Alice S T Wong

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1α to promote angiogenesis
    Kar Wah Leung
    School of Biological Sciences, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Pokfulam, Hong Kong
    Angiogenesis 14:515-22. 2011
  2. pmc Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2
    B H Y Yeung
    School of Biological Sciences, The University of Hong Kong, Hong Kong, PR China
    Br J Cancer 99:283-93. 2008
  3. pmc Pharmacology of ginsenosides: a literature review
    Kar Wah Leung
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, PR China
    Chin Med 5:20. 2010
  4. pmc Ovarian surface epithelium: family history and early events in ovarian cancer
    Alice S T Wong
    Department of Zoology, University of Hong Kong, Hong Kong
    Reprod Biol Endocrinol 1:70. 2003
  5. ncbi request reprint Role of endocrine and growth factors on the ovarian surface epithelium
    Alice S T Wong
    Department of Zoology, University of Hong Kong, Hong Kong, China
    J Obstet Gynaecol Res 33:3-16. 2007
  6. pmc c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2
    Maggie K S Tang
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Neoplasia 12:128-38. 2010
  7. ncbi request reprint p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells
    Yuen L Pon
    School of Biological Sciences, University of Hong Kong, Hong Kong
    Cancer Res 68:6524-32. 2008
  8. ncbi request reprint Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells
    Hong Y Zhou
    Department of Zoology, The University of Hong Kong, China
    Endocrinology 147:2557-66. 2006
  9. doi request reprint Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK
    Hong Yan Zhou
    School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong
    FEBS Lett 582:3415-22. 2008
  10. ncbi request reprint Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Biol Chem 281:36280-8. 2006

Collaborators

Detail Information

Publications35

  1. pmc Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1α to promote angiogenesis
    Kar Wah Leung
    School of Biological Sciences, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Pokfulam, Hong Kong
    Angiogenesis 14:515-22. 2011
    ..These results define a hypoxia-independent activation of HIF-1α, uncovering a novel mechanism for Rg1 that could play a major role in angiogenesis and vascular remodeling...
  2. pmc Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2
    B H Y Yeung
    School of Biological Sciences, The University of Hong Kong, Hong Kong, PR China
    Br J Cancer 99:283-93. 2008
    ....
  3. pmc Pharmacology of ginsenosides: a literature review
    Kar Wah Leung
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, PR China
    Chin Med 5:20. 2010
    ..The multiple biological actions make ginsenosides as important resources for developing new modalities. Yet, low bioavailability of ginsenoside is one of the major hurdles needs to be overcome to advance its use in clinical settings...
  4. pmc Ovarian surface epithelium: family history and early events in ovarian cancer
    Alice S T Wong
    Department of Zoology, University of Hong Kong, Hong Kong
    Reprod Biol Endocrinol 1:70. 2003
    ..mutational hotspot of BRCA mutation for ovarian cancer? Second, why do mutations in BRCA1 and BRCA2, which are ubiquitously expressed genes that participate in general cellular activities, lead preferentially to breast and ovarian cancer?..
  5. ncbi request reprint Role of endocrine and growth factors on the ovarian surface epithelium
    Alice S T Wong
    Department of Zoology, University of Hong Kong, Hong Kong, China
    J Obstet Gynaecol Res 33:3-16. 2007
    ..This review summarizes the current knowledge in the field of endocrinology and its relationship to the biology and pathology of the OSE...
  6. pmc c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2
    Maggie K S Tang
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Neoplasia 12:128-38. 2010
    ..These findings shed new light on the apoptotic resistance mechanism of nonadherent ovarian cancer ascites cells and may have important clinical implications...
  7. ncbi request reprint p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells
    Yuen L Pon
    School of Biological Sciences, University of Hong Kong, Hong Kong
    Cancer Res 68:6524-32. 2008
    ..These results indicate that p70(S6K) may play a critical role in tumor progression in ovarian cancer through the induction of EMT. Targeting p70(S6K) may thus be a useful strategy to impede cancer cell invasion and metastasis...
  8. ncbi request reprint Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells
    Hong Y Zhou
    Department of Zoology, The University of Hong Kong, China
    Endocrinology 147:2557-66. 2006
    ..These data suggest that interfering p70(S6K) may provide a novel means of controlling tumor cell invasiveness...
  9. doi request reprint Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK
    Hong Yan Zhou
    School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong
    FEBS Lett 582:3415-22. 2008
    ..We also demonstrated that PI3K induced activation of JNK, with Akt as a potential point of this cross-talk. These results provide new insights into the molecular mechanism responsible for NPC progression and metastasis...
  10. ncbi request reprint Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Biol Chem 281:36280-8. 2006
    ..In addition, the GR antagonist RU486 was able to inhibit Rg1-induced PI3K/Akt and beta-catenin activation. These findings provide new insights into the mechanism responsible for Rg1 functions...
  11. ncbi request reprint Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9
    Lydia W T Cheung
    Department of Zoology, University of Hong Kong, Hong Kong
    Cancer Res 66:10902-10. 2006
    ..These results indicate for the first time an expanded role for GnRH in other aspects of ovarian tumor progression, such as metastasis, via activation of MMP and the subsequent increase in cell migration and invasion...
  12. ncbi request reprint Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells
    Lydia W T Cheung
    Department of Zoology, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
    Endocrinology 147:4179-91. 2006
    ..This study is the first to demonstrate a role of PEDF in OSE biology and ovarian cancer and suggests that the loss of PEDF may e of relevance in carcinogenesis...
  13. doi request reprint Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1
    Lydia W T Cheung
    School of Biological Sciences, University of Hong Kong, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong
    Cardiovasc Res 89:419-25. 2011
    ..Rg1 can activate the glucocorticoid receptor (GR). However, the mechanism that transmits these pro-angiogenic effects is still unclear...
  14. ncbi request reprint Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation
    Alice S T Wong
    Department of Zoology, University of Hong Kong, Hong Kong
    Exp Cell Res 299:248-56. 2004
    ..Taken together, our data correlate specific responses to HGF-mediated signaling with specific signaling pathways and with progressive neoplastic changes...
  15. ncbi request reprint Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: role of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase
    Hong Y Zhou
    University of Hong Kong, School of Biological Sciences, 4S 14 Kadoorie Biological Sciences Building, Hong Kong
    Endocrinology 148:5195-208. 2007
    ..These findings provide insights into the mechanism of the malignant progression of ovarian cancer...
  16. ncbi request reprint Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway
    Yuen Lam Pon
    Department of Zoology, University of Hong Kong, Hong Kong
    J Biol Chem 280:15438-48. 2005
    ....
  17. doi request reprint BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis
    Maggie K S Tang
    School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong
    Cancer Lett 346:139-47. 2014
    ..These findings highlight a novel role for BRCA1 in protective autophagy, which may make its essential contribution to tumorigenesis and prognosis. ..
  18. pmc Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion
    Lydia W T Cheung
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Mol Ther 21:78-90. 2013
    ..These results define a new role for GnRH receptor in early metastasis and offer the possibility of novel therapeutic targets...
  19. ncbi request reprint Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 up-regulation via the beta-catenin/T-cell factor signaling pathway
    Yuen Lam Pon
    Department of Zoology, University of Hong Kong, Pokfulam Road, Hong Kong
    Mol Endocrinol 20:3336-50. 2006
    ..These findings suggest that the participation of beta-catenin in adhesion and signaling may represent a novel mechanism through which gonadotropins may regulate the cellular fate of human OSE...
  20. ncbi request reprint Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies
    Qing Yu He
    Department of Chemistry, University of Hong Kong, Hong Kong Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong
    Gynecol Oncol 98:68-76. 2005
    ..To study the pattern of protein expression associated with a predisposition to develop ovarian cancer...
  21. ncbi request reprint HGF/MET signaling in ovarian cancer
    Hong Yan Zhou
    School of Biological Sciences, University of Hong Kong, Hong Kong
    Curr Mol Med 8:469-80. 2008
    ..Finally, the most recent progress in drug development and future areas of research in terms of their potential clinical implications are discussed...
  22. doi request reprint Human female reproductive tract epithelial cell culture
    Rachel W S Chan
    Department of Pathology, School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Methods Mol Biol 945:347-63. 2013
    ..These cultures can be useful models for investigating the molecular and cellular functions of these epithelia in both normal and pathological states...
  23. ncbi request reprint CpG/CpNpG motifs in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes
    Lydia W T Cheung
    School of Biological Sciences, University of Hong Kong, Hong Kong
    FEBS Lett 581:4668-74. 2007
    ..This suggests that methylation-dependent DNA alterations would be a major mechanism for mutagenesis...
  24. doi request reprint Nur77: a potential therapeutic target in cancer
    Sally K Y To
    University of Hong Kong, School of Biological Sciences, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong, China
    Expert Opin Ther Targets 16:573-85. 2012
    ..Nur77 signaling is deregulated in many cancers and constitutes an important molecule for drug targeting...
  25. doi request reprint Exploiting p70 S6 kinase as a target for ovarian cancer
    Carman K M Ip
    University of Hong Kong, School of Biological Sciences, 4S 14 Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong, China
    Expert Opin Ther Targets 16:619-30. 2012
    ..Therefore, blocking p70(S6K) expression or activity may present a promising strategy for anticancer treatment...
  26. doi request reprint Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues
    Lydia W T Cheung
    School of Biological Sciences, University of Hong Kong, China
    FEBS J 275:5479-95. 2008
    ..Finally, we discuss how a common GnRHR may mediate different, even opposite, responses to GnRH in the same tissue/cell type and whether an additional receptor(s) for GnRH exists...
  27. ncbi request reprint Normal ovarian surface epithelium
    Alice S T Wong
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, B C, V6H 3V5, Canada
    Cancer Treat Res 107:161-83. 2002
  28. ncbi request reprint Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line
    Sarah L Maines-Bandiera
    Department of Obstetrics and Gynaecology, University of British Columbia, BC Women s Hospital, 4490 Oak Street, Vancouver, BC V6H 3V5, Canada
    Differentiation 72:150-61. 2004
    ....
  29. doi request reprint Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha
    Se Hyung Park
    Department of Obstetrics and Gynecology, University of British Columbia, 2H 30, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Mol Endocrinol 22:2085-98. 2008
    ..Collectively, this study provides a compelling argument that estrogen can potentiate tumor progression by EMT induction and highlights the crucial role of ERalpha in ovarian tumorigenesis...
  30. ncbi request reprint Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion
    Chien Lin Chen
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan, China
    Endocrine 31:311-20. 2007
    ..Taken together, these observations suggest that GnRH-I and GnRH-II play key regulatory roles in ovarian tumor cell invasion and extracellular matrix degradation...
  31. ncbi request reprint Gonadotropins and ovarian cancer
    Jung Hye Choi
    Department of Obstetrics and Gynecology, Zhejiang University School of Medicine, China
    Endocr Rev 28:440-61. 2007
    ..Finally, we will discuss the clinical applications of gonadotropins in ovarian cancer and the recent progress in drug development...
  32. pmc Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin
    Alice S T Wong
    Dept of Cell Biology, School of Medicine, University of Virginia, PO Box 800732, Charlottesville, VA 22903, USA
    J Cell Biol 161:1191-203. 2003
    ..However, alteration in the beta-catenin/TCF transcriptional regulation of target genes is not required for the invasion suppressor activity of E-cadherin, suggesting the involvement of other beta-catenin-binding proteins...
  33. doi request reprint Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells
    Alice Y S Law
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Exp Cell Res 314:1823-30. 2008
    ..Collectively, this is the first report to show that STC2 was aberrantly hypermethylated in human cancer cells. The findings demonstrated that STC2 epigenetic inactivation may interfere with HIF-1 mediated activation of STC2 expression...