Y X J Wang

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. doi request reprint Biomedical imaging in the safety evaluation of new drugs
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Lab Anim 42:433-41. 2008
  2. ncbi request reprint Recent advances in superparamagnetic iron oxide nanoparticles for cellular imaging and targeted therapy research
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Curr Pharm Des 19:6575-93. 2013
  3. doi request reprint The volumetric relationship of white matter lesion and contrast-enhanced lesion in delayed radiation brain injury: an MRI-based study
    Y X J Wang
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P R China
    Br J Neurosurg 27:662-7. 2013
  4. pmc Prevalence and sex difference of lumbar disc space narrowing in elderly chinese men and women: osteoporotic fractures in men (Hong Kong) and osteoporotic fractures in women (Hong Kong) studies
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong, China
    Arthritis Rheum 65:1004-10. 2013
  5. doi request reprint T1rho and T2 relaxation times for lumbar disc degeneration: an in vivo comparative study at 3.0-Tesla MRI
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Eur Radiol 23:228-34. 2013
  6. pmc Vertebral body corner oedema vs gadolinium enhancement as biomarkers of active spinal inflammation in ankylosing spondylitis
    Y X J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Br J Radiol 85:e702-8. 2012
  7. doi request reprint Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity
    Xiao Ming Zhu
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P R China
    Nanoscale 4:5744-54. 2012
  8. pmc Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: two case reports and review of the literature
    Dan Fang Yan
    Department of Radiation Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, PR China
    BMC Cancer 10:49. 2010
  9. doi request reprint Relationship between hip bone mineral density and lumbar disc degeneration: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Magn Reson Imaging 33:916-20. 2011
  10. doi request reprint Relationship between gender, bone mineral density, and disc degeneration in the lumbar spine: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system
    Y X J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Osteoporos Int 22:91-6. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint Biomedical imaging in the safety evaluation of new drugs
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Lab Anim 42:433-41. 2008
    ..Imaging offers the opportunity to carry forward the same methodology in animal experiments into human studies and has an important role in clinical trials when other safety biomarkers for early toxicities are not available...
  2. ncbi request reprint Recent advances in superparamagnetic iron oxide nanoparticles for cellular imaging and targeted therapy research
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Curr Pharm Des 19:6575-93. 2013
    ..Other potential applications of SPIO include magnetofection and gene delivery, targeted retention of labeled stem cells, sentinel lymph nodes mapping, and magnetic force targeting and cell orientation for tissue engineering. ..
  3. doi request reprint The volumetric relationship of white matter lesion and contrast-enhanced lesion in delayed radiation brain injury: an MRI-based study
    Y X J Wang
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P R China
    Br J Neurosurg 27:662-7. 2013
    ..This study investigated the volumetric relationship of white matter lesion (WML) and contrast-enhanced lesion (CEL) in delayed radiation brain injury (RBI) during the course of evolution...
  4. pmc Prevalence and sex difference of lumbar disc space narrowing in elderly chinese men and women: osteoporotic fractures in men (Hong Kong) and osteoporotic fractures in women (Hong Kong) studies
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong, China
    Arthritis Rheum 65:1004-10. 2013
    ....
  5. doi request reprint T1rho and T2 relaxation times for lumbar disc degeneration: an in vivo comparative study at 3.0-Tesla MRI
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Eur Radiol 23:228-34. 2013
    ..To determine the relative performance of T1rho and T2 relaxation times in disc degeneration assessment...
  6. pmc Vertebral body corner oedema vs gadolinium enhancement as biomarkers of active spinal inflammation in ankylosing spondylitis
    Y X J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Br J Radiol 85:e702-8. 2012
    ..To investigate the relative performance of T(2) weighted short tau inversion-recovery (STIR) and fat-suppressed T(1) weighted gadolinium contrast-enhanced sequences in depicting active inflammatory lesions in ankylosing spondylitis (AS)...
  7. doi request reprint Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity
    Xiao Ming Zhu
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P R China
    Nanoscale 4:5744-54. 2012
    ..05 ± 0.03 μg ml(-1) for DOX/SPIO, while it was 0.13 ± 0.02 μg ml(-1) for free DOX base. These results suggested SPIO nanoshells might be a promising intracellular carrier for hydrophobic anticancer drugs...
  8. pmc Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: two case reports and review of the literature
    Dan Fang Yan
    Department of Radiation Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, PR China
    BMC Cancer 10:49. 2010
    ..Herein, we report the first two cases of brain metastasis hemorrhage that might be involved with the use of gefitinib...
  9. doi request reprint Relationship between hip bone mineral density and lumbar disc degeneration: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Magn Reson Imaging 33:916-20. 2011
    ..To study the relationship between hip bone mineral density (BMD), lumbar disc degeneration, and lumbar disc space narrowing in elderly subjects...
  10. doi request reprint Relationship between gender, bone mineral density, and disc degeneration in the lumbar spine: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system
    Y X J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Osteoporos Int 22:91-6. 2011
    ..Females had more severe disc degeneration than males. Lumbar spine lower BMD was associated with less severe disc degeneration. Lumbar disc spaces were more likely to be narrower when vertebral BMD was higher...
  11. doi request reprint The use of diffusion tensor tractography to measure the distance between the anterior tip of the Meyer loop and the temporal pole in a cohort from Southern China
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Neurosurg 113:1144-51. 2010
    ..In this study, the distance of the anterior tip of the Meyer loop to the temporal lobe pole (ML-TP) in the Southern Chinese population was assessed...
  12. doi request reprint Effect of menopause on lumbar disk degeneration: potential etiology
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Radiology 257:318-20. 2010
    ..Increasing evidence suggests that sex hormones also influence the severity of disk degeneration...
  13. doi request reprint T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Radiology 259:712-9. 2011
    ..To correlate spin-lattice relaxation time in the rotating frame (T1ρ) measurements with degree of liver fibrosis in a rat model...
  14. doi request reprint Low-intensity pulsed ultrasound increases cellular uptake of superparamagnetic iron oxide nanomaterial: results from human osteosarcoma cell line U2OS
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    J Magn Reson Imaging 31:1508-13. 2010
    ..To determine whether low-intensity pulsed ultrasound (LIPUS) is able to facilitate the uptake of a superparamagnetic iron oxide (SPIO) nanomaterial by cells that do not express high endocytosis capacity...
  15. doi request reprint Menopause causes vertebral endplate degeneration and decrease in nutrient diffusion to the intervertebral discs
    Yi Xiang J Wang
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Med Hypotheses 77:18-20. 2011
    ..If the hypothesis is confirmed, then low dose hormone replacement treatment may retard disc degeneration in post menopausal women and thereby limit the consequences associated with disc degeneration such as low back pain...
  16. doi request reprint Rat lumbar vertebrae bone densitometry using multidetector CT
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Eur Radiol 19:882-90. 2009
    ..7 +/- 6.7% BMD reduction at 28 days. Clinical MDCT can reliably and accurately measure rat lumbar vertebral BMD and is much faster than pQCT...
  17. doi request reprint Vertebral blood perfusion reduction associated with vertebral bone mineral density reduction: a dynamic contrast-enhanced MRI study in a rat orchiectomy model
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    J Magn Reson Imaging 28:1515-8. 2008
    ..To investigate the relationship between vertebral blood perfusion and vertebral bone mineral density (BMD) in a rat orchiectomy (ORX) model...
  18. ncbi request reprint Characterisation of brain disorders and evaluation of therapy by functional and molecular magnetic resonance techniques
    Y X Wang
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 14:469-78. 2008
    ..To review advanced functional and molecular magnetic resonance techniques that are currently clinically useful or with potential clinical use in the near future...
  19. doi request reprint An in vivo magnetic resonance imaging technique for measurement of rat lumbar vertebral body blood perfusion
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Lab Anim 43:261-5. 2009
    ..5 T clinical scanner and a small surface coil is feasible and reliable. This technique offers a non-invasive means to probe vertebral blood perfusion changes associated with rat disease models...
  20. doi request reprint Reduced bone perfusion in proximal femur of subjects with decreased bone mineral density preferentially affects the femoral neck
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Bone 45:711-5. 2009
    ..In low bone mass and osteoporotic subjects there was a tendency for perfusion in the femoral neck to reduce to a greater degree relative to that in the femoral head and shaft...
  21. doi request reprint Prevalence and risk factors of radiographic vertebral fractures in elderly Chinese men and women: results of Mr. OS (Hong Kong) and Ms. OS (Hong Kong) studies
    A W L Kwok
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR, China
    Osteoporos Int 24:877-85. 2013
    ..9 %) and women (16.5 %). Majority of the deformities in men were mild (9.9 %, grade = 1). The prevalence of vertebral fractures (grade ≥ 2) was 5.0 % among men and 12.1 % among women...
  22. pmc Compromised perfusion in femoral head in normal rats: distinctive perfusion MRI evidence of contrast washout delay
    Y X J Wang
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Br J Radiol 85:e436-41. 2012
    ..The femoral head is prone to osteonecrosis. This study investigated dynamic contrast-enhanced (DCE) MRI contrast washout features of the femoral head and compared the data with data from other bony compartments in normal rats...
  23. ncbi request reprint How would composite traditional Chinese medicine protect the brain--an example of the composite formula "Pien Tze Huang"
    L Zhang
    Brain Research Centre, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Curr Med Chem 18:3590-4. 2011
    ..We illustrate with our study on Pien Tze Huang (PZH) the use of in vivo tests in the study of composite TCM. Our results show evidence that PZH might have neuropreventive effects in rats...
  24. ncbi request reprint Modified Pfirrmann grading system for lumbar intervertebral disc degeneration
    James F Griffith
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Spine (Phila Pa 1976) 32:E708-12. 2007
    ..A reliability study was conducted. OBJECTIVE.: To modify a grading system for lumbar disc degeneration and to test the reliability of this modified grading system...
  25. doi request reprint Reduced bone perfusion in osteoporosis: likely causes in an ovariectomy rat model
    James F Griffith
    Departments of Diagnostic Radiology and Organ Imaging, Anatomy, Physiology, and Orthopedics and Traumatology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Radiology 254:739-46. 2010
    ..c) RSNA, 2010 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.09090608/-/DC1...
  26. doi request reprint Biological and magnetic contrast evaluation of shape-selective Mn-Fe nanowires
    Ken Cham Fai Leung
    Center of Novel Functional Molecules, Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    IEEE Trans Nanobioscience 8:192-8. 2009
    ..7). These cells' viability and proliferation potential were not affected when the labeling concentration was less than 50 microg/mL...
  27. pmc Liver T1ρ MRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence
    M Deng
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Br J Radiol 85:e590-5. 2012
    ..The aim of this study was to explore the technical feasibility of T(1)ρ MRI for the liver, and to determine the normal range of liver T(1)ρ in healthy subjects at clinical 3 T...
  28. doi request reprint Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: a dynamic contrast-enhanced MRI study
    Ya Feng Zhang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Magn Reson Imaging 30:1139-44. 2009
    ..To investigate the differences in proximal femoral bone marrow blood perfusion indices between hypertensive and normotensive rats using perfusion magnetic resonance imaging (MRI)...
  29. doi request reprint Durable mesenchymal stem cell labelling by using polyhedral superparamagnetic iron oxide nanoparticles
    Hao Hao Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Chemistry 15:12417-25. 2009
    ..The noncytotoxic polyhedral SPIO@SiO(2)-NH(2) nanoparticle-labelled MSCs were successfully implanted in rabbit brain and erector spinae muscle, and demonstrated long-lasting, durable MRI labelling efficacy after 8-12 weeks...
  30. doi request reprint Tissue characterization using terahertz pulsed imaging in reflection geometry
    S Y Huang
    Department of Electronic Engineering, Chinese University of Hong Kong, Hong Kong
    Phys Med Biol 54:149-60. 2009
    ..We found statistically significant differences between the tissue types. These results show that TPI has the potential to accurately differentiate between tissue types non-invasively...
  31. doi request reprint Evolution of radiation-induced brain injury: MR imaging-based study
    Yi Xiang J Wang
    Department of Diagnostic Radiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Radiology 254:210-8. 2010
    ..To evaluate the temporal lobes in patients previously treated for nasopharyngeal carcinoma to provide a better understanding of delayed radiation-induced injury in the brain unaffected by the underlying tumor...
  32. doi request reprint Magnetic nanochains of FeNi3 prepared by a template-free microwave-hydrothermal method
    Juncai Jia
    Department of Chemistry, Environmental Science Programme, Prince of Wales Hospital, and Department of Biochemistry and Environmental Science Program, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    ACS Appl Mater Interfaces 2:2579-84. 2010
    ..Toxicity tests of FeNi3 nanochains show that the as-prepared nanochains are nontoxic to zebrafish larvae. In vitro magnetic resonance imaging (MRI) confirms the effectiveness of the FeNi3 nanochains as sensitive MRI probes...
  33. doi request reprint Concatenated and parallel optimization for the estimation of T1 map in FLASH MRI with multiple flip angles
    Defeng Wang
    Department of Computer Science and Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Magn Reson Med 63:1431-6. 2010
    ..In experimental comparison with Fram's method and the Fitter Tool in Jim, the proposed methods are capable of achieving significantly higher efficiency and more accurate estimations...
  34. doi request reprint Small field-of-view surface coil mr imaging of talar osteochondral lesions
    James F Griffith
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Foot Ankle Int 31:517-22. 2010
    ..We report our experience that the depiction of OCL can be improved by using a small field-of-view (FOV) surface coil...