W Yeo

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients
    Sheng Zhong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Med Virol 66:428-34. 2002
  2. ncbi request reprint A comparison of three transarterial lipiodol-based formulations for hepatocellular carcinoma: in vivo biodistribution study in humans
    Simon Chun Ho Yu
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Cardiovasc Intervent Radiol 31:289-98. 2008
  3. pmc Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma
    Qian Zhou
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong Cancer Drug Testing Unit, State Key Laboratory of Oncology in South China, Hong Kong Cancer Institute and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong
    Int J Hepatol 2013:103830. 2013
  4. doi request reprint Hepatitis B virus reactivation associated with anti-neoplastic therapy
    Winnie Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Gastroenterol Hepatol 28:31-7. 2013
  5. pmc Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Res
    Winnie Yeo
    Department of Clinical Oncology, State Key Lab of Oncology in South China, Prince of Wales Hospital Shatin, Chinese University of Hong Kong, Hong Kong, China
    J Clin Oncol 30:3361-7. 2012
  6. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Liver Int 25:266-72. 2005
  7. ncbi request reprint Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy
    W Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Ann Oncol 15:1661-6. 2004
  8. ncbi request reprint Hepatitis B virus reactivation during cytotoxic chemotherapy-enhanced viral replication precedes overt hepatitis
    W Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Med Virol 65:473-7. 2001
  9. pmc Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy
    W Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Br J Cancer 90:1306-11. 2004
  10. ncbi request reprint Psychosocial impact of breast cancer surgeries in Chinese patients and their spouses
    W Yeo
    Departments of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Psychooncology 13:132-9. 2004

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients
    Sheng Zhong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Med Virol 66:428-34. 2002
    ..It is concluded that replicative intermediate forms of TTV DNA are present in both PBMCs and BMCs, indicating that blood cells may be a site of TTV replication...
  2. ncbi request reprint A comparison of three transarterial lipiodol-based formulations for hepatocellular carcinoma: in vivo biodistribution study in humans
    Simon Chun Ho Yu
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Cardiovasc Intervent Radiol 31:289-98. 2008
    ..013). This study showed that LEM is associated with a greater embolic effect in intrahepatic HCC at 4 weeks, and a comparable degree of lung shunting and decomposition rates, compared with ethanol-free Lipiodol formulations...
  3. pmc Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma
    Qian Zhou
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong Cancer Drug Testing Unit, State Key Laboratory of Oncology in South China, Hong Kong Cancer Institute and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong
    Int J Hepatol 2013:103830. 2013
    ..Our findings demonstrated that the everolimus/patupilone combination, which had potent antitumor activity, was a potential therapeutic strategy for HCC...
  4. doi request reprint Hepatitis B virus reactivation associated with anti-neoplastic therapy
    Winnie Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Gastroenterol Hepatol 28:31-7. 2013
    ....
  5. pmc Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Res
    Winnie Yeo
    Department of Clinical Oncology, State Key Lab of Oncology in South China, Prince of Wales Hospital Shatin, Chinese University of Hong Kong, Hong Kong, China
    J Clin Oncol 30:3361-7. 2012
    ..The objectives were to determine dose-limiting toxicity and maximum-tolerated dose (MTD), to assess pharmacokinetics in phase I, and to assess activity of and explore potential biomarkers for response in phase II...
  6. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Liver Int 25:266-72. 2005
    ..To determine the presence of ras association domain family 1A (RASSF1A) promoter methylation in the tumor tissues and plasma of patients with hepatocellular carcinoma (HCC)...
  7. ncbi request reprint Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy
    W Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Ann Oncol 15:1661-6. 2004
    ..A prospective study was conducted to determine the incidence of HBV reactivation, the associated morbidity and mortality, and possible risk factors...
  8. ncbi request reprint Hepatitis B virus reactivation during cytotoxic chemotherapy-enhanced viral replication precedes overt hepatitis
    W Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Med Virol 65:473-7. 2001
    ..During the course of a longitudinal study of HBsAg-seropositive cancer patients who were monitored during standard chemotherapy, the opportunity was available to test this hypothesis...
  9. pmc Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy
    W Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Br J Cancer 90:1306-11. 2004
    ..A predictive model was developed from the current data, based on a logistic regression method...
  10. ncbi request reprint Psychosocial impact of breast cancer surgeries in Chinese patients and their spouses
    W Yeo
    Departments of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Psychooncology 13:132-9. 2004
    ..This pilot study assesses the psychosocial impact of different modalities of breast cancer surgery in Chinese patients and their husbands...
  11. ncbi request reprint Use of lamivudine to prevent hepatitis B virus reactivation during chemotherapy in breast cancer patients
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Breast Cancer Res Treat 88:209-15. 2004
    ..1% vs. 45.9%, p=0.006). We conclude that prophylactic lamivudine significantly reduces the incidence of HBV reactivation and the overall morbidity of breast cancer patients undergoing chemotherapy...
  12. ncbi request reprint Hepatitis B virus reactivation in breast cancer patients receiving cytotoxic chemotherapy: a prospective study
    Winnie Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Med Virol 70:553-61. 2003
    ..The present study highlights the importance of monitoring HBsAg-seropositive patients who are receiving chemotherapy for common solid tumors such as breast cancer...
  13. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A in tumorous and non-tumourous tissue of breast cancer
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Pathology 37:125-30. 2005
    ..To determine the presence of RASSF1A promoter methylation in tumorous and non-tumorous tissues of breast cancer...
  14. ncbi request reprint Phase II study of docetaxel and epirubicin in Chinese patients with metastatic breast cancer
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Anticancer Drugs 13:655-62. 2002
    ..We conclude that docetaxel-epirubicin chemotherapy is highly effective for recurrent metastatic/locoregional breast cancer, with myelosuppression being the main toxicity...
  15. doi request reprint A randomized study of aprepitant, ondansetron and dexamethasone for chemotherapy-induced nausea and vomiting in Chinese breast cancer patients receiving moderately emetogenic chemotherapy
    Winnie Yeo
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Breast Cancer Res Treat 113:529-35. 2009
    ..The secondary objective was to compare the patient-reported quality of life in these two groups of patients...
  16. doi request reprint Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab
    Winnie Yeo
    Department of Clinical Oncology, Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    J Clin Oncol 27:605-11. 2009
    ....
  17. ncbi request reprint Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicenter study by the Cancer Therapeutics Research Group (CTRG)
    W Yeo
    Comprehensive Cancer Trials Unit, Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Cancer Chemother Pharmacol 59:295-300. 2007
    ..The purpose of this study was to evaluate the tolerability and efficacy of irofulven, a DNA interacting acylfulvene analog, as first line therapy for patients with recurrent or metastatic gastric cancer...
  18. ncbi request reprint Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma
    W Yeo
    Department of Clinical Oncology and Surgery, Centre for Clinical Trials, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Ann Oncol 17:1083-9. 2006
    ..The objective of this study was to evaluate whether patient-reported baseline quality of life (QoL) measured by the EORTC QLQ-C30 instrument is predictive of survival for these patients...
  19. ncbi request reprint Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors
    W Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    J Med Virol 62:299-307. 2000
    ..In HBV endemic areas, patients with risk factors for HBV reactivation should be identified prior to receiving cytotoxic treatment and monitored closely. The potential benefit of lamivudine requires further confirmation...
  20. ncbi request reprint Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy
    Winnie Yeo
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hepatology 43:209-20. 2006
  21. ncbi request reprint Prevention of hepatitis B virus reactivation in patients with nasopharyngeal carcinoma with lamivudine
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Clin Oncol 28:379-84. 2005
    ..This study assessed the role of lamivudine in preventing HBV reactivation and its associated morbidity in NPC patients who have chronic HBV infection and are undergoing chemotherapy...
  22. ncbi request reprint High hepatitis B virus (HBV) DNA viral load is an important risk factor for HBV reactivation in breast cancer patients undergoing cytotoxic chemotherapy
    S Zhong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Viral Hepat 11:55-9. 2004
    ..Such information may be useful in determining which patients would benefit most from prophylactic antiviral therapy during cytotoxic chemotherapy...
  23. ncbi request reprint The evolution of psychological distress trajectories in women diagnosed with advanced breast cancer: a longitudinal study
    W W T Lam
    Centre for Psycho Oncology Research and Training, Division of Behavioural Health, School of Public Health, The University of Hong Kong, Hong Kong
    Psychooncology 22:2831-9. 2013
    ..This study describes trajectories of distress and their determinants in Chinese women with ABC...
  24. ncbi request reprint Liver resection after irinotecan, 5-fluorouracil, and folinic acid for patients with unresectable colorectal liver metastases: a multicenter phase II study by the Cancer Therapeutic Research Group
    Wing M Ho
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Med Oncol 22:303-12. 2005
    ..In a subgroup of patients with initial inoperable liver metastases, this regimen was able to down-stage the disease to an operable stage...
  25. ncbi request reprint Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    Clin Cancer Res 6:3516-21. 2000
    ..The combination of these epigenetic markers may prove valuable for noninvasive HCC diagnosis and disease monitoring...
  26. ncbi request reprint Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma
    T W Leung
    Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, New Territories
    Clin Cancer Res 5:1676-81. 1999
    ..Complete pathological remission is possible with this systemic combination. Apparently, persistent radiological lesions may still represent complete pathological resolution of active disease...
  27. ncbi request reprint Quantitative correlation of cytokeratin 19 mRNA level in peripheral blood with disease stage and metastasis in breast cancer patients: potential prognostic implications
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
    Int J Oncol 18:633-8. 2001
    ..045). Quantification of CK19 mRNA may prove useful for cancer staging, disease monitoring and prognostic assessment among BC patients...
  28. ncbi request reprint A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Natl Cancer Inst 97:1532-8. 2005
    ..Cisplatin, interferon, doxorubicin, and fluorouracil (PIAF) used in combination, by contrast, has shown promise in a phase II study. We compared doxorubicin to PIAF in patients with unresectable HCC in a phase III trial...
  29. ncbi request reprint Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy
    Winnie Yeo
    MRCP, Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong winnieyeo cuhk edu hk
    J Clin Oncol 22:927-34. 2004
    ....
  30. ncbi request reprint Pharmacokinetic study of intralesional cisplatin for the treatment of hepatocellular carcinoma
    T S Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Cancer 91:2369-77. 2001
    ..In the current study the authors examined the pharmacokinetics of direct intralesional injection of cisplatin/epinephrine/bovine collagen gel in patients with hepatocellular carcinoma and cirrhosis...
  31. ncbi request reprint A multi-centre randomized phase II study of nolatrexed versus doxorubicin in treatment of Chinese patients with advanced hepatocellular carcinoma
    T S Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Cancer Chemother Pharmacol 44:307-11. 1999
    ....
  32. ncbi request reprint Adjuvant chemoradiation for gastric cancer: experience in the Chinese population
    W K Tsang
    Department of Clinical Oncology, Prince of Wales Hospital, Medical Faculty, The Chinese University of Hong Kong, China
    Clin Oncol (R Coll Radiol) 19:333-40. 2007
    ..Although confirmatory studies are in progress, few data are available regarding its application to the Chinese population. We describe our radiotherapy technique and report the treatment results in Hong Kong...
  33. ncbi request reprint A double-blind placebo-controlled randomized study of Chinese herbal medicine as complementary therapy for reduction of chemotherapy-induced toxicity
    T S K Mok
    Department of Clinical Oncology, Prince of Wales Hospital, Institute of Chinese Medicine, Hong Kong Cancer Institute, Chinese University of Hong Kong, Hong Kong Special Administrative Region HKSAR, China
    Ann Oncol 18:768-74. 2007
    ..This study applied the highest standard of clinical trial methodology to examine the role of CHM in reducing chemotherapy-induced toxicity, while maintaining a tailored approach to therapy...
  34. ncbi request reprint Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients
    S Zhong
    Department of Clinical Oncology, Institute of Molecular Oncology at the Sir Y. K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Ann N Y Acad Sci 945:84-92. 2001
    ..It remains to be elucidated whether such findings are specific to cancer patients or occur in all seriously ill subjects...
  35. ncbi request reprint Quantitative and genotypic analysis of TT virus infection in Chinese blood donors
    S Zhong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Transfusion 41:1001-7. 2001
    ..Its association with specific diseases has not been established, and screening of blood donors has not been implemented. To date, 16 genotypes have been identified...
  36. ncbi request reprint Circulating tumor cell mRNAs in peripheral blood from hepatocellular carcinoma patients under radiotherapy, surgical resection or chemotherapy: a quantitative evaluation
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer Lett 167:183-91. 2001
    ..In conjunction with the serum alpha-fetoprotein test, sequential afp-mRNA quantification could predict clinical metastasis/recurrence in 56% of patients during a 4-year follow-up...
  37. ncbi request reprint Hematogenous dissemination of hepatocytes and tumor cells after surgical resection of hepatocellular carcinoma: a quantitative analysis
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region
    Clin Cancer Res 5:4021-7. 1999
    ..Sequential quantification of both alb and afp mRNAs may provide insights for risk assessment and prognostic indication...
  38. ncbi request reprint Phase II study of Temodal in the treatment of patients with advanced nasopharyngeal carcinoma
    A T Chan
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Cancer Chemother Pharmacol 42:247-9. 1998
    ..A single-institution phase II trial of Temodal (temozolomide, SCH52365) in Chinese patients with advance nasopharyngeal carcinoma was undertaken to determine the efficacy and safety of the drug in this population...
  39. doi request reprint High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinoma
    Henry Lik Yuen Chan
    Department of Clinical Oncology, Sir YK Pao Center for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Oncol 26:177-82. 2008
    ..We aimed to investigate the impact of hepatitis B virus (HBV) DNA and HBV genotypes/subgenotypes on the risk of hepatocellular carcinoma (HCC)...
  40. ncbi request reprint The cost of palliative care for hepatocellular carcinoma in Hong Kong
    A T Chan
    Department of Clinical Oncology, Sir YK Pao Cancer Centre, Chinese University of Hong Kong, Prince of Wales Hospital
    Pharmacoeconomics 19:947-53. 2001
    ..Hepatocellular carcinoma (HCC) is endemic in parts of Asia and Africa and most patients are not suitable for treatment with a curative approach. Little is known about the cost of palliative care for HCC...
  41. ncbi request reprint High carriage rate of TT virus in the cervices of pregnant women
    P K Chan
    Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Clin Infect Dis 32:1376-7. 2001
    ..In this study, a high rate of cervical carriage (66%) of TTV DNA was found by polymerase chain reaction, which suggests that perinatal and sexual transmission is possible...
  42. ncbi request reprint Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial
    A T C Chan
    Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    J Clin Oncol 20:2038-44. 2002
    ..Nasopharyngeal carcinoma (NPC) is highly sensitive to both radiotherapy (RT) and chemotherapy. This randomized phase III trial compared concurrent cisplatin-RT (CRT) with RT alone in patients with locoregionally advanced NPC...
  43. ncbi request reprint Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, serum carcinoembryonic antigen level and tum
    I H Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Cancer Lett 162:65-73. 2001
    ..0001). Of relevance, the CK19 mRNA level increased with advancing Dukes' stage and correlated directly with the serum CEA level (P=0.016). CK19 mRNA quantification may prove valuable for cancer staging and disease monitoring...
  44. ncbi request reprint Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas
    Sheng Zhong
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Administrative Region, China
    Clin Cancer Res 9:3376-82. 2003
    ....
  45. ncbi request reprint Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma
    Anthony T C Chan
    Department of Clinical Oncology, Sir Y K Pao Center for Cancer, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T Hong Kong
    J Natl Cancer Inst 97:536-9. 2005
    ..013, HR = 0.51 [95% CI = 0.3 to 0.88]), favoring the CRT arm. The regimen of weekly concurrent CRT is a promising standard treatment strategy for locoregionally advanced nasopharyngeal carcinoma patients...
  46. doi request reprint Lymphedema and quality of life in Chinese women after treatment for breast cancer
    S S Mak
    Department of Clinical Oncology, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR
    Eur J Oncol Nurs 13:110-5. 2009
    ..To determine the magnitude of arm symptom-associated distress and quality of life in patients suffering from lymphedema after axillary dissection for breast cancer...
  47. ncbi request reprint False-negative rate of abdominal sonography for detecting hepatocellular carcinoma in patients with hepatitis B and elevated serum alpha-fetoprotein levels
    Tony S K Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China
    AJR Am J Roentgenol 183:453-8. 2004
    ....
  48. ncbi request reprint Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas
    Sheng Zhong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    Clin Cancer Res 8:1087-92. 2002
    ....
  49. pmc Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas
    H Jin
    Cancer Epigenetics Laboratory, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Chinese University of Hong Kong, China
    Oncogene 26:7490-8. 2007
    ..Thus, through functional epigenetics, we identified ADAMTS18 as a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas...
  50. pmc Isoelectric focusing of alphafetoprotein in patients with hepatocellular carcinoma--frequency of specific banding patterns at non-diagnostic serum levels
    S Ho
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Br J Cancer 73:985-8. 1996
    ..Bands that are characteristic of hepatocellular carcinoma (bands +II or +III) are seen in the great majority of hepatocellular carcinoma patients; their absence makes a diagnosis of hepatocellular carcinoma extremely unlikely...
  51. ncbi request reprint Hemorrhagic pyelitis, ureteritis, and cystitis secondary to cyclophosphamide: case report and review of the literature
    T M Wong
    Department of Clinical Oncology, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gynecol Oncol 76:223-5. 2000
    ..We report here a patient who developed severe hemorrhagic pyelitis, ureteritis, and cystitis after one cycle of cyclophosphamide-containing combination chemotherapy...
  52. ncbi request reprint Acute toxicity of adjuvant doxorubicin and cyclophosphamide for early breast cancer -- a retrospective review of Chinese patients and comparison with an historic Western series
    Brigette Ma
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Shatin, NT, Hong Kong
    Radiother Oncol 62:185-9. 2002
    ..The higher incidence of hepatoxicity was possibly associated with endemic chronic hepatitis B infection in this geographical area...
  53. ncbi request reprint Prevalence of breast cancer predisposition gene mutations in Chinese women and guidelines for genetic testing
    N L Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, SAR, Hong Kong, China
    Clin Chim Acta 313:179-85. 2001
    ..It is not clear if the differences in cancer incidence between Caucasians and Chinese are due to genetic or environmental factors...
  54. ncbi request reprint Cross-cultural validation of the McGill Quality of Life questionnaire in Hong Kong Chinese
    R S Lo
    Palliative Care Unit, Department of Medicine and Geriatrics, Shatin Hospital, Hong Kong
    Palliat Med 15:387-97. 2001
    ....
  55. ncbi request reprint A Phase I-II study of sequential administration of topotecan and oral etoposide (toposiomerase I and II inhibitors) in the treatment of patients with small cell lung carcinoma
    Tony S K Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China
    Cancer 95:1511-9. 2002
    ..The objectives of this study were to establish the maximum tolerated dose and to determine the efficacy of the sequential combination of intravenous topotecan and oral etoposide in the treatment of patients with SCLC...
  56. doi request reprint Predictors of lymphedema in patients with breast cancer undergoing axillary lymph node dissection in Hong Kong
    So Shan Mak
    Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
    Nurs Res 57:416-25. 2008
    ..The incidence rate of breast cancer is rising rapidly in Hong Kong. Lymphedema is a serious long-term complication of breast cancer surgery and radiation therapy...
  57. doi request reprint Transarterial ethanol ablation of hepatocellular carcinoma with lipiodol ethanol mixture: phase II study
    Simon C H Yu
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Vasc Interv Radiol 19:95-103. 2008
    ..This prospective trial aimed to evaluate the safety and effectiveness of transarterial ethanol ablation (TEA) of intrahepatic lesions of hepatocellular carcinoma (HCC) with a Lipiodol-ethanol mixture...
  58. ncbi request reprint Phase II randomized study comparing the toxicity profile of gemcitabine plus cisplatin with gemcitabine plus oral etoposide in the treatment of advanced non-small cell lung cancer
    Tony S K Mok
    Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China
    Oncology 68:485-92. 2005
    ..This is a randomized phase II study designed to compare the toxicity profile of a non-platinum-based with a platinum-based regimen in the treatment of advanced non-small cell lung cancer...
  59. doi request reprint New utility of an old marker: serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy
    Stephen L Chan
    Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Clin Oncol 27:446-52. 2009
    ..The use of serial alpha-fetoprotein (AFP) in monitoring response has not been rigorously evaluated. We aimed to study the clinical value of AFP trend in an attempt to validate AFP as a surrogate serologic end point...
  60. ncbi request reprint Embolization efficacy and treatment effectiveness of transarterial therapy for unresectable hepatocellular carcinoma: a case-controlled comparison of transarterial ethanol ablation with lipiodol-ethanol mixture versus transcatheter arterial chemoembolizat
    Simon C H Yu
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Vasc Interv Radiol 20:352-9. 2009
    ....
  61. doi request reprint The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines
    Brigette B Y Ma
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Invest New Drugs 28:107-14. 2010
    ..This study provided the basis for a phase II clinical trial of PXD101 in inoperable hepatitis-B associated HCC...
  62. doi request reprint TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance
    Nathalie Wong
    Department of Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Int J Cancer 124:644-52. 2009
    ..5 to 10-fold compared to Doxorubicin alone (p<0.028). Our study highlighted for the first time the prognostic value of TOP2A in HCC and the potential use of TOP2A reactive agents in therapy...
  63. doi request reprint Role of alpha-fetoprotein in hepatocellular carcinoma: prognostication, treatment monitoring or both?
    Stephen L Chan
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Future Oncol 5:889-99. 2009
    ..In this review, the evidence regarding the prognostic value of serum alpha-fetoprotein and the value of serial alpha-fetoprotein in the monitoring of treatment efficacy will be discussed, with emphasis on recent data...
  64. pmc T-cell response to human papillomavirus type 58 L1, E6, And E7 peptides in women with cleared infection, cervical intraepithelial neoplasia, or invasive cancer
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Clin Vaccine Immunol 17:1315-21. 2010
    ..In summary, this study has identified a few immunogenic epitopes for HPV-58 E6 and E7 proteins. It is worthwhile to further investigate whether responses to these epitopes have a role in clearing an established cervical lesion...
  65. ncbi request reprint Phase II study of neoadjuvant carboplatin and paclitaxel followed by radiotherapy and concurrent cisplatin in patients with locoregionally advanced nasopharyngeal carcinoma: therapeutic monitoring with plasma Epstein-Barr virus DNA
    Anthony T C Chan
    Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 22:3053-60. 2004
    ....
  66. ncbi request reprint An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results
    Tony S K Mok
    Department of Clinical Oncology, Prince of Wales Hospital, School of Public Health, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Clin Oncol 23:8041-7. 2005
    ..To study the incidence and treatment outcomes of hepatocellular carcinoma (HCC) detected in an intensive surveillance program (ISP) of hepatitis B virus (HBV) carriers...
  67. ncbi request reprint A phase I safety and pharmacokinetic study of OGT 719 in patients with liver cancer
    Tony S K Mok
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong, China
    Acta Oncol 43:245-51. 2004
    ..None of the patients had a significant tumor response. Elimination half-life of OGT 719 by 3-h intravenous infusion is short and monophasic. Toxicity was minimal at the highest dose level...
  68. ncbi request reprint Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Hepatology 45:1382-9. 2007
    ..0217; hazard ratio = 1.650; 95% CI 1.076-2.531) affected survival significantly. Exploratory analysis revealed that high levels of pretreatment HBV DNA had a significantly higher incidence of severe hepatitis during chemotherapy...
  69. ncbi request reprint Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study
    Tony S K Mok
    Department of Clinical Oncology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Oncology 71:292-6. 2006
    ..In this study, the cytotoxic effects of patupilone (epothilone B; EPO906) were assessed in a panel of hepatocellular carcinoma (HCC) cell lines, and were compared with doxorubicin and the microtubule-stabilizing taxanes...
  70. ncbi request reprint Sequential chemotherapy with combination irinotecan and cisplatin followed by docetaxel for treatment-naïve patients with advanced non-small cell lung cancer
    Tony S K Mok
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Department of Clinical Oncology and Hong Kong Cancer Institute, The Chinese University of Hong Kong, Shatin, New Territories, China
    J Thorac Oncol 2:838-44. 2007
    ..This study was designed to evaluate the efficacy and tolerability of sequential administration of irinotecan and cisplatin and then docetaxel in patients with advanced non-small cell lung cancer (NSCLC)...
  71. ncbi request reprint A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women
    S S C Chan
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    BJOG 114:1510-5. 2007
    ..To study the prophylactic use of levonorgestrel intrauterine system (LNG-IUS) in the prevention of endometrial pathology in women having breast cancer treated with tamoxifen...
  72. ncbi request reprint Brain metastasis responding to gefitinib alone
    Annette N Y Poon
    Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China
    Oncology 67:174-8. 2004
    ..The patient remains well 9 months after initiation of gefitinib. It is proposed that gefitinib may have a role in treatment of brain metastases from NSCLC...
  73. doi request reprint Validation of the Chinese version of the short-form Supportive Care Needs Survey Questionnaire (SCNS-SF34-C)
    A Au
    Centre for Psycho Oncology Research and Training, Department of Community Medicine and Unit for Behavioural Sciences, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong
    Psychooncology 20:1292-300. 2011
    ..This study aimed to assess the validity and reliability of the Chinese version of the Supportive Care Needs Survey short form (SCNS-SF34-C) in Chinese women with breast cancer (BC)...
  74. ncbi request reprint Chemotherapy induced complete remission in malignant phyllodes tumor of the prostate metastasizing to the lung
    Kwok Chi Lam
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince Wales Hospitals, Shatin, New Territories, Hong Kong
    J Urol 168:1104-5. 2002
  75. ncbi request reprint Imatinib-induced interstitial lung disease and sunitinib-associated intra-tumour haemorrhage
    H H Loong
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 14:495-8. 2008
    ..This case report illustrates the dilemmas and complexities associated with treating patients with gastro-intestinal stromal tumours with the new tyrosine kinase inhibitors...
  76. ncbi request reprint Knowledge, perceptions, and attitudes of Hong Kong Chinese women on screening mammography and early breast cancer management
    Margaret S T Chua
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Breast J 11:52-6. 2005
    ..Interventions to improve the accuracy of information and to encourage preventive health care behaviors will have a positive impact on establishing cancer screening programs and providing quality cancer care in the future...
  77. ncbi request reprint Unusual abdominal tumors: case 4. Multiple lymphomatous polyposis in mantle cell lymphoma
    Kwok C Lam
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, People s Republic of China
    J Clin Oncol 21:955-6. 2003
  78. ncbi request reprint Delayed radiation myelopathy after concurrent chemoradiation for hypopharyngeal-esophageal carcinoma
    Lam Chan
    Acta Oncol 44:177-9. 2005
  79. doi request reprint The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle
    Guo Hua Qiu
    Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore
    J Hepatol 48:433-41. 2008
    ..The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor suppressor genes. DLEC1 was selected for further characterization in primary hepatocellular carcinomas and cell lines...
  80. ncbi request reprint Prediction of chemotherapeutic response in ovarian cancer with DNA microarray expression profiling
    Zachariah E Selvanayagam
    Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
    Cancer Genet Cytogenet 154:63-6. 2004
    ..Hence, gene expression profiling by means of DNA microarray may be applied diagnostically for predicting treatment response in ovarian cancer...
  81. ncbi request reprint Quality of life of palliative care patients in the last two weeks of life
    Raymond S K Lo
    Palliative Care Unit, Department of Medicine and Geriatrics, Shatin Hospital, 33 A Kung Kok Street, Ma On Shan, New Territories, Hong Kong
    J Pain Symptom Manage 24:388-97. 2002
    ..04). In conclusion, QOL evaluation during the terminal phase identifies important aspects requiring improvement during the last two weeks of life. Physical and existential domains of dying cancer patients needed more attention...