Ning Wang


Affiliation: The University of Hong Kong
Country: China


  1. Qu Y, Dou B, Tan H, Feng Y, Wang N, Wang D. Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment. Mol Cancer. 2019;18:69 pubmed publisher
  2. Wang N, Tan H, Feng Y, Zhang C, Chen F, Feng Y. microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance. Cancers (Basel). 2018;11: pubmed publisher
    ..Several transcriptional and epigenetic factors may contribute to the dysregulation of miR-23a in cancer. This evidence highlights the essential role of miR-23a in the application of cancer diagnosis, prognosis, and treatment. ..
  3. Zhang C, Wang N, Xu Y, Tan H, Li S, Feng Y. Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study. Int J Mol Sci. 2018;19: pubmed publisher
    ..Furthermore, hepatic metabolic dysregulation may be the predominant pathological mechanism involved in TCM-induced hepatotoxic impairment. ..
  4. Li S, Wang N, Hong M, Tan H, Pan G, Feng Y. Hepatoprotective Effects of a Functional Formula of Three Chinese Medicinal Herbs: Experimental Evidence and Network Pharmacology-Based Identification of Mechanism of Action and Potential Bioactive Components. Molecules. 2018;23: pubmed publisher
  5. Wang X, Wang N, Li H, Liu M, Cao F, Yu X, et al. Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. Int J Mol Sci. 2016;17:577 pubmed publisher
    ..In conclusion, our findings identified for the first time that inactivation of uPA receptor by up-regulation of PAI-1 and down-regulation of uPA is involved in the inhibitory effect of berberine on HCC cell invasion and migration. ..
  6. Hong M, Tan H, Li S, Cheung F, Wang N, Nagamatsu T, et al. Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds. Int J Mol Sci. 2016;17: pubmed publisher
    ..However, further studies are needed to clarify the potential of clinical application of CMs and their active compounds as complementary and alternative therapy in this field. ..
  7. Tan H, Wang N, Takahashi M, Feng Y, Li H, Feng Y. New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of Hepatocellular Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
    ..NYG suppressed tumor expansion of HCC via inhibiting neovascularization, and may be potential adjuvant treatment for HCC. ..
  8. Wang N, Wang X, Tan H, Li S, Tsang C, Tsao S, et al. Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells. Int J Mol Sci. 2016;17: pubmed
    ..Our results shed light on berberine's potential as an anti-tumor agent for clinical cancer therapy. ..
  9. Hong M, Li S, Tan H, Cheung F, Wang N, Huang J, et al. A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines. Molecules. 2017;22: pubmed publisher
    ..Based on the theoretical predictions, further experimental verification should be performed to validate the accuracy of the predicted interactions between herbal ingredients and protein targets in the future. ..

More Information


  1. Lam P, Cheung F, Tan H, Wang N, Yuen M, Feng Y. Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities. Int J Mol Sci. 2016;17:465 pubmed publisher
    ..This review aims to provide new insight into how Chinese medicinal herbs work in therapeutic strategies for liver diseases. ..
  2. Li S, Tan H, Wang N, Zhang Z, Lao L, Wong C, et al. The Role of Oxidative Stress and Antioxidants in Liver Diseases. Int J Mol Sci. 2015;16:26087-124 pubmed publisher
    ..Various factors that cause oxidative stress in liver and effects of antioxidants in the prevention and treatment of liver diseases were summarized, questioned, and discussed. ..
  3. Hong M, Li S, Wang N, Tan H, Cheung F, Feng Y. A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets. Int J Mol Sci. 2017;18: pubmed publisher
  4. Hong M, Zhang Y, Li S, Tan H, Wang N, Mu S, et al. A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae. Molecules. 2017;22: pubmed publisher
    ..The network pharmacology strategy used provides a forceful tool for searching the action mechanism of traditional herbal medicines and novel bioactive ingredients. ..
  5. Zhang C, Xu Y, Tan H, Li S, Wang N, Zhang Y, et al. Neuroprotective effect of He-Ying-Qing-Re formula on retinal ganglion cell in diabetic retinopathy. J Ethnopharmacol. 2018;214:179-189 pubmed publisher
    ..HF administration was a valid therapeutic approach for DR treatment, oriented at the blockade of endoplasmic reticulum- and mitochondria-dependent oxidative stress-induced retinal neurodegeneration including RGC apoptosis. ..
  6. Hong M, Li S, Tan H, Wang N, Tsao S, Feng Y. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. Int J Mol Sci. 2015;16:28705-45 pubmed publisher
  7. Hong M, Wang N, Tan H, Tsao S, Feng Y. MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy. Cancers (Basel). 2015;7:1643-57 pubmed publisher
  8. Wang N, Feng Y, Cheung F, Chow O, Wang X, Su W, et al. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats. BMC Complement Altern Med. 2012;12:239 pubmed publisher