winnie Wai Ying Li
  • Mingwei Wang
  • Sheng Xi Wu
  • Qi Li
  • Ai Qun Zhang
  • Zhongtang Feng
  • Xiaoping Chen
  • Lihua Li
  • Helen W L Lai
  • Pawel M Kindler
  • Lai Sin Kung
  • Sau Cheung Tiu
  • Chin Hung Cheng
  • Kenneth K H Lee
  • H C Tang
  • Chi Man Koon
  • Elaine Wat
  • Judy Yuet Wa Chan
  • Clara Bik San Lau
  • P Luan
  • Chun Hay Ko
  • M Fan
  • Sai Ming Ngai
  • Karen Li
  • Kam Sze Tsang
  • Chun Ling Meng
  • Sau Na Tsai
  • J C Y Lam
  • Zhong Chao Han
  • Wai P Lam
  • Yeuk W Wong
  • Jin fang Zhang
  • Yong Liang
  • Eric Y P Cho
  • Zhen Ying Ge
  • Jiajia Wu
  • Cleo C L Lee
  • E Lucy Forster
  • Elizabeth Lucy Foster
  • Gregory E Antonio

Detail Information

Publications56

  1. ncbi request reprint Long term ketamine and ketamine plus alcohol toxicity - what can we learn from animal models?
    M S M Wai
    Brain Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Mini Rev Med Chem 13:273-9. 2013
    ..Mechanisms of damages of ketamine might be due to 1) up-regulation of NMDA receptors leading to overestimation of glutamatergic system or 2) the metabolite of ketamine which was a hydroquinone exerted toxicity...
  2. ncbi request reprint DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment
    Lihong Zhang
    Brain Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Curr Neurovasc Res 9:167-75. 2012
    ..The beneficial effects of NBP post-treatment were greater in WKY than in SHR. Results indicated that NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted therapeutic effect in WKY...
  3. pmc Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    Dietrich E Lorke
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Box 17666, Al Ain, United Arab Emirates
    BMC Neurosci 7:36. 2006
    ..Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (n=6) and normal age-matched controls (n = 7)...
  4. ncbi request reprint Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison
    D T Yew
    Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories, China
    Exp Gerontol 34:117-33. 1999
    ..Although there was little difference in the levels of NCAM in the occipital cortex and hippocampus of the two groups, there were significantly fewer positive NCAM neurons in the frontal cortex of AD than normal aging individuals...
  5. doi request reprint 5-HT 1A and 2A receptor positive cells in the cerebella of mice and human and their decline during aging
    David T Yew
    Department of Anatomy, Chinese University of Hong Kong, Shatin, N T, Hong Kong S A R, China
    Microsc Res Tech 72:684-9. 2009
    ..Although there was a decline in these positive cells during aging, no regional difference in the positive cells were observed in the anterior, middle, and posterior regions of the cerebella...
  6. pmc Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke
    Lihong Zhang
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Chin Med 5:35. 2010
    ..This study aims to investigate the potential mechanisms of the preventive effects of Pien Tze Huang on brain damage caused by chronic ischemia and hypertensive stroke in rats...
  7. ncbi request reprint Serotonin and its receptors in the human CNS with new findings - a mini review
    A S M Hung
    School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Curr Med Chem 18:5281-8. 2011
    ..It is hoped that this review will give a map of these major 5-HT receptors and serotonergic neurons in the human CNS to facilitate further deciphering of their functions...
  8. ncbi request reprint Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains
    David T Yew
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, SAR, China
    Neurosci Lett 367:113-7. 2004
    ..Furthermore, we had confirmed that in most neurons Fas and caspase 8 did not exist concomitantly and that the glial cells (astrocytes) did not express caspase 8 in Alzheimer patients...
  9. ncbi request reprint Chromatographic identification of a biochemical alteration in the aqueous humour of megalophthalmic Black Moor goldfish
    D T Yew
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories
    J Chromatogr B Biomed Sci Appl 751:349-55. 2001
    ..To observe if any biochemical abnormalities exist between the eye of megalophthalmic and non-megalophthalmic goldfish by high-performance liquid chromatography (HPLC)...
  10. doi request reprint Mechanism of the specific neuronal toxicity of a type I ribosome-inactivating protein, trichosanthin
    Ou Sha
    Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin NT, Hong Kong, China
    Neurotox Res 18:161-72. 2010
    ..In sharp contrast, RTA can enter vascular endothelial cells and damage the vascular endothelium, resulting in retinitis and necrosis...
  11. doi request reprint A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew)
    Sze Wa Chan
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Eur J Pharmacol 668:340-6. 2011
    ..Further, GLP-1 receptors in the ventromedial hypothalamus appear to play an important role in the regulation of glucose homeostasis in S. murinus...
  12. doi request reprint Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: implication in the migration
    Guo Li
    Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Adv Exp Med Biol 720:51-68. 2011
    ..Our study indicates that a bunch of migration-related proteins are pivotal in governing the migration capacity of MSC...
  13. ncbi request reprint Diffusion tensor imaging (DTI) of rodent brains in vivo using a 1.5T clinical MR scanner
    Francis K H Lee
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    J Magn Reson Imaging 23:747-51. 2006
    ..To evaluate the feasibility of using a clinical 1.5T MR scanner to perform magnetic resonance (MR) diffusion tensor imaging (DTI) on in vivo rodent brains and to trace major rodent neuronal bundles with anatomical correlation...
  14. doi request reprint A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor κB (NFκB) pathway
    David Wing Shing Cheung
    Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Ethnopharmacol 145:776-83. 2013
    ..Since intima-media thickening is the hallmark of atherosclerotic disease, the etiology of which is inflammation of the arterial wall, the mechanism underlying the effect of DG may be related to its anti-inflammatory activities...
  15. doi request reprint Exocytosis of MTT formazan could exacerbate cell injury
    Lanhai Lü
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Northern Campus, Guangzhou, Guangdong, China
    Toxicol In Vitro 26:636-44. 2012
    ..The present data suggest MTT method should be carefully chosen; otherwise the cell viability would be underestimated and incomparable...
  16. pmc An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA
    Chin Hung Cheng
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Mol Biol Cell 13:3696-705. 2002
    ..Endogenous antisense RNA-mediated regulation may represent a new mechanism through which the activity of ion channels can be regulated in the human CNS...
  17. doi request reprint Postmortem MRI changes of the brains of the rats of different ages
    Jie Xu
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    Int J Neurosci 118:1039-50. 2008
    ..This study pointed out not only brain degenerative changes after death were associated with age, it also revealed that the MRI T(2) evaluations could be used as a way in postmortem investigation...
  18. doi request reprint Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew)
    Sze Wa Chan
    Emesis Research Group, Neuro degeneration, Development and Repair, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Neuropharmacology 70:141-7. 2013
    ..05). These data suggest that exendin-4 exerts its emetic effects in the brainstem and/or hypothalamus via GLP-1 receptors. The action of exendin-4 to suppress feeding may involve non-classical GLP-1 receptors or other mechanisms...
  19. ncbi request reprint Perinatal hypoxia induces anterior chamber changes in the eyes of offspring fish
    Chu Yan Chan
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, PR China
    J Reprod Dev 53:1159-67. 2007
    ..Further investigation should be initiated to develop strategies to prevent developmental disability due to perinatal hypoxia and to increase survivability of the offspring...
  20. doi request reprint Simultaneous determination of amino acids in discrete brain areas in Suncus murinus by high performance liquid chromatography with electrochemical detection
    Sze Wa Chan
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    J Pharm Biomed Anal 53:705-9. 2010
    ..The method was successfully applied for the measurement of amino acids under fed and fasted conditions...
  21. doi request reprint Effects of ageing and Alzheimer's disease on mitochondrial function of human platelets
    Chun Shi
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University Guangzhou, Guangdong 510080, China
    Exp Gerontol 43:589-94. 2008
    ..Therefore, blood platelets might serve as a biomarker for detection of mitochondrial function and age-related disease...
  22. doi request reprint Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer's disease patients
    Maria Sen Mun Wai
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Biogerontology 10:457-69. 2009
    ..Some hyperphosphorylated tau cells with cleaved caspases had TUNEL positive nuclei. These findings suggest that these latter cells went through the apoptotic process or DNA fragmentation...
  23. ncbi request reprint Caspase-3 immunoreactivity in different cortical areas of young and aging macaque (Macaca mulatta) monkeys
    Aiqun Zhang
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Neurosignals 15:64-73. 2006
    ..This clustering of caspase-3 indicates increased vulnerability of a subset of pyramidal cells in the aging brain...
  24. doi request reprint Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells
    Guo Li
    Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, PR China
    Phytother Res 24:571-6. 2010
    ..Our study demonstrated that the EFLL is capable of enhancing osteogenic differentiation of MSCs. It might be useful for treating diseases with inadequate bone formation, including osteoporosis...
  25. doi request reprint Different in vitro toxicities of structurally similar type I ribosome-inactivating proteins (RIPs)
    Ou Sha
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Toxicol In Vitro 24:1176-82. 2010
    ..The present findings may shed light on the apoptotic pathway induced by RIPs. RTA may be useful for studying the shift in cell death...
  26. ncbi request reprint The effect of Ginkgo biloba on the cerebellum of aging SAMP mouse--a TUNEL, bcl-2, and fMRI study
    Maria S M Wai
    Department of Anatomy, Chinese University of Hong Kong, Shatin, Hong Kong
    Microsc Res Tech 70:671-6. 2007
    ....
  27. ncbi request reprint Age related changes of various markers of astrocytes in senescence-accelerated mice hippocampus
    Yan Wu
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Neurochem Int 46:565-74. 2005
    ..However, no such increase was observed for either GS or S100 beta. These results suggested that GFAP, rather than GS or S100 beta, played a more important role in the age related deficits in learning and memory...
  28. ncbi request reprint Changes of apoptosis-related proteins in hippocampus of SAM mouse in development and aging
    Yan Wu
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Neurobiol Aging 27:782.e1-782.e10. 2006
    ..Our results suggest apoptosis and cell loss are minor events in the hippocampus of SAM mice and are unlikely to be the cause of functional decline during aging in SAM...
  29. ncbi request reprint fMRI mapping of cortical centers following visual stimulation in postnatal pigs of different ages
    Marong Fang
    Department of Anatomy, Zhejiang University, Hangzhou, China
    Life Sci 78:1197-201. 2006
    ..It is concluded that the visual pathway of the pig mainly involves cortical areas that mature at 6 months of age...
  30. ncbi request reprint Distribution of neuropeptide Y-immunoreactive neurons in the human brainstem, cerebellum, and cortex during development
    Sen Mun Wai
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    Cell Mol Neurobiol 24:667-84. 2004
    ..6. Our results show a wide distribution of the NPY-ir cells in the developing human brain and offer supporting evidence for the important modulatory role of NPY in both the fetus and adult...
  31. ncbi request reprint How would composite traditional Chinese medicine protect the brain--an example of the composite formula "Pien Tze Huang"
    L Zhang
    Brain Research Centre, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Curr Med Chem 18:3590-4. 2011
    ..We illustrate with our study on Pien Tze Huang (PZH) the use of in vivo tests in the study of composite TCM. Our results show evidence that PZH might have neuropreventive effects in rats...
  32. doi request reprint Retrograde transport of a traditional Chinese medicine, alpha-trichosanthin, and its selective neural toxicity
    Wei Zai Shen
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Toxicol (Phila) 47:876-83. 2009
    ..To investigate the peripheral neuronal toxicity of a traditional Chinese medicine, alpha-trichosanthin (TCS)...
  33. ncbi request reprint Morphogenesis of the different types of photoreceptors of the chicken (Gallus domesticus) retina and the effect of amblyopia in neonatal chicken
    Maria Sen Mun Wai
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People s Republic of China
    Microsc Res Tech 69:99-107. 2006
    ..Unilateral occlusion of the eyes of posthatching chicken reduced the proportion of double cones to single cones in the retina, indicating dependence of retinal morphogenesis upon functional activity of visual cells...
  34. doi request reprint The toxic effect of ketamine on SH-SY5Y neuroblastoma cell line and human neuron
    Ying T Mak
    School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Microsc Res Tech 73:195-201. 2010
    ..Therefore, long-term ketamine treated cell or animal models should be sought to study this multiorgan effects of ketamine...
  35. doi request reprint Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells
    Chun Shi
    Department of Anatomy, Sun Yat Sen University Guangzhou, Guangdong, China
    Apoptosis 15:715-27. 2010
    ..Since modern technology allows production of purified bilobalide with high bioavailability, bilobalide may be useful in developing therapy for diseases involving age-associated neurodegeneration...
  36. ncbi request reprint bcl2, bax, and nestin in the brains of patients with neurodegeneration and those of normal aging
    Gang Lu
    Department of Anatomy, Chinese University of Hong Kong
    J Mol Neurosci 27:167-74. 2005
    ..Both astrocytes and neurons demonstrated positive nestin sites. The difference in pattern between groups will lead to further understanding of cellular changes in neurodegenerative patients and those of normal aging...
  37. doi request reprint Development of the human insular cortex: differentiation, proliferation, cell death, and appearance of 5HT-2A receptors
    Maria S M Wai
    Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Histochem Cell Biol 130:1199-204. 2008
    ..In addition, proliferation as well as apoptosis were demonstration. Expression of 5HT (serotonin) 2A receptor positive cells in development was indicative of the insula as a significant psychiatric center...
  38. ncbi request reprint Hypoxia-induced differential apoptosis in the central nervous system of the sturgeon (Acipenser shrenckii)
    Gang Lu
    Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Microsc Res Tech 68:258-63. 2005
    ..Olfactory lobe, cerebellum, and pons/medulla had relatively few apoptotic cells. The CNS of sturgeon showed a differential pattern of apoptosis in response to hypoxia...
  39. ncbi request reprint The eyes of anencephalic babies: a morphological and immunohistochemical evaluation
    Winnie Wai Ying Li
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Int J Neurosci 117:121-34. 2007
    ..If the brains degenerate after retinal maturation, then the survival of the retinae does not appear to rely on its linkage with the brain at birth, again apart from the degeneration of nerve fibers...
  40. ncbi request reprint Novel identification of the different types of cones in the retina of the chicken
    Sen Mun Wai
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, People s Republic of China
    Cell Mol Neurobiol 22:177-84. 2002
    ..91 in the central region, 1:0.92 in the midperiphery, and 1:0.84 in the periphery...
  41. ncbi request reprint Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice
    Jie Xu
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University Guangzhou, Guangdong 510080, China
    J Bioenerg Biomembr 39:195-202. 2007
    ....
  42. ncbi request reprint Possible role of mitochondrial dysfunction in central neurodegeneration of ovariectomized rats
    Chun Shi
    Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong, China
    Cell Biochem Funct 26:172-8. 2008
    ....
  43. ncbi request reprint The pattern of c-fos activation in the CNS is related to behavior in the mudskipper, Periophthalmus cantonensis
    Maria S M Wai
    Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Behav Brain Res 167:318-27. 2006
    ....
  44. ncbi request reprint Pien Tze Huang protects the liver against carbon tetrachloride-induced damage
    Kenneth K H Lee
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Pharmacol Toxicol 91:185-92. 2002
    ..We thus postulate that the ability of Pien Tze Huang to protect the liver from damage is attained through its ability to modulate the activity of these important signal transduction pathways...
  45. ncbi request reprint A cytological study on the development of the different types of visual cells in the chicken (Gallus domesticus)
    Sen Mun Wai
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories
    Cell Mol Neurobiol 22:57-85. 2002
    ..Glycogen bodies were demonstrated firstly in rods and accessory cones at stage 43 and their development was completed by stage 45. In essence, all the essential elements of the visual cells were fully developed by hatching...
  46. ncbi request reprint Age-related alterations in cytochrome c-mediated caspase activation in rhesus macaque monkey (Macaca mulatta) brains
    Aiqun Zhang
    Institute of Neuroanatomy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Brain Res Mol Brain Res 123:112-20. 2004
    ..These results suggest that the aging rhesus macaque brain has a lower threshold to apoptotic stimuli...
  47. ncbi request reprint Development of the human cerebral cortex: a histochemical study
    Sau Cheung Tiu
    Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
    Prog Histochem Cytochem 38:3-149. 2003
    ..It is hoped that knowledge of the normal developmental process can lead to better understanding of the causes and mechanisms of "disorders of cortical development", and to better treatments...
  48. ncbi request reprint Three-dimensional reconstruction of brain surface anatomy based on magnetic resonance imaging diffusion-weighted imaging: a new approach
    Xiangyang Gong
    Department of Radiology, 2nd Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, China
    J Biomed Sci 11:711-6. 2004
    ..The structures in the 12 cases with acute or chronic cerebrum infarcts were also satisfactorily demonstrated with this new technique...
  49. ncbi request reprint Development of catecholaminergic neurons in the human medulla oblongata
    Dietrich E Lorke
    Department of Neuroanatomy, Institute of Anatomy, University Hospital Eppendorf, Martinistr 52 D 20246 Hamburg, Germany
    Life Sci 73:1315-31. 2003
    ..Our results indicate that CA neurons in the human medulla, which are presumably involved in the control of ventilation and blood pressure, though generated rather early during development, mature relatively late...
  50. pmc Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro
    Xiaoping Chen
    Department of Neurophysiology, Institute of Basic Medical Sciences, Beijing 100850, China
    Mol Biol Cell 16:3140-51. 2005
    ..Our results demonstrate the myogenic lineage-committed human myoblasts can dedifferentiate at a clonal level and CNTF is a novel regulator of skeletal myoblast dedifferentiation via p44/p42 MAPK pathway...
  51. ncbi request reprint N-methyl-D-aspartate receptor and apoptosis in Alzheimer's disease and multiinfarct dementia
    Marong Fang
    The Institute of Cellbiology, Medical College of Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    J Neurosci Res 81:269-74. 2005
    ....
  52. ncbi request reprint A fMRI study of age-related differential cortical patterns during cued motor movement
    Marong Fang
    Institute of Cell Biology, Medical School of Zhejiang University, China
    Brain Topogr 17:127-37. 2005
    ..Furthermore, areas like insula and cingulate gyrus might be activated in motor tasks. We conclude that different motor activities triggered diverse activation patterns which differed in different age groups...
  53. ncbi request reprint Postmortem changes in the central nervous system and adrenal medulla of the heroin addicts
    Lihua Li
    Department of Forensic Pathology, Kunming Medical College, Kunming, China
    Int J Neurosci 115:1443-9. 2005
    ..Degeneration of CNS neurons and fibers, alterations in hormonal and blood pressure regulation therefore would be the prime targets of heroin addiction in human subjects...
  54. ncbi request reprint Microscopic analysis of the different regions of three Alzheimer brains aged 93, 94, and 104 years old
    Yonghong Zhu
    Department of Histology and Embryology School of Preclinical Medicine, Sun Yat Sen University, Guangzhou, China
    Int J Neurosci 117:1403-13. 2007
    ..Both apoptosis and necrosis were observed in the different cerebral regions of these very old patients, as expected...
  55. ncbi request reprint Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP(8))
    Yonghong Zhu
    Department of Histology and Embryology, School of Preclinical Medicine, Sun Yat Sen University, Guangzhou, China
    Biogerontology 8:537-44. 2007
    ..Taken together, the data suggests that the aging SAMP(8) strain displays differential Purkinje cell death in the medial cerebellum and that some of the dying cells are likely to be catecholaminergic...
  56. ncbi request reprint Changes of brain activity in the aged SAMP mouse
    Lihong Zhang
    Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, People s Republic of China
    Biogerontology 8:81-8. 2007
    ..These results demonstrated a lack of neuronal deaths but an increase in the activated brain area with age...