Amin Nanji

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. ncbi Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration
    A A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong, Hong Kong, China
    J Pharmacol Exp Ther 299:638-44. 2001
  2. ncbi Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines
    A A Nanji
    Department of Pathology, The University of Hong Kong and Queen Mary Hospital, Hong Kong
    Am J Physiol Gastrointest Liver Physiol 281:G1348-56. 2001
  3. ncbi Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration
    A A Nanji
    Department of Pathology and Centre for The Study of Liver Diseases, University of Hong Kong and Queen Mary Hospital, Hong Kong
    J Pharmacol Exp Ther 299:832-9. 2001
  4. ncbi Macrophage migration inhibitory factor expression in male and female ethanol-fed rats
    A A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong and Queen Mary Hospital, Hong Kong
    J Interferon Cytokine Res 21:1055-62. 2001
  5. ncbi Pathogenesis of alcoholic liver disease--recent advances
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong and Queen Mary Hospital
    Alcohol Clin Exp Res 26:731-6. 2002
  6. ncbi Role of Kupffer cells in alcoholic hepatitis
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Alcohol 27:13-5. 2002
  7. ncbi Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease
    El-Nasir Lalani
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, UK
    Int J Mol Med 15:811-7. 2005
  8. ncbi Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
  9. ncbi A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Alcohol Clin Exp Res 32:669-82. 2008
  10. ncbi Increased severity of alcoholic liver injury in female verses male rats: a microarray analysis
    Meena R Sharma
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 84:46-58. 2008

Research Grants

  1. CYCLOOXYGENASE-2 AND ALCOHOLIC LIVER DISEASE
    Amin Nanji; Fiscal Year: 2003

Collaborators

Detail Information

Publications20

  1. ncbi Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration
    A A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong, Hong Kong, China
    J Pharmacol Exp Ther 299:638-44. 2001
    ..The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased activation of NF-kappaB and reduced levels of TNF-alpha and Cox-2...
  2. ncbi Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines
    A A Nanji
    Department of Pathology, The University of Hong Kong and Queen Mary Hospital, Hong Kong
    Am J Physiol Gastrointest Liver Physiol 281:G1348-56. 2001
    ..TNF-alpha and COX-2 upregulation are probably important in causing liver injury but do not explain gender-related differences...
  3. ncbi Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration
    A A Nanji
    Department of Pathology and Centre for The Study of Liver Diseases, University of Hong Kong and Queen Mary Hospital, Hong Kong
    J Pharmacol Exp Ther 299:832-9. 2001
    ..The therapeutic effects of arginine are probably secondary to increased levels of nitric oxide but other effects of arginine cannot be excluded...
  4. ncbi Macrophage migration inhibitory factor expression in male and female ethanol-fed rats
    A A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong and Queen Mary Hospital, Hong Kong
    J Interferon Cytokine Res 21:1055-62. 2001
    ..MIF is an important mediator of the inflammatory response in alcoholic liver disease and a potential therapeutic target...
  5. ncbi Pathogenesis of alcoholic liver disease--recent advances
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong and Queen Mary Hospital
    Alcohol Clin Exp Res 26:731-6. 2002
    ..French...
  6. ncbi Role of Kupffer cells in alcoholic hepatitis
    Amin A Nanji
    Department of Pathology and Center for the Study of Liver Diseases, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Alcohol 27:13-5. 2002
    ..Inflammatory cytokines and cyclooxygenase-2 are up-regulated in response to binding of NF-kappa B. A combined role for tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 is important in the pathogenesis of alcoholic hepatitis...
  7. ncbi Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease
    El-Nasir Lalani
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, UK
    Int J Mol Med 15:811-7. 2005
    ..Thus, up-regulation of HGF and c-met occurred in the presence of the necrosis and inflammation suggesting that HGF may be acting to protect against liver injury or accelerate the regenerative process...
  8. ncbi Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Physiol Gastrointest Liver Physiol 284:G321-7. 2003
    ..Thus curcumin prevents experimental ALD, in part by suppressing induction of NF-kappaB-dependent genes...
  9. ncbi A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Alcohol Clin Exp Res 32:669-82. 2008
    ....
  10. ncbi Increased severity of alcoholic liver injury in female verses male rats: a microarray analysis
    Meena R Sharma
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 84:46-58. 2008
    ....
  11. ncbi Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats
    Terrence M Donohue
    Liver Study Unit, VA Nebraska, Western Iowa Health Care Network, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 31:1944-52. 2007
    ..Here, we determined whether differential liver injury occurred in male and female rats after feeding these animals liquid diets containing either ethanol or isocaloric dextrose with fish oil as the sole source of lipid...
  12. ncbi Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection
    Hai Ying Zhang
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Liver Int 25:571-9. 2005
    ..Macrophage migration inhibitory factor (MIF) has emerged to be a pivotal cytokine in immune-mediated diseases...
  13. ncbi Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Founders 7 103, Philadelphia, PA 19104, USA
    Alcohol 34:21-5. 2004
    ..The mechanisms through which the fatty acids promote alcoholic liver disease include enhanced oxidative stress, production of endotoxin, and increased expression of proinflammatory cytokines...
  14. ncbi Animal models of alcoholic liver disease--focus on the intragastric feeding model
    Amin A Nanji
    Department of Pathology, University of Pennsylvania, Philadelphia, USA
    Alcohol Res Health 27:325-30. 2003
    ..This model allows scientists to rigorously control an animal's consumption of both alcohol and dietary nutrients and is providing important information on the mechanisms of injury of alcoholic liver disease...
  15. ncbi Decreased proteasome activity is associated with increased severity of liver pathology and oxidative stress in experimental alcoholic liver disease
    Terrence M Donohue
    Liver Study Unit, The Omaha Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Alcohol Clin Exp Res 28:1257-63. 2004
    ..This study examined the relationship of proteasome activity and content with ethanol-induced oxidative stress and the degree of liver injury...
  16. ncbi Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Pharmacol Exp Ther 310:417-24. 2004
    ....
  17. ncbi Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats
    Carol A Casey
    Liver Study Unit, Department of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE 68198, USA
    J Appl Physiol 96:76-80. 2004
    ..These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content...
  18. ncbi Role of apoptosis in alcoholic liver injury
    Hiromasa Ishii
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Alcohol Clin Exp Res 27:1207-12. 2003
    ..C. Fernández-Checa; (4) Toxicity of ethanol in HepG2 cells that express CYP2E1, by A.I. Cederbaum; (5) Is alcohol-enhanced liver apoptosis a pathogenic factor in alcoholic liver disease? by I.V. Deaciuc...
  19. ncbi Induction of CYP3A by ethanol in multiple in vitro and in vivo models
    Dennis E Feierman
    Department of Anesthesiology, The Mount Sinai Medical Center, New York, New York 10029 6574, USA
    Alcohol Clin Exp Res 27:981-8. 2003
    ..Because ethanol is used widely, its potential interaction with CYP3A is of great interest. The effects of ethanol on CYP3A content and activity were assessed in different in vivo and in vitro models...
  20. ncbi A voluntary oral-feeding rat model for pathological alcoholic liver injury
    George L Tipoe
    Department of Anatomy, The University of Hong Kong, Hong Kong, SAR China
    Methods Mol Biol 447:11-31. 2008
    ....

Research Grants3

  1. CYCLOOXYGENASE-2 AND ALCOHOLIC LIVER DISEASE
    Amin Nanji; Fiscal Year: 2003
    ..The prevention and treatment of alcoholic liver injury by Cox-2 inhibitors in these experiments should provide data for the testing of these drugs in patients with alcoholic liver disease. ..