R C W Ma

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Effects of treatment targets on subsequent cardiovascular events in Chinese patients with type 2 diabetes
    Alice P S Kong
    Li Ka Shing Institute of Health Sciences, Hong Kong, China
    Diabetes Care 30:953-9. 2007
  2. pmc A man with labile blood pressure
    Ronald C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    PLoS Med 4:e111. 2007
  3. pmc Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects
    Claudia Ha Ting Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 5:e11428. 2010
  4. doi request reprint Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes
    R C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong Lee Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong Electronic address
    Diabetes Res Clin Pract 103:328-37. 2014
  5. doi request reprint Gestational diabetes, maternal obesity, and the NCD burden
    Ronald C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    Clin Obstet Gynecol 56:633-41. 2013
  6. pmc Early life opportunities for prevention of diabetes in low and middle income countries
    Mark A Hanson
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    BMC Public Health 12:1025. 2012
  7. pmc Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case-control cohort analysis
    Ross K K Leung
    Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, SAR, China
    BMC Nephrol 14:162. 2013
  8. pmc Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States
    Ronald C W Ma
    Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China
    Ann N Y Acad Sci 1281:64-91. 2013
  9. pmc Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
    R C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR, People s Republic of China
    Diabetologia 56:1291-305. 2013
  10. pmc Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study
    Rose Z W Ting
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Cardiovasc Diabetol 9:77. 2010

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Effects of treatment targets on subsequent cardiovascular events in Chinese patients with type 2 diabetes
    Alice P S Kong
    Li Ka Shing Institute of Health Sciences, Hong Kong, China
    Diabetes Care 30:953-9. 2007
    ..We examined risk associations between achieving treatment targets for glycemia, blood pressure and lipid control, and other risk factors on subsequent cardiovascular events in Chinese patients with type 2 diabetes...
  2. pmc A man with labile blood pressure
    Ronald C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    PLoS Med 4:e111. 2007
  3. pmc Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects
    Claudia Ha Ting Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 5:e11428. 2010
    ..We examined the associations of the reported common variants of these genes with T2D and glucose homeostasis in three independent Chinese cohorts...
  4. doi request reprint Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes
    R C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong Lee Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong Electronic address
    Diabetes Res Clin Pract 103:328-37. 2014
    ..This study aimed to evaluate associations between recently reported type 2 diabetes (T2D) susceptibility genetic variants and cancer risk in a prospective cohort of Chinese patients with T2D...
  5. doi request reprint Gestational diabetes, maternal obesity, and the NCD burden
    Ronald C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
    Clin Obstet Gynecol 56:633-41. 2013
    ..We use an evolutionary perspective to elucidate the origins of gestational diabetes. Focusing efforts on maternal health is an important approach to combating the growing burden of diabetes and other noncommunicable diseases. ..
  6. pmc Early life opportunities for prevention of diabetes in low and middle income countries
    Mark A Hanson
    Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Mailpoint 887, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    BMC Public Health 12:1025. 2012
    ..However, interventions to promote diet and lifestyle in prospective parents before conception have not received sufficient attention, especially in low- and middle-income countries undergoing socio-economic transition...
  7. pmc Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case-control cohort analysis
    Ross K K Leung
    Hong Kong Bioinformatics Centre, The Chinese University of Hong Kong, Hong Kong, SAR, China
    BMC Nephrol 14:162. 2013
    ..In a database with comprehensive collection of phenotypes and genotypes, we compared the performance of common machine learning methods to generate mathematical models to predict diabetic kidney disease (DKD)...
  8. pmc Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States
    Ronald C W Ma
    Department of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China
    Ann N Y Acad Sci 1281:64-91. 2013
    ..While more research is needed to explain these interethnic differences, urgent and concerted actions are needed to raise awareness, facilitate early diagnosis, and encourage preventive strategies to combat these growing disease burdens...
  9. pmc Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
    R C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR, People s Republic of China
    Diabetologia 56:1291-305. 2013
    ..We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians...
  10. pmc Lipid control and use of lipid-regulating drugs for prevention of cardiovascular events in Chinese type 2 diabetic patients: a prospective cohort study
    Rose Z W Ting
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Cardiovasc Diabetol 9:77. 2010
    ..Yet, the effectiveness of lipid regulating drugs in Asians is lacking. We examined the effects of lipid control and treatment with lipid regulating drugs on new onset of CVD in Chinese type 2 diabetic patients...
  11. pmc Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients--a longitudinal observational study
    Wilson Y Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Cardiovasc Diabetol 8:57. 2009
    ..This study examined the benefit and harm of low-dose aspirin (daily dose < 300 mg) in patients with type 2 diabetes...
  12. pmc Impacts of chronic kidney disease and albuminuria on associations between coronary heart disease and its traditional risk factors in type 2 diabetic patients - the Hong Kong diabetes registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 6:37. 2007
    ..We used novel statistical analyses to examine how albuminuria and chronic kidney disease (CKD) may influence the effects of other risk factors on coronary heart disease (CHD)...
  13. pmc Development and validation of a risk score for hospitalization for heart failure in patients with Type 2 diabetes mellitus
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 7:9. 2008
    ..Based on the Hong Kong Diabetes Registry, this study aimed to develop and validate a risk score for predicting heart failure that needs hospitalisation in T2DM...
  14. pmc Association between physical activity and cardiovascular risk in Chinese youth independent of age and pubertal stage
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    BMC Public Health 10:303. 2010
    ..We examined the association of self-reported level of physical activity and cardiovascular risk in Hong Kong Chinese youth of school-age...
  15. pmc Genome-wide linkage scan for factors of metabolic syndrome in a Chinese population
    Claudia H T Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    BMC Genet 11:14. 2010
    ..Shared genetic factors may contribute to the phenotypic clustering of different components of the metabolic syndrome (MES). This study aims to identify genetic loci that contribute to individual or multiple factors related to MES...
  16. doi request reprint Sonographic measurement of mesenteric fat predicts presence of fatty liver among subjects with polycystic ovary syndrome
    R C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Endocrinol Metab 96:799-807. 2011
    ..In this study, we examined the relationship between mesenteric fat thickness and other sonographic indices of adiposity and the presence of fatty liver among subjects with polycystic ovary syndrome (PCOS)...
  17. doi request reprint Pregnancy and diabetes scenario around the world: China
    Ronald C W Ma
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Int J Gynaecol Obstet 104:S42-5. 2009
    ....
  18. ncbi request reprint Genetic variants of the protein kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes
    Ronald C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    JAMA 304:881-9. 2010
    ..Protein kinase C-beta (PKC-beta) is a cell-signaling intermediate implicated in development of diabetic complications...
  19. ncbi request reprint Drug-induced endocrine and metabolic disorders
    Ronald C W Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Drug Saf 30:215-45. 2007
    ....
  20. pmc Carbamazepine and false positive dexamethasone suppression tests for Cushing's syndrome
    Ronald C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    BMJ 330:299-300. 2005
  21. pmc Recurrent hypoglycaemia in a patient with metastatic pancreatic carcinoma
    Ronald C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS Med 3:e331. 2006
  22. ncbi request reprint Prediction of cardiovascular and total mortality in Chinese type 2 diabetic patients by the WHO definition for the metabolic syndrome
    G T C Ko
    Department of Medicine, AH Nethersole Hospital, Tai Po, Hong Kong, China
    Diabetes Obes Metab 8:94-104. 2006
    ....
  23. ncbi request reprint Triglyceride predicts cardiovascular mortality and its relationship with glycaemia and obesity in Chinese type 2 diabetic patients
    W B Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong
    Diabetes Metab Res Rev 21:183-8. 2005
    ..To examine the lipid profile in Chinese type 2 diabetic patients and their relationship with anthropometric parameters, glycaemic control and cardiovascular mortality...
  24. doi request reprint Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome
    L P Cheung
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Hum Reprod 23:1431-8. 2008
    ..Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidaemia and hypertension which are characteristic features of the metabolic syndrome (MetS)...
  25. ncbi request reprint Interactive effect of retinopathy and macroalbuminuria on all-cause mortality, cardiovascular and renal end points in Chinese patients with Type 2 diabetes mellitus
    P C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, NT, Hong Kong
    Diabet Med 24:741-6. 2007
    ..To examine the effect of albuminuria and retinopathy on the risk of cardiovascular and renal events, and all-cause mortality in patients with Type 2 diabetes...
  26. ncbi request reprint Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients-- interaction with ACE insertion/deletion polymorphism
    W Y So
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong
    Kidney Int 69:1438-43. 2006
    ..In conclusion, inhibition of RAAS was associated with reduced risk of mortality and occurrence of renal end point in Chinese type 2 diabetic patients. These benefits were most evident among II and DI carriers...
  27. ncbi request reprint Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients
    Y Wang
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Diabet Med 27:376-83. 2010
    ..To examine the independent and joint effects of multiple genetic variants on a cardiac end-point in an 8-year prospective study of a Chinese diabetic cohort...
  28. ncbi request reprint The efficacy and tolerability of fosinopril in Chinese type 2 diabetic patients with moderate renal insufficiency
    P C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, NT, Hong Kong
    Diabetes Obes Metab 8:342-7. 2006
    ..We examined the efficacy and tolerability of fosinopril, an ACE inhibitor with dual hepatic and renal clearance, in 38 type 2 diabetic patients with moderate renal impairment (plasma creatinine 130-300 micromol/l) over a 2-year period...
  29. doi request reprint Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents
    J L Y Mong
    Department of Biochemistry, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Obes (Lond) 33:1446-53. 2009
    ..Five single-nucleotide polymorphisms (SNPs) at IGF-binding protein-3 (IGFBP3) were genotyped to find their associations with IGF-1 activity level and common clinical metabolic traits...
  30. ncbi request reprint The NCEP-ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease
    A O Y Luk
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong
    Diabet Med 25:1419-25. 2008
    ....
  31. ncbi request reprint Assessment of glomerular filtration rate in addition to albuminuria is important in managing type II diabetes
    A P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR
    Kidney Int 69:383-7. 2006
    ..001). Measurement of serum creatinine alone without GFR may underestimate renal impairment in type II diabetic patients. Decreasing GFR was significantly associated with increasing frequency of micro- and macrovascular complications...
  32. doi request reprint Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling
    X Y Song
    Department of Statistics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, People s Republic of China
    Diabetologia 52:1543-53. 2009
    ..We used structural equation modelling (SEM) to evaluate the independent and combined effects of phenotypes and genotypes implicated in cardiovascular diseases on renal function in type 2 diabetes...
  33. ncbi request reprint Association of the POU class 2 homeobox 1 gene (POU2F1) with susceptibility to Type 2 diabetes in Chinese populations
    M C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Diabet Med 27:1443-9. 2010
    ..We examined the association of POU2F1 genetic variants with Type 2 diabetes in Hong Kong Chinese using two independent cohorts...
  34. ncbi request reprint Polycystic ovarian syndrome in Hong Kong Chinese women: patient characteristics and diagnostic criteria
    P M Lam
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 11:336-41. 2005
    ..To identify the characteristics of Hong Kong Chinese women with polycystic ovarian syndrome and to compare different diagnostic criteria...
  35. ncbi request reprint Increased leptin concentrations and lack of gender difference in Type 2 diabetic patients with nephropathy
    W B Chan
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Diabetes Res Clin Pract 64:93-8. 2004
    ....
  36. pmc Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents
    Claudia H T Tam
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 58:765-9. 2009
    ..We examined the associations of two common genetic polymorphisms of GCKR and GCK with metabolic traits in healthy Chinese adults and adolescents...
  37. pmc Aldose reductase genotypes and cardiorenal complications: an 8-year prospective analysis of 1,074 type 2 diabetic patients
    Wing Yee So
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Diabetes Care 31:2148-53. 2008
    ..In this expanded cohort, we examined their predictive roles on new onset of cardiorenal complications using a prospective design...
  38. ncbi request reprint Pancreatic islet beta-cell deficit and glucose intolerance in rats with uninephrectomy
    Y Sui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin N T, Hong Kong, China
    Cell Mol Life Sci 64:3119-28. 2007
    ..These data suggest that chronic renal impairment and RAS activation may contribute to islet beta-cell loss and glucose intolerance. RAS blockade may therefore prevent these disorders...
  39. doi request reprint Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    Maggie C Y Ng
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Endocrinol Metab 95:2418-25. 2010
    ..Recent genome-wide association studies have identified multiple novel loci associated with obesity in Europeans. We hypothesized that these genetic variants may be associated with obesity and type 2 diabetes (T2D) in Chinese...
  40. ncbi request reprint Addressing different biases in analysing drug use on cancer risk in diabetes in non-clinical trial settings--what, why and how?
    X L Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Diabetes Obes Metab 14:579-85. 2012
    ..In conclusion, drug use indication bias and prevalent user bias but not immortal time bias are major biases in the design and analysis of drug use effects among patients with diabetes in non-clinical trial settings...
  41. doi request reprint Use of anti-diabetic drugs and glycaemic control in type 2 diabetes-tThe Hong Kong Diabetes Registry
    Peter C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Diabetes Res Clin Pract 82:346-52. 2008
    ..Early intensification of therapy and system improvement are needed to enhance the effectiveness of these drugs in clinical practice...
  42. ncbi request reprint The associations of body mass index, C-peptide and metabolic status in Chinese Type 2 diabetic patients
    W B Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong and The Diabetes Mellitus and Endocrine Centre, The Prince of Wales Hospital, Shatin, Hong Kong
    Diabet Med 21:349-53. 2004
    ..We compared the clinical features, C peptide and metabolic status between lean/normal weight and obese diabetic subjects...
  43. pmc Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    Diabetes Care 34:375-80. 2011
    ..Both metformin and apolipoprotein A1 activate the AMPK signaling pathway. We hypothesize that the anticancer effects of metformin may be particularly evident in type 2 diabetic patients with low HDL cholesterol...
  44. doi request reprint Low triglyceride and nonuse of statins is associated with cancer in type 2 diabetes mellitus: the Hong Kong Diabetes Registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Hong Kong, China
    Cancer 117:862-71. 2011
    ..In this analysis, the authors explored associations of cancer risk with high/low triglyceride in T2DM and possible modifying effects of statins on this risk association, if any...
  45. ncbi request reprint Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Endocrinol Metab 92:3733-7. 2007
    ..However, data for Chinese and comprehensive survey of the whole gene are lacking...
  46. pmc Low LDL cholesterol, albuminuria, and statins for the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Diabetes Care 32:1826-32. 2009
    ..We explored the 1) interaction between low LDL cholesterol and albuminuria and 2) interaction between copresence of these two risk factors and statin use for cancer in type 2 diabetes...
  47. pmc Diabetes-related distress and physical and psychological health in chinese type 2 diabetic patients
    Rose Z W Ting
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong S A R, China
    Diabetes Care 34:1094-6. 2011
    ..To validate a Chinese version of the Diabetes Distress Scale (CDDS)...
  48. doi request reprint Use of sulphonylurea and cancer in type 2 diabetes-The Hong Kong Diabetes Registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Diabetes Res Clin Pract 90:343-51. 2010
    ..Hyperglycaemia is a risk factor for cancer and some sulphonylureas have anti-oxidant properties. This study examined associations between use of sulphonylureas and cancer...
  49. doi request reprint White blood cell count and renin-angiotensin system inhibitors for the risk of cancer in type 2 diabetes
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China
    Diabetes Res Clin Pract 87:117-25. 2010
    ..We hypothesize that RAS inhibitors may reduce cancer risk associated with high WBC in type 2 diabetes mellitus (T2DM)...
  50. ncbi request reprint Using illness scripts to teach clinical reasoning skills to medical students
    Anna Lee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Fam Med 42:255-61. 2010
    ..We conducted a randomized controlled trial to determine if a workshop that uses "illness scripts" could improve students' clinical reasoning skills when making diagnoses of patients portrayed in written scenarios...
  51. pmc Additive interaction between the renin-angiotensin system and lipid metabolism for cancer in type 2 diabetes
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Diabetes 58:1518-25. 2009
    ..The aim of this study was to explore interactions between these two systems in mediating cancer risk in type 2 diabetes...
  52. pmc Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry
    Andrea O Y Luk
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Diabetes Care 31:2357-61. 2008
    ..We examined risk associations of metabolic syndrome with new onset of chronic kidney disease (CKD) in 5,829 Chinese patients with type 2 diabetes enrolled between 1995 and 2005...
  53. ncbi request reprint Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy
    W Y So
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, SAR, Hong Kong, China
    J Diabetes Complications 17:369-73. 2003
    ..Other potential candidate genes should be looked for to account for the high prevalence of young-onset diabetes and nephropathy in this population...
  54. ncbi request reprint Effect of angiotensin-converting enzyme inhibition on survival in 3773 Chinese type 2 diabetic patients
    Wing Yee So
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Hypertension 44:294-9. 2004
    ..The effects of ACE inhibitors in type 2 diabetic patients with normoalbuminuria require further evaluation...
  55. ncbi request reprint Prognostic effect of insertion/deletion polymorphism of the ace gene on renal and cardiovascular clinical outcomes in Chinese patients with type 2 diabetes
    Ying Wang
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Diabetes Care 28:348-54. 2005
    ..The aim of the present study was to investigate the prognostic effect of I/D polymorphism on renal and cardiovascular clinical outcomes in Chinese patients with type 2 diabetes...
  56. ncbi request reprint Association of testosterone, insulin-like growth factor-I, and C-reactive protein with metabolic syndrome in Chinese middle-aged men with a family history of type 2 diabetes
    Peter C Y Tong
    Department of Medicine and Therapeutics, School of Public Health, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Endocrinol Metab 90:6418-23. 2005
    ..Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES)...
  57. ncbi request reprint Effects of chronic hyperglycaemia on incident stroke in Hong Kong Chinese patients with type 2 diabetes
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR
    Diabetes Metab Res Rev 23:220-6. 2007
    ..It remains unclear whether hyperglycaemia as measured by HbA(1c) is a significant risk factor for stroke in patients with type 2 diabetes mellitus (T2DM)...
  58. ncbi request reprint Hematocrit, independent of chronic kidney disease, predicts adverse cardiovascular outcomes in chinese patients with type 2 diabetes
    Peter C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Diabetes Care 29:2439-44. 2006
    ..We examined the association between hematocrit, stratified by the presence of CKD, and cardiovascular events in a cohort of Chinese subjects with type 2 diabetes...
  59. ncbi request reprint The effect of orlistat-induced weight loss, without concomitant hypocaloric diet, on cardiovascular risk factors and insulin sensitivity in young obese Chinese subjects with or without type 2 diabetes
    Peter C Y Tong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Arch Intern Med 162:2428-35. 2002
    ..We examined the weight-losing effect of orlistat treatment on insulin sensitivity and cardiovascular risk factors in a group of severely obese young Chinese patients with or without type 2 diabetes mellitus...
  60. ncbi request reprint Progression to impaired glucose regulation, diabetes and metabolic syndrome in Chinese women with a past history of gestational diabetes
    Wing Hung Tam
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR
    Diabetes Metab Res Rev 23:485-9. 2007
    ..To examine the risk of developing impaired glucose regulation (IGR), diabetes mellitus (DM) and metabolic syndrome (MetS) in Chinese women with history of gestational diabetes...
  61. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  62. ncbi request reprint Predicting values of lipids and white blood cell count for all-site cancer in type 2 diabetes
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Endocr Relat Cancer 15:597-607. 2008
    ..The adjusted area under receiver operating characteristic curve was 0.712. In conclusion, BMI, lipids and WBC count have predicting values for cancer...
  63. pmc Additive interaction of hyperglycemia and albuminuria on risk of ischemic stroke in type 2 diabetes: Hong Kong Diabetes Registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Diabetes Care 31:2294-300. 2008
    ..The study aims to test whether biological interaction between hyperglycemia and albuminuria can explain the inconsistent findings from epidemiological studies and clinical trials about effects of hyperglycemia on stroke in type 2 diabetes...
  64. ncbi request reprint Development and validation of a total coronary heart disease risk score in type 2 diabetes mellitus
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Am J Cardiol 101:596-601. 2008
    ..External validations are required in other Chinese populations...
  65. ncbi request reprint Diabetes and pregnancy: perspectives from Asia
    G E Tutino
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Tianjin, China
    Diabet Med 31:302-18. 2014
    ....
  66. doi request reprint Development and validation of an all-cause mortality risk score in type 2 diabetes
    Xilin Yang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Arch Intern Med 168:451-7. 2008
    ..Diabetes reduces life expectancy by 10 to 12 years, but whether death can be predicted in type 2 diabetes mellitus remains uncertain...
  67. ncbi request reprint Risk factors in V-shaped risk associations with all-cause mortality in type 2 diabetes-The Hong Kong Diabetes Registry
    Wing Yee So
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, China
    Diabetes Metab Res Rev 24:238-46. 2008
    ..Body mass index (BMI) is associated with death in a V-shaped manner in general populations but it is unknown whether BMI or other risk factors also exhibit V-shaped relationships with death in type 2 diabetic patients...
  68. ncbi request reprint Fever, headache, and a stiff neck
    R C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    Lancet 363:1868. 2004
  69. ncbi request reprint Long-term outcomes and predictors of chronic insomnia: a prospective study in Hong Kong Chinese adults
    Jihui Zhang
    Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region
    Sleep Med 13:455-62. 2012
    ..We aimed to determine the longitudinal course and outcome of chronic insomnia in a five-year prospective study in Hong Kong Chinese adults...
  70. ncbi request reprint A Chinese family with familial paraganglioma syndrome due to succinate dehydrogenase deficiency
    Ronald C W Ma
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 13:151-4. 2007
    ..Genetic analysis of the succinate dehydrogenase genes can provide a specific diagnosis and allow for genetic screening of at-risk individuals...
  71. pmc Independent associations between low-density lipoprotein cholesterol and cancer among patients with type 2 diabetes mellitus
    Xilin Yang
    The Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    CMAJ 179:427-37. 2008
    ..The risk association between low-density lipoprotein (LDL) cholesterol and cancer remains controversial and largely unexplored for people not receiving statin therapy...
  72. pmc Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry
    Xilin Yang
    Department of Medicine and Therapeutics, The Chinese Universityof Hong Kong, Hong Kong, People s Republic of China
    Diabetes 59:1254-60. 2010
    ..CONCLUSIONS In Chinese patients with type 2 diabetes, hyperglycemia predicts cancer, whereas insulin usage was associated with a reduced cancer risk...
  73. ncbi request reprint Clinical picture. Metastatic calcification
    Ronald C W Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shantin, Hong Kong
    Lancet 359:293. 2002
  74. pmc A 67-year-old woman with recurrent hypoglycemia: non-islet cell tumour hypoglycemia
    Ronald C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    CMAJ 173:359-61. 2005
  75. ncbi request reprint Reference values for serum levels of insulin-like growth factor (IGF-1) and IGF-binding protein 3 (IGFBP-3) and their ratio in Chinese adolescents
    Alice P S Kong
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Biochem 40:1093-9. 2007
    ..To establish the reference values for serum levels of IGF-1 and IGFBP-3 and their ratio in Chinese adolescents aged 12-19 years...
  76. doi request reprint Evaluation of functional and malignant adrenal incidentalomas
    Vanessa W S Ng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Arch Intern Med 170:2017-20. 2010
    ..Adrenal incidentalomas are adrenal masses discovered inadvertently. We undertook this study to review the clinical characteristics of patients with adrenal incidentalomas who presented to a tertiary endocrine center in Hong Kong...
  77. doi request reprint Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up
    Marco Ho bun Lam
    Department of Psychiatry, The Chinese University of Hong Kong, China
    Arch Intern Med 169:2142-7. 2009
    ..We investigated long-term psychiatric morbidities and chronic fatigue among SARS survivors...
  78. ncbi request reprint Glomerular filtration rate, cardiorenal end points, and all-cause mortality in type 2 diabetic patients
    Wing Yee So
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR
    Diabetes Care 29:2046-52. 2006
    ..We investigated the effects of stages of renal function using the estimated glomerular filtration rate (eGFR) on all-cause mortality and cardiovascular end points in a prospective cohort of Chinese type 2 diabetic patients...
  79. pmc A woman with recurrent cardiac ischemia without coronary artery disease
    Ronald C W Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    CMAJ 176:171-3. 2007
  80. ncbi request reprint Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    ..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
  81. ncbi request reprint Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium
    Zhiheng He
    Research Division, Joslin Diabetes Center, Harvard Medical School and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    J Biol Chem 280:15719-26. 2005
    ....
  82. ncbi request reprint Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats
    Emi Arikawa
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1410-20. 2007
    ..Thus, PKCbeta or ACE inhibitors may ameliorate cardiac metabolism and function in diabetes partly by normalization of fuel metabolic gene expression directly in the myocardium...
  83. ncbi request reprint Acute renal failure following oral sodium phosphate bowel preparation in diabetes
    Ronald C W Ma
    Diabetes Care 30:182-3. 2007