Terence C W Poon

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi Opportunities and limitations of SELDI-TOF-MS in biomedical research: practical advices
    Terence C W Poon
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Expert Rev Proteomics 4:51-65. 2007
  2. doi Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome
    Terence C W Poon
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Electrophoresis 33:1894-900. 2012
  3. ncbi Serial analysis of plasma proteomic signatures in pediatric patients with severe acute respiratory syndrome and correlation with viral load
    Terence C W Poon
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Clin Chem 50:1452-5. 2004
  4. ncbi Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: a pilot study
    Terence C W Poon
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong Special Administrative Region, China
    Clin Chem 51:328-35. 2005
  5. ncbi Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma
    Terence C W Poon
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    World J Gastroenterol 11:6701-6. 2005
  6. ncbi Serum proteomic fingerprints of adult patients with severe acute respiratory syndrome
    Ronald T K Pang
    Centre for Emerging Infectious Diseases, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Clin Chem 52:421-9. 2006
  7. ncbi Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: a glycoproteomic approach
    Irene L Ang
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR
    J Proteome Res 5:2691-700. 2006
  8. ncbi A prospective study of pre-treatment cell kinetics and clinical outcome in nasopharyngeal carcinoma
    Edwin P Hui
    Department of Clinical Oncology at the Sir YK Pao Cancer Centre, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
    Radiother Oncol 69:53-62. 2003
  9. ncbi High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis
    Richard K T Kam
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Clin Chem 53:1254-63. 2007
  10. ncbi Pharmacoproteomics study of cetuximab in nasopharyngeal carcinoma
    Fion L Sung
    Hong Kong Cancer Institute, Department of Clinical Oncology, The Sir Y K Pao Center for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People s Republic of China
    J Proteome Res 5:3260-7. 2006

Collaborators

Detail Information

Publications29

  1. ncbi Opportunities and limitations of SELDI-TOF-MS in biomedical research: practical advices
    Terence C W Poon
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Expert Rev Proteomics 4:51-65. 2007
    ..This review provides an overview of the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, discusses its limitations and provides some possible solutions to help apply this technology to biomarker research...
  2. doi Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome
    Terence C W Poon
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Electrophoresis 33:1894-900. 2012
    ..Our results suggest that PF4 and beta-TG may also play similar roles in the development of ARDS in SARS patients...
  3. ncbi Serial analysis of plasma proteomic signatures in pediatric patients with severe acute respiratory syndrome and correlation with viral load
    Terence C W Poon
    Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Clin Chem 50:1452-5. 2004
  4. ncbi Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: a pilot study
    Terence C W Poon
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong Special Administrative Region, China
    Clin Chem 51:328-35. 2005
    ..This study was designed to identify serum proteomic signatures associated with liver fibrosis and to develop a proteome-based fingerprinting model for prediction of liver fibrosis...
  5. ncbi Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma
    Terence C W Poon
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    World J Gastroenterol 11:6701-6. 2005
    ..To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance...
  6. ncbi Serum proteomic fingerprints of adult patients with severe acute respiratory syndrome
    Ronald T K Pang
    Centre for Emerging Infectious Diseases, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Clin Chem 52:421-9. 2006
    ..Specific proteomic patterns might be present in serum in response to the infection and could be useful for early detection of the disease...
  7. ncbi Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma: a glycoproteomic approach
    Irene L Ang
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR
    J Proteome Res 5:2691-700. 2006
    ..The combined use of Hp and AFP could greatly improve the diagnostic accuracy. A unique pattern of Hp glycoforms with altered sialylation and fucosylation is specific to HCC and associated tumor progression...
  8. ncbi A prospective study of pre-treatment cell kinetics and clinical outcome in nasopharyngeal carcinoma
    Edwin P Hui
    Department of Clinical Oncology at the Sir YK Pao Cancer Centre, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
    Radiother Oncol 69:53-62. 2003
    ..To study pre-treatment cell kinetics and their clinical correlations in nasopharyngeal carcinoma (NPC)...
  9. ncbi High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis
    Richard K T Kam
    Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Clin Chem 53:1254-63. 2007
    ..In this study, we attempted to establish a high-throughput quantitative assay for profiling serum N-glycome, and we applied the new assay to identifying serum N-glycans for diagnosis of liver fibrosis and cirrhosis...
  10. ncbi Pharmacoproteomics study of cetuximab in nasopharyngeal carcinoma
    Fion L Sung
    Hong Kong Cancer Institute, Department of Clinical Oncology, The Sir Y K Pao Center for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People s Republic of China
    J Proteome Res 5:3260-7. 2006
    ..Pharmacoproteomic study may also help to identify clinical responders for drug treatment and provide insight for new drug development...
  11. ncbi Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes
    Terence C W Poon
    Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong, The People s Republic of China
    Clin Chem 49:752-60. 2003
    ..Detection of hepatocellular carcinoma (HCC) in patients with chronic liver disease (CLD) is difficult. We investigated the use of comprehensive proteomic profiling of sera to differentiate HCC from CLD...
  12. ncbi A magnetic bead-based serum proteomic fingerprinting method for parallel analytical analysis and micropreparative purification
    Melody Y M Wong
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, PR China
    Electrophoresis 31:1721-30. 2010
    ..Because of its high efficiency and reproducibility, our method has great potentials in clinical research, especially in biomarker discovery...
  13. ncbi Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma--a prospective study
    Brigette B Y Ma
    Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territory, Hong Kong SAR, China
    Head Neck 25:864-72. 2003
    ....
  14. ncbi Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnostic serum total alpha-fetoprotein
    Terence C W Poon
    Department of Clinical Oncology, the Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Chem 48:1021-7. 2002
    ..We describe two strategies for quantitative analysis of msAFP and explore their diagnostic accuracy in cases of HCC with nondiagnostic serum total AFP concentrations...
  15. ncbi A tumor progression model for hepatocellular carcinoma: bioinformatic analysis of genomic data
    Terence C W Poon
    Department of Medicine and Therapeutics, Sir Y K Pao Cancer Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, N T, Hong Kong, The People s Republic of China
    Gastroenterology 131:1262-70. 2006
    ..Aberrant patterns of chromosomal changes may represent useful information that can be used in classifying the complex traits of liver cancer cases for the genetic events involved in tumor carcinogenesis, tumor progression, and prognosis...
  16. pmc Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker
    Lei Chen
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Ann Surg Oncol 17:2518-25. 2010
    ..We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguishing HCC and liver cirrhosis (LC) and to compare the accuracy of SELDI-TOF-MS profile and alpha-fetoprotein (AFP) level in HCC diagnosis...
  17. doi Elevated perioperative transaminase level predicts intrahepatic recurrence in hepatitis B-related hepatocellular carcinoma after curative hepatectomy
    Yue Sun Cheung
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR
    Asian J Surg 31:41-9. 2008
    ....
  18. ncbi Advances in MALDI mass spectrometry in clinical diagnostic applications
    Eddy W Y Ng
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    Top Curr Chem 336:139-75. 2014
    ..Theoretically, all these technologies can be combined, leading to the next generation of the MALDI MS technologies. Real applications of MALDI MS technologies in clinical diagnostics should be forthcoming. ..
  19. doi Prediction of outcome in cancer patients with febrile neutropenia: a prospective validation of the Multinational Association for Supportive Care in Cancer risk index in a Chinese population and comparison with the Talcott model and artificial neural netwo
    Edwin Pun Hui
    Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Support Care Cancer 19:1625-35. 2011
    ....
  20. doi A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein
    Yan Chen
    School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Proteome Res 10:299-304. 2011
    ..The results indicate that Sch B triggers the Raf/MEK/ERK signaling pathway, presumably by downregulating RKIP, thereby protecting against carbon tetrachloride-induced cytotoxicity...
  21. ncbi A Double-Blind Randomised Controlled Trial of Fish Oil-Based versus Soy-Based Lipid Preparations in the Treatment of Infants with Parenteral Nutrition-Associated Cholestasis
    Hugh S Lam
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong Kong
    Neonatology 105:290-6. 2014
    ..Replacement of SLP with FOLP in PN-dependent infants who develop PNAC may be considered. © 2014 S. Karger AG, Basel. ..
  22. doi Gut-associated biomarkers L-FABP, I-FABP, and TFF3 and LIT score for diagnosis of surgical necrotizing enterocolitis in preterm infants
    Eddy W Y Ng
    From the Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Ann Surg 258:1111-8. 2013
    ....
  23. ncbi Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival
    Edwin P Hui
    Departments of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Cancer Res 8:2595-604. 2002
    ....
  24. ncbi Biomarkers for prediction and diagnosis of necrotizing enterocolitis
    Pak C Ng
    Department of Paediatrics, The Chinese University of Hong Kong, Shatin NT, Hong Kong SAR, The People s Republic of China
    Clin Perinatol 40:149-59. 2013
    ....
  25. doi Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro
    Jun Yu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Int J Biochem Cell Biol 42:948-57. 2010
    ..It is likely that PPARgamma reverses fibrosis by reducing HSCs proliferation, inducing cell cycle arrest and apoptosis...
  26. doi Identification of hemopexin in tear film
    Jeffrey C F Pong
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong
    Anal Biochem 404:82-5. 2010
    ..The results implied clinical interest of hemopexin in the tear proteome and eye diseases...
  27. ncbi Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia
    Chi Chiu Wang
    Li Ka Shing Institute of Health Sciences, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR
    Clin Chem 53:42-52. 2007
    ..Our aim was to identify the circulating factors present in preeclampsia and to investigate their relationship to the underlying systemic immune response responsible for the associated clinical manifestations...
  28. ncbi Serum amyloid A is not useful in the diagnosis of severe acute respiratory syndrome
    Ronald T K Pang
    Clin Chem 52:1202-4. 2006
  29. ncbi Diagnosis of gastric cancer by serum proteomic fingerprinting
    Terence C W Poon
    Institute of Digestive Diseases of the Chinese University of Hong Kong, Hong Kong, Special Administrative Region, The People s Republic of China
    Gastroenterology 130:1858-64. 2006
    ..Accurate serum biomarkers for gastric cancer currently are lacking. We attempted to identify potential diagnostic serum markers for gastric cancer with the use of the surface-enhanced laser desorption/ionization ProteinChip technology...