Margaret Heung-Ling Ng

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Alterations of RAS signalling in Chinese multiple myeloma patients: absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript
    Margaret H L Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Br J Haematol 123:637-45. 2003
  2. pmc A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia
    Chi Keung Cheng
    Haematologica 98:913-7. 2013
  3. pmc Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma
    Pei Liang
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, China
    Haematologica 98:288-95. 2013
  4. ncbi request reprint HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003)
    Margaret H L Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
    Ann Hematol 85:535-41. 2006
  5. ncbi request reprint Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome
    Margaret H L Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Infect Dis 190:515-8. 2004
  6. ncbi request reprint DNA methylation changes and multiple myeloma
    M H Ng
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, SAR, China
    Leuk Lymphoma 34:463-72. 1999
  7. ncbi request reprint Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma
    M H Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Cancer Res 7:1724-9. 2001
  8. ncbi request reprint Chromosomal aberrations of multiple myeloma in Chinese patients at diagnosis: a study by combined G-banding and multicolor spectral karyotyping
    Margaret Heung Ling Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T Hong Kong SAR
    Oncol Rep 10:587-91. 2003
  9. ncbi request reprint Death associated protein kinase: from regulation of apoptosis to tumor suppressive functions and B cell malignancies
    M H L Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, CUHK, Prince of Wales Hospital, Shatin, HKSAR, People s Republic of China
    Apoptosis 7:261-70. 2002
  10. ncbi request reprint Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: a review of literature of t(8;13) associated myeloproliferative diseases
    Wai Shan Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Leuk Res 31:235-8. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Alterations of RAS signalling in Chinese multiple myeloma patients: absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript
    Margaret H L Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Br J Haematol 123:637-45. 2003
    ..In our current studies of Chinese MM patients, these alterations involved frequent RASSF1A inactivation (60%) as a result of transcriptional silencing or expression of a non-functional variant transcript...
  2. pmc A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia
    Chi Keung Cheng
    Haematologica 98:913-7. 2013
    ..Together, our findings uncover a microRNA-mediated control of NPM1 expression that contributes to disease heterogeneity and suggest additional prognostic values of NPM1 in acute myeloid leukemia...
  3. pmc Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma
    Pei Liang
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, China
    Haematologica 98:288-95. 2013
    ..Together, our preclinical data indicate that PF4 may be a potential new targeting agent for the treatment of myeloma...
  4. ncbi request reprint HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003)
    Margaret H L Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
    Ann Hematol 85:535-41. 2006
    ..006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. Taken together, our findings support the involvement of HLA in Chinese high-risk childhood ALL...
  5. ncbi request reprint Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome
    Margaret H L Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Infect Dis 190:515-8. 2004
    ..0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs...
  6. ncbi request reprint DNA methylation changes and multiple myeloma
    M H Ng
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, SAR, China
    Leuk Lymphoma 34:463-72. 1999
    ..The reversibility of this epigenetic inactivation of the p16 and p15 genes in MM may also provide a broad clinical application in the development of new therapeutic interventions in this uniformly fatal form of cancer...
  7. ncbi request reprint Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma
    M H Ng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Cancer Res 7:1724-9. 2001
    ....
  8. ncbi request reprint Chromosomal aberrations of multiple myeloma in Chinese patients at diagnosis: a study by combined G-banding and multicolor spectral karyotyping
    Margaret Heung Ling Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T Hong Kong SAR
    Oncol Rep 10:587-91. 2003
    ..However, there were notably higher incidences of -22/22q- (4/11) and structural aberrations of chromosome X but a lower incidence of -X. The biological implications of these findings, if confirmed, deserve further evaluation...
  9. ncbi request reprint Death associated protein kinase: from regulation of apoptosis to tumor suppressive functions and B cell malignancies
    M H L Ng
    Hematology Section, Department of Anatomical and Cellular Pathology, CUHK, Prince of Wales Hospital, Shatin, HKSAR, People s Republic of China
    Apoptosis 7:261-70. 2002
    ....
  10. ncbi request reprint Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: a review of literature of t(8;13) associated myeloproliferative diseases
    Wai Shan Wong
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Leuk Res 31:235-8. 2007
    ..Also differential clonal TcRgamma gene rearrangements in the BM and LN samples were observed. These findings provide novel insights into the genetic pathogenesis...
  11. doi request reprint The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines
    Brigette B Y Ma
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Cancer Drug Testing Unit, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
    Invest New Drugs 28:413-20. 2010
    ..AKT upregulation following RAD001 treatment suggests the presence of a feedback loop on AKT signaling in NPC which warrants further investigation...
  12. ncbi request reprint Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese
    Celeste B L Man
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 48:1015-8. 2007
    ..Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals...
  13. ncbi request reprint 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4
    Suk Hang Cheng
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Blood 109:2089-99. 2007
    ..These data have opened up a new approach in the molecular targeting therapy and provide novel insights into MM tumorigenesis...
  14. ncbi request reprint Hematocrit, independent of chronic kidney disease, predicts adverse cardiovascular outcomes in chinese patients with type 2 diabetes
    Peter C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Diabetes Care 29:2439-44. 2006
    ..We examined the association between hematocrit, stratified by the presence of CKD, and cardiovascular events in a cohort of Chinese subjects with type 2 diabetes...
  15. ncbi request reprint Thrombocytopenia in patients with severe acute respiratory syndrome (review)
    Mo Yang
    Department of Paediatrics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hematology 10:101-5. 2005
    ....
  16. ncbi request reprint Identification of TPO receptors on central nervous system-a preliminary report
    Mo Yang
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:494-7. 2004
    ..In conclusion, the first evidence showed the expression of TPO receptor c-mpl in central nervous system. Moreover, the effect of TPO on neural cell proliferation and anti-apoptosis was also demonstrated on in vitro neural cells...
  17. ncbi request reprint A prospective, randomized, placebo-controlled study of the dose effect of oral oestradiol on menopausal symptoms, psychological well being, and quality of life in postmenopausal Chinese women
    Christopher J Haines
    Department of Obstetrics and Gynaecology, The Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong, PR China
    Maturitas 44:207-14. 2003
    ..The aims of this study were to measure menopausal symptoms, mood and QOL in postmenopausal Chinese women and to assess the effect of different doses of oestrogen on these outcome indicators...
  18. ncbi request reprint A prospective, randomized, placebo-controlled study of the dose effect of oral estradiol on bone mineral density in postmenopausal Chinese women
    Christopher J Haines
    Department of Obstetrics and Gynecology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Maturitas 45:169-73. 2003
    ..The aim of this study was to compare changes in bone mineral density (BMD) measurements using conventional and lower dose estradiol...
  19. doi request reprint New testing approach in HLA genotyping helps overcome barriers in effective clinical practice
    Suk Hang Cheng
    Departments of Anatomical and Cellular Pathology and Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR
    Clin Chem 55:1568-72. 2009
    ....
  20. pmc Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis
    Raymond S M Wong
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    BMJ 326:1358-62. 2003
    ..To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS)...
  21. pmc The familial risk and HLA susceptibility among narcolepsy patients in Hong Kong Chinese
    Lei Chen
    Department of Psychiatry, The Chinese University of Hong Kong, Prince of Wales and Shatin Hospitals, Shatin, Hong Kong SAR
    Sleep 30:851-8. 2007
    ..To explore the familial aggregation and HLA susceptibility of narcolepsy in Hong Kong Chinese by objective sleep measurements and HLA typing...
  22. doi request reprint Role of 'atypical pathogens' among adult hospitalized patients with community-acquired pneumonia
    Grace Lui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Respirology 14:1098-105. 2009
    ..This study examined the role of these 'atypical pathogens' (AP) among adult hospitalized patients with CAP...
  23. ncbi request reprint Childhood acute myeloid leukemia with CBFbeta-MYH11 rearrangement: study of incidence, morphology, cytogenetics, and clinical outcomes of Chinese in Hong Kong
    Natalie P H Chan
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Am J Hematol 76:300-3. 2004
    ..This is the first clinicopathological study and documentation of the incidence of CBFbeta-MYH11 in childhood AML of Chinese in Hong Kong...
  24. doi request reprint Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia
    Chi Keung Cheng
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Blood 112:3391-402. 2008
    ..Taken together, RUNX3 was the first transcriptional target found to be commonly repressed by the t(8;21) and inv(16) fusion proteins and might have an important role in core-binding factor AML...