H Wise

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc The roles played by highly truncated splice variants of G protein-coupled receptors
    Helen Wise
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    J Mol Signal 7:13. 2012
  2. ncbi request reprint Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells
    Helen Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S A R, China
    Eur J Pharmacol 535:69-77. 2006
  3. ncbi request reprint Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation
    H Wise
    Department of Pharmacology, The Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Prostaglandins Leukot Essent Fatty Acids 58:77-84. 1998
  4. ncbi request reprint Multiple signalling options for prostacyclin
    Helen Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Acta Pharmacol Sin 24:625-30. 2003
  5. ncbi request reprint Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323
    Helen Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Recept Signal Transduct Res 23:83-97. 2003
  6. ncbi request reprint Prostanoid signal integration and cross talk
    H Wise
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, China
    Neurosignals 11:20-8. 2002
  7. ncbi request reprint Characterization of chimeric prostacyclin/prostaglandin D(2) receptors
    H Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    Eur J Pharmacol 386:89-96. 1999
  8. pmc Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics
    K B Chow
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S.A.R, China
    Br J Pharmacol 134:1375-84. 2001
  9. doi request reprint Nerve growth factor-induced differentiation of PC12 cells is accompanied by elevated adenylyl cyclase activity
    H S Yung
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, SAR, China
    Neurosignals 18:32-42. 2010
  10. ncbi request reprint Factors affecting prostacyclin receptor agonist efficacy in different cell types
    Y Kam
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, SAR, Hong Kong, China
    Cell Signal 13:841-7. 2001

Collaborators

  • R L Jones
  • Kevin B S Chow
  • Yung H Wong
  • Christopher H K Cheng
  • Po Ki Leung
  • Chi Bun Chan
  • Kit Man Chu
  • H S Yung
  • Pui Ngan Lau
  • Rico K H Lo
  • Y H Wong
  • K B S Chow
  • K Y Ng
  • Kai Yu Ng
  • K H Lai
  • Yu Pong Ng
  • Wing Tai Cheung
  • K B Chow
  • Rama Kamesh Bikkavilli
  • B H S Yeung
  • D K Rowlands
  • Y Kam
  • Z Wu
  • K W K Tsim
  • N Y Ip
  • Zhenguo Wu
  • Nancy Y Ip
  • Karl W K Tsim
  • Andrew M F Liu
  • Wai Man Tang
  • Wing Hung Ko
  • Sai Ming Ngai
  • Susanna Sau Tuen Lee
  • Jing Xin Sun
  • Sup Yin Tsang
  • C Kao

Detail Information

Publications27

  1. pmc The roles played by highly truncated splice variants of G protein-coupled receptors
    Helen Wise
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    J Mol Signal 7:13. 2012
    ..So, instead of assuming that highly truncated GPCRs are associated with faulty transcription processes, it is time to reassess their potential benefit to the host organism...
  2. ncbi request reprint Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells
    Helen Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S A R, China
    Eur J Pharmacol 535:69-77. 2006
    ..In conclusion, PGE2 mediated increases in adenylyl cyclase activity in primary sensory neurones is likely to be mediated by activation of prostanoid EP4 receptors, and is not under inhibitory control by prostanoid EP3 receptors...
  3. ncbi request reprint Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation
    H Wise
    Department of Pharmacology, The Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Prostaglandins Leukot Essent Fatty Acids 58:77-84. 1998
    ....
  4. ncbi request reprint Multiple signalling options for prostacyclin
    Helen Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Acta Pharmacol Sin 24:625-30. 2003
    ..This review will highlight the different signalling options available to prostacyclin, and discuss the consequences for cell responses...
  5. ncbi request reprint Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323
    Helen Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Recept Signal Transduct Res 23:83-97. 2003
    ..Site-directed mutagenesis studies suggest that isoleucine at position 323 in the IPN-VII/DPC receptor plays an important role in mediating the increased potency of this chimeric receptor...
  6. ncbi request reprint Prostanoid signal integration and cross talk
    H Wise
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, China
    Neurosignals 11:20-8. 2002
    ....
  7. ncbi request reprint Characterization of chimeric prostacyclin/prostaglandin D(2) receptors
    H Wise
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    Eur J Pharmacol 386:89-96. 1999
    ..Therefore, substitution of just the carboxyl-terminal tail of the IP receptor by that of the DP receptor appears to result in a chimeric IP/DP receptor with all the properties of a constitutively-active receptor...
  8. pmc Prostacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimetics
    K B Chow
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S.A.R, China
    Br J Pharmacol 134:1375-84. 2001
    ..These results suggest that non-prostanoid prostacyclin mimetics can specifically inhibit [(3)H]-inositol phosphate production by targeting G(q/11) and/or phospholipase C in CHO cells, and that this effect is independent of IP receptors...
  9. doi request reprint Nerve growth factor-induced differentiation of PC12 cells is accompanied by elevated adenylyl cyclase activity
    H S Yung
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, SAR, China
    Neurosignals 18:32-42. 2010
    ..These findings highlight that NGF has a subtle influence on adenylyl cyclase activity in PC12 cells which may influence more than the neurite extension process classically associated with neuronal differentiation...
  10. ncbi request reprint Factors affecting prostacyclin receptor agonist efficacy in different cell types
    Y Kam
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, SAR, Hong Kong, China
    Cell Signal 13:841-7. 2001
    ..Furthermore, protein kinase A (PKA) inhibition appears to enhance IP receptor signalling through both G(s) and G(q) in mIP-CHO cells...
  11. pmc Regulation of prostacyclin and prostaglandin E(2) receptor mediated responses in adult rat dorsal root ganglion cells, in vitro
    D K Rowlands
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong S.A.R, China
    Br J Pharmacol 133:13-22. 2001
    ....
  12. ncbi request reprint Agonists can discriminate between cloned human and mouse prostacyclin receptors
    K B S Chow
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Prostaglandins Leukot Essent Fatty Acids 70:423-9. 2004
    ..A further distinction between hIP and mIP receptors was found with taprostene, which had greater efficacy at hIP receptors (AC 94%, PLC 14%) than at mIP receptors (AC 77%, PLC 0%) (cicaprost=100% in each assay)...
  13. pmc Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations
    R L Jones
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Br J Pharmacol 149:110-20. 2006
    ..The current study examined the utility of the recently described prostacyclin (prostanoid IP) receptor antagonist RO1138452 (2-(4-(4-isopropoxybenzyl)-phenylamino) imidazoline) as a tool for classifying prostanoid receptors...
  14. ncbi request reprint Prostacyclin receptor-mediated activation of extracellular signal-regulated kinases 1 and 2
    Kit Man Chu
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S A R, China
    Cell Signal 16:477-86. 2004
    ..Therefore, IP receptor-mediated activation of ERK1/2 in CHO cells occurs through a Gq/11/protein kinase C-dependent and a phosphoinoside 3-kinase-dependent process which is insensitive to IP receptor-generated cyclic AMP...
  15. doi request reprint Gi-coupled prostanoid receptors are the likely targets for COX-1-generated prostanoids in rat pheochromocytoma (PC12) cells
    H S Yung
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Prostaglandins Leukot Essent Fatty Acids 81:65-71. 2009
    ..The functional role of NGF-stimulated COX-1 remains to be determined since we found no strong evidence of a role for EP3 receptors in the morphological changes induced by NGF during the early stages of differentiation of PC12 cells...
  16. ncbi request reprint Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent
    Kevin B S Chow
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Eur J Pharmacol 474:7-13. 2003
    ..Therefore, although both human and mouse IP receptors couple to Gs and Gq/11-mediated signalling pathways in a cell type-dependent manner, we could find no evidence for IP receptor coupling to Gi...
  17. doi request reprint The constitutive activity of ghrelin receptors is decreased by co-expression with vasoactive prostanoid receptors when over-expressed in human embryonic kidney 293 cells
    Kevin B S Chow
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Int J Biochem Cell Biol 40:2627-37. 2008
    ....
  18. pmc Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells
    K Y Ng
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Br J Pharmacol 168:746-60. 2013
    ....
  19. doi request reprint Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Galpha(s) and Galpha(16) hybrid signaling
    Rico K H Lo
    Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Cell Signal 20:2095-106. 2008
    ..Taken together, our observations illustrate that co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP...
  20. ncbi request reprint Identification and characterization of surrogate peptide ligand for orphan G protein-coupled receptor mas using phage-displayed peptide library
    Rama Kamesh Bikkavilli
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biochem Pharmacol 71:319-37. 2006
    ....
  21. doi request reprint The constitutive activity of the ghrelin receptor attenuates apoptosis via a protein kinase C-dependent pathway
    Pui Ngan Lau
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Mol Cell Endocrinol 299:232-9. 2009
    ..In conclusion, our data suggests that the constitutive activity of sbGHS-R1a may be sufficient alone to attenuate apoptosis via a protein kinase C-dependent pathway...
  22. doi request reprint Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation
    Yu Pong Ng
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong, SAR, China
    Neurosignals 17:111-20. 2009
    ..Our observations provide novel insights on the signalling mechanisms underlying the regulation of neuronal differentiation by NGF and cAMP...
  23. doi request reprint The role of glial cells in influencing neurite extension by dorsal root ganglion cells
    Kai Yu Ng
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Neuron Glia Biol 6:19-29. 2010
    ....
  24. ncbi request reprint Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK
    Rico K H Lo
    Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Cell Signal 18:307-17. 2006
    ..Taken together, these results demonstrate for the first time that hIP activation by cicaprost can lead to STAT1 and STAT3 phosphorylations via signaling pathways involving PTX-insensitive G proteins, ERK and JNK...
  25. ncbi request reprint Signal transduction mechanism of the seabream growth hormone secretagogue receptor
    Chi Bun Chan
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    FEBS Lett 577:147-53. 2004
    ..Moreover, sbGHSR-1a may trigger multiple signal transduction cascades to exert its physiological functions...
  26. ncbi request reprint Over-expression of the truncated ghrelin receptor polypeptide attenuates the constitutive activation of phosphatidylinositol-specific phospholipase C by ghrelin receptors but has no effect on ghrelin-stimulated extracellular signal-regulated kinase 1/2 ac
    Kit Man Chu
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, SAR, China
    Int J Biochem Cell Biol 39:752-64. 2007
    ....
  27. ncbi request reprint The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor
    Po Ki Leung
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Cell Signal 19:1011-22. 2007
    ..Therefore, GHS-R1b appears to act as a dominant-negative mutant of the full-length GRLN-R...