Research Topics
Species | Margaret Heung-Ling NgSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
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Detail Information
Publications
Alterations of RAS signalling in Chinese multiple myeloma patients: absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcriptMargaret H L Ng
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
Br J Haematol 123:637-45. 2003..In our current studies of Chinese MM patients, these alterations involved frequent RASSF1A inactivation (60%) as a result of transcriptional silencing or expression of a non-functional variant transcript...
Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myelomaPei Liang
Haematologica 98:288-95. 2013..Together, our preclinical data indicate that PF4 may be a potential new targeting agent for the treatment of myeloma...- HLA-B67 may be a male-specific HLA marker of susceptibility to relapsed childhood ALL in Hong Kong Chinese and HLA-A33 or HLA-B17 signifies a higher presentation leukocytosis: A retrospective analysis on 53 transplant candidates (1989-2003)Margaret H L Ng
Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
Ann Hematol 85:535-41. 2006..006) or HLA-B17 (p < 0.001) signifies higher leukocytosis at presentation. Taken together, our findings support the involvement of HLA in Chinese high-risk childhood ALL... - DNA methylation changes and multiple myelomaM H Ng
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, SAR, China
Leuk Lymphoma 34:463-72. 1999..The reversibility of this epigenetic inactivation of the p16 and p15 genes in MM may also provide a broad clinical application in the development of new therapeutic interventions in this uniformly fatal form of cancer... - Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndromeMargaret H L Ng
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
J Infect Dis 190:515-8. 2004..0%) in our SARS group was significantly higher (P=3x10(-9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs... - Chromosomal aberrations of multiple myeloma in Chinese patients at diagnosis: a study by combined G-banding and multicolor spectral karyotypingMargaret Heung Ling Ng
Hematology Section, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T Hong Kong SAR
Oncol Rep 10:587-91. 2003..However, there were notably higher incidences of -22/22q- (4/11) and structural aberrations of chromosome X but a lower incidence of -X. The biological implications of these findings, if confirmed, deserve further evaluation... - Death associated protein kinase: from regulation of apoptosis to tumor suppressive functions and B cell malignanciesM H L Ng
Hematology Section, Department of Anatomical and Cellular Pathology, CUHK, Prince of Wales Hospital, Shatin, HKSAR, People s Republic of China
Apoptosis 7:261-70. 2002.... - Frequent death-associated protein kinase promoter hypermethylation in multiple myelomaM H Ng
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Clin Cancer Res 7:1724-9. 2001.... - Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: a review of literature of t(8;13) associated myeloproliferative diseasesWai Shan Wong
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
Leuk Res 31:235-8. 2007..Also differential clonal TcRgamma gene rearrangements in the BM and LN samples were observed. These findings provide novel insights into the genetic pathogenesis... - Thrombocytopenia in patients with severe acute respiratory syndrome (review)Mo Yang
Department of Paediatrics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Hematology 10:101-5. 2005.... 
The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell linesBrigette B Y Ma
State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Cancer Drug Testing Unit, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
Invest New Drugs 28:413-20. 2010..AKT upregulation following RAD001 treatment suggests the presence of a feedback loop on AKT signaling in NPC which warrants further investigation...- Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han ChineseCeleste B L Man
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 48:1015-8. 2007..Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals... - 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4Suk Hang Cheng
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
Blood 109:2089-99. 2007..These data have opened up a new approach in the molecular targeting therapy and provide novel insights into MM tumorigenesis... - Hematocrit, independent of chronic kidney disease, predicts adverse cardiovascular outcomes in chinese patients with type 2 diabetesPeter C Y Tong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Diabetes Care 29:2439-44. 2006..We examined the association between hematocrit, stratified by the presence of CKD, and cardiovascular events in a cohort of Chinese subjects with type 2 diabetes... - Identification of TPO receptors on central nervous system-a preliminary reportMo Yang
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:494-7. 2004..In conclusion, the first evidence showed the expression of TPO receptor c-mpl in central nervous system. Moreover, the effect of TPO on neural cell proliferation and anti-apoptosis was also demonstrated on in vitro neural cells... - A prospective, randomized, placebo-controlled study of the dose effect of oral oestradiol on menopausal symptoms, psychological well being, and quality of life in postmenopausal Chinese womenChristopher J Haines
Department of Obstetrics and Gynaecology, The Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong, PR China
Maturitas 44:207-14. 2003..The aims of this study were to measure menopausal symptoms, mood and QOL in postmenopausal Chinese women and to assess the effect of different doses of oestrogen on these outcome indicators... - A prospective, randomized, placebo-controlled study of the dose effect of oral estradiol on bone mineral density in postmenopausal Chinese womenChristopher J Haines
Department of Obstetrics and Gynecology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Maturitas 45:169-73. 2003..The aim of this study was to compare changes in bone mineral density (BMD) measurements using conventional and lower dose estradiol... - The familial risk and HLA susceptibility among narcolepsy patients in Hong Kong ChineseLei Chen
Department of Psychiatry, The Chinese University of Hong Kong, Prince of Wales and Shatin Hospitals, Shatin, Hong Kong SAR
Sleep 30:851-8. 2007..To explore the familial aggregation and HLA susceptibility of narcolepsy in Hong Kong Chinese by objective sleep measurements and HLA typing... - New testing approach in HLA genotyping helps overcome barriers in effective clinical practiceSuk Hang Cheng
Departments of Anatomical and Cellular Pathology and Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR
Clin Chem 55:1568-72. 2009.... - Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysisRaymond S M Wong
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
BMJ 326:1358-62. 2003..CONCLUSIONS: Abnormal haematological variables were common among patients with SARS. Lymphopenia and the depletion of T lymphocyte subsets may be associated with disease activity... - Childhood acute myeloid leukemia with CBFbeta-MYH11 rearrangement: study of incidence, morphology, cytogenetics, and clinical outcomes of Chinese in Hong KongNatalie P H Chan
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Am J Hematol 76:300-3. 2004..This is the first clinicopathological study and documentation of the incidence of CBFbeta-MYH11 in childhood AML of Chinese in Hong Kong... - Role of 'atypical pathogens' among adult hospitalized patients with community-acquired pneumoniaGrace Lui
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Respirology 14:1098-105. 2009..This study examined the role of these 'atypical pathogens' (AP) among adult hospitalized patients with CAP... - Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemiaChi Keung Cheng
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
Blood 112:3391-402. 2008..Taken together, RUNX3 was the first transcriptional target found to be commonly repressed by the t(8;21) and inv(16) fusion proteins and might have an important role in core-binding factor AML...