W K Liu

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line
    Wing Keung Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    Eur J Pharmacol 498:71-8. 2004
  2. doi request reprint Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells
    Wing Keung Liu
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Nat Prod 75:586-90. 2012
  3. ncbi request reprint Apoptotic activity of isomalabaricane triterpenes on human promyelocytic leukemia HL60 cells
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Cancer Lett 230:102-10. 2005
  4. ncbi request reprint Stellettin A induces oxidative stress and apoptosis in HL-60 human leukemia and LNCaP prostate cancer cell lines
    W K Liu
    Department of Anatomy and School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Nat Prod 69:934-7. 2006
  5. ncbi request reprint Wheat germ lectin induces G2/M arrest in mouse L929 fibroblasts
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Cell Biochem 91:1159-73. 2004
  6. doi request reprint Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells
    Wing Keung Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Nat Prod 71:842-6. 2008
  7. ncbi request reprint Jolkinolide B induces neuroendocrine differentiation of human prostate LNCaP cancer cell line
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong
    Biochem Pharmacol 63:951-7. 2002
  8. ncbi request reprint Growth inhibitory activity of lemnabourside on human prostate cancer cells
    W K Liu
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories
    Life Sci 70:843-53. 2002
  9. ncbi request reprint Suppression of cell cycle progression by a fungal lectin: activation of cyclin-dependent kinase inhibitors
    W Liua
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Biochem Pharmacol 61:33-7. 2001
  10. ncbi request reprint Anti-proliferative effect of ginseng saponins on human prostate cancer cell line
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Life Sci 67:1297-306. 2000

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line
    Wing Keung Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    Eur J Pharmacol 498:71-8. 2004
    ....
  2. doi request reprint Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells
    Wing Keung Liu
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Nat Prod 75:586-90. 2012
    ..Taken together, 1 is an endoplasmic reticulum stressor that inhibits the growth of B16 melanoma cells by induction of abnormal protein glycosylation and autophagy...
  3. ncbi request reprint Apoptotic activity of isomalabaricane triterpenes on human promyelocytic leukemia HL60 cells
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Cancer Lett 230:102-10. 2005
    ..Taken together our results suggest that geoditin A markedly induced reactive oxygen species, decreased mitochondrial membrane potential and mediated a caspases 3 apoptosis pathway...
  4. ncbi request reprint Stellettin A induces oxidative stress and apoptosis in HL-60 human leukemia and LNCaP prostate cancer cell lines
    W K Liu
    Department of Anatomy and School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    J Nat Prod 69:934-7. 2006
    ..All available evidence suggests that 1 induces oxidative cell death through a FasL-caspase-3-apoptotic pathway...
  5. ncbi request reprint Wheat germ lectin induces G2/M arrest in mouse L929 fibroblasts
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Cell Biochem 91:1159-73. 2004
    ..These results suggest that WGA arrested L929 proliferation after one cell cycle in the G2/M phase through activation of the p21Cip1/WAF1 and suppression of Cyclin B-Cdc2...
  6. doi request reprint Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells
    Wing Keung Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Nat Prod 71:842-6. 2008
    ..Thus, 1 blocked cell cycle progression at the G 1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery...
  7. ncbi request reprint Jolkinolide B induces neuroendocrine differentiation of human prostate LNCaP cancer cell line
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong
    Biochem Pharmacol 63:951-7. 2002
    ..Taken all data together, jolkinolide B seems to play a role in the regulation of proliferation, differentiation, and apoptosis of LNCaP cells...
  8. ncbi request reprint Growth inhibitory activity of lemnabourside on human prostate cancer cells
    W K Liu
    Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories
    Life Sci 70:843-53. 2002
    ..5 microM) indicated that caspase-3 apoptosis pathway is one of the possible antiproliferative activities mediated by lemnabourside...
  9. ncbi request reprint Suppression of cell cycle progression by a fungal lectin: activation of cyclin-dependent kinase inhibitors
    W Liua
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Biochem Pharmacol 61:33-7. 2001
    ..Flow cytometric analysis demonstrated an accumulation of cells in the G2/M phase in a time- and dose-dependent manner, indicating that VVL arrested cell proliferation by blocking cell cycle progression in the G2/M phase...
  10. ncbi request reprint Anti-proliferative effect of ginseng saponins on human prostate cancer cell line
    W K Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Life Sci 67:1297-306. 2000
    ....
  11. ncbi request reprint Volvariella volvacea lectin activates mouse T lymphocytes by a calcium dependent pathway
    S C W Sze
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Cell Biochem 92:1193-202. 2004
    ....
  12. doi request reprint Sodium 5,6-benzylidene-L-ascorbate induces oxidative stress, autophagy, and growth arrest in human colon cancer HT-29 cells
    F W K Cheung
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Cell Biochem 111:412-24. 2010
    ....
  13. ncbi request reprint Tangutorine induces p21 expression and abnormal mitosis in human colon cancer HT-29 cells
    B P L Liu
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, PR China
    Biochem Pharmacol 70:287-99. 2005
    ..Taken all results together, tangutorine induced a p21 suppression of all cyclins and their associated kinases, such as the topoisomerase II, and thus inhibited normal DNA replication and mitosis...
  14. ncbi request reprint A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea
    Q B She
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Biochem Biophys Res Commun 247:106-11. 1998
    ..As revealed by its N-terminal amino acid sequence, VVL possessed a molecular structure distinct from other immunomodulatory proteins previously reported in the same fungus...
  15. ncbi request reprint Mitogenic activity of edible mushroom lectins
    J C K Ho
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Biochim Biophys Acta 1671:9-17. 2004
    ..Taken all results together, VVL induced mitogenesis through T cell receptors and the subsequent calcium signaling pathway...
  16. ncbi request reprint Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice
    J C K Ho
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Life Sci 75:1343-56. 2004
    ..However, the expression of vascular endothelial cell growth factor (VEGF) in these tumors was suppressed. In conclusion, anti-angiogenesis should be one of the pathways through which PSP mediated its anti-tumor activity...
  17. pmc Photodynamic activity of BAM-SiPc, an unsymmetrical bisamino silicon(IV) phthalocyanine, in tumour-bearing nude mice
    S C H Leung
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Br J Pharmacol 154:4-12. 2008
    ..The unsymmetrical bisamino silicon(IV) phthalocyanine BAM-SiPc is one of the most potent compounds. In in vitro cell culture, it exhibits high phototoxicity against a number of cancer cell lines...
  18. ncbi request reprint Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains
    David T Yew
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, SAR, China
    Neurosci Lett 367:113-7. 2004
    ..Furthermore, we had confirmed that in most neurons Fas and caspase 8 did not exist concomitantly and that the glial cells (astrocytes) did not express caspase 8 in Alzheimer patients...
  19. ncbi request reprint Peptidomics analysis of neuropeptides involved in copulatory behavior of the mollusk Lymnaea stagnalis
    Z el Filali
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, De Boelelaan 1085, Vrije Universiteit, 1081 HV, Amsterdam, The Netherlands
    J Proteome Res 5:1611-7. 2006
    ..Finally, application of synthetic -FVRIamide peptides to an in vitro posterior vas deferens preparation showed inhibitory effect on the spontaneous contraction/relaxation cycle of the vas deferens...
  20. ncbi request reprint Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy
    W K Liu
    Department of Pharmacology, Mayo Clinic Jacksonville, FL 32224, USA
    Ann Neurol 50:494-502. 2001
    ..The H1 haplotype had no effect on the 4R to 3R ratio or on tau and amyloid burdens. In summary, the H1 haplotype does not have a major influence on the pathological or biochemical phenotype of PSP...