Research Topics
| Lawrence KS WongSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
| Collaborators
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Detail Information
Publications
Progression of middle cerebral artery occlusive disease and its relationship with further vascular events after strokeKa Sing Wong
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR
Stroke 33:532-6. 2002..Serial changes of flow velocities of transcranial Doppler ultrasound (TCD) in symptomatic middle cerebral artery (MCA) occlusive disease may be related to the occurrence of further vascular events, but prospective data are lacking...
Use of magnetic resonance angiography to predict long-term outcomes of ischemic stroke patients with concurrent stenoses in Hong KongB L Man
Division of Neurology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, SAR, China
Cerebrovasc Dis 28:112-8. 2009..To determine the long-term outcome of ischemic stroke patients with concurrent intracranial and extracranial atherosclerosis using magnetic resonance angiography...
Correlation of large artery intracranial occlusive disease with carotid intima-media thickness and presence of carotid plaqueXin Yi Leng
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
Stroke 44:68-72. 2013..Carotid intima-media thickness (CIMT) and presence of carotid plaque are also related to subsequent ischemic stroke. However, the correlation between these and LAICOD is less clear...
External counterpulsation augments blood pressure and cerebral flow velocities in ischemic stroke patients with cerebral intracranial large artery occlusive diseaseWenhua Lin
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong Kong SAR
Stroke 43:3007-11. 2012..We hypothesized that ECP may augment cerebral blood flow of ischemic stroke patients via induced hypertension...
Current management of intracerebral haemorrhage in China: a national, multi-centre, hospital register studyJade W Wei
The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia
BMC Neurol 11:16. 2011..We aimed to examine current practice of the management and secondary prevention of intracerebral haemorrhage (ICH) in China where the disease is more common than in Western populations...
Variability of magnetic resonance angiography and computed tomography angiography in grading middle cerebral artery stenosisK S Wong
Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Stroke 27:1084-7. 1996..We sought to study the interobserver and intraobserver variabilities of magnetic resonance angiography and computed tomography angiography in grading middle cerebral artery stenosis...
Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised studyKa Sing Wong
Department of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
Lancet Neurol 6:407-13. 2007..We compared the efficacy of a low-molecular-weight heparin (LMWH), nadroparin calcium, with aspirin in Asian acute stroke patients with LAOD...
A door-to-door survey of intracranial atherosclerosis in Liangbei County, ChinaK S Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Neurology 68:2031-4. 2007..53; 95% CI 1.12 to 5.72), glycosuria (OR 3; 1.19 to 7.97), heart disease (OR 4; 1.39 to 11.6), and family history of stroke (OR 5.2; 1.38 to 20). Intracranial atherosclerosis is not uncommon among asymptomatic Chinese subjects...
Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhagesK S Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
Neurology 60:511-3. 2003..001) and more extensive (mean number of microbleeds 13.3 vs 0.4, p < 0.001) in the intracerebral hemorrhage group than in the control group. Asymptomatic microbleeds may be a risk factor for aspirin-associated intracerebral hemorrhage...
Mechanisms of acute cerebral infarctions in patients with middle cerebral artery stenosis: a diffusion-weighted imaging and microemboli monitoring studyKa Sing Wong
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR
Ann Neurol 52:74-81. 2002....
Long-term mortality and recurrent stroke risk among Chinese stroke patients with predominant intracranial atherosclerosisKa Sing Wong
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR
Stroke 34:2361-6. 2003..The goal of this study was to document the long-term outcome of ischemic stroke patients in a population with predominant intracranial atherosclerosis and risk factors for a recurrent event...
Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel diseaseAdrian Wong
Dept of Medicine and Therapeutics Chinese, University of Hong Kong, Prince of Wales Hospital Shatin, New Territories, Hong Kong
J Neurol 253:441-7. 2006....
Is the measurement of cerebral microembolic signals a good surrogate marker for evaluating the efficacy of antiplatelet agents in the prevention of stroke?K S Lawrence Wong
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China
Eur Neurol 53:132-9. 2005..Studies currently in progress should provide further insight into the value of the measurement of MES in clinical studies in stroke prevention...
Global burden of intracranial atherosclerosisLawrence K S Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Int J Stroke 1:158-9. 2006
A pilot study of microembolic signals in patients with middle cerebral artery stenosisK S Wong
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
J Neuroimaging 11:137-40. 2001..The number of emboli ranged from 1 to 6 per 30 minutes. This is the first report of the presence of microembolic signals in acute stroke patients with MCA stenosis...
Low-molecular-weight heparin versus aspirin for acute ischemic stroke with large artery occlusive disease: subgroup analyses from the Fraxiparin in Stroke Study for the treatment of ischemic stroke (FISS-tris) studyQiao shu Wang
Department of Neurology, Shanghai First People s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, PR China
Stroke 43:346-9. 2012..This study aims to evaluate the efficacy of LMWH and aspirin in selected subgroups so as to generate hypotheses for further studies...
Use of transcranial Doppler ultrasound to predict outcome in patients with intracranial large-artery occlusive diseaseK S Wong
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR
Stroke 31:2641-7. 2000..Relatively little is known about the clinical significance of finding such lesions. We investigate whether the presence and the extent of these vascular lesions help predict outcome after stroke...
Risk factors for early death in acute ischemic stroke and intracerebral hemorrhage: A prospective hospital-based study in Asia. Asian Acute Stroke Advisory PanelK S Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Stroke 30:2326-30. 1999..In Asia, there has been no international study to investigate the risk factors for early death in patients with ischemic stroke and intracerebral hemorrhage...
Prevalence of asymptomatic intracranial atherosclerosis in high-risk patientsK S Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Neurology 68:2035-8. 2007..The prevalence escalated quadratically with increasing number of associated factors: from 7.2% for one, to 29.6% for four associated factors. Asymptomatic middle cerebral artery stenosis is common in patients with vascular risk factors...
Multiple acute cerebral infarcts on diffusion-weighted imaging and risk of recurrent strokeH M Wen
Division of Neurology, Department of Medicine, Chinese University of Hong Kong, Hong Kong
Neurology 63:1317-9. 2004..MACI was the only significant independent predictor for vascular events and death (odd ratio [OR]] = 4.34; p = 0.001) and stroke recurrence (OR = 5.93; p = 0.001)...
Long-term outcomes of ischemic stroke patients with concurrent intracranial and extracranial stenoses and ischemic heart diseaseB L Man
Division of Neurology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, SAR, China
Cerebrovasc Dis 29:236-41. 2010..This study aims to investigate the long-term outcomes of ischemic stroke patients with concurrent stenoses and IHD...
Electrophysiological, clinical and epidemiological study of Guillain-Barre Syndrome in Hong Kong ChineseAndrew C F Hui
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, The Chinese University of Hong Kong, Hong Kong SAR, China
J Clin Neurosci 12:134-6. 2005..The majority of cases in this locality consists of the demyelinating form of GBS; epidemic, acute motor axonal neuropathy is not the predominant form. The incidence of GBS in this region of China was 0.44 per 100,000...
Genetic predisposition of white matter infarction with protein S deficiency and R355C mutationT W Leung
Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Neurology 75:2185-9. 2010..The association between protein S deficiency (PSD) and ischemic stroke is controversial and warrants further investigation...
Cerebral microbleeds and symptom severity of post-stroke depression: a magnetic resonance imaging studyW K Tang
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
J Affect Disord 129:354-8. 2011..This study examines the association between post-stroke depression (PSD) symptom severity and CMBs...
White matter hyperintensities in post-stroke depression: a case control studyW K Tang
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
J Neurol Neurosurg Psychiatry 81:1312-5. 2010..The aim of this study was to evaluate the relationship between WMHs and PSD in Chinese patients with first or recurrent stroke...
Potential value of post stroke extracranial arterial blood flow volume in the prediction of stroke functional outcomeStella S Y Ho
Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, SAR, China
Cerebrovasc Dis 21:54-9. 2006..This study attempted to explore the potential value of post stroke extracranial arterial blood flow volume in the prediction of stroke patients' functional outcome...
Microbleeds and post-stroke emotional labilityW K Tang
Department of Psychiatry, Shatin Hospital, Shatin, NT, Hong Kong SAR, China
J Neurol Neurosurg Psychiatry 80:1082-6. 2009..Lesions located in various cortical and subcortical areas are thought to be involved in the pathophysiology of post-stroke emotional lability (PSEL). This study examined the association between PSEL and MBs...
Carotid intima-media thickness in patients with head and neck irradiation for the treatment of nasopharyngeal carcinomaN M C So
Departments of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Hong Kong
Clin Radiol 57:600-3. 2002..In this study, we aimed to examine the IMT in patients with nasopharyngeal carcinoma (NPC) who received irradiation to the carotid arteries during radiotherapy, and compared them with a control group...
Long-term outcome of carpal tunnel syndrome after conservative treatmentA C F Hui
Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Int J Clin Pract 58:337-9. 2004..Few patients who were not operated on (11.4%) remain asymptomatic...
Incidence of carotid stenosis in nasopharyngeal carcinoma patients after radiotherapyW W Lam
Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR China
Cancer 92:2357-63. 2001..This study examined the incidence of stenosis in the extracranial carotid arteries of nasopharyngeal carcinoma patients after radiotherapy...
Clinically underdetected asymptomatic and symptomatic carotid stenosis as a late complication of radiotherapy in Chinese nasopharyngeal carcinoma patientsW W Lam
Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Head Neck 23:780-4. 2001..This complication has, however, a significant impact with increased risk of stroke causing mortality and morbidity. Clinicians' awareness of this complication and early detection is therefore important...
B0 images obtained from diffusion-weighted echo planar sequences for the detection of intracerebral bleedsW W M Lam
Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, Ngan Shing Street, Shatin, New Territories, Hong Kong
J Neuroimaging 13:99-105. 2003..To evaluate the accuracy of B0 echo planar imaging (EPI) sequences for the detection of intracerebral bleeds...
Local vs systemic corticosteroids in the treatment of carpal tunnel syndromeS M Wong
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
Neurology 56:1565-7. 2001..This study demonstrated the superiority of local steroid injection to oral steroid in the treatment of CTS...
Recurrence after a first untreated seizure in the Hong Kong Chinese populationA C Hui
Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong Special Administrative Region, China
Epilepsia 42:94-7. 2001..Estimates for the risk of recurrence range from 26 to 71%. We investigated the likelihood of a second attack in Hong Kong Chinese patients...
Hyperintense middle cerebral artery sign using MRIW W M Lam
Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
Clin Radiol 58:542-4. 2003..The results were also compared with computed tomography (CT)...
Sonographic characterisation of radiation-induced carotid artery stenosisW W M Lam
Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, ROC
Cerebrovasc Dis 13:168-73. 2002..To study the distribution, extent and sonographic characterisation of radiation-induced carotid artery stenosis in nasopharyngeal carcinoma (NPC) patients...
Transcranial Doppler evaluation of microembolism immediately after direct-current cardioversion for atrial fibrillation in anticoagulated patientsR Kay
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, China
Am J Cardiol 84:937-8, A7. 1999..Transcranial Doppler monitoring showed no evidence of microemboli for 10 minutes after direct-current cardioversion for atrial fibrillation...
Plaque volume measurement by magnetic resonance imaging as an index of remodeling of middle cerebral artery: correlation with transcranial color Doppler and magnetic resonance angiographyW W M Lam
Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
Cerebrovasc Dis 17:166-9. 2004..The results were correlated with magnetic resonance angiography (MRA) and transcranial color Doppler (TCD) findings...
Status epilepticus in Hong Kong Chinese: aetiology, outcome and predictors of death and morbidityAndrew C F Hui
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China
Seizure 12:478-82. 2003..04, 95% CI 1.01-1.07), delay in treatment (OR=3.52, 95%CI 1.01-12.18), SE due to cerebrovascular disease (OR=9.73, 95% CI 1.58-59.96) and CNS infection (OR=30.27, 95% CI 3.14-292.19)...
Have medical therapy and stenting been fairly compared? A repercussion upon termination of recruitment in the SAMMPRIS trialThomas W Leung
Department of Medicine and Therapeutics, Division of Neurology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Int J Stroke 6:312-4. 2011..The authors discussed on the potential pitfalls, which may render this conclusion premature and explained the needs for continuing efforts in investigating treatment for intracranial stenosis...
Refractory epilepsy in a Chinese populationAndrew C F Hui
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Clin Neurol Neurosurg 109:672-5. 2007..To investigate the proportion of Chinese patients with intractable seizures and the risk factors leading to refractory epilepsy...
Agreement between initial and final diagnosis of first seizures, epilepsy and non-epileptic events: a prospective studyH Leung
Department of Medicine and Therapeutics, Division of Neurology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
J Neurol Neurosurg Psychiatry 79:1144-7. 2008..This study aims to investigate the agreement between the initial diagnosis at the accident and emergency (A&E) department and the final diagnosis following inpatient neurological evaluation of seizure disorders...
Consensus statement on ischaemic stroke care in Hong KongP W Ng
Department of Medicine, United Christian Hospital, Kwun Tong, Hong Kong
Hong Kong Med J 10:124-9. 2004..To issue guidelines for the care of acute stroke in Hong Kong, with the target audience of all health care professionals who are involved in acute stroke care...
The significance of microembolic signals and new cerebral infarcts on the progression of neurological deficit in acute stroke patients with large artery stenosisQ Hao
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, China
Cerebrovasc Dis 29:424-30. 2010..We sought to investigate the correlation between the progression of microembolic signal (MES), ischemic infarcts and the neurological deficits in the acute phase of stroke patients with large artery occlusive disease...
Albuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patientsG N Thomas
Department of Community Medicine, 5 F Academic and Administration Block, Faculty of Medicine Building, University of Hong Kong, 21 Sassoon Road, Hong Kong, People s Republic of China
Diabetologia 47:1528-34. 2004..The aim of this study was to investigate the association between albuminuria and intracranial and extracranial vascular involvement in Chinese Type 2 diabetic patients...
Renal impairment in patients with multiple myelomaC C Chow
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong
Hong Kong Med J 9:78-82. 2003..8%). CONCLUSION: The incidence rate noted was comparable to other published studies. Renal impairment at presentation was common in patients with multiple myeloma and was associated with poor survival...
Cerebrovascular disease among Chinese populations--recent epidemiological and neuroimaging studiesK S Wong
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 7:50-7. 2001....
Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vesselsB L Man
Department of Medicine and Geriatrics, Division of Neurology, Tuen Mun Hospital, 23 Tsing Chung Koon Road, Tuen Mun, New Territories, Hong Kong, China
J Clin Neurosci 17:1244-7. 2010..This study shows that genetic polymorphisms affecting homocysteine and lipid metabolism are possible risk factors for stroke and concurrent stenoses...
Association of smoking with increasing vascular involvement in type 2 diabetic Chinese patientsG N Thomas
Department of Community Medicine, University of Hong Kong, Pokfulam, Hong Kong
Exp Clin Endocrinol Diabetes 114:301-5. 2006..To identify the relationship between smoking and the metabolic profile and existing vascular disease in Chinese type 2 diabetic patients...
Stroke caused by small vessel occlusion in a patient taking etoricoxib and thalidomideEdward H C Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
J Neuroimaging 17:87-8. 2007....
Cognitive impairment and functional outcome after stroke associated with small vessel diseaseV C T Mok
Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
J Neurol Neurosurg Psychiatry 75:560-6. 2004..We aimed to evaluate the frequency of the varying severity levels of cognitive impairment, the determinants of severe cognitive impairment, and the association of cognitive impairment with functional outcome after SSVD...
Relationship between adequacy of dialysis and nutritional status, and their impact on patient survival on CAPD in Hong KongW K Lo
Renal Unit of Tung Wah Hospital, University of Hong Kong, Hong Kong
Perit Dial Int 21:441-7. 2001..This study examined the relationship between indices of dialysis adequacy and nutrition and patient survival on CAPD in Hong Kong...
Role of magnetic resonance imaging for preoperative evaluation of patients with refractory epilepsyA C F Hui
Division of Neurology, Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 9:20-4. 2003....
Discriminatory sonographic criteria for the diagnosis of carpal tunnel syndromeS M Wong
Department of Medicine, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Arthritis Rheum 46:1914-21. 2002..To determine its usefulness and the best diagnostic criterion, sonograms of patients with the disease were compared with sonograms of healthy subjects in a case-control study...
Spontaneous basilar artery dissectionZ Han
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 13:144-6. 2007..Magnetic resonance angiography combined with magnetic resonance imaging is a useful diagnostic tool prior to invasive angiography...
The nurse specialist role in Hong Kong: perceptions of nurse specialists, doctors and staff nursesK P Chang
Department of Nursing and Health Sciences, Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China
J Adv Nurs 36:32-40. 2001..The purpose of this study is to review and delineate the impact in terms of the perceived importance as well as the role components of nurse specialists in Hong Kong...
Validation of the ABCD2 score to identify the patients with high risk of late stroke after a transient ischemic attack or minor ischemic strokeJie Yang
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Stroke 41:1298-300. 2010..The ABCD(2) score is able to predict the short-term risk of stroke after a transient ischemic attack/minor stroke. We aimed to explore its predictive value for long-term recurrent stroke...
