Elly S W Ngan

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. doi Prokineticin-signaling pathway
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Biochem Cell Biol 40:1679-84. 2008
  2. pmc Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
    Elly Sau Wai Ngan
    Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China
    J Clin Invest 121:3467-78. 2011
  3. doi A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong, SAR, China
    J Natl Cancer Inst 101:162-75. 2009
  4. ncbi Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong
    Biochim Biophys Acta 1783:467-78. 2008
  5. ncbi Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, SAR, China
    Biochim Biophys Acta 1773:536-45. 2007
  6. doi Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3
    Thomas Y Y Leon
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Pediatr Surg 44:1904-12. 2009
  7. doi Functional analyses of RET mutations in Chinese Hirschsprung disease patients
    Thomas Y Y Leon
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    Birth Defects Res A Clin Mol Teratol 94:47-51. 2012
  8. ncbi Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, SAR, China, and Department of Pediatric Surgery, The Second Affiliated Hospital of China Medical University, Shenyang, China
    Clin Cancer Res 13:868-75. 2007
  9. ncbi Endocrine gland-derived vascular endothelial growth factor is expressed in human peri-implantation endometrium, but not in endometrial carcinoma
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, Hong Kong, SAR, China
    Endocrinology 147:88-95. 2006
  10. ncbi Two Inr elements are important for mediating the activity of the proximal promoter of the human gonadotropin-releasing hormone receptor gene
    Ruby L C Hoo
    Department of Zoology, The University of Hong Kong, Hong Kong, Hong Kong
    Endocrinology 144:518-27. 2003

Collaborators

Detail Information

Publications10

  1. doi Prokineticin-signaling pathway
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Int J Biochem Cell Biol 40:1679-84. 2008
    ..The physiological and patho-physiological roles of prokineticin signaling are just beginning to be revealed and a better understanding of the system should lead to the development of useful therapies for various diseases...
  2. pmc Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
    Elly Sau Wai Ngan
    Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China
    J Clin Invest 121:3467-78. 2011
    ..Collectively, we defined PTCH1 and DLL3 as HSCR susceptibility genes and suggest that Hedgehog/Notch-induced premature gliogenesis may represent a new disease mechanism for HSCR...
  3. doi A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong, SAR, China
    J Natl Cancer Inst 101:162-75. 2009
    ..Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition...
  4. ncbi Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong
    Biochim Biophys Acta 1783:467-78. 2008
    ..Taken together, these findings provide evidence that Prok-1 crosstalks with GDNF/Ret signaling and probably provides an additional layer of signaling refinement to maintain proliferation and differentiation of enteric NCCs...
  5. ncbi Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, SAR, China
    Biochim Biophys Acta 1773:536-45. 2007
    ..Taken together, it is the first report demonstrating that Prok-1 acts as a gut mucosa/mesenchyme-derived factor and maintains proliferation and differentiation of enteric NCCs...
  6. doi Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3
    Thomas Y Y Leon
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Pediatr Surg 44:1904-12. 2009
    ..In this study, we further delineated Nkx2-1-mediated RET Transcription...
  7. doi Functional analyses of RET mutations in Chinese Hirschsprung disease patients
    Thomas Y Y Leon
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    Birth Defects Res A Clin Mol Teratol 94:47-51. 2012
    ..Although an increasing number of HSCR-associated RET coding sequence (CDS) mutations have been identified in recent years, not many have been investigated for functional consequence on the RET protein...
  8. ncbi Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, SAR, China, and Department of Pediatric Surgery, The Second Affiliated Hospital of China Medical University, Shenyang, China
    Clin Cancer Res 13:868-75. 2007
    ..In this report, we further elucidate its role in neuroblastoma progression...
  9. ncbi Endocrine gland-derived vascular endothelial growth factor is expressed in human peri-implantation endometrium, but not in endometrial carcinoma
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, Hong Kong, SAR, China
    Endocrinology 147:88-95. 2006
    ..It may imply that EG-VEGF may only play a role in vascular function of peri-implantation endometrium, but is unlikely to be associated with the etiology of endometrial cancer development...
  10. ncbi Two Inr elements are important for mediating the activity of the proximal promoter of the human gonadotropin-releasing hormone receptor gene
    Ruby L C Hoo
    Department of Zoology, The University of Hong Kong, Hong Kong, Hong Kong
    Endocrinology 144:518-27. 2003
    ..Additional mechanisms are needed to modulate the efficiencies of individual promoters for developmental and/or tissue-specific regulations...