Research Topics
| I O NgSummaryAffiliation: The University of Hong Kong Country: China Publications
| Collaborators
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Detail Information
Publications
Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parametersKe Hao
1Rosetta Inpharmatics LLC, Merck Research Laboratories, Seattle, WA, USA
BMC Cancer 9:389. 2009..However, the results are not consistent due to lack of systemic approach to establish a prediction model incorporating all these parameters...
DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1I O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital, China
Cancer Res 60:6581-4. 2000..Our findings suggest that DLC-1 may play an important role in hepatocarcinogenesis...- Microsatellite analysis in post-transplantation lymphoproliferative disorder to determine donor/recipient originI O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam
Mod Pathol 13:1180-5. 2000..Moreover, the finding of the relatively indolent nature of PTLD of donor origin supports that determination of the donor/recipient origin of PTLD is of prognostic significance... - Microsatellite alterations in squamous cell carcinoma of the head and neck - clustering of loss of heterozygosity in a distinct subsetI O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Room 127B UPB, Pokfulam, Hong Kong
Oral Oncol 36:484-90. 2000..Our data show that the incidence of microsatellite alterations in SCCHN from Hong Kong Chinese is low. However, LOH may be one of the genetic mechanisms in the carcinogenesis of a subset of SCCHN (hypopharyngeal-laryngeal cancers)... - Expression of insulin-like growth factor II mRNA in hepatocellular carcinomaI O Ng
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam
J Gastroenterol Hepatol 13:152-7. 1998.... - Expression of p21/waf1 in oral squamous cell carcinomas--correlation with p53 and mdm2 and cellular proliferation indexI O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital, People s Republic of China
Oral Oncol 35:63-9. 1999..Overexpression of p21 alone appeared to be insufficient to suppress tumor progression... - Combined hepatocellular-cholangiocarcinoma: a clinicopathological studyI O Ng
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam
J Gastroenterol Hepatol 13:34-40. 1998..The overall survival times of patients with HCC-CC were short. In conclusion, HCC-CC showed clinical and pathological features more akin to those of ordinary HCC than to CC... - Prognostic significance of pathological and biological factors in hepatocellular carcinomaI O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital
J Gastroenterol Hepatol 13:666-70. 1998..The influence of gender on survival is also reviewed. In conclusion, pathological and biological factors are useful and help to guide clinicians in the management of patients and in assessment of long-term prognosis... - Better survival in women with resected hepatocellular carcinoma is not related to tumor proliferation or expression of hormone receptorsI O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam
Am J Gastroenterol 92:1355-8. 1997..We previously showed that the better prognosis in female patients is related to a higher incidence of tumor encapsulation and less invasive tumors. However, the underlying mechanism is still obscure... - Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective studyR T Poon
Centre of Liver Diseases, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Ann Surg 233:227-35. 2001..To evaluate the correlation between serum vascular endothelial growth factor (VEGF) level and the clinicopathologic features in patients with hepatocellular carcinoma (HCC)... - Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cellsT K Lee
Department of Pathology, The University of Hong Kong, Hong Kong
Int J Cancer 93:393-400. 2001..In conclusion, this receptor-mediated gene transfer system appears to work specifically in HCC cells with high efficiency, and may be promising in delivering apoptotic and other genes into HCC cells... - Long-term prognosis after resection of hepatocellular carcinoma associated with hepatitis B-related cirrhosisR T Poon
Centre of Liver Disease, Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
J Clin Oncol 18:1094-101. 2000..This study evaluated the long-term results and prognostic factors after resection of HCC complicating HBV-related cirrhosis... - Clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma: a study of a prospective cohortR T Poon
Center for Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
J Clin Oncol 19:3037-44. 2001..This study aims to clarify the clinicopathologic features of long-term survivors and disease-free survivors after resection of hepatocellular carcinoma (HCC)... - Liver transplantation in Asian patients with chronic hepatitis B using lamivudine prophylaxisC M Lo
Centre of Liver Diseases, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
Ann Surg 233:276-81. 2001..To report the results of liver transplantation in 31 Asian patients with chronic hepatitis B using lamivudine prophylaxis in an open-label study... - Hepatectomy for hepatocellular carcinoma: the surgeon's role in long-term survivalS T Fan
Department of Surgery, The University of Hong Kong, Queen Mary Hospital, China
Arch Surg 134:1124-30. 1999..The surgeon can contribute substantially to the long-term survival rate of patients undergoing hepatectomy for hepatocellular carcinoma (HCC)... - Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinomaI O Ng
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam
Am J Clin Pathol 116:838-45. 2001..The differential up-regulation of Flt-1 suggests that it may have an important role in angiogenesis in HCC... - Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinomaR T Poon
Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
Am J Surg 182:298-304. 2001..This study evaluated the role of serum bFGF as a biological marker of tumor invasiveness and postresection recurrence in hepatocellular carcinoma (HCC)... - Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysisL F Qin
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
Hum Pathol 32:778-84. 2001.... - Exogenous expression of p21(WAF1/CIP1) exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cellsL F Qin
Room 127B, University Pathology Building, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
Cancer Lett 172:7-15. 2001.... - Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 yearsR T Poon
Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
Ann Surg 234:63-70. 2001.... - Follicular dendritic cell tumor of the liver. Evidence for an Epstein-Barr virus-related clonal proliferation of follicular dendritic cellsT W Shek
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
Am J Surg Pathol 20:313-24. 1996..The strong expression of latent membrane protein restricted to the tumor cells and the clonality of the EBV suggest that the virus may be involved in the pathogenesis of this tumor and not present merely as a "bystander.".. - beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significanceC M Wong
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
Cancer 92:136-45. 2001..CONCLUSIONS: beta-catenin mutation and deregulation may play an important role in hepatocarcinogenesis. Nonnuclear type beta-catenin overexpression appeared to have pathologic and prognostic significance... - Liver transplantation in rats using small-for-size grafts: a study of hemodynamic and morphological changesK Man
Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
Arch Surg 136:280-5. 2001..CONCLUSIONS: In a rat model, the portal hemodynamic changes in small-for-size grafts are transient. Progressive damage of the graft may result from microcirculatory failure due to irreversible endothelial injury after reperfusion... - Clinicopathologic significance of genetic alterations in hepatocellular carcinomaA Pang
University Department of Medicine Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
Cancer Genet Cytogenet 146:8-15. 2003..Consistent patterns of genetic alterations were defined in HCC, which might represent distinctive pathways in hepatocarcinogenesis... - Impact of precore and core promoter mutations on hepatic histology in patients with chronic hepatitis BH J Yuan
Department of Medicine, The University of Hong Kong, Queen Mary Hospital
Aliment Pharmacol Ther 22:301-7. 2005..The details of liver histology of patients with precore and core promoter mutations are still not clear... - Low molecular weight heparin-induced liver toxicityC K Hui
Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102, Pokfulam Road, Hong Kong, China
J Clin Pharmacol 41:691-4. 2001..Liver biopsy in the woman demonstrated balloon degeneration with scattered foci of hepatocytic necrosis, suggesting a complement-mediated hepatocellular damage...