B C Wong

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. ncbi request reprint A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong
    B C Y Wong
    Departments of Medicine 2Clinical Biochemistry, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Eur J Cancer Prev 14:181-4. 2005
  2. ncbi request reprint Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use
    Kam Chuen Lai
    Departments of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    N Engl J Med 346:2033-8. 2002
  3. ncbi request reprint Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase
    Benjamin Chun Yu Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Gastroenterology 126:136-47. 2004
  4. pmc Current Understanding of the Role of PPARgamma in Gastrointestinal Cancers
    Bing Zou
    Department of Medicine Centre Cancer Research, The University of Hong Kong, Pok Fu Lam Road, Hong Kong
    PPAR Res 2009:816957. 2009
  5. ncbi request reprint High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:493-503. 2001
  6. ncbi request reprint Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer
    Benjamin Chun Yu Wong
    Department of Medicine, Unoversity of Hong Kong, Hong Kong, Republic of China
    Oncogene 22:1189-97. 2003
  7. ncbi request reprint 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells
    B C Wong
    Department of Medicine, Department of Pharmacology and Institute of Molecular Biology, University of Hong Kong, Hong Kong, China
    Carcinogenesis 22:1349-54. 2001
  8. ncbi request reprint Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:1959-65. 2001
  9. ncbi request reprint Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    JAMA 291:187-94. 2004
  10. ncbi request reprint A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population
    B C Y Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 18:941-6. 2003

Collaborators

Detail Information

Publications95

  1. ncbi request reprint A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong
    B C Y Wong
    Departments of Medicine 2Clinical Biochemistry, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Eur J Cancer Prev 14:181-4. 2005
    ..In conclusion, health education is important for ensuring high acceptance and implementation of colorectal cancer screening in Hong Kong Chinese. FOBT is an acceptable and feasible screening method in Hong Kong...
  2. ncbi request reprint Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use
    Kam Chuen Lai
    Departments of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    N Engl J Med 346:2033-8. 2002
    ..The role of gastric acid suppression in preventing the recurrence of ulcer complications after the eradication of Helicobacter pylori infection in patients taking long-term low-dose aspirin is uncertain...
  3. ncbi request reprint Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase
    Benjamin Chun Yu Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Gastroenterology 126:136-47. 2004
    ..The aim of this study is to determine how specific COX-2 inhibitor SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway...
  4. pmc Current Understanding of the Role of PPARgamma in Gastrointestinal Cancers
    Bing Zou
    Department of Medicine Centre Cancer Research, The University of Hong Kong, Pok Fu Lam Road, Hong Kong
    PPAR Res 2009:816957. 2009
    ..In this review, the authors discuss the recent developments in the role of PPARgamma in gastrointestinal cancers...
  5. ncbi request reprint High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:493-503. 2001
    ..Diversity in metronidazole susceptibility and genotypes of Helicobacter pylori have been reported with varying results in different areas...
  6. ncbi request reprint Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer
    Benjamin Chun Yu Wong
    Department of Medicine, Unoversity of Hong Kong, Hong Kong, Republic of China
    Oncogene 22:1189-97. 2003
    ..Our study suggests an important molecular mechanism by which COX-2 inhibitors reduce inflammation and suppress carcinogenesis in gastrointestinal tract...
  7. ncbi request reprint 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells
    B C Wong
    Department of Medicine, Department of Pharmacology and Institute of Molecular Biology, University of Hong Kong, Hong Kong, China
    Carcinogenesis 22:1349-54. 2001
    ..The biochemical characteristics of apoptosis were p53-independent combined with a decrease in bcl-2 expression. Caspase-7 was proteolytically activated and responsible for the apoptosis execution...
  8. ncbi request reprint Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:1959-65. 2001
    ..Rabeprazole is a new proton pump inhibitor with more potent acid suppressive and anti-Helicobacter effects...
  9. ncbi request reprint Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    JAMA 291:187-94. 2004
    ..Although chronic Helicobacter pylori infection is associated with gastric cancer, the effect of H pylori treatment on prevention of gastric cancer development in chronic carriers is unknown...
  10. ncbi request reprint A sensitive guaiac faecal occult blood test is less useful than an immunochemical test for colorectal cancer screening in a Chinese population
    B C Y Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 18:941-6. 2003
    ..The optimal faecal occult blood test, whether guaiac or immunochemical, for colorectal cancer screening in the Chinese population remains to be defined...
  11. ncbi request reprint Cyclooxygenase-2 inhibition and gastric cancer
    Xiao hua Jiang
    Department of Medicine, University of Hong Kong, Hong Kong
    Curr Pharm Des 9:2281-8. 2003
    ..Human studies are underway to examine the use of COX-2 inhibitor in the treatment of pre-cancerous lesions. COX-2 inhibitors have a promising role in the prevention and treatment of gastric cancer...
  12. ncbi request reprint Virtual colonoscopy for the detection of colorectal polyps and cancers in a Chinese population
    Benjamin Chun Yu Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 17:1323-7. 2002
    ..The aim of this study is to assess the sensitivity of virtual colonoscopy in detecting colorectal polyps and cancers in a Chinese population...
  13. ncbi request reprint Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study
    W M Wong
    Departments of Medicine and Statistics and Actuarial Science, University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 18:595-604. 2003
    ..Population-based data on gastro-oesophageal reflux disease in Chinese are lacking. The prevalence, clinical spectrum and health care-seeking behaviour of subjects with gastro-oesophageal reflux disease were studied...
  14. ncbi request reprint Evaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population
    Benjamin Chun Yu Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong S A R, China
    J Gastroenterol Hepatol 18:26-31. 2003
    ..The aim of this study is to compare the accuracy of these two tests in the diagnosis of Helicobacter pylori infection in the Chinese population...
  15. pmc Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents
    W H Wang
    Department of Gastroenterology, First Hospital, Peking University, Beijing, China
    Gut 52:490-5. 2003
    ..The interaction between aspirin and H pylori in vitro is also not clear. We investigated the effect of aspirin on the growth of H pylori and on the susceptibility of H pylori to antimicrobials...
  16. ncbi request reprint Systematic review on epidemiology of gastroesophageal reflux disease in Asia
    Benjamin C Y Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Clin Gastroenterol Hepatol 4:398-407. 2006
    ..The epidemiology of gastroesophageal reflux disease (GERD) has been a subject of much interest in recent years. This review ascertains the prevalence of GERD in eastern and southeastern Asia, and reports on complications and risk factors...
  17. ncbi request reprint Attitudes and knowledge of colorectal cancer and screening in Hong Kong: a population-based study
    Benjamin Cy Wong
    Department of Medicine and Institute of Molecular Biology, University of Hong Kong, Hong Kong, China
    J Gastroenterol Hepatol 21:41-6. 2006
    ..However, participation in the CRC screening program depends on the knowledge and attitude of the population. The aim of this study is to investigate the knowledge and attitude towards CRC screening in the Hong Kong population...
  18. ncbi request reprint Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy
    B C Wong
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 15:1251-6. 2000
    ..A study on the outcome of open-access upper endoscopy in contrast with the conventional referral system was conducted...
  19. ncbi request reprint Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 14:1529-35. 2000
    ..Studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of Helicobacter pylori infection and healing of duodenal ulcers in Asian and African countries are limited...
  20. ncbi request reprint Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized controlled study
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:843-9. 2001
    ..To compare the efficacy and tolerability of a 3-day quadruple therapy with a standard 7-day triple therapy in eradicating Helicobacter pylori infection and healing duodenal ulcers...
  21. ncbi request reprint An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:505-11. 2001
    ..Different tests are available for diagnosing Helicobacter pylori infection...
  22. ncbi request reprint One-week ranitidine bismuth citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:403-9. 2001
    ..To compare 1-week ranitidine bismuth citrate-based (RBC) triple therapy vs. omeprazole-based (O) triple therapy for the eradication of Helicobacter pylori infection in Hong Kong with high prevalence of metronidazole resistance...
  23. ncbi request reprint Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage
    K C Lai
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Aliment Pharmacol Ther 14:1071-6. 2000
    ..To study the efficacy of a 2-week anti-Helicobacter therapy in the healing of H. pylori-associated bleeding peptic ulcers...
  24. ncbi request reprint Inhibition of proteasome function induced apoptosis in gastric cancer
    X M Fan
    Department of Medicine, University of Hong Kong, Hong Kong
    Int J Cancer 93:481-8. 2001
    ..Our present study suggests that inhibition of proteasome function in gastric cancer cells induces apoptosis and proteasomal inhibitors have potential use as novel anticancer drugs in gastric cancer...
  25. ncbi request reprint Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways
    X M Fan
    Department of Medicine, University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 16:1098-104. 2001
    ..CONCLUSIONS: Our results demonstrated that in human gastric cancer cells, IL-1beta upregulates the COX-2 gene expression through the activation of MEK/p44/42 and p38 MAP kinases pathway...
  26. ncbi request reprint Clinical and endoscopic characteristics of non-Helicobacter pylori, non-NSAID duodenal ulcers: a long-term prospective study
    H H Xia
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Aliment Pharmacol Ther 15:1875-82. 2001
    ..pylori, non-NSAID duodenal ulcers. CONCLUSIONS: Non-H. pylori, non-NSAID duodenal ulcers exhibit certain distinct clinical and endoscopic characteristics. The presence of concomitant diseases is an important predictive factor...
  27. ncbi request reprint An evaluation of the PyloriTek test for the diagnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapy
    W M Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    J Gastroenterol Hepatol 16:976-80. 2001
    ..It enhances clinical decision-making by allowing the clinicians or endoscopists to start therapy on the same day of an endoscopy visit. One biopsy from the antrum is highly reliable for this purpose...
  28. ncbi request reprint Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak
    X M Zhou
    Department of Medicine and Institute of Molecular Biology, University of Hong Kong, Hong Kong, People's Republic of China
    Carcinogenesis 22:1393-7. 2001
    ..Bax and bak are important in the chemoprevention of gastric cancer...
  29. pmc Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc
    G H Zhu
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Cancer 79:393-400. 1999
    ..In conclusion, NSAIDs induce apoptosis in gastric cancer cells which may be mediated by up-regulation of c-myc proto-oncogene. PKC activation can abrogate the effects of NSAIDs by decreasing c-myc expression...
  30. ncbi request reprint Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3
    X H Jiang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Int J Cancer 91:173-9. 2001
    ..The potential use of this compound in the treatment of gastric cancer is worth further investigation...
  31. ncbi request reprint Twenty-minute 50 mg 13C-urea breath test without test meal for the diagnosis of Helicobacter pylori infection in Chinese
    W M Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Aliment Pharmacol Ther 15:1499-504. 2001
    ..CONCLUSIONS: A 20-min 50 mg 13C-urea breath test without citrate produced highly accurate results for the diagnosis of Helicobacter pylori infection and is more economical and convenient for the Chinese population...
  32. ncbi request reprint Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication
    B C Wong
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, P.R. China
    Aliment Pharmacol Ther 15:1459-65. 2001
    ..H. pylori could induce the expression of EGFR but not the EGF in the antral mucosa. The expression of EGFR could be a contributing factor for ulcer healing in patients with H. pylori infection...
  33. ncbi request reprint Distribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Helicobacter 6:317-24. 2001
    ..The association of these virulence genes and duodenal ulcer disease needs reappraisal, particularly under geographic considerations...
  34. ncbi request reprint Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats
    X Guo
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Li Shu Fan Bldg, 5 Sassoon Road, SAR, Hong Kong, People's Republic of China
    Eur J Pharmacol 411:193-203. 2001
    ....
  35. ncbi request reprint An evaluation of whole blood testing for Helicobacter pylori infection in the Chinese population
    B C Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong S A R, China
    Aliment Pharmacol Ther 14:331-5. 2000
    ..Near patient tests for Helicobacter pylori were developed to assist in the management of dyspepsia patients in general practice. Most studies were performed in western populations...
  36. ncbi request reprint Macrophage migration inhibitory factor is an important mediator in the pathogenesis of gastric inflammation in rats
    X R Huang
    Department of Medicine, The University of Hong Kong, Hong Kong
    Gastroenterology 121:619-30. 2001
    ..Inhibition of acute gastric ulcer by blockade of MIF indicates that MIF is a key inflammatory mediator and plays a pathogenic role in gastric inflammation...
  37. ncbi request reprint Prolonged storage of frozen unbuffered rapid urease test
    F H Ng
    Department of Medicine and Pathology, Ruttonjee Hospital, Hong Kong, China
    J Clin Gastroenterol 31:142-3. 2000
    ..The corresponding specificity were 97%, 88%, 97%, and 100%. Our RUT remains highly sensitive and specific when it is stored at -20 degrees C for 4 months...
  38. ncbi request reprint Influence of gender difference and gastritis on gastric ulcer formation in rats
    E S Liu
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Gastroenterol Hepatol 16:740-7. 2001
    ..Gastric PGE(2) not only contributes to this process, but also together with gastric mucus participates in the ulcer-healing process in the stomach...
  39. ncbi request reprint The role of cholecystectomy in reducing recurrent gallstone pancreatitis
    C K Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Endoscopy 36:206-11. 2004
    ..This is a retrospective study to assess whether cholecystectomy can decrease the incidence of RAP in patients with gallstone-related pancreatitis...
  40. ncbi request reprint Gastric cancer: past, present and future
    A O Chan
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, ROC
    Can J Gastroenterol 15:469-74. 2001
    ..This article reviews the changing views of gastric cancer and the latest developments...
  41. ncbi request reprint Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats
    W P Wang
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China
    Am J Physiol Gastrointest Liver Physiol 281:G586-94. 2001
    ....
  42. ncbi request reprint Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients
    Wai Man Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    J Gastroenterol Hepatol 20:935-40. 2005
    ..The effects were compared of 7-day low-dose and high dose rabeprazole in RAM for the primary treatment of H. pylori infection in Chinese patients...
  43. ncbi request reprint Prevalence and time trend of intestinal metaplasia in Hong Kong
    Yuk Kei Yee
    Department of Medicine, The University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 24:896-9. 2009
    ....
  44. doi request reprint Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions
    Fook Hong Ng
    Department of Medicine and Geriatric, Ruttonjee Hospital, Hong Kong, China
    Gastroenterology 138:82-8. 2010
    ..We compared the efficacy of high-dose famotidine with that of pantoprazole in preventing recurrent symptomatic ulcers/erosions...
  45. doi request reprint Epidemiology of colorectal cancer in Asia
    Yuk Kei Yee
    Medicare Endoscopy Centre, The University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 24:1810-6. 2009
    ..Dietary modification or supplementation may not be effective in preventing colorectal cancer. Surveillance of colorectal cancer in high-risk groups, according to current recommendation, is probably most effective...
  46. ncbi request reprint Gastro-oesophageal reflux disease in Asia : birth of a 'new' disease?
    Ting K Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Drugs 68:399-406. 2008
    ..Proton pump inhibitors remain the most effective medical treatment for GORD. GORD will undoubtedly be a great challenge to clinicians both in primary care and in gastroenterology practice in the Asia-Pacific region in the coming years...
  47. ncbi request reprint Comparison between empirical prokinetics, Helicobacter test-and-treat and empirical endoscopy in primary-care patients presenting with dyspepsia: a one-year study
    Wayne H C Hu
    Department of Medicine, University of Hong Kong, China
    World J Gastroenterol 12:5010-6. 2006
    ..To investigate the optimal strategy to treat dyspeptic patients in primary care...
  48. ncbi request reprint Influence of positive family history on clinical characteristics of functional constipation
    Annie On On Chan
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Clin Gastroenterol Hepatol 5:197-200. 2007
    ..Their clinical characteristics have not been studied. The aim of this study was to investigate the clinical characteristics of patients with functional constipation with and without a positive family history...
  49. ncbi request reprint Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease
    Annie On On Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    JAMA 298:1412-9. 2007
    ..Colorectal neoplasm and coronary artery disease (CAD) share similar risk factors, and their co-occurrence may be associated...
  50. ncbi request reprint Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation
    Annie Oo Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    World J Gastroenterol 11:5362-6. 2005
    ..To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls...
  51. ncbi request reprint A Chinese patient with non-HFE-linked iron overload
    C Kng
    Department of Medicine, Ruttonjee Hospital, Hong Kong, SAR
    J Clin Gastroenterol 33:69-71. 2001
    ..In this case report, we describe a Chinese woman with marked hepatic iron overload that was nonfamilial, with unusual biopsy findings, in whom neither the C282Y nor the H63D mutations in HFE were found...
  52. ncbi request reprint Helicobacter pylori sero-prevalence in asthma
    K W Tsang
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, SAR, China
    Respir Med 94:756-9. 2000
    ..43, P = 0.004). Despite the sero-epidemiological association of H. pylori infection with many inflammatory conditions, our data showed no such association for middle age asthmatic patients with mild intermittent asthma in our locality...
  53. ncbi request reprint Familial aggregation in constipated subjects in a tertiary referral center
    Annie O O Chan
    Department of Medicine, Univresity of Hong Kong, Queen Mary Hospital, Hong Kong
    Am J Gastroenterol 102:149-52. 2007
    ..Clinical observation showed that there is family aggregation in constipated subjects, but formal data are lacking. This prompted us to conduct a formal family study in constipated subjects...
  54. doi request reprint Gastrointestinal bleeding in patients receiving a combination of aspirin, clopidogrel, and enoxaparin in acute coronary syndrome
    Fook Hong Ng
    Department of Medicine, Ruttonjee Hospital, Hong Kong, China
    Am J Gastroenterol 103:865-71. 2008
    ..The combination of aspirin, clopidogrel, and enoxaparin (combination therapy) is the standard treatment for acute coronary syndrome but is associated with gastrointestinal bleeding. However, information in this area is scarce...
  55. ncbi request reprint Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials
    Wei Hong Wang
    Department of Gastroenterology, Peking University First Hospital, Beijing, China
    Clin Gastroenterol Hepatol 5:178-85; quiz 140. 2007
    ....
  56. ncbi request reprint Symptom resolution does not predict healing of erosive oesophagitis in Chinese
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Digestion 75:128-34. 2007
    ..Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population...
  57. ncbi request reprint Helicobacter pylori eradication for gastric cancer prevention
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    J Gastroenterol 42:10-5. 2007
    ..Longer follow-up and additional studies are needed to clarify this issue...
  58. doi request reprint Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia
    Senlin Zhu
    Department of Gastroenterology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Dig Dis Sci 54:996-1002. 2009
    ..This study was to determine whether gastric expression of homeoproteins is altered in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia (IM)...
  59. ncbi request reprint Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: resource implication for cancer screening
    Annie O O Chan
    Department of Medicine, University of Hong Kong, SAR, China
    Digestion 73:84-8. 2006
    ..The incidence of colorectal cancer (CRC) in Hong Kong is rising. The trend of colonoscopy demand is uncertain...
  60. ncbi request reprint Trend of colorectal cancer in Hong Kong: 1983-2006
    Yuk Kei Yee
    HK Health Enhancement Research Centre, The University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 25:923-7. 2010
    ..The incidence of colorectal cancer (CC) is increasing in many Asian countries, but decreasing in western countries. The present study examined the local incidence of CC in the past few decades...
  61. doi request reprint Clarithromycin-amoxycillin-containing triple therapy: a valid empirical first-line treatment for Helicobacter pylori eradication in Hong Kong?
    Ivan F N Hung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Helicobacter 14:505-11. 2009
    ..pylori infection in Hong Kong...
  62. ncbi request reprint Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring
    Ying L Xiao
    Department of Gastroenterology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Gastroenterol Hepatol 24:1113-8. 2009
    ..To investigate the reflux profile of Chinese gastroesophageal reflux disease (GERD) patients with the aid of combined multichannel intraluminal impedance-pH (MII-pH) monitoring technique...
  63. doi request reprint Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils
    Guo Qing Li
    Department of Medicine, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Helicobacter 13:20-9. 2008
    ..Aspirin has anti-inflammatory and antineoplastic activity. The aim of the present study was to determine the effects of aspirin on H. pylori-induced gastritis and the development of heterotopic proliferative glands...
  64. doi request reprint Treatment of Helicobacter pylori and prevention of gastric cancer
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    J Dig Dis 9:8-13. 2008
    ..A longer follow-up and additional studies are needed for better understanding this issue...
  65. doi request reprint Gastroesophageal reflux disease is associated with poor asthma control, quality of life, and psychological status in Chinese asthma patients
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, People s Republic of China
    Chest 135:1181-5. 2009
    ..Our aim was to determine the prevalence of GERD in asthmatic patients at a major hospital in Hong Kong, and to examine the impact of GERD and its association with asthma control...
  66. ncbi request reprint The role of negative superhelicity and length of homology in the formation of paranemic joints promoted by RecA protein
    B C Wong
    Department of Biochemistry, University of Hong Kong, Hong Kong
    J Biol Chem 273:12120-7. 1998
    ..These results support a model of two distinct kinds of DNA unwinding occurring in paranemic joint formation: an initial unwinding caused by heterologous contacts during synapsis and a later one during pairing of the homologous molecules...
  67. ncbi request reprint Clinico-biochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography
    C L Liu
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Aliment Pharmacol Ther 22:423-31. 2005
    ..Occult biliary stones escape detection on conventional investigations, and clinico-biochemical systems proposed for predicting biliary pancreatitis has low predictive values...
  68. ncbi request reprint Factors affecting physicians' practices related to Helicobacter pylori infection: effect of experience and mode of practice
    Yuk Kei Yee
    Hong Kong Health Enhancement Research Centre, Hong Kong, SAR, China
    Digestion 78:77-81. 2008
    ..Studies found that guidelines on the management of Helicobacter pylori were not always followed in clinical practice. This study investigated factors that were responsible for the deviation...
  69. pmc Essential role for macrophage migration inhibitory factor in gastritis induced by Helicobacter pylori
    Benny L W Wong
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Am J Pathol 174:1319-28. 2009
    ..Results from this study indicated that inhibition of HP-induced innate immune responses and Th1-mediated immune injury may be the key mechanisms by which KO mice failed to develop gastritis after HP infection...
  70. doi request reprint Quality of life and psychological impact in patients with noncardiac chest pain
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    J Clin Gastroenterol 43:13-8. 2009
    ..Chest pain is common and data regarding noncardiac chest pain (NCCP) in Asia are lacking...
  71. doi request reprint Quality of life in patients with laryngopharyngeal reflux
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, SAR, China
    Digestion 79:52-7. 2009
    ..Laryngopharyngeal reflux (LPR) disease is an extraesophageal manifestation of gastroesophageal reflux disease (GERD). The impact of GERD-related LPR on the psychological well-being and quality of life (QOL) in Chinese is not known...
  72. doi request reprint Serum macrophage migration-inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer
    Harry Hua Xiang Xia
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Cancer 115:5441-9. 2009
    ..This study aimed to determine the potential diagnostic value of migration-inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer...
  73. doi request reprint Chemoprophylaxis in colorectal cancer: current concepts and a practical algorithm for use
    Victoria P Y Tan
    University of Hong Kong, Queen Mary Hospital, Center for Cancer Research, Department of Medicine, Hong Kong
    Expert Opin Investig Drugs 19:S57-66. 2010
    ..However, the role of chemoprophylaxis is likely to grow significantly in the next decade as understanding of the stepwise tumorigenesis cascade becomes better understood and current clinical trials are completed...
  74. ncbi request reprint Is proton pump inhibitor testing an effective approach to diagnose gastroesophageal reflux disease in patients with noncardiac chest pain?: a meta-analysis
    Wei Hong Wang
    Department of Gastroenterology, Peking University First Hospital, Beijing, China
    Arch Intern Med 165:1222-8. 2005
    ..Results of studies evaluating the accuracy of a proton pump inhibitor (PPI) treatment as a diagnostic test for GERD-related NCCP have varied. We evaluated the overall accuracy of this modality...
  75. ncbi request reprint Upper gastrointestinal bleeding in patients with aspirin and clopidogrel co-therapy
    Fook Hong Ng
    Department of Medicine and Surgery, Ruttonjee Hospital, Hong Kong, SAR, China
    Digestion 77:173-7. 2008
    ..The major complication of aspirin and clopidogrel (A+C) co-therapy is upper gastrointestinal bleeding (UGIB). However, data are unavailable for real-life situations. Furthermore, the treatment effect of antisecretory agents is unknown...
  76. ncbi request reprint Accuracy of a new near patient test for the diagnosis of Helicobacter pylori infection in Chinese
    Wai Man Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Gastroenterol Hepatol 17:1272-7. 2002
    ..The aim of this study is to evaluate the accuracy of a new near patient test (Signify H. pylori) for the diagnosis of H. pylori and the usefulness of the Signify H. pylori test for a test and treat strategy...
  77. ncbi request reprint Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis
    Xiaomeng An
    Integrative Chemical Biology Laboratory, Department of Chemistry, The University of Hong Kong, China
    Eur J Cancer 46:1752-61. 2010
    ..These results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb...
  78. ncbi request reprint Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice
    Edgar S L Liu
    Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, People s Republic of China
    Carcinogenesis 24:1407-13. 2003
    ..This tumor development is associated with the inhibition of cellular apoptosis and supported by increased angiogenesis...
  79. ncbi request reprint The Hong Kong index of dyspepsia: a validated symptom severity questionnaire for patients with dyspepsia
    Wayne H C Hu
    Department of Medicine, University of Hong Kong, China
    J Gastroenterol Hepatol 17:545-51. 2002
    ..Locally validated symptom questionnaires are essential instruments in dyspepsia research. A symptom score for Chinese dyspeptics was developed. Multiple aspects of validity and reliability were assessed...
  80. ncbi request reprint An inverse correlation between Interleukin-6 and select gene promoter methylation in patients with gastric cancer
    Li Ping Tang
    Department of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Digestion 74:85-90. 2006
    ..Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers...
  81. doi request reprint Normal values of 24-hour combined esophageal multichannel intraluminal impedance and pH monitoring in the Chinese population
    Ying L Xiao
    Department of Gastroenterology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Digestion 79:109-14. 2009
    ..There is a lack of data on combined esophageal multichannel intraluminal impedance and pH (MII-pH) monitoring in the Chinese population...
  82. ncbi request reprint Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers
    Bing Zou
    Department of Gastroenterology, Rui Jin Hospital, Shanghai Jiao Tong University, Shanghai, China
    Gastroenterology 131:1835-43. 2006
    ..The aim of this study was to examine the novel pattern of methylation of XAF1 in gastric and colon cancers and locate the important CpG sites for transcriptional regulation and tumor progression...
  83. ncbi request reprint Decreasing trend of esophageal adenocarcinoma in Hong Kong
    Yuk Kei Yee
    Department of Medicine, University of Hong Kong, Hong Kong
    Cancer Epidemiol Biomarkers Prev 16:2637-40. 2007
    ..The incidence of esophageal adenocarcinoma was increasing in the Western Europe and United States, but not in East Asian countries. Population based study on the trend of esophageal adenocarcinoma in Hong Kong was not available...
  84. doi request reprint Oncogene functions of FHL2 are independent from NF-kappaBIalpha in gastrointestinal cancer
    Liang Qiao
    Department of Medicine, The University of Hong Kong, Hong Kong, China
    Pathol Oncol Res 15:31-6. 2009
    ..We therefore concluded that under the physiological condition, FHL2 may activate NF-kappaB pathway, even though such an activation may not be mediated by a direct binding of FHL2 to NF-kappaB inhibitor protein IkappaB...
  85. doi request reprint A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
    Roberta Pang
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
    Cell Stem Cell 6:603-15. 2010
    ..Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy...
  86. ncbi request reprint Noncardiac chest pain--an Asia-Pacific survey on the views of primary care physicians
    Ting Kin Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Dig Dis Sci 52:3043-8. 2007
    ....
  87. ncbi request reprint XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer
    Li Fen Yu
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer 109:1996-2003. 2007
    ..The aim of the study was to investigate the correlation between the ERK1/2 signaling pathway and XAF1 in colon cancer...
  88. ncbi request reprint [13C]-urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese
    Fook Hong Ng
    Department of Medicine, Ruttonjee Hospital, Hong Kong
    J Gastroenterol Hepatol 17:834-8. 2002
    ..However, recent studies have suggested that prior fasting and test meal may not be essential. We aimed to determine the accuracy of a new [13C]-UBT protocol without fasting in Chinese...
  89. ncbi request reprint 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
    Jing Wu
    Department of Medicine, University of Hong Kong, Hong Kong, P R China
    Carcinogenesis 24:243-7. 2003
    ..These findings demonstrated that SC-236 induced apoptosis in gastric cancer cells via up-regulation of 15-LOX-1, and 13-S-HODE. These are potential and new targets for prevention and treatment of gastric cancer...
  90. ncbi request reprint Pyogenic liver abscess: retrospective analysis of 80 cases over a 10-year period
    Wai Man Wong
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    J Gastroenterol Hepatol 17:1001-7. 2002
    ..A total of 80 patients with pyogenic liver abscess managed at a single institution over a 10-year period were studied...
  91. ncbi request reprint Pathophysiology of gastroesophageal reflux diseases in Chinese--role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction
    Wai Man Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Am J Gastroenterol 99:2088-93. 2004
    ..Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before...
  92. ncbi request reprint A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori
    Ruiguang Ge
    Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Pokfulam Road, Hong Kong, People s Republic of China
    J Biol Inorg Chem 12:831-42. 2007
    ..Our data suggest that the inhibition of proteases, modulation of cellular oxidative stress and interference with nickel homeostasis may be key processes underlying the molecular mechanism of bismuth's actions against H. pylori...
  93. ncbi request reprint Topographic association of gastric epithelial expression of Ki-67, Bax, and Bcl-2 with antralization in the gastric incisura, body, and fundus
    Harry Hua Xiang Xia
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 97:3023-31. 2002
    ..The aim of this study was to determine the topographic associations of Ki-67 (a protein expressed in proliferative cells), Bax (a pro-apoptotic protein), and Bcl-2 (an antiapoptotic protein) expression with antralization...
  94. ncbi request reprint [Chronic Helicobacter pylori infection induces apoptosis-resistance in gastric epithelial cells]
    Xing Xiang He
    Department of Gastroenterology, The First Affiliated Hospital, Sun Yat Sen University of Medical Sciences, Guangzhou 510080, China
    Zhonghua Yi Xue Za Zhi 83:42-5. 2003
    ..To establish a cell model by chronically infecting human gastric epithelial cells with H.pylori, and to determine the effect of chronic H.pylori infection on apoptosis of gastric epithelial cells...