W S Poon

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Predicting one year clinical outcome in traumatic brain injury (TBI) at the beginning of rehabilitation
    W S Poon
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Acta Neurochir Suppl 93:207-8. 2005
  2. pmc Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson's disease
    Xiao Hong Wang
    Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 250012 Jinan, Shandong, China
    BMC Neurosci 13:142. 2012
  3. pmc Knockdown of interferon-induced transmembrane proteinĀ 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
    Fang Yu
    Brain Tumour Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Neurooncol 103:187-95. 2011
  4. pmc Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis
    David Y L Chan
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    J Neurooncol 86:273-83. 2008
  5. pmc Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage: an updated systemic review and meta-analysis
    George K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Road, Shatin, NT, Hong Kong SAR, PR China
    Crit Care 15:R52. 2011
  6. pmc AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome
    Lingling Mei
    Division of Life Science and Applied Genomics Centre, Hong Kong University of Science and Technology, 1 University Road, Clear Water Bay, Kowloon, Hong Kong, China
    BMC Genomics 12:564. 2011
  7. ncbi request reprint Cerebral blood flow (CBF)-directed management of ventilated head-injured patients
    W S Poon
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Acta Neurochir Suppl 95:9-11. 2005
  8. doi request reprint Great hospitals of Asia: neurosurgery at Prince of Wales Hospital
    Wai S Poon
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    World Neurosurg 75:383-6. 2011
  9. ncbi request reprint Migration of bone marrow stem cells in ischaemic brain
    W S Poon
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Acta Neurochir Suppl 99:123-4. 2006
  10. ncbi request reprint Pseudoprogression of malignant glioma in Chinese patients receiving concomitant chemoradiotherapy
    Danny T M Chan
    The CUHK Brain Tumour Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 18:221-5. 2012

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Predicting one year clinical outcome in traumatic brain injury (TBI) at the beginning of rehabilitation
    W S Poon
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Acta Neurochir Suppl 93:207-8. 2005
    ..The accuracy of prediction for a good Glasgow Outcome Score is 68% and an outcome for disability (either moderate or severe) is 83%. Validation of this model using a new set of data is required...
  2. pmc Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson's disease
    Xiao Hong Wang
    Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 250012 Jinan, Shandong, China
    BMC Neurosci 13:142. 2012
    ..Correlations of gait parameters with tyrosine hydroxylase (TH) protein levels in the substantia nigra (SN) were also investigated...
  3. pmc Knockdown of interferon-induced transmembrane proteinĀ 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
    Fang Yu
    Brain Tumour Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Neurooncol 103:187-95. 2011
    ..Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas...
  4. pmc Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis
    David Y L Chan
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    J Neurooncol 86:273-83. 2008
    ..We conclude that the combination of lovastatin and TRAIL enhances apoptosis synergistically. Moreover, lovastatin sensitized glioblastoma cells to TRAIL, suggesting a new strategy to treat glioblastoma...
  5. pmc Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage: an updated systemic review and meta-analysis
    George K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Road, Shatin, NT, Hong Kong SAR, PR China
    Crit Care 15:R52. 2011
    ..Our aim was thus to perform an up-to-date systemic review and meta-analysis of published data on the use of magnesium sulphate infusion in aneurysmal SAH patients...
  6. pmc AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome
    Lingling Mei
    Division of Life Science and Applied Genomics Centre, Hong Kong University of Science and Technology, 1 University Road, Clear Water Bay, Kowloon, Hong Kong, China
    BMC Genomics 12:564. 2011
    ..With over one million Alu elements distributed throughout the genome, they are well positioned to facilitate genome-wide sequence amplification and capture of regions likely to harbor genetic variation hotspots of biological relevance...
  7. ncbi request reprint Cerebral blood flow (CBF)-directed management of ventilated head-injured patients
    W S Poon
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Acta Neurochir Suppl 95:9-11. 2005
    ....
  8. doi request reprint Great hospitals of Asia: neurosurgery at Prince of Wales Hospital
    Wai S Poon
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    World Neurosurg 75:383-6. 2011
    ....
  9. ncbi request reprint Migration of bone marrow stem cells in ischaemic brain
    W S Poon
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Acta Neurochir Suppl 99:123-4. 2006
    ..This could also occur in clusters of cells. Preferential migration of these cells took place in lesioned areas...
  10. ncbi request reprint Pseudoprogression of malignant glioma in Chinese patients receiving concomitant chemoradiotherapy
    Danny T M Chan
    The CUHK Brain Tumour Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 18:221-5. 2012
    ....
  11. ncbi request reprint A rare anatomic variant of a solitary internal carotid artery associated with moyamoya phenomenon of the middle cerebral artery
    G K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, Chinese University of Hong Kong, SAR, China
    AJNR Am J Neuroradiol 27:2012-3. 2006
    ..This rare anomaly was an incidental finding at cerebral angiography in a patient with a poor-grade subarachnoid hemorrhage and a ruptured anterior communicating artery aneurysm...
  12. ncbi request reprint Intravenous magnesium sulfate to improve outcome after aneurysmal subarachnoid hemorrhage: interim report from a pilot study
    R Boet
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Acta Neurochir Suppl 95:263-4. 2005
    ..In this randomized, double-blind study we evaluated the safety and efficacy of MgSO4 infusion to improve clinical outcome after aneurysmal SAH...
  13. ncbi request reprint Monitoring of autoregulation using intracerebral microdialysis in patients with severe head injury
    T V Chan
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Acta Neurochir Suppl 95:113-6. 2005
    ..001). The correlation between extracellular glutamate concentration (by microdialysis) and CPP is a useful index of autoregulation in head-injured patients. It predicts clinical outcome and may be used to guide therapy...
  14. ncbi request reprint Clinical and angiographic outcome of intracranial aneurysms treated with Matrix detachable coils in Chinese patients
    George K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, Chinese University of Hong Kong, China
    Surg Neurol 67:122-6; discussion 126. 2007
    ..The purpose of this study was to evaluate the efficacy and safety of the Matrix detachable coils in patients with intracranial aneurysms and aneurysmal recurrence rate...
  15. doi request reprint Stereoscopic virtual reality simulation for microsurgical excision of cerebral arteriovenous malformation: case illustrations
    George K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Surg Neurol 72:69-72; discussion 72-3. 2009
    ..Use of virtual reality planning and rehearsal for planning and training of cerebral aneurysm clipping was recently reported. We aimed to illustrate its applications in preoperative planning and training for cerebral AVM excision...
  16. ncbi request reprint Re-defining the ischemic threshold for jugular venous oxygen saturation--a microdialysis study in patients with severe head injury
    M T V Chan
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Acta Neurochir Suppl 95:63-6. 2005
    ..Extracellular glucose decreased when SjvO2 dropped below 42%. Our findings suggested that the ischemic threshold for SjvO2 in patients with severe head injury is 45%, below which secondary brain damage occurred...
  17. ncbi request reprint Magnesium sulfate for brain protection during temporary cerebral artery occlusion
    M T V Chan
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Acta Neurochir Suppl 95:107-11. 2005
    ..However, tissue hypoxia was less severe and the rate of PtO2 decline was slower in the magnesium group. Our data suggested that magnesium enhances tissue oxygenation and attenuates hypoxia during temporary artery occlusion...
  18. doi request reprint Spontaneous resolution of an aneurysm arising from a penetrating branch of the middle cerebral artery
    George K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Ngan Shing Street, Shatin 1077, New Territories, Hong Kong SAR, China
    J Clin Neurosci 16:601-2. 2009
    ..Follow-up angiography two years later showed resolution of the aneurysm. The aetiologies and treatment options are reviewed...
  19. ncbi request reprint Cerebral haemodynamic assessment in patients with thalamic haemorrhage: a pilot study with continuous compliance monitoring
    S C P Ng
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Acta Neurochir Suppl 95:299-301. 2005
    ....
  20. doi request reprint Traumatic intracerebral haemorrhage: is the CT pattern related to outcome?
    G K Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Br J Neurosurg 23:601-5. 2009
    ..In addition to age and GCS score, the CT patterns of bilateral haematomas, temporal haematomas and associated subdural haematomas were suggestive of poor outcome or mortality...
  21. doi request reprint Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH): a randomized, double-blinded, placebo-controlled, multicenter phase III trial
    George Kwok Chu Wong
    FRCS, Department of Surgery Prince of Wales Hospital, Shatin, NT, Hong Kong 852, China
    Stroke 41:921-6. 2010
    ..This Phase III study aimed to compare intravenous magnesium sulfate infusion with saline placebo among such patients...
  22. ncbi request reprint Aneurysm recurrence after treatment of paraclinoid/ophthalmic segment aneurysms--a treatment-modality assessment
    R Boet
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Neurochir (Wien) 147:611-6; discussion 616. 2005
    ....
  23. ncbi request reprint Temozolomide in the treatment of recurrent malignant glioma in Chinese patients
    D T M Chan
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 11:452-6. 2005
    ..To determine the anti-tumour efficacy and safety profile of temozolomide in local Chinese patients with recurrent malignant glioma. DESIGN. Open-label trial...
  24. ncbi request reprint Vermal hemorrhage with fourth ventricle extension due to ruptured posterior inferior cerebellar artery aneurysm
    George K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Chinese University of Hong Kong, China
    J Clin Neurosci 15:203-5. 2008
    ..We report a ruptured distal PICA aneurysm in a 50-year-old man who presented with sudden onset of coma. The management and clinical significance are highlighted...
  25. ncbi request reprint The management of residual and recurrent intracranial aneurysms after previous endovascular or surgical treatment--a report of eighteen cases
    R Boet
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Acta Neurochir (Wien) 143:1093-101. 2001
    ..CONCLUSIONS: The treatment of cerebral aneurysm remnants can be performed effectively using a variety of modalities. The original purpose of the treatment, which is total occlusion of the lesion, can thus be achieved...
  26. ncbi request reprint Chronic hydrocephalus that requires shunting in aneurysmal subarachnoid haemorrhage [a-SAH]: its impact on clinical outcome
    W S Poon
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Acta Neurochir Suppl 102:129-30. 2008
    ..Chronic hydrocephalus is a common occurrence following aneurismal subarachnoid haemorrhage [a-SAH] but its impact on neurological outcome has not been re reviewed systematically...
  27. ncbi request reprint Association of molecular marker O(6)Methylguanine DNA methyltransferase and concomitant chemoradiotherapy with survival in Southern Chinese glioblastoma patients
    Danny T M Chan
    The CUHK Brain Tumour Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 17:184-8. 2011
    ..2) To determine the methylation status of O(6)Methylguanine DNA methyltransferase in Chinese primary glioblastoma, and to assess the prognostic value of O(6)Methylguanine DNA methyltransferase methylation status in such patients...
  28. ncbi request reprint Effect of ischemic preconditioning on brain tissue gases and pH during temporary cerebral artery occlusion
    M T V Chan
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Acta Neurochir Suppl 95:93-6. 2005
    ..Brief occlusion of the proximal artery may be a simple maneuver for brain protection during complex cerebrovascular surgery...
  29. ncbi request reprint The impact of an armless frameless neuronavigation system on routine brain tumour surgery: a prospective analysis of 51 cases
    G K Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Minim Invasive Neurosurg 44:99-103. 2001
    ..3 days versus 16 +/- SD 6.7 days, p = 0.01). Outcome at 3 months was comparable in both the supratentorial glioma and meningioma group. Problems such as setup time and brain shift are addressed and discussed...
  30. ncbi request reprint Decompressive craniectomy for hemispheric infarction: predictive factors for six month rehabilitation outcome
    G K Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Acta Neurochir Suppl 102:331-3. 2008
    ..We aimed to determine possible factors predictive of outcome following decompressive craniectomy for ischemic infarction from review of oneurological outcome in our patients at six months...
  31. ncbi request reprint Cerebral vasoreactivity: a comparison of color velocity imaging quantification and stable xenon-enhanced CT
    S S Y Ho
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Ngan Shing St, Shatin, New Territories, Hong Kong
    AJR Am J Roentgenol 184:948-52. 2005
    ..In this study, we sought to determine whether extracranial arterial blood flow volume measured on color velocity imaging quantification could be predictive of cerebral vasoreactivity after the administration of acetazolamide...
  32. ncbi request reprint Apolipoprotein e genotype and outcome in aneurysmal subarachnoid hemorrhage
    Clarence H S Leung
    Division of Neurosurgery, Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Stroke 33:548-52. 2002
    ..Current clinical grading scales are imprecise, with low interobserver reproducibility. Therefore, outcome prediction remains inconsistent and decision making becomes difficult, especially for patients with poor clinical grade...
  33. ncbi request reprint Intracranial electroencephalogram to evaluate refractory temporal and frontal lobe epilepsy
    Lisa Au
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 17:453-9. 2011
    ..We undertook a collaborative study in a multidisciplinary team to channel refractory epilepsy patients to test a hypothesis about placement of intracranial electroencephalography arrays...
  34. doi request reprint A venographic operational classification for transvenous embolization of dural carotid-cavernous fistula
    Simon C H Yu
    Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Neuroradiology 53:993-9. 2011
    ....
  35. pmc Triple coaxial catheter technique for transfacial superior ophthalmic vein approach for embolization of dural carotid-cavernous fistula
    M H Yuen
    Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong, China
    Interv Neuroradiol 16:264-8. 2010
    ..This technique has two advantages over the double coaxial catheter technique because it offers additional length and support for the distal navigation of microcatheter into the SOV...
  36. ncbi request reprint Surgical treatment of a neonate with refractory seizures secondary to congenital giant cell astrocytoma: case report and literature review
    S F Hon
    Division of Neurosurgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 12:222-4. 2006
    ..Imaging studies revealed a right frontal calcified tumour. Surgical resection was performed successfully and pathology revealed the tumour to be a giant cell astrocytoma. The child was seizure-free afterwards...
  37. ncbi request reprint Endovascular coiling versus neurosurgical clipping for ruptured intracranial aneurysms: significant benefits in clinical outcome and reduced consumption of hospital resources in Hong Kong Chinese patients
    Simon C H Yu
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 13:271-8. 2007
    ....
  38. ncbi request reprint Use of Onyx (a patented ethylene-vinyl alcohol copolymer formulation) embolisation of cerebral arteriovenous malformations in Hong Kong: initial experience
    George K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 15:359-64. 2009
    ..To review the experience with Onyx embolisation of cerebral arteriovenous malformation...
  39. ncbi request reprint Klebsiella meningitis mimicking clinical deterioration from hemorrhage of a complex posterior fossa arteriovenous malformation
    George K C Wong
    Division of Neurosurgery, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Am J Forensic Med Pathol 27:271-3. 2006
    ..However, postmortem examination revealed the direct cause of death was due to Klebsiella meningitis. The clinical catch is highlighted, and the importance of early and prompt detection of this condition is emphasized...
  40. ncbi request reprint Diffuse leptomeningeal gliomatosis with oligodendroglioma
    H K Ng
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Hong Kong
    Pathology 31:59-63. 1999
    ..To our knowledge, this is the fifth case of diffuse oligodendrogliomatosis reported in the English language literature...
  41. ncbi request reprint Cerebral hemisphere asymmetry in cerebrovascular regulation in ventilated traumatic brain injury
    S C P Ng
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Acta Neurochir Suppl 96:21-3. 2006
    ..Significant hemisphere asymmetries were found in BFV and PAR. Impairment in CVR was associated with unfavorable outcomes and bilateral CVR impairment predicted mortality...
  42. ncbi request reprint Trispan-assisted coiling of a wide-necked Persistent Trigeminal Artery aneurysm
    D T M Chan
    Department of Surgery, Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Acta Neurochir (Wien) 146:87-8; discussion 88. 2004
  43. ncbi request reprint Is transcranial Doppler ultrasonography (TCD) good enough in determining CO2 reactivity and pressure autoregulation in head-injured patients?
    S C P Ng
    Neurosurgical Unit, Department of Surgery, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Acta Neurochir Suppl 81:125-7. 2002
    ....
  44. ncbi request reprint Neurochemical changes in ventilated head-injured patients with cerebral perfusion pressure treatment failure
    W S Poon
    Neurosurgical Unit, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Acta Neurochir Suppl 81:335-8. 2002
    ....
  45. ncbi request reprint Pre-operative grading of intracranial glioma
    W W Lam
    Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Acta Radiol 42:548-54. 2001
    ..299). CONCLUSION: MR-determined NI was useful for pre-operative grading of intracranial gliomas but SPECT thallium-201 imaging was not...
  46. ncbi request reprint A review of isolated third nerve palsy without subarachnoid hemorrhage using computed tomographic angiography as the first line of investigation
    G K Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, PR China
    Clin Neurol Neurosurg 107:27-31. 2004
    ..We reviewed our experience in using computed tomographic angiography (CTA) as the first line investigation for patients presenting with isolated third nerve palsy without subarachnoid hemorrhage...
  47. ncbi request reprint Analysis of loss of heterozygosity on chromosomes 10q, 11, and 16 in medulloblastomas
    X L Yin
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
    J Neurosurg 94:799-805. 2001
    ....
  48. ncbi request reprint An uncommon mimic of spontaneous subarachnoid haemorrhage
    Rebecca Y T Ng
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 19:80-1. 2013
    ..Investigations revealed no underlying vascular lesion and leptomeningeal biopsy showed diffuse melanocytosis. We go on to discuss the diagnostic features and clinical course of this entity...
  49. doi request reprint Evaluation of cognitive impairment by the Montreal cognitive assessment in patients with aneurysmal subarachnoid haemorrhage: prevalence, risk factors and correlations with 3 month outcomes
    George Kwok Chu Wong
    Department of Surgery, 4 F Clinical Science Building, Prince of Wales Hospital, 1 Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China
    J Neurol Neurosurg Psychiatry 83:1112-7. 2012
    ..S. National Institute of Neurological Disorder, in the chronic post-stroke setting. We hypothesised that the MoCA has a better correlation with functional outcome at 3 months than the MMSE...
  50. ncbi request reprint The surgical treatment of intracranial aneurysms based on computer tomographic angiography alone--streamlining the acute mananagement of symptomatic aneurysms
    R Boet
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Neurochir (Wien) 145:101-5; discussion 105. 2003
    ..We aimed to prospectively assess the usefulness of computer tomographic angiography (CTA) in streamlining the management of symptomatic intracranial aneurysms in a tertiary neurosurgical unit, from admission to surgery...
  51. ncbi request reprint Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury? Interim result of a randomized controlled trial
    X L Zhu
    Neurosurgical Unit, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong
    Br J Neurosurg 15:464-73. 2001
    ..Intensive rehabilitation may improve the early functional outcome of TBI patients. The interim results indicate that the study should be continued...
  52. ncbi request reprint Meteorological factors and aneurysmal subarachnoid haemorrhage in Hong Kong
    H Y Law
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 15:85-9. 2009
    ..To evaluate the influence of meteorological factors on the onset of aneurysmal subarachnoid haemorrhage in Hong Kong...
  53. ncbi request reprint Cefepime vs. Ampicillin/Sulbactam and Aztreonam as antibiotic prophylaxis in neurosurgical patients with external ventricular drain: result of a prospective randomized controlled clinical trial
    G K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China
    J Clin Pharm Ther 31:231-5. 2006
    ..We aimed to find out whether single board spectrum antibiotic prophylaxis was as good as dual specific antibiotic prophylaxis in neurosurgical patients with external ventricular drain (EVD) in situ...
  54. ncbi request reprint Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury (TBI)? A randomized controlled trial
    X L Zhu
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, PR China
    Brain Inj 21:681-90. 2007
    ..To evaluate the effects of an increase in the intensity of rehabilitation on the functional outcome of patients with traumatic brain injury (TBI)...
  55. ncbi request reprint Management of spinal injury
    D T F Sun
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories East
    Surgeon 4:293-7. 2006
    ..General principles of pre-hospital management, resuscitation, medical treatment, surgical intervention and future advancement are reviewed...
  56. ncbi request reprint Transvenous embolisation of a carotid-trigeminal cavernous fistula
    Y L Chan
    Department of Diagnostic Radiology and Organ Imaging, The Chineses University of Hong Kong, Prince of Wales Hospital, Shatin
    Hong Kong Med J 12:310-2. 2006
    ..The absence of an associated trigeminal artery aneurysm allowed a transvenous approach for endovascular treatment with coils and complete obliteration of the cavernous fistula...
  57. ncbi request reprint Transvenous embolization for dural transverse sinus fistulas with occluded sigmoid sinus
    G K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Acta Neurochir (Wien) 149:929-35; discussion 935-6. 2007
    ..We concluded that transvenous embolization remains a safe and feasible technique other than surgery for patients with transverse sinus dural fistula, achieving a long-term occlusion of the pathology...
  58. ncbi request reprint Cervical meningocele with tethered cervical cord in a Chinese infant
    J H M Wong
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 11:113-5. 2005
    ..Treatment aims to prevent future neurological deterioration, and should include careful intradural exploration with untethering of the cord...
  59. ncbi request reprint Spinal cord pilocytic astrocytoma with cranial meningeal metastases
    H K Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, P R China
    J Clin Neurosci 8:374-7. 2001
    ..Spinal cord JPA can rarely metastasize to the cranial meninges. Similar to intracranial tumours which spread to the spinal cord, such metastatic lesions are indolent...
  60. ncbi request reprint The comparative impact of video-consultation on neurosurgical health services
    W S Poon
    Division of Neurosurgery, Prince of Wales Hospital and United Christian Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Int J Med Inform 62:175-80. 2001
    ..The interim data of this prospective randomized trial suggests that video-consultation may have a favourable impact on emergency neurosurgical consultations...
  61. ncbi request reprint Hemangioblastoma of filum terminale associated with arteriovenous shunting
    George K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Surg Neurol 68:211-4; discussion 214-5. 2007
    ..In contrast, spinal hemangioblastomas usually occur in adults, and the most common presentation is pain with radiculopathy. Location in the filum terminale is very rare...
  62. pmc Failure of regular external ventricular drain exchange to reduce cerebrospinal fluid infection: result of a randomised controlled trial
    G K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Neurol Neurosurg Psychiatry 73:759-61. 2002
    ..It is controversial whether regular changes of external ventricular drains can reduce cerebrospinal fluid (CSF) infection...
  63. doi request reprint Functional outcome after head injury: comparison of 12-45 year old male and female hormonally active patients
    Ada Hoi Yan Yu
    Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Hong Kong
    Injury 43:603-7. 2012
    ..The purpose of this study was to identify factors affecting functional outcome in hormonally active patients 6 months after head injury...
  64. ncbi request reprint Paradoxical enlargement of tuberculous brain abscess during drug treatment: a case report
    S K Ng
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territorries
    Singapore Med J 42:325-7. 2001
    ..The same drug regimen was continued. This was followed by complete resolution of the lesions in 12 months. Hence TB brain abscess which remains culture and smear positive after four weeks treatment may not represent treatment failure...
  65. ncbi request reprint Epithelioid haemangioendothelioma of the brain: a case report
    Y L Chan
    Department of Diagnostic Radiology and Organ Imaging Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin
    Neuroradiology 43:848-50. 2001
    ..We report a rare epithelioid haemangioendothelioma in the frontal lobe. The CT and MRI findings are characteristic and correspond to histological features intermediate between those a cavernous haemangioma and an aggressive vascular tumour...
  66. ncbi request reprint Concurrent hypermethylation of multiple genes is associated with grade of oligodendroglial tumors
    S M Dong
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
    J Neuropathol Exp Neurol 60:808-16. 2001
    ..Taken together, we conclude that hypermethylation of CpG islands is a common epigenetic event that is associated with the development of oligodendroglial tumors...
  67. doi request reprint Rivastigmine for cognitive impairment after spontaneous subarachnoid haemorrhage: a pilot study
    G K C Wong
    Division of Neurosurgery, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Pharm Ther 34:657-63. 2009
    ..The aim of the study is to evaluate the efficacy and safety of rivastigmine 3 mg/day over 12 weeks in patients with aneurysmal subarachnoid haemorrhage and persistent cognitive impairment...
  68. doi request reprint Flow diverters for treatment of intracranial aneurysms: current status and ongoing clinical trials
    George K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Clin Neurosci 18:737-40. 2011
    ..The results of ongoing studies may resolve whether flow diverters can replace coil embolization for the treatment of all, or selected, intracranial aneurysms...
  69. ncbi request reprint Non-accidental subdural haemorrhage in Hong Kong: incidence, clinical features, management and outcome
    David T F Sun
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories East, Hong Kong
    Childs Nerv Syst 22:593-8. 2006
    ..We aim to identify the incidence and the characteristics of non-accidental subdural haemorrhage in Hong Kong in children under the age of 5 years...
  70. ncbi request reprint Childhood posterior fossa pial-dural arteriovenous fistula treated by endovascular occlusion
    R Boet
    Department of Surgery, Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Childs Nerv Syst 17:681-4. 2001
    ..We report a case of a 2-year-old girl with such a fistula, who presented clinically with progressive neurological deficit. The lesion was treated by endovascular occlusion, resulting in radiological and clinical cure...
  71. ncbi request reprint Endovascular GDC-mediated flow-reversal for complex posterior circulation saccular aneurysms. A report of two cases and critical appraisal
    R Boet
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Minim Invasive Neurosurg 46:220-7. 2003
    ..However, persistent incomplete thrombosis of these aneurysms following flow-reversal should lead to the consideration of alternate treatment strategies...
  72. ncbi request reprint Non-surgical primary treatment of chronic subdural haematoma: Preliminary results of using dexamethasone
    T F D Sun
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University, Hong Kong
    Br J Neurosurg 19:327-33. 2005
    ..253) and 50% (2/4, p = 0.039), respectively. Our results suggest that steroid treatment in a selected group of patients is a good option, particularly in patients with co-morbidity...
  73. ncbi request reprint Extrusion of a coil from the internal carotid artery through the middle ear
    M W Chow
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 10:215-6. 2004
  74. ncbi request reprint Fluoroscopic frameless computer-assisted navigation for transsphenoidal surgery: a clinical assessment of accuracy in spatial position and trajectory
    G K Wong
    Division of Neurosurgery, Department of Surgery Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong
    Minim Invasive Neurosurg 47:29-31. 2004
    ..To assess the clinical accuracy of the above technique in the transsphenoidal surgery, we performed this study...
  75. pmc Early computed tomography features in extensive middle cerebral artery territory infarct: prediction of survival
    W W M Lam
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, c o Rm 27029, X Ray Department, Prince of Wales Hospital, Ngan Shing Street, Shatin, N T, Hong Kong
    J Neurol Neurosurg Psychiatry 76:354-7. 2005
    ..To assess the predictive value of prognosis of different computed tomography (CT) features and National Institutes of Health Stroke Scale score (NIHSS) in acute extensive middle cerebral artery (MCA) infarct...
  76. ncbi request reprint The role of haematoma aspiration in the management of patients with thalamic haemorrhage: a pilot study with continuous compliance monitoring
    S C P Ng
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Acta Neurochir Suppl 86:469-71. 2003
    ..Management is mainly supportive and very rarely do neurosurgeons have to resort to evacuation of the haematoma. We hypothesised that haematoma aspiration may help to improve the outcome of the group of patients with thalamic haemorrhage...
  77. ncbi request reprint Diffusion MR imaging in glioma: does it have any role in the pre-operation determination of grading of glioma?
    W W M Lam
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Clin Radiol 57:219-25. 2002
    ..To investigate the role of the diffusion MR weighted sequence in the pre-operative grading of gliomas, and its application in defining the different components of these tumours...
  78. doi request reprint Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage
    G K Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Clin Neurosci 15:654-5. 2008
    ..A CSF lactate level of above 4 mmol/L should prompt suspicion of CSF infection in intraventricular haemorrhage patients with an external ventricular drain...
  79. doi request reprint MR imaging of nonmalignant polyps and masses of the nasopharynx and sphenoid sinus after radiotherapy for nasopharyngeal carcinoma
    A D King
    Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    AJNR Am J Neuroradiol 29:1209-14. 2008
    ..The purpose of this study was to document the MR appearance of unusual nonmalignant polyps or masses (NMPMs) in the nasopharynx and sphenoid sinus arising after radiation treatment of nasopharyngeal carcinoma...
  80. ncbi request reprint Metastatic solitary fibrous tumor of the meninges. Case report
    H K Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, People s Republic of China
    J Neurosurg 93:490-3. 2000
    ..The potentially malignant nature of cranial SFTs, especially those with atypical histological features and high mitotic counts, should be recognized...
  81. ncbi request reprint Cerebellar astrocytoma associated with von Hippel-Lindau disease: case report with molecular findings
    H K Ng
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong
    Br J Neurosurg 13:504-7. 1999
    ..This case illustrates that astrocytomas are rarely found in the von Hippel-Lindau disease and they may contain genetic changes common to both haemangioblastomas and some astrocytomas...
  82. ncbi request reprint Propofol requirement is decreased in patients with large supratentorial brain tumor
    M T Chan
    Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Anesthesiology 90:1571-6. 1999
    ..The authors compared the quantal dose-response curves for propofol in patients having large (> or = 30 mm, mass effect) brain tumor with those having smaller (< 30 mm) lesions and with control patients undergoing noncranial surgery...
  83. ncbi request reprint Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase
    G G Chen
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Apoptosis 10:185-92. 2005
    ..Such differential roles in the induction of glioblastoma cell death can be of significant value in selecting and/or optimizing the treatment for this malignant brain tumor...
  84. ncbi request reprint Cutaneous stimulation improves function of a chronic patient with cerebellar damage
    A S Chan
    Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China
    Eur J Neurol 10:265-9. 2003
    ....
  85. doi request reprint Bicycle related injuries presenting to a trauma centre in Hong Kong
    J H H Yeung
    Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Injury 40:555-9. 2009
    ..The aim of this study is firstly to describe bicycle related injuries presenting to a regional trauma centre in Hong Kong, and secondly to compare patients aged > 15 years with those patients aged < or = 15 years...
  86. ncbi request reprint Beneficial effect of cerebrolysin on moderate and severe head injury patients: result of a cohort study
    G K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Acta Neurochir Suppl 95:59-60. 2005
    ..The results suggest that Cerebrolysin is beneficial in regard to the outcome in these patients, especially in elderly patients...
  87. pmc Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours
    Z Dong
    1Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Br J Cancer 91:1105-11. 2004
    ..3, in which two minimally deleted regions are mapped, and markedly reduced the number of candidate genes to be screened for their involvement in OT development...
  88. ncbi request reprint Spinal shock in spontaneous cervical spinal epidural haematoma
    D T M Chan
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Acta Neurochir (Wien) 146:1161-2; discussion 1162-3. 2004
    ..Immediate MRI diagnosis followed by emergency decompression with six hours of presentation resulted in complete recovery...
  89. ncbi request reprint The use of stereotactic navigation guidance in minimally invasive transnasal nasopharyngectomy: a comparison with the conventional open transfacial approach
    E W H To
    Division of Head and Neck Plastic and Reconstructive Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Br J Radiol 75:345-50. 2002
    ..We compare 15 patients who underwent the stereotactic navigation guidance approach with 20 patients who received a conventional open transfacial approach...
  90. ncbi request reprint Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
    A B Hui
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
    Lab Invest 81:717-23. 2001
    ..3%), EGFR (57.1%), CSE1L (57.1%), NRAS (50%), MYCN (42.9%), FGR (35.7%), ESR (35.7%), PGY1 (35.7%), and D17S167 (35.7%). These genes are suggested to be involved in the GBM tumorigenesis...
  91. ncbi request reprint The ISAT trial
    Clarence H S Leung
    Lancet 361:430-1; author reply 432. 2003
  92. ncbi request reprint Clipping vs coiling of posterior communicating artery aneurysms with third nerve palsy
    George K C Wong
    Neurology 66:1959-60; author reply 1959-60. 2006
  93. ncbi request reprint Symptomatic autoregulatory failure in acute ischemic stroke
    George K C Wong
    Neurology 69:222; author reply 222. 2007
  94. ncbi request reprint Trial design in "magnesium sulphate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial"
    George K C Wong
    Stroke 36:2530-1; author reply 2531-2. 2005
  95. ncbi request reprint Meta-analysis of APOE genotype and subarachnoid hemorrhage: clinical outcome and delayed ischemia
    L A Lanterna
    Department of Neurosurgery, Ospedali Riuniti, Bergamo, Italy
    Neurology 69:766-75. 2007
    ..A genetic variable predicting the individual clinical course is currently lacking...
  96. ncbi request reprint Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage
    George K C Wong
    Stroke 36:2532; author reply 2532. 2005
  97. ncbi request reprint Identification of novel regions of allelic loss in ependymomas by high-resolution allelotyping with 384 microsatellite markers
    C Y Tong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
    J Neurosurg 95:9-14. 2001
    ..It is believed that potential tumor suppressor genes that reside in these commonly deleted regions may contribute to the molecular tumorigenesis of ependymomas...
  98. ncbi request reprint Is there an interaction between pravastatin and clinical events other than vasospasm in patients with aneurysmal subarachnoid hemorrhage?
    George K C Wong
    Stroke 37:335; author reply 335. 2006
  99. ncbi request reprint Radiation-induced spinal glioblastoma multiforme
    Y F Yeung
    Acta Oncol 45:87-90. 2006
  100. ncbi request reprint Inferior vena caval filters following deep vein thrombosis in patients with ruptured intracranial aneurysm
    K C Wong
    Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 8:288-90. 2002
    ..Both patients had clinical resolution of the lower limb swelling and no radiological evidence of propagation of the thrombus. During 18 months of follow-up there were no complications and no evidence of post-thrombotic syndrome...
  101. doi request reprint Re: Magnesium sulfate in the management of patients with aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, dose-adapted trial (Muroi et al. Surg Neurol 2008;69:33-39)
    George K C Wong
    Surg Neurol 70:109-10; author reply 110. 2008