Joseph J Sung

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions
    J J Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Pathol 157:729-35. 2000
  2. pmc Increased expression of survivin in gastric cancer patients and in first degree relatives
    J Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Br J Cancer 87:91-7. 2002
  3. doi request reprint The use of Pillcam Colon in assessing mucosal inflammation in ulcerative colitis: a multicenter study
    J Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Endoscopy 44:754-8. 2012
  4. pmc One-year delayed effect of fog on malaria transmission: a time-series analysis in the rain forest area of Mengla County, south-west China
    Linwei Tian
    Stanley Ho Center for Emerging Infectious Diseases, School of Public Health, Chinese University of Hong Kong, Hong Kong, PR China
    Malar J 7:110. 2008
  5. pmc Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological study
    Rui Wang
    Second Military Medical University, Shanghai, China
    Health Qual Life Outcomes 8:128. 2010
  6. pmc Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation
    Siu Po Ip
    School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
    Chin Med 5:8. 2010
  7. pmc Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology
    Xiaoyan Yan
    Department of Health Statistics, Second Military Medical University, Shanghai, China
    BMC Gastroenterol 9:86. 2009
  8. pmc A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China
    Jia He
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    BMC Gastroenterol 10:94. 2010
  9. pmc IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese
    Shiyan Wang
    Institute of Digestive Disease and Department of Meddicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    BMC Gastroenterol 10:15. 2010
  10. ncbi request reprint Current management of peptic ulcer bleeding
    Joseph Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Nat Clin Pract Gastroenterol Hepatol 3:24-32. 2006

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions
    J J Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Pathol 157:729-35. 2000
    ..Both premalignant and malignant gastric lesions demonstrate strong COX-2 expression. Successful eradication of H. pylori leads to down-regulation of COX-2 expression but failed to reverse IM at 1 year...
  2. pmc Increased expression of survivin in gastric cancer patients and in first degree relatives
    J Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Br J Cancer 87:91-7. 2002
    ..Co-expression of survivin and cyclo-oxygenase-2 may suggest multiple pathways contributing to the inhibition of apoptosis in gastric cancer...
  3. doi request reprint The use of Pillcam Colon in assessing mucosal inflammation in ulcerative colitis: a multicenter study
    J Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Endoscopy 44:754-8. 2012
    ..The aim of this multicenter study was to test whether mucosal appearance, as reported by colon capsule endoscopy (CCE), can be used to differentiate active from inactive ulcerative colitis...
  4. pmc One-year delayed effect of fog on malaria transmission: a time-series analysis in the rain forest area of Mengla County, south-west China
    Linwei Tian
    Stanley Ho Center for Emerging Infectious Diseases, School of Public Health, Chinese University of Hong Kong, Hong Kong, PR China
    Malar J 7:110. 2008
    ..This study explored the impact of climate variability on the transmission of malaria in the tropical rain forest area of Mengla County, south-west China...
  5. pmc Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological study
    Rui Wang
    Second Military Medical University, Shanghai, China
    Health Qual Life Outcomes 8:128. 2010
    ....
  6. pmc Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation
    Siu Po Ip
    School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
    Chin Med 5:8. 2010
    ..The procedures developed in the present study will serve as a protocol for other poly-herbal Chinese medicine studies...
  7. pmc Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology
    Xiaoyan Yan
    Department of Health Statistics, Second Military Medical University, Shanghai, China
    BMC Gastroenterol 9:86. 2009
    ..The aim of this study was to validate a methodology for the epidemiological investigation of gastrointestinal symptoms and endoscopic findings in China...
  8. pmc A population-based survey of the epidemiology of symptom-defined gastroesophageal reflux disease: the Systematic Investigation of Gastrointestinal Diseases in China
    Jia He
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
    BMC Gastroenterol 10:94. 2010
    ..This study aimed to determine the prevalence of symptom-defined GERD across five regions of China, and to investigate variables associated with GERD...
  9. pmc IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese
    Shiyan Wang
    Institute of Digestive Disease and Department of Meddicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    BMC Gastroenterol 10:15. 2010
    ....
  10. ncbi request reprint Current management of peptic ulcer bleeding
    Joseph Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Nat Clin Pract Gastroenterol Hepatol 3:24-32. 2006
    ..The choice between surgery and repeat endoscopic therapy should be based on the pre-existing comorbidities of the patient and the characteristics of the ulcer...
  11. ncbi request reprint Early gastric cancer: diagnosis, treatment and prevention
    Joseph Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, China
    Eur J Gastroenterol Hepatol 18:817-9. 2006
  12. pmc Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis
    Joseph J Y Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 56:1364-73. 2007
    ..Hemoclips, injection therapy and thermocoagulation (heater probe or electrocoagulation) are the most commonly used types of endoscopic hemostasis for the control of non-variceal gastrointestinal bleeding...
  13. ncbi request reprint Increasing incidence of colorectal cancer in Asia: implications for screening
    Joseph J Y Sung
    Institute of Digestive Diseases, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Lancet Oncol 6:871-6. 2005
    ..Although epidemiological data are scanty, most Asian populations are not aware of the growing problem of colorectal cancer. More work is needed to elucidate the magnitude of the problem in Asia...
  14. ncbi request reprint Changing role of endoscopy in the new millennium. Bushell Lecture, Asia-Pacific Digestive Week 2001
    Joseph Jy Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 17:369-73. 2002
    ..Endoscopists should keep their mind open and be prepared for the changing role of endoscopy in the new millennium...
  15. ncbi request reprint The role of acid suppression in the management and prevention of gastrointestinal hemorrhage associated with gastroduodenal ulcers
    Joseph J Sung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Gastroenterol Clin North Am 32:S11-23. 2003
    ..Ongoing clinical studies should show whether the theoretical advantage translates into clinically meaningful benefits...
  16. pmc Avoid complacency--prepare for the worst
    J J Y Sung
    Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Epidemiol Community Health 57:775-6. 2003
  17. pmc Westernisation of gastrointestinal diseases in Asia
    J J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Gut 53:152. 2004
    ..Report on the Asia Pacific Congress of Gastroenterology Digestive Week, Singapore, 2003..
  18. ncbi request reprint Should we eradicate Helicobacter pylori in non-steroidal anti-inflammatory drug users?
    J J Y Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 20:65-70. 2004
    ..Whether or not one should test-and-treat H. pylori before prescribing NSAIDs is a complicated issue. Factors such as the ulcer risk of patients, previous history of NSAID usage and the use of aspirin or NSAIDs would guide the strategy...
  19. ncbi request reprint The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison
    Joseph J Y Sung
    Endoscopy Center, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Ann Intern Med 139:237-43. 2003
    ..The optimal treatment of ulcers with nonbleeding visible vessels and adherent clots is unclear...
  20. ncbi request reprint Screening for colorectal cancer in Chinese: comparison of fecal occult blood test, flexible sigmoidoscopy, and colonoscopy
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Gastroenterology 124:608-14. 2003
    ..The aim of this study was to compare the accuracy and safety of these 3 screening procedures in a general population of ethnic Chinese...
  21. ncbi request reprint Agreements among traditional Chinese medicine practitioners in the diagnosis and treatment of irritable bowel syndrome
    J J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Aliment Pharmacol Ther 20:1205-10. 2004
    ..Traditional Chinese Medicine was frequently used by patients with irritable bowel syndrome...
  22. ncbi request reprint Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 128:1890-7. 2005
    ..This study aimed to determine whether intrahepatic hepatitis B virus (HBV) covalently closed circular (ccc) DNA and total HBV DNA levels at the end of therapy would predict sustained response to therapy...
  23. pmc Acupuncture for gastrointestinal disorders: myth or magic
    J J Y Sung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong
    Gut 51:617-9. 2002
    ..Exploration of its clinical applications should focus on conditions for which conventional medicine can find no satisfactory remedy...
  24. doi request reprint Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: rationale/design of Peptic Ulcer Bleed study
    J J Y Sung
    Institute of Digestive Diseases, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Aliment Pharmacol Ther 27:666-77. 2008
    ..A limited number of trials have investigated the efficacy of proton pump inhibitors for peptic ulcer bleeding, and some study design issues have been identified...
  25. doi request reprint Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B
    Joseph J Y Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, People s Republic of China
    J Hepatol 48:728-35. 2008
    ..We aimed to evaluate nucleoside/nucleotide combination therapy in treatment-naïve HBeAg-positive patients with chronic hepatitis B (CHB)...
  26. ncbi request reprint Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding
    Joseph J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 60:1170-7. 2011
    ..Aspirin should be resumed soon after stabilisation and clopidogrel alone is no safer than aspirin plus a PPI. When dual antiplatelet agents are used, prophylactic use of a PPI reduces the risk of adverse gastrointestinal events...
  27. ncbi request reprint Reversible Kupffer cell suppression in biliary obstruction is caused by hydrophobic bile acids
    J J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT
    J Hepatol 30:413-8. 1999
    ..We studied the superoxide generation of Kupffer cell in biliary obstruction and after incubation with bile acids to elucidate the mechanism of impaired intracellular killing of these phagocytes...
  28. doi request reprint Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding
    J J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Endoscopy 43:291-5. 2011
    ..The safety and effectiveness of Hemospray for hemostasis of active peptic ulcer bleeding in humans was evaluated...
  29. ncbi request reprint One-week ranitidine bismuth citrate in combinations with metronidazole, amoxycillin and clarithromycin in the treatment of Helicobacter pylori infection: the RBC-MACH study
    J J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 13:1079-84. 1999
    ..We have previously shown that ranitidine bismuth citrate (RBC)-based triple therapy is comparable to proton pump inhibitor-based triple therapy in eradicating Helicobacter pylori infection...
  30. doi request reprint Patients with polyps larger than 5 mm in computed tomography colonoscopy screening have high risk for advanced colonic neoplasia in Asia
    Joseph J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Gastroenterol Hepatol 9:47-51. 2011
    ..We estimated the risk of advanced colonic neoplasia (ACN) from polyps <10 mm and the risk of ACN detection failure if patients with polyps <10 mm are not referred for colonoscopy...
  31. ncbi request reprint Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study
    J J Sung
    Endoscopy Center, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 119:7-14. 2000
    ..We studied if H. pylori eradication would alter the course of premalignant histologic changes in the stomach...
  32. ncbi request reprint Non-steroidal anti-inflammatory drug toxicity in the upper gastrointestinal tract
    J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT
    J Gastroenterol Hepatol 15:G58-68. 2000
    ..The use of potent anti-ulcer therapy, treatment of H. pylori infection and the development of Cox-II inhibitor will change the scenario of NSAID/aspirin-related gastrointestinal toxicity in the next millennium...
  33. doi request reprint Treatment of chronic hepatitis B in Asia-Pacific countries: is the Asia-Pacific consensus statement being followed?
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Antivir Ther 15:607-16. 2010
    ..We aimed to determine whether clinicians in the Asia-Pacific region are treating patients with chronic hepatitis B according to the Asia-Pacific consensus statement on the management of chronic hepatitis B...
  34. doi request reprint Marshall and Warren Lecture 2009: peptic ulcer bleeding: an expedition of 20 years from 1989-2009
    Joseph J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 25:229-33. 2010
    ..Instead of merely focusing on safety in the gastrointestinal tract, striking a balance between risk and benefit of continuing anti-platelet agents should be a top agenda...
  35. ncbi request reprint Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Diseases, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Ann Intern Med 150:455-64. 2009
    ..Use of proton-pump inhibitors in the management of peptic ulcer bleeding is controversial because discrepant results have been reported in different ethnic groups...
  36. doi request reprint Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial
    Joseph J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong
    Ann Intern Med 152:1-9. 2010
    ..It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin...
  37. doi request reprint Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases
    Joseph J Y Sung
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Am J Gastroenterol 105:84-9. 2010
    ..Despite advances in endoscopic and pharmacological treatment for peptic ulcer bleeding (PUB), mortality remains at 5-10% worldwide. Our aim was to investigate the causes of death in a prospective cohort of PUB in a tertiary referral center...
  38. doi request reprint Systematic review: the global incidence and prevalence of peptic ulcer disease
    J J Y Sung
    Institute of Digestive Disease, Chinese University of Hong Kong, Sha Tin, Hong Kong, China
    Aliment Pharmacol Ther 29:938-46. 2009
    ..The management of H. pylori infection has improved radically in recent years; however, the prescription of ASA and NSAIDs has increased over the same period...
  39. doi request reprint Asia Pacific consensus recommendations for colorectal cancer screening
    J J Y Sung
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 57:1166-76. 2008
    ..There is no consensus on whether nurses should be trained to perform endoscopic procedures for screening of colorectal neoplasia...
  40. doi request reprint Asian perspectives in the management of inflammatory bowel disease: findings from a recent survey
    Joseph J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    J Gastroenterol Hepatol 25:183-93. 2010
    ..The present study aims to investigate the number of existing and new cases of IBD and to understand the current practice of diagnosis and treatment of IBD in different Asian countries...
  41. pmc Accuracy of endoscopic ultrasonography in diagnosing ascites and predicting peritoneal metastases in gastric cancer patients
    Y T Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin NT, Hong Kong, China
    Gut 54:1541-5. 2005
    ..Preoperative diagnosis of peritoneal metastases (PM) is difficult in patients with gastric cancer (GC)...
  42. ncbi request reprint Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen
    F K Chan
    Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    N Engl J Med 344:967-73. 2001
    ..It is uncertain whether infection with Helicobacter pylori is a risk factor for bleeding in such patients...
  43. ncbi request reprint Validation of a new immunoblot assay for the diagnosis of Helicobacter pylori in the Asian population
    W K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:423-8. 2001
    ..Currently available serology tests often show sub-optimal accuracy when used for Asian patients...
  44. ncbi request reprint Comparison of two new rapid serology tests for diagnosis of Helicobacter pylori infection in Chinese patients
    C T Hung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Dig Liver Dis 34:111-5. 2002
    ..Rapid serology test is a simple and convenient way for diagnosing Helicobacter pylori infection. However performances of these tests are usually less satisfactory than expected, particularly in developing countries...
  45. ncbi request reprint Helicobacter pylori infection in Chinese subjects with type 2 diabetes
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Pirnce of Wales Hospital, Shatin
    Endocr Res 27:171-7. 2001
    ..No association was found between HP infection, glycaemic status, and duration of diabetes and upper gastrointestinal symptoms in these diabetic subjects...
  46. ncbi request reprint Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong
    J H You
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Aliment Pharmacol Ther 15:1009-15. 2001
    ..One-week triple regimens have been shown to be effective for the treatment of Helicobacter pylori-related peptic ulcer disease...
  47. ncbi request reprint Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer
    K F To
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
    Life Sci 70:483-9. 2001
    ..Our results suggested that alterations of FzE3 or hsFRP were frequent in gastric cancer. These provide alternative mechanisms leading to activation of Wnt signaling pathway in gastric carcinogenesis...
  48. ncbi request reprint Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues
    W K Leung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR
    Cancer 91:2294-301. 2001
    ..Transcriptional silencing by CpG-island hypermethylation now is believed to be an important mechanism of tumorigenesis. To date, studies on CpG-island hypermethylation in gastric carcinoma and adjacent normal tissues are few...
  49. ncbi request reprint Role of acid suppressants in prophylaxis of NSAID damage
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong
    Best Pract Res Clin Gastroenterol 15:433-45. 2001
    ..pylori -infected NSAID users. The efficacy of PPIs for the prevention of ulcer complications in H. pylori-negative NSAID users remains uncertain...
  50. ncbi request reprint Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upper GI bleeding? A prospective study of 977 patients
    H L Chan
    Departments of Medicine and Therapeutics, Surgery, and Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
    Gastrointest Endosc 53:438-42. 2001
    ..Whether it is a significant problem in the Orient is unclear. The aim of this study was to investigate the incidence of non-H pylori, non-NSAID ulcers presenting with GI bleeding...
  51. ncbi request reprint Apoptosis and proliferation in Helicobacter pylori-associated gastric intestinal metaplasia
    W K Leung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Aliment Pharmacol Ther 15:1467-72. 2001
    ..Imbalance between apoptosis and proliferation may be one of the mechanisms underlying H. pylori associated gastric carcinogenesis...
  52. ncbi request reprint Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin
    Aliment Pharmacol Ther 12:1201-5. 1998
    ..We investigated the effects of H. pylori eradication on the healing of NSAID-associated bleeding peptic ulcers...
  53. ncbi request reprint Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Hepatogastroenterology 46:1816-8. 1999
    ..The use of this simple and non-invasive diagnostic technique in protein-losing enteropathy is discussed...
  54. ncbi request reprint Salvage therapies after failure of Helicobacter pylori eradication with ranitidine bismuth citrate-based therapies
    F K Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong
    Aliment Pharmacol Ther 14:91-5. 2000
    ..Salvage therapies after initial Helicobacter pylori eradication failure of ranitidine bismuth citrate (RBC)-based regimens remain undefined...
  55. ncbi request reprint EUS-guided injection of cyanoacrylate for bleeding gastric varices
    Y T Lee
    Departments of Medicine and Therapeutics and Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, China
    Gastrointest Endosc 52:168-74. 2000
    ..Our aim was to investigate the use of endosonography (EUS) in monitoring cyanoacrylate injection to obliterate gastric varices...
  56. ncbi request reprint Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:19-24. 2001
    ..Prophylactic misoprostol or non-steroidal anti-inflammatory drugs (NSAIDs) with low gastric toxicity (nabumetone) has been shown to reduce mucosal injury...
  57. ncbi request reprint Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis
    F K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:187-93. 2001
    ..There are conflicting reports on the expression of cyclooxygenase in Helicobacter pylori infection...
  58. doi request reprint Closure of a gastrotomy after transgastric tubal ligation by using the Eagle Claw VII: a survival experiment in a porcine model (with video)
    Philip W Chiu
    Institute of Digestive Disease, Department of Surgery, The Chinese University of Hong Kong, Hong Kong
    Gastrointest Endosc 68:554-9. 2008
    ..Transgastric access to the peritoneal cavity presents new opportunities for novel endoscopic surgery. Secure closure of the gastrotomy site is critical to the success of transgastric endoscopic surgery...
  59. ncbi request reprint Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia
    J Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Aliment Pharmacol Ther 15:1505-11. 2001
    ..pylori-associated intestinal metaplasia. Eradication of H. pylori infection reverses the aberrant expression of cyclin D2 and p27 in intestinal metaplasia...
  60. doi request reprint Inhibition of HBV gene expression and replication by stably expressed interferon-alpha1 via adeno-associated viral vectors
    Zhi Li
    Department of Microbiology, The University of Hong Kong, Hong Kong, China
    J Gene Med 10:619-27. 2008
    ..Frequent and repeated injection is also a big burden for patients. In the present study, a single dose of vector-delivered IFNalpha1 was tested for its anti-HBV effects...
  61. ncbi request reprint Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others?
    Ignatius T Yu
    Centre for Emerging Infectious Disease, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China
    Clin Infect Dis 44:1017-25. 2007
    ..We systematically analyzed the risk factors for nosocomial outbreaks of SARS among hospital wards in Guangzhou and Hong Kong, China...
  62. ncbi request reprint Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer
    T L Lee
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Cancer Lett 168:133-40. 2001
    ..07). The results from this study suggest that gastric cancer with microsatellite instability or COX-2 overexpression present with diverse clinicopathological features...
  63. ncbi request reprint Correlation between Helicobacter pylori infection, gastric inflammation and serum homocysteine concentration
    W K Leung
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Helicobacter 6:146-50. 2001
    ..CONCLUSIONS: The postulated link between H. pylori infection and ischemic heart disease, if it actually exists, is unlikely to be mediated through hyperhomocysteinemia...
  64. ncbi request reprint Incidence of gastroesophageal malignancy in patients with dyspepsia in Hong Kong: implications for screening strategies
    J J Sung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gastrointest Endosc 54:454-8. 2001
    ..This finding raises concerns as to the safety of the "test-and-treat" strategy for the management of patients with dyspepsia in Asia...
  65. ncbi request reprint Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis
    J C Wu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Aliment Pharmacol Ther 15:1913-9. 2001
    ..Helicobacter pylori infection has been suggested to be protective against gastro-oesophageal reflux disease. However, a significant proportion of patients with gastro-oesophageal reflux disease are infected by H. pylori...
  66. pmc Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
    W K Leung
    Departments of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Br J Cancer 84:335-9. 2001
    ..3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer...
  67. ncbi request reprint Early gastric cancer
    Wai K Leung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Rev Gastroenterol Mex 68:67-8. 2003
  68. ncbi request reprint Metastatic thymic neuroendocrine carcinoma presenting as a pancreatic tumor
    Y T Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Endoscopy 38:E58-9. 2006
  69. ncbi request reprint Epidemiology of hepatitis A in Asia and experience with the HAV vaccine in Hong Kong
    J J Sung
    Division of Gastroenterology and Hepatology, Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Viral Hepat 7:27-8. 2000
    ..Hepatitis A vaccination of patients with or without chronic HBV infection has been shown to be efficacious and associated with a good safety profile...
  70. ncbi request reprint Esophageal small-cell cancer mimicking stromal tumor
    Y T Lee
    Institute of Digestive Diseases, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Endoscopy 38:E21-2. 2006
  71. ncbi request reprint Role of laboratory variables in differentiating SARS-coronavirus from other causes of community-acquired pneumonia within the first 72 h of hospitalization
    N Lee
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Eur J Clin Microbiol Infect Dis 25:765-72. 2006
    ....
  72. doi request reprint Cost-effectiveness analysis of high-dose omeprazole infusion before endoscopy for patients with upper-GI bleeding
    Kelvin K F Tsoi
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Gastrointest Endosc 67:1056-63. 2008
    ..The use of intravenous (i.v.) proton pump inhibitors (PPI) before an endoscopy in upper-GI bleeding (UGIB) was shown to reduce the need of endoscopic therapy and shorten hospital stay...
  73. ncbi request reprint Short-term outcome of critically ill patients with severe acute respiratory syndrome
    Charles D Gomersall
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, ROC
    Intensive Care Med 30:381-7. 2004
    ..To document the outcome and determine prognostic factors for patients with severe acute respiratory syndrome who require admission to an intensive care unit...
  74. ncbi request reprint Helicobacter pylori and benign upper digestive disease
    Larry H Lai
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, NT, Hong Kong SAR, China
    Best Pract Res Clin Gastroenterol 21:261-79. 2007
    ..Although there is little evidence to support a causal relationship between H. pylori and non-ulcer dyspepsia, treatment of the infection gives a modest improvement of symptoms...
  75. ncbi request reprint Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia
    Alfa H C Bai
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Int J Cancer 112:846-53. 2004
    ..Our study demonstrated the early and specific involvement of promoter hypermethylation in the colorectal adenoma-carcinoma sequence...
  76. ncbi request reprint Is the prevalence of idiopathic ulcers really on the increase?
    Dorothy K L Chow
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Nat Clin Pract Gastroenterol Hepatol 4:176-7. 2007
  77. doi request reprint Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
    Jun Yu
    Department of Medicine, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong
    Hepatology 48:508-18. 2008
    ..Moreover, UCHL1 directly interacts with p53 and stabilizes p53 through the ubiquitination pathway...
  78. pmc High prevalence of the CD14-159CC genotype in patients infected with severe acute respiratory syndrome-associated coronavirus
    Fang F Yuan
    Cell Biology Laboratory, ARCBS Endeavour, 153 Clarence Street, Sydney, NSW 2000, Australia
    Clin Vaccine Immunol 14:1644-5. 2007
    ..029; odds ratio, 2.74; 95% confidence interval, 1.15 to 6.57; controls, P = 0.04; odds ratio, 2.41; 95% confidence interval, 1.05 to 5.54), and both CD14-159CC and FcgammaRIIA-RR131 are risk genotypes for severe SARS-CoV infection...
  79. ncbi request reprint Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells
    Michael W Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China
    Oncol Rep 18:1557-62. 2007
    ..RNA interference may be a promising alternative to specific COX-2 inhibitors in the prevention and treatment of gastric cancer...
  80. ncbi request reprint Airflow and droplet spreading around oxygen masks: a simulation model for infection control research
    Margaret Ip
    Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Am J Infect Control 35:684-9. 2007
    ..Respiratory assist devices, such as oxygen masks, may enhance the potential to spread infectious aerosols from patients with respiratory infections...
  81. doi request reprint OLGA gastritis staging in young adults and country-specific gastric cancer risk
    Massimo Rugge
    Department of Medical Diagnostic Sciences and Special Therapies II Pathology Unit, University of Padova, Italy
    Int J Surg Pathol 16:150-4. 2008
    ..In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients...
  82. ncbi request reprint Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in post-mortem tissues
    Julian W Tang
    Department of Microbiology, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong SAR, China
    J Med Virol 79:1245-53. 2007
    ..This quantitative assessment further supports SARS-CoV has a specific tropism for the human respiratory and gastrointestinal tracts, which may be related to the density of SARS-CoV receptors...
  83. ncbi request reprint Colorectal neoplasia in Asia: a multicenter colonoscopy survey in symptomatic patients
    Wai K Leung
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Gastrointest Endosc 64:751-9. 2006
    ..The incidence of colorectal cancer is rising rapidly in some Asian countries...
  84. ncbi request reprint Lamivudine for patients with chronic hepatitis B and advanced liver disease
    Yun Fan Liaw
    Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    N Engl J Med 351:1521-31. 2004
    ..The effectiveness of antiviral therapy in preventing disease progression in patients with chronic hepatitis B and advanced fibrosis or cirrhosis is unknown...
  85. ncbi request reprint A five-year follow-up study on the pathological changes of gastric mucosa after H. pylori eradication
    Liya Zhou
    Department of Gastroenterology, the Third Hospital of Peking University, Beijing 100083, China
    Chin Med J (Engl) 116:11-4. 2003
    ..pylori eradication in H. pylori-positive subjects in a high incidence region of gastric cancer...
  86. ncbi request reprint A major outbreak of severe acute respiratory syndrome in Hong Kong
    Nelson Lee
    Department of Medicine, Chinese University of Hong Kong, Hong Kong, China
    N Engl J Med 348:1986-94. 2003
    ..There has been an outbreak of the severe acute respiratory syndrome (SARS) worldwide. We report the clinical, laboratory, and radiologic features of 138 cases of suspected SARS during a hospital outbreak in Hong Kong...
  87. ncbi request reprint Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells
    Alex Y Hui
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 41:251-8. 2004
    ..We assessed the impact of COX-2 inhibition and PGE(2) on the regulation of TGF-beta 1-stimulated matrix synthesis in an immortalized human HSC line, LX-1 and corroborated these findings in primary stellate cells...
  88. pmc Diagnostic criteria during SARS outbreak in Hong Kong
    Louis Y Chan
    Emerg Infect Dis 10:1168-70. 2004
  89. ncbi request reprint Management options for patients with ulcer hemorrhage
    James Y W Lau
    Ann Intern Med 140:845-6. 2004
  90. ncbi request reprint The spectrum of severe acute respiratory syndrome-associated coronavirus infection
    Timothy H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Ann Intern Med 140:614-9. 2004
    ..Objectives: To describe the spectrum of SARS coronavirus infection in a large outbreak and to compare diagnoses based on clinical judgment with the SARS coronavirus test...
  91. ncbi request reprint Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases
    Aric J Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China
    Gastrointest Endosc 59:44-8. 2004
    ..Anticoagulants and antiplatelet agents commonly are used to treat patients with cardiovascular and cerebrovascular diseases. Data on the safety of the use of these drugs before colonoscopic polypectomy are scanty...
  92. ncbi request reprint Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma
    Jun Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China
    Int J Oncol 22:1025-31. 2003
    ..Thus, gastric cancers with methylation in cox-2 may not be good candidates for treatment with specific COX-2 inhibitors...
  93. ncbi request reprint Detection of SARS coronavirus in plasma by real-time RT-PCR
    Paul R Grant
    N Engl J Med 349:2468-9. 2003
  94. ncbi request reprint Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells
    Zhi Min Liu
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Oncogene 23:503-13. 2004
    ....
  95. ncbi request reprint Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Mol Carcinog 37:91-7. 2003
    ..These results suggest that HLTF promoter hypermethylation is frequently demonstrated in human gastric cancer, and inactivation of HLTF or the chromatin-remodeling complex may play a crucial role in gastric carcinogenesis...
  96. ncbi request reprint Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: preliminary experience
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 228:810-5. 2003
    ..To report the initial experience regarding thin-section computed tomographic (CT) findings in patients with severe acute respiratory syndrome (SARS) who improved clinically after treatment...
  97. ncbi request reprint Fatal outcome of SARS in a patient with reactivation of chronic hepatitis B
    Alex Y Hui
    Am J Med 115:334-6. 2003
  98. ncbi request reprint Imaging of severe acute respiratory syndrome in Hong Kong
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong, Republic of China
    AJR Am J Roentgenol 181:11-7. 2003
  99. ncbi request reprint Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
    J Clin Virol 31:304-9. 2004
    ..The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown...
  100. ncbi request reprint Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period
    Ka Tak Wong
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong, China
    J Comput Assist Tomogr 28:790-5. 2004
    ..To evaluate thin-section computed tomography findings of patients with severe acute respiratory syndrome (SARS) in the convalescent period and to correlate the results with clinical parameters and lung function tests...
  101. ncbi request reprint Airflows around oxygen masks: A potential source of infection?
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, Peoples Republic of China
    Chest 130:822-6. 2006
    ..An analysis of captured digital images showed that the exhaled air at the peak of simulated exhalation reached a distance of approximately 0.40 m...