Thian Sze Wong
Affiliation: The University of Hong Kong
Wong T, Ho W, Chan J, Ng R, Wei W. Mature miR-184 and squamous cell carcinoma of the tongue. ScientificWorldJournal. 2009;9:130-2 pubmed publisher
..The data suggested that miR-184 is linked to the pathogenesis of tongue SCC. Further studies are warranted to evaluate the use of microRNA-based serological markers in monitoring tongue SCC. ..
Wong T, Liu X, Wong B, Ng R, Yuen A, Wei W. Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue. Clin Cancer Res. 2008;14:2588-92 pubmed publisher
..The aim of this study was to evaluate the microRNA expression patterns in squamous cell carcinoma (SCC) of the tongue...
Wong T, Man O, Tsang C, Tsao S, Tsang R, Chan J, et al
. MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression. J Cancer Res Clin Oncol. 2011;137:415-22 pubmed publisher
..DNA methylation is a potential regulatory pathway, which is affected when let-7 is suppressed in NPC cells. However, the extent of DNA hypermethylation/hypomethylation in regulating let-7 expression requires further elucidation. ..
Wong T, Chan W, Li C, Liu R, Tang W, Tsao S, et al
. Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin. Anticancer Res. 2010;30:2851-6 pubmed
..The negative correlation of NF-kappaB and E-cadherin was confirmed in the mouse xenograft model. Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-kappaB and activating E-cadherin expression. ..