N Wong

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Transcriptional profiling identifies gene expression changes associated with IFN-alpha tolerance in hepatitis C-related hepatocellular carcinoma cells
    Nathalie Wong
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Clin Cancer Res 11:1319-26. 2005
  2. ncbi request reprint A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping
    N Wong
    Departments of Clinical Oncology at the Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, SAR Hong Kong, China
    Hepatology 32:1060-8. 2000
  3. pmc Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma
    N Wong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Am J Pathol 159:465-71. 2001
  4. doi request reprint TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance
    Nathalie Wong
    Department of Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Int J Cancer 124:644-52. 2009
  5. ncbi request reprint Molecular cytogenetic characterization of nasopharyngeal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping
    Nathalie Wong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, China
    Cancer Genet Cytogenet 140:124-32. 2003
  6. ncbi request reprint Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression
    Nathalie Wong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, SAR Hong Kong, People s Republic of China
    J Hepatol 38:298-306. 2003
  7. ncbi request reprint Differential gene expression of hepatocellular carcinoma using cDNA microarray analysis
    W Y Lau
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, SAR
    Oncol Res 12:59-69. 2000
  8. ncbi request reprint Karyotypic imbalances and differential gene expressions in the acquired doxorubicin resistance of hepatocellular carcinoma cells
    Elizabeth Pang
    Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Lab Invest 85:664-74. 2005
  9. ncbi request reprint Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma
    Kathy Y Y Chan
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, People s Republic of China
    Int J Cancer 114:902-8. 2005
  10. ncbi request reprint Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest
    Jennifer W M Gho
    Li Ka Shing Institute of Health Sciences, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cancer Res 68:6743-51. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Transcriptional profiling identifies gene expression changes associated with IFN-alpha tolerance in hepatitis C-related hepatocellular carcinoma cells
    Nathalie Wong
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Clin Cancer Res 11:1319-26. 2005
    ..Hence, delineation of molecular targets implicated in the resistant pathway holds value in refining the therapeutic benefits of IFN-alpha...
  2. ncbi request reprint A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping
    N Wong
    Departments of Clinical Oncology at the Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, SAR Hong Kong, China
    Hepatology 32:1060-8. 2000
    ..These breakpoint clusters may thus prove to be more important in the liver carcinogenesis and targets for further molecular investigations...
  3. pmc Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma
    N Wong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Am J Pathol 159:465-71. 2001
    ..Our findings suggest a role for Sat2 demethylation in the early stages of the stepwise progression of liver carcinogenesis...
  4. doi request reprint TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance
    Nathalie Wong
    Department of Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Int J Cancer 124:644-52. 2009
    ..5 to 10-fold compared to Doxorubicin alone (p<0.028). Our study highlighted for the first time the prognostic value of TOP2A in HCC and the potential use of TOP2A reactive agents in therapy...
  5. ncbi request reprint Molecular cytogenetic characterization of nasopharyngeal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping
    Nathalie Wong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, China
    Cancer Genet Cytogenet 140:124-32. 2003
    ..These breakpoints included 3p21, 3q26, 5q31, 6p21.1 approximately p25, 7p14 approximately p22, and 8q22. Our finding of regional gains and losses and breakpoints represents information that may contribute to NPC studies in vitro...
  6. ncbi request reprint Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression
    Nathalie Wong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, SAR Hong Kong, People s Republic of China
    J Hepatol 38:298-306. 2003
    ..Current cytogenetic evidences confer much importance on 1q21-q22, where a role in drug resistance, tumor metastasis and shorter patient survival had been implicated...
  7. ncbi request reprint Differential gene expression of hepatocellular carcinoma using cDNA microarray analysis
    W Y Lau
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, SAR
    Oncol Res 12:59-69. 2000
    ..It is concluded that cDNA microarray analysis is an effective method in the detection of differential gene expression in HCC...
  8. ncbi request reprint Karyotypic imbalances and differential gene expressions in the acquired doxorubicin resistance of hepatocellular carcinoma cells
    Elizabeth Pang
    Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Lab Invest 85:664-74. 2005
    ..Our present study highlighted areas of genomic imbalances and candidate genes in the acquired doxorubicin-resistance behavior of HCC cells...
  9. ncbi request reprint Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma
    Kathy Y Y Chan
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, People s Republic of China
    Int J Cancer 114:902-8. 2005
    ..001). In our study, the novel finding of common ACP5 downregulation in HCC may provide basis for further investigations on the role of acid phosphatase in hepatocarcinogenesis...
  10. ncbi request reprint Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest
    Jennifer W M Gho
    Li Ka Shing Institute of Health Sciences, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cancer Res 68:6743-51. 2008
    ..In conclusion, our finding supports a tumor suppressive role for ATF5 in HCC, and highlighted ID1 as a potential downstream target...
  11. ncbi request reprint Genetic alterations in doxorubicin-resistant hepatocellular carcinoma cells: a combined study of spectral karyotyping, positional expression profiling and candidate genes
    Ying Hu
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Int J Oncol 25:1357-64. 2004
    ..Our present study highlights the usefulness of multimodality approaches in identifying genetic markers, and further describes the novel finding of ECHS1 down-regulation in the DX chemo-resistance of HCC...
  12. ncbi request reprint Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas
    Sheng Zhong
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Administrative Region, China
    Clin Cancer Res 9:3376-82. 2003
    ....
  13. ncbi request reprint Identification of PEG10 as a progression related biomarker for hepatocellular carcinoma
    Wai Ki Ip
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Cancer Lett 250:284-91. 2007
    ..Our results also suggested that PEG10 may be a potential biomarker in the progressive development of HCC, and that genomic gain represents one of the major mechanisms in the induction of PEG10 over-expressions...
  14. ncbi request reprint Novel identification of zyxin upregulations in the motile phenotype of hepatocellular carcinoma
    Shirley M H Sy
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, NT, SAR Hong Kong, China
    Mod Pathol 19:1108-16. 2006
    ..005). In summary, mapping of chromosome 7q34-q36 has led to the identification of frequent zyxin overexpressions in hepatocellular carcinoma, and a potential role for zyxin in conferring a motile phenotype...
  15. ncbi request reprint Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines
    Elizabeth Pang
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, SAR Hong Kong, China
    Genes Chromosomes Cancer 33:150-9. 2002
    ....
  16. ncbi request reprint Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma
    Kathy Y Y Chan
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, SAR Hong Kong, China
    Mod Pathol 19:1546-54. 2006
    ..016). In summary, transcriptional mapping by microarray indicated a number of previously undescribed downregulated genes in hepatocellular carcinoma, and highlighted potential candidates within common deleted regions...
  17. ncbi request reprint Distinct patterns of genetic alterations in adenocarcinoma and squamous cell carcinoma of the lung
    S M H Sy
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, SAR Hong Kong, China
    Eur J Cancer 40:1082-94. 2004
    ..Specific chromosomal imbalances and translocation partners found in SqC and AdC have highlighted regions for further molecular investigation into gene(s) that may hold importance in the carcinogenesis of NSCLC...
  18. ncbi request reprint Regional over-representations on chromosomes 1q, 3q and 7q in the progression of hepatitis B virus-related hepatocellular carcinoma
    Shirley M H Sy
    Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, N T, SAR Hong Kong, China
    Mod Pathol 18:686-92. 2005
    ..05). In this study, our novel identification of specific chromosomal aberrations in relation to the advanced stage tumors may represent a first step towards mapping genes linked to the progression of hepatocellular carcinoma...
  19. doi request reprint MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1
    Queenie W L Wong
    Department of Anatomical and Cellular Pathology at the Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, SAR Hong Kong, China
    Gastroenterology 135:257-69. 2008
    ..Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined...
  20. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A in tumor and plasma of patients with hepatocellular carcinoma
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Liver Int 25:266-72. 2005
    ..To determine the presence of ras association domain family 1A (RASSF1A) promoter methylation in the tumor tissues and plasma of patients with hepatocellular carcinoma (HCC)...
  21. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A in tumorous and non-tumourous tissue of breast cancer
    Winnie Yeo
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Pathology 37:125-30. 2005
    ..To determine the presence of RASSF1A promoter methylation in tumorous and non-tumorous tissues of breast cancer...
  22. ncbi request reprint Clonal relationship of tumor nodules in hepatocellular carcinoma: a hierarchical clustering analysis of comparative genomic hybridization data
    Queenie Wing Lei Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, SAR Hong Kong, China
    Hum Pathol 36:893-8. 2005
    ..3%) of 24 cases to cluster concordantly, signifying a high incidence of clonal similarity. In sum, bioinformatic analysis of genomic profiles may represent a reliable research tool in analyzing clonal relationships among tumor nodules...
  23. ncbi request reprint Spectral karyotyping indicates complex rearrangements in lung adenocarcinoma of nonsmokers
    Shirley Ming Hui Sy
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, SAR Hong Kong, China
    Cancer Genet Cytogenet 153:57-9. 2004
    ..Simple and complex structural rearrangements were indicated. A ploidy status of hypertetraploidy was suggested in both cases, with recurring derivative translocations involving chromosome arms 3q, 8q, 12q, 15q, 22q, and Xq...
  24. doi request reprint Reduced CRYL1 expression in hepatocellular carcinoma confers cell growth advantages and correlates with adverse patient prognosis
    Ibis K C Cheng
    Department of Anatomical and Cellular Pathology at the Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Pathol 220:348-60. 2010
    ..Given that regional chromosome 13q12-q14 loss is a causal genomic event in HCC tumourigenesis, our finding may have implications for identifying a novel TSG CRYL1 within this important locus...
  25. ncbi request reprint Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: a pilot study
    Terence C W Poon
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong Special Administrative Region, China
    Clin Chem 51:328-35. 2005
    ..This study was designed to identify serum proteomic signatures associated with liver fibrosis and to develop a proteome-based fingerprinting model for prediction of liver fibrosis...
  26. ncbi request reprint Chromosomal aberrations of multiple myeloma in Chinese patients at diagnosis: a study by combined G-banding and multicolor spectral karyotyping
    Margaret Heung Ling Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T Hong Kong SAR
    Oncol Rep 10:587-91. 2003
    ..However, there were notably higher incidences of -22/22q- (4/11) and structural aberrations of chromosome X but a lower incidence of -X. The biological implications of these findings, if confirmed, deserve further evaluation...
  27. ncbi request reprint Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
    Alfred S L Cheng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
    Int J Oncol 23:113-9. 2003
    ..In conclusion, specific COX-2 inhibitor suppresses cell proliferation and induces apoptosis in HCC cell lines that express COX-2. Our finding suggests that COX-2 inhibition may offer a new approach for HCC chemoprevention...
  28. ncbi request reprint Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma
    Nathalie Wong
    Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    J Hepatol 37:633-9. 2002
    ..Cholangiocarcinoma comprises 5-20% of all primary malignant tumors of the liver. However, the lack of information about the genetic basis of cholangiocarcinoma has impeded characterization and understanding of its biological behavior...
  29. ncbi request reprint Recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13 in Chinese IgD multiple myeloma detected by G-banding and multicolor spectral karyotyping: a review of IgD karyotype literature
    M H Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T. Hong Kong SAR
    Hum Pathol 32:1016-20. 2001
    ..We also identified recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13, which may suggest to be unique aberrations that may underline the pathogenesis of this distinctive biological MM subtype...
  30. ncbi request reprint Identification of PFTAIRE protein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells
    Etonia Y T Pang
    Li Ka Shing Institute of Health, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Hepatology 46:436-45. 2007
    ..CONCLUSION: In this study, we have thus provided preliminary evidence that overexpression of PFTK1 may confer a motile phenotype in malignant hepatocytes that accounts for the association of upregulation of this gene in metastatic HCC...
  31. ncbi request reprint A tumor progression model for hepatocellular carcinoma: bioinformatic analysis of genomic data
    Terence C W Poon
    Department of Medicine and Therapeutics, Sir Y K Pao Cancer Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, N T, Hong Kong, The People s Republic of China
    Gastroenterology 131:1262-70. 2006
    ..Aberrant patterns of chromosomal changes may represent useful information that can be used in classifying the complex traits of liver cancer cases for the genetic events involved in tumor carcinogenesis, tumor progression, and prognosis...
  32. pmc Regulation of APC/CCdc20 activity by RASSF1A-APC/CCdc20 circuitry
    C Chow
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Oncogene 31:1975-87. 2012
    ..This circuitry is essential for the timely degradation of Cyclin A. To conclude, our results propose a new model for RASSF1A-APC/C(Cdc20) interaction in ensuring the sequential progression of mitosis...
  33. doi request reprint A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility
    W K C Leung
    Department of Anatomical and Cellular Pathology at the Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin
    Oncogene 30:4464-75. 2011
    ..Taken together, our data propose a novel, oncogene-tumor suppressor interplay, where oncogenic PFTK1 confers HCC cell motility through inactivating the actin-binding motile suppressing function of TAGLN2 via phosphorylation...
  34. pmc Consistent copy number gain in chromosome 12 in primary diffuse large cell lymphomas of the stomach
    W Y Chan
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Am J Pathol 152:11-6. 1998
    ..Our findings suggested that many DLCL were not derived from transformation of low grade MALT lymphomas...
  35. ncbi request reprint Sinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniques
    K F Wong
    Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, SAR, Hong Kong, China
    Cancer Genet Cytogenet 129:64-8. 2001
    ..The identification of these karyotypic changes has been facilitated by the application of comparative genomic hybridization and spectral karyotyping...
  36. ncbi request reprint Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes
    S W Tsao
    Department of Anatomy, Faculty of Medicine, University of Hong Kong, SAR, Hong Kong, China
    Cancer Genet Cytogenet 130:141-9. 2001
    ..Identification of nonrandom chromosomal imbalance in immortalized HOSE cells may facilitate the identification of specific chromosomes harboring genes involved in the immortalization of human ovarian surface epithelial cells...
  37. ncbi request reprint Identification of four distinct regions of allelic imbalances on chromosome 1 by the combined comparative genomic hybridization and microsatellite analysis on hepatocellular carcinoma
    Thomas H Y Leung
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Mod Pathol 15:1213-20. 2002
    ..The SORs delineated should provide basis for further molecular investigation in hepatocarcinogenesis on genes residing on these chromosomal regions...
  38. doi request reprint MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling
    Queenie W L Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Cancer Res 16:867-75. 2010
    ..This study aims to profile the expressions of 156 microRNAs (miRNA) in hepatocellular carcinoma (HCC) and to characterize the functions of miR-222, the most significantly upregulated candidate identified...
  39. doi request reprint Elevated perioperative transaminase level predicts intrahepatic recurrence in hepatitis B-related hepatocellular carcinoma after curative hepatectomy
    Yue Sun Cheung
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR
    Asian J Surg 31:41-9. 2008
    ....
  40. ncbi request reprint Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity
    Shirley M H Sy
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, SAR, Hong Kong
    Lung Cancer 41:91-9. 2003
    ..006). In particular, regional over-representations of 13q21-q34 (P=0.044), 17q25 (P=0.015), 19q13.1 (P=0.044) and 22q (P=0.044) may have implications for the pathologic pathways associated with the tobacco-related lung adenocarcinoma...
  41. ncbi request reprint High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis
    Richard K T Kam
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Clin Chem 53:1254-63. 2007
    ..In this study, we attempted to establish a high-throughput quantitative assay for profiling serum N-glycome, and we applied the new assay to identifying serum N-glycans for diagnosis of liver fibrosis and cirrhosis...
  42. ncbi request reprint RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
    Alfred S L Cheng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Cancer Lett 253:43-52. 2007
    ..These results suggest that RNA interference-mediated HBx suppression exerts potent anti-proliferative and chemosensitizing effects in human HCC...
  43. ncbi request reprint Size distributions of maternal and fetal DNA in maternal plasma
    K C Allen Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Clin Chem 50:88-92. 2004
    ..The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive prenatal diagnosis. Despite the rapid expansion in clinical applications, the molecular characteristics of plasma DNA in pregnant women remain unclear...
  44. ncbi request reprint Investigation of the genomic representation of plasma DNA in pregnant women by comparative genomic hybridization analysis: a feasibility study
    K C Allen Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region
    Clin Chem 51:2398-401. 2005
  45. ncbi request reprint Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and involvement of alpha B-crystallin in nasopharyngeal carcinoma
    Hong Lok Lung
    Department of Biology and Center for Cancer Research, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Int J Cancer 122:1288-96. 2008
    ..Both promoter hypermethylation and allelic loss may be involved in the inactivation of this gene, suggesting its possible role in NPC development...
  46. ncbi request reprint Generation of hybrid cell lines with endothelial potential from spontaneous fusion of adult bone marrow cells with embryonic fibroblast feeder
    Jianwen Que
    National University Medical Institute, National University of Singapore, Singapore
    In Vitro Cell Dev Biol Anim 40:143-9. 2004
    ....
  47. ncbi request reprint Profiling genomic copy number changes in retinoblastoma beyond loss of RB1
    Ella Bowles
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Genes Chromosomes Cancer 46:118-29. 2007
    ..Gene specific analysis of one bone marrow metastasis of RB, prechemotherapy and postchemotherapy, showed the typical genomic changes of RB pretreatment, which normalized after chemotherapy...
  48. ncbi request reprint Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells
    Pok Man Hau
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
    FEBS Lett 580:4727-36. 2006
    ..An implication for chemotherapy is that some cancer cells can be sensitized to genotoxic agents by a preceding step that induces polyploidization...