Jennifer Man Fan Wan

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. ncbi Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury
    Jennifer Man Fan Wan
    Food and Nutritional Science Division, Department of Zoology, The University of Hong Kong, Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong, SAR, China
    Int Immunopharmacol 6:750-8. 2006
  2. ncbi Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30
    Jennifer Man Fan Wan
    Food and Nutritional Science Division, School of Biological Sciences, The University of Hong Kong, Hong Kong SAR, PR China
    Int J Oncol 32:689-99. 2008
  3. pmc Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells
    Jennifer Man Fan Wan
    Agricultural, Food and Nutritional Sciences Division, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Chin Med 5:16. 2010
  4. ncbi Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells
    Kenrie Pui Yan Hui
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, P R China
    Oncol Rep 14:145-55. 2005
  5. doi Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity
    Leo Lap Yan Wong
    School of Biological Sciences, The University of Hong Kong, HKSAR, China
    Hum Exp Toxicol 30:1369-81. 2011
  6. ncbi Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: analysis of significant proteins that manipulate T cells proliferation and immunosuppression
    Cheuk Lun Lee
    School of Biological Science, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Int Immunopharmacol 7:1311-24. 2007
  7. ncbi Serial changes in urinary proteome profile of membranous nephropathy: implications for pathophysiology and biomarker discovery
    Heidi Hoi Yee Ngai
    Department of Zoology, The University of Hong Kong, HKSAR, P R China
    J Proteome Res 5:3038-47. 2006
  8. doi Regulatory properties of polysaccharopeptide derived from Coriolus versicolor and its combined effect with ciclosporin on the homeostasis of human lymphocytes
    Cheuk Lun Lee
    School of Biological Sciences, Kadoorie Biological Sciences Building, The University of Hong Kong, Pokfulam Road, Hong Kong SAR
    J Pharm Pharmacol 62:1028-36. 2010
  9. ncbi The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells
    Xiaotong Yang
    Department of Zoology, The University of Hong Kong, Pokfalum Road, Hong Kong, SAR, P R China
    Oncol Rep 13:1201-10. 2005
  10. doi Premature delivery reduces intestinal cytoskeleton, metabolism, and stress response proteins in newborn formula-fed pigs
    Pingping Jiang
    School of Biological Sciences, University of Hong Kong, Hong Kong SAR, China
    J Pediatr Gastroenterol Nutr 56:615-22. 2013

Collaborators

  • Per Torp Sangild
  • Visith Thongboonkerd
  • Paul C Turner
  • Hani El-Nezami
  • Thomas Thymann
  • George L Tipoe
  • Mette Schmidt
  • Wai Hung Sit
  • Pingping Jiang
  • Cheuk Lun Lee
  • Hualin Wang
  • Ping Ping Jiang
  • Leo Lai Chan
  • Heidi Hoi Yee Ngai
  • Leo Lap Yan Wong
  • Carol Yee Ki Lee
  • Lam Yim Murphy Wan
  • Ivor John Hodgkiss
  • Irene Wing Yan Jor
  • Sheung Tat Fan
  • Kwan Man
  • Paul Kwan Sing Lam
  • Fanya Zeng
  • Kenrie Pui Yan Hui
  • Xiaotong Yang
  • Samuel Chun Lap Lo
  • Abby Sin Chi Mak
  • John Hon Kei Lum
  • Wat Hung Sit
  • Chung Yung Jetty Lee
  • Chit Shing Jackson Woo
  • Malene S Cilieborg
  • Tim Kåre Jensen
  • Birgitte Smith
  • Christian Nielsen
  • Niels Qvist
  • Guang Wu
  • Hyoung Jin Park
  • Michael Ladegaard Jensen
  • Malene Skovsted Cilieborg
  • Leo Jld Van Griensven
  • Kin Tung Tam
  • Richard H Siggers
  • Wai Lim Ling
  • Murphy Lam Yim Wan
  • Xiatong Yang
  • Kian Cheng Tan-Un
  • Jayda Lee Ann Siggers
  • Ivy Wing Yan So
  • David Dudgeon
  • Dennis Paul Hsientang Hsieh
  • Nicola Man Chi Choi
  • Alvin Yam Tat Ho
  • Ruo Jun Xu
  • Da Zhi Wang
  • Hong Nong Chou
  • Daniel Kwong On Chan
  • Maria Gar Yee Lo
  • Chung Chau Hon
  • Ivy Ka Man Law
  • Raymond Kin Hi Hui
  • Victor Wai Lap Ng
  • Ken Yan Ching Chow
  • Frederick Chi Ching Leung
  • Xiao tong Yang

Detail Information

Publications26

  1. ncbi Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury
    Jennifer Man Fan Wan
    Food and Nutritional Science Division, Department of Zoology, The University of Hong Kong, Kadoorie Biological Sciences Building, Pokfulam Road, Hong Kong, SAR, China
    Int Immunopharmacol 6:750-8. 2006
    ..The present study explains some known biological activities of SM, and supports the clinical application of SM in the prevention of inflammatory diseases induced by Gram-negative bacteria...
  2. ncbi Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30
    Jennifer Man Fan Wan
    Food and Nutritional Science Division, School of Biological Sciences, The University of Hong Kong, Hong Kong SAR, PR China
    Int J Oncol 32:689-99. 2008
    ..This study provides further insight into the synergistic mechanisms of PSP and supports the hypothesis that the anticancer potentials of PSP is not limited to leukemia but may also be used as an adjuvant therapy for breast cancers...
  3. pmc Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells
    Jennifer Man Fan Wan
    Agricultural, Food and Nutritional Sciences Division, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Chin Med 5:16. 2010
    ..The present study aims to investigate whether PSP pre-treatment can increase the response of the human leukemia HL-60 cells to apoptosis induction by Camptothecin (CPT)...
  4. ncbi Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells
    Kenrie Pui Yan Hui
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, P R China
    Oncol Rep 14:145-55. 2005
    ..Our data support the potential development of PSP as an adjuvant for leukemia treatment, but also imply the importance of understanding its interaction with individual anticancer agents...
  5. doi Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity
    Leo Lap Yan Wong
    School of Biological Sciences, The University of Hong Kong, HKSAR, China
    Hum Exp Toxicol 30:1369-81. 2011
    ..In this rat model, we profiled hepatic proteome alterations in response to CCl(4) intoxication. The findings should facilitate understanding of the mechanism of CCl(4)-induced liver injury...
  6. ncbi Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: analysis of significant proteins that manipulate T cells proliferation and immunosuppression
    Cheuk Lun Lee
    School of Biological Science, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Int Immunopharmacol 7:1311-24. 2007
    ..Most of these altered proteins have functional significance in protein degradation, the antioxidant pathway, energy metabolism and immune cell regulation...
  7. ncbi Serial changes in urinary proteome profile of membranous nephropathy: implications for pathophysiology and biomarker discovery
    Heidi Hoi Yee Ngai
    Department of Zoology, The University of Hong Kong, HKSAR, P R China
    J Proteome Res 5:3038-47. 2006
    ..These data underscore the significant impact of urinary proteomics in unraveling disease pathophysiology and biomarker discovery...
  8. doi Regulatory properties of polysaccharopeptide derived from Coriolus versicolor and its combined effect with ciclosporin on the homeostasis of human lymphocytes
    Cheuk Lun Lee
    School of Biological Sciences, Kadoorie Biological Sciences Building, The University of Hong Kong, Pokfulam Road, Hong Kong SAR
    J Pharm Pharmacol 62:1028-36. 2010
    ..This was done by investigating the mechanistic actions of PSP in relation to ciclosporin by performing cell cycle and cell death analysis of human lymphocytes in vitro...
  9. ncbi The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells
    Xiaotong Yang
    Department of Zoology, The University of Hong Kong, Pokfalum Road, Hong Kong, SAR, P R China
    Oncol Rep 13:1201-10. 2005
    ....
  10. doi Premature delivery reduces intestinal cytoskeleton, metabolism, and stress response proteins in newborn formula-fed pigs
    Pingping Jiang
    School of Biological Sciences, University of Hong Kong, Hong Kong SAR, China
    J Pediatr Gastroenterol Nutr 56:615-22. 2013
    ....
  11. ncbi Use of two-dimensional gel electrophoresis to differentiate morphospecies of Alexandrium minutum, a paralytic shellfish poisoning toxin-producing dinoflagellate of harmful algal blooms
    Leo Lai Chan
    Department of Ecology and Biodiversity, The University of Hong Kong, Hong Kong
    Proteomics 5:1580-93. 2005
    ..minutum. Initial studies revealed that the expression pattern of T1 was tightly correlated to toxin biosynthesis in the examined alga and may be used to serve as a potential toxin indicator...
  12. doi Intestinal proteome changes during infant necrotizing enterocolitis
    Pingping Jiang
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Pediatr Res 73:268-76. 2013
    ..Changes in the intestinal and colonic proteome in patients with necrotizing enterocolitis (NEC) may help to characterize the disease pathology and identify new biomarkers and treatment targets for NEC...
  13. doi Bacterial colonization affects the intestinal proteome of preterm pigs susceptible to necrotizing enterocolitis
    Pingping Jiang
    School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR, China
    Neonatology 99:280-8. 2011
    ..We hypothesized that the initial bacterial colonization of the gut affects the intestinal proteome independently of enteral feeding...
  14. pmc Antibiotics increase gut metabolism and antioxidant proteins and decrease acute phase response and necrotizing enterocolitis in preterm neonates
    Pingping Jiang
    School of Biological Sciences, The University of Hong Kong, Hong Kong, People s Republic of China
    PLoS ONE 7:e44929. 2012
    ..We hypothesized that broad-spectrum antibiotics, given immediately after preterm birth, would reduce NEC sensitivity and support intestinal protective mechanisms...
  15. ncbi The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation
    Carol Yee Ki Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, P R China
    Int J Oncol 36:991-8. 2010
    ..This study provides novel mechanistic insights into the modulation of DHA on human hepatocarcinoma...
  16. doi Enteral feeding in utero induces marked intestinal structural and functional proteome changes in pig fetuses
    Pingping Jiang
    School of Biological Sciences, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    Pediatr Res 69:123-8. 2011
    ..Hence, immediate postnatal feeding-induced gut changes are largely independent of factors related to the birth transition...
  17. ncbi Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray
    Fanya Zeng
    Department of Zoology, The University of Hong Kong, Hong Kong, SAR, P R China
    Int J Oncol 27:513-23. 2005
    ..The present study provides new insight into the molecular mechanisms involved in PSP-induced apoptosis in leukemic HL-60 cells analyzed by cDNA microarray...
  18. ncbi Immunoregulatory and antioxidant performance of alpha-tocopherol and selenium on human lymphocytes
    Chung Yung Jetty Lee
    Department of Zoology, University of Hong Kong, SAR, China
    Biol Trace Elem Res 86:123-36. 2002
    ..This suggests that micronutrient status is an important factor in considering when interpreting the results of in vitro assays of lymphocyte function...
  19. doi Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells
    Lam Yim Murphy Wan
    School of Biological Sciences, Faculty of Science, Kadoorie Biological Sciences Building, The University of Hong Kong, Pokfulam, Hong Kong
    Toxicol Lett 220:238-46. 2013
    ..These also provide a better understanding of the possible effects of Fusarium toxins, alone or in combinations on the immunological defense mechanisms of IECs, which would contribute to the risk assessment of these toxins. ..
  20. ncbi Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach
    Heidi Hoi Yee Ngai
    Department of Zoology, The University of Hong Kong, HKSAR, People s Republic of China
    J Proteome Res 6:3313-20. 2007
    ..Our findings may lead to a significant advance in the attempt to define a new therapeutic target and/or novel biomarker for human MN...
  21. ncbi Proteomic study of a model causative agent of harmful algal blooms, Prorocentrum triestinum II: the use of differentially expressed protein profiles under different growth phases and growth conditions for bloom prediction
    Leo Lai Chan
    Department of Ecology and Biodiversity, The University of Hong Kong, HKSAR, PR China
    Proteomics 4:3214-26. 2004
    ....
  22. doi Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways
    Cheuk Lun Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China
    J Pharm Pharmacol 60:1491-9. 2008
    ..These findings refine our understanding of the effects of PSP on T lymphocytes and its adjuvant properties with the immunosuppressant ciclosporin for possible control of autoimmune diseases...
  23. pmc Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis
    Hualin Wang
    Food and Nutrition Division, School of Biological Sciences, The University of Hong Kong, Hong Kong, SAR, China
    Chin Med 7:23. 2012
    ..abstract:..
  24. ncbi The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding
    Pingping Jiang
    Division of Agricultural, Food and Nutritional Science, School of Biological Sciences, The University of Hong Kong, Hong Kong S A R, P R China
    J Nutr 138:1895-901. 2008
    ..The data provided novel mechanistic insights into the pathogenesis of NEC and the insults of a formulated diet to the premature gut...
  25. doi Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study
    Hualin Wang
    School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, Hubei, China Food and Nutrition Division, School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Food Chem Toxicol 74:131-8. 2014
    ..Our findings confirmed the benefits of EVOO against chronic liver injury, which may be attributable to the antioxidant effects, hepatocellular function regulation and hepatic metabolism modification effects of EVOO. ..
  26. ncbi Identification and characterization of a "biomarker of toxicity" from the proteome of the paralytic shellfish toxin-producing dinoflagellate Alexandrium tamarense (Dinophyceae)
    Leo Lai Chan
    TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin, PR China
    Proteomics 6:654-66. 2006
    ..Potentially, immunoassays could be developed to detect the presence of toxic algae in routine monitoring programs as well as to predict bloom development and movement...