Edmund K Li

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Gout: a review of its aetiology and treatment
    E K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 10:261-70. 2004
  2. doi request reprint Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis?
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Rheumatology (Oxford) 48:892-8. 2009
  3. doi request reprint Bone microarchitecture assessment by high-resolution peripheral quantitative computed tomography in patients with systemic lupus erythematosus taking corticosteroids
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 37:1473-9. 2010
  4. doi request reprint Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation
    E K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
    Rheumatology (Oxford) 47:1358-63. 2008
  5. ncbi request reprint Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial
    Edmund K Li
    Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Arthritis Rheum 57:1143-50. 2007
  6. doi request reprint High prevalence of asymptomatic vertebral fractures in Chinese women with systemic lupus erythematosus
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 36:1646-52. 2009
  7. pmc Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid
    Edmund K Li
    Department of Medicine, The Chinese University of Hong Kong, Prince Wales Hospital, 30 32 Ngan Shing Street, Sha Tin, NT, Hong Kong, PR China
    Arthritis Res Ther 12:R198. 2010
  8. ncbi request reprint Leflunomide in the treatment of rheumatoid arthritis
    Edmund K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, ROC
    Clin Ther 26:447-59. 2004
  9. doi request reprint Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Semin Arthritis Rheum 42:333-45. 2013
  10. doi request reprint Socioeconomic burden of psoriatic arthritis in Hong Kong: direct and indirect costs and the influence of disease pattern
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Rheumatol 37:1214-20. 2010

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Gout: a review of its aetiology and treatment
    E K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 10:261-70. 2004
    ..To review the current understanding of the causes and the management of gout...
  2. doi request reprint Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis?
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Rheumatology (Oxford) 48:892-8. 2009
    ..To assess if combination rituximab and cyclophosphamide is more effective than rituximab monotherapy as an induction therapy for proliferative lupus nephritis...
  3. doi request reprint Bone microarchitecture assessment by high-resolution peripheral quantitative computed tomography in patients with systemic lupus erythematosus taking corticosteroids
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 37:1473-9. 2010
    ....
  4. doi request reprint Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation
    E K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
    Rheumatology (Oxford) 47:1358-63. 2008
    ..To examine the short-term efficacy and safety of MTX in combination with infliximab compared with infliximab and placebo in the treatment of AS using MRI to monitor its effect...
  5. ncbi request reprint Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial
    Edmund K Li
    Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Arthritis Rheum 57:1143-50. 2007
    ....
  6. doi request reprint High prevalence of asymptomatic vertebral fractures in Chinese women with systemic lupus erythematosus
    Edmund K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
    J Rheumatol 36:1646-52. 2009
    ..To investigate the prevalence of vertebral fractures and to identify risk factors associated with vertebral fractures in Chinese women with systemic lupus erythematosus (SLE)...
  7. pmc Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid
    Edmund K Li
    Department of Medicine, The Chinese University of Hong Kong, Prince Wales Hospital, 30 32 Ngan Shing Street, Sha Tin, NT, Hong Kong, PR China
    Arthritis Res Ther 12:R198. 2010
    ....
  8. ncbi request reprint Leflunomide in the treatment of rheumatoid arthritis
    Edmund K Li
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, ROC
    Clin Ther 26:447-59. 2004
    ..Drugs are needed that are able to suppress inflammation and modify the underlying immune response with improved tolerability. Leflunomide is an agent that affects the inflammatory process, particularly in RA...
  9. doi request reprint Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Semin Arthritis Rheum 42:333-45. 2013
    ....
  10. doi request reprint Socioeconomic burden of psoriatic arthritis in Hong Kong: direct and indirect costs and the influence of disease pattern
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Rheumatol 37:1214-20. 2010
    ..To estimate the direct costs and indirect costs of patients with psoriatic arthritis (PsA) in Hong Kong...
  11. ncbi request reprint Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study
    Lai S Tam
    Department of Medicine and Therapeutics, Department of Radiology, and the Clinical Immunology Unit, Hong Kong Cancer Institute, Hong Kong
    J Rheumatol 32:275-82. 2005
    ..We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE...
  12. ncbi request reprint Rapid improvement in rheumatoid arthritis patients on combination of methotrexate and infliximab: clinical and magnetic resonance imaging evaluation
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hongkong, People s Republic of China
    Clin Rheumatol 26:941-6. 2007
    ..Assessment of enhancing synovial volume and perfusion indices on serial MRI examination was helpful in documenting the effect of treatment over this short period...
  13. pmc Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China
    Arthritis Res Ther 14:R80. 2012
    ..This study evaluated whether abnormal host innate immune response in lupus patients may enhance HPV persistence...
  14. doi request reprint Labour and non-labour market productivity in Chinese patients with systemic lupus erythematosus
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, 9 F Clinical Sciences Building, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, N T, Hong Kong
    Rheumatology (Oxford) 51:284-92. 2012
    ..A cross-sectional study was performed to assess the self-reported loss of labour and non-labour market productivity, as well as to characterize the risk factors of loss of productivity in patients with SLE...
  15. doi request reprint The impact of flare on disease costs of patients with systemic lupus erythematosus
    Tracy Y Zhu
    Prince of Wales Hospital and The Chinese University of Hong Kong, Shatin, Hong Kong
    Arthritis Rheum 61:1159-67. 2009
    ....
  16. doi request reprint Relationship between flare and health-related quality of life in patients with systemic lupus erythematosus
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, New Territory, Hong Kong, China
    J Rheumatol 37:568-73. 2010
    ....
  17. doi request reprint Bone density and microarchitecture: relationship between hand, peripheral, and axial skeletal sites assessed by HR-pQCT and DXA in rheumatoid arthritis
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Calcif Tissue Int 91:343-55. 2012
    ..Future longitudinal studies will be needed to investigate whether assessment by HR-pQCT can be used as a marker of disease activity and a predictor of disease progression in RA...
  18. doi request reprint Infliximab is associated with improvement in arterial stiffness in patients with early rheumatoid arthritis -- a randomized trial
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 39:2267-75. 2012
    ..To determine the efficacy of methotrexate (MTX) with infliximab (IFX) compared with MTX alone in the prevention of atherosclerosis and arterial stiffness in patients with early rheumatoid arthritis (RA)...
  19. doi request reprint Increased organ damage associated with deterioration in volumetric bone density and bone microarchitecture in patients with systemic lupus erythematosus on longterm glucocorticoid therapy
    Xiao lin Tang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Rheumatol 39:1955-63. 2012
    ..To evaluate bone quality in patients with systemic lupus erythematosus (SLE) who were undergoing longterm glucocorticoid (GC) therapy, and to focus on the correlation between bone quality and organ damage...
  20. doi request reprint Risk factors for squamous intraepithelial lesions in systemic lupus erythematosus: a prospective cohort study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital and The Chinese University of Hong Kong, Hong Kong, China
    Arthritis Care Res (Hoboken) 63:269-76. 2011
    ..We undertook a prospective cohort study to ascertain the risk factors for the development of squamous intraepithelial lesions (SIL) in patients with systemic lupus erythematosus (SLE)...
  21. doi request reprint Subclinical carotid atherosclerosis in patients with psoriatic arthritis
    Lai Shan Tam
    The Prince of Wales Hospital and The Chinese University of Hong Kong, Hong Kong, China
    Arthritis Rheum 59:1322-31. 2008
    ..To examine the prevalence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) compared with healthy controls, and to identify clinical and biologic markers for atherosclerotic disease in this patient population...
  22. doi request reprint Structure and strength of the distal radius in female patients with rheumatoid arthritis: a case-control study
    Tracy Y Zhu
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Bone Miner Res 28:794-806. 2013
    ..Ulnovolar periosteal apposition of the distal radius is a feature of chronic, severe RA with wrist deformity...
  23. doi request reprint Societal costs of rheumatoid arthritis in Hong Kong: a prevalence-based cost-of-illness study
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Rheumatology (Oxford) 50:1293-301. 2011
    ..To estimate the direct and indirect costs among a cohort of Chinese patients with RA in Hong Kong...
  24. doi request reprint Natural history of cervical papilloma virus infection in systemic lupus erythematosus - a prospective cohort study
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 37:330-40. 2010
    ....
  25. ncbi request reprint The relationship between neuropsychiatric, clinical, and laboratory variables and quality of life of Chinese patients with systemic lupus erythematosus
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Rheumatol 35:1038-45. 2008
    ..To investigate the role of neuropsychiatric (NP), clinical, and laboratory variables in influencing the health related quality of life (HRQOL) of Chinese patients with systemic lupus erythematosus (SLE)...
  26. pmc Acupuncture in the treatment of rheumatoid arthritis: a double-blind controlled pilot study
    Lai Shan Tam
    The Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    BMC Complement Altern Med 7:35. 2007
    ....
  27. pmc The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin
    Miao Hu
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Lipid Res 53:1384-9. 2012
    ....
  28. doi request reprint Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    J Clin Immunol 29:738-46. 2009
    ..Abnormal activation of intracellular signaling molecules in lymphocytes by inflammatory cytokines can instigate the inflammation in SLE...
  29. doi request reprint Systemic lupus erythematosus with neuropsychiatric manifestation incurs high disease costs: a cost-of-illness study in Hong Kong
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong
    Rheumatology (Oxford) 48:564-8. 2009
    ..To determine the direct and indirect costs of SLE in Hong Kong, and to ascertain the relationship between neuropsychiatric SLE (NPSLE) and disease costs...
  30. ncbi request reprint Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid
    Alice Y K Chan
    Rheumatology Unit, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Rheumatol Int 25:388-90. 2005
    ..Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy...
  31. ncbi request reprint Risk factors and clinical features for tuberculosis among patients with systemic lupus erythematosus in Hong Kong
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Scand J Rheumatol 31:296-300. 2002
    ..To determine the risk factors associated with and to describe the clinical course of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE)...
  32. doi request reprint Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis
    Da P Chen
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Cell Mol Immunol 8:469-78. 2011
    ..Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA...
  33. doi request reprint Evaluation of spinal mobility measurements in predicting axial psoriatic arthritis
    Ying Ying Leung
    Department of Medicine and Geriatrics, Tai Po Hospital, 9 Chuen On Road, Tai Po, NT, Hong Kong SAR, China
    Clin Rheumatol 30:1157-62. 2011
    ..619, 0.626, and 0.618). Spinal mobility measurements and BASMI were useful in differentiating axial and peripheral PsA. Lumber side flexion and modified schober test best differentiate axial and peripheral PsA...
  34. doi request reprint Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity
    C K Wong
    Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Clin Immunol 30:45-52. 2010
    ..CXCL13 can induce the trafficking of CXCR5+ T lymphocyte subset designated as follicular helper T lymphocytes (T(FH)) which are specifically involved in autoantibody production...
  35. ncbi request reprint The influence of illness and variables associated with functional limitations in Chinese patients with ankylosing spondylitis
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong and Hong Kong Society for Rehabilitation, Hong Kong
    J Rheumatol 34:1032-9. 2007
    ..To assess the effect of illness and the functional outcome of Chinese patients with ankylosing spondylitis (AS), and to identify variables associated with a poor functional outcome...
  36. ncbi request reprint Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Clin Rheumatol 26:1495-8. 2007
    ..Nonetheless, the atherogenic index, LDL-cholesterol/HDL-cholesterol ratio, and the LDL/apoB ratio remained unchanged. Infliximab improves insulin sensitivity and alters lipid profile in patients with active RA...
  37. doi request reprint The socioeconomic burden of systemic lupus erythematosus: state-of-the-art and prospects
    Tracy Y Zhu
    Department of Medicine and Therapeutics, 9 F Clinical Sciences Building, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Expert Rev Pharmacoecon Outcomes Res 12:53-69. 2012
    ..Several methodological considerations and unsolved issues will also be emphasized...
  38. pmc Immunopathological roles of cytokines, chemokines, signaling molecules, and pattern-recognition receptors in systemic lupus erythematosus
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Clin Dev Immunol 2012:715190. 2012
    ....
  39. pmc Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production
    Shui Lian Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e23855. 2011
    ..Pattern recognition receptors (PRRs) such as Toll-like receptors are aberrantly expressed of peripheral blood mononuclear cells (PBMCs) in systemic lupus erythematosus (SLE) patients, for playing immunopathological roles...
  40. pmc Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Arthritis Res Ther 12:R129. 2010
    ..Elevated expression of IL-27 has been detected in the synovial membranes and fluid of rheumatoid arthritis (RA)...
  41. doi request reprint Cost-of-illness studies in systemic lupus erythematosus: A systematic review
    Tracy Y Zhu
    The Chinese University of Hong Kong, Shatin, Hong Kong
    Arthritis Care Res (Hoboken) 63:751-60. 2011
    ..To summarize the state of knowledge regarding the economic burden of systemic lupus erythematosus (SLE) and to evaluate the quality of cost-of-illness (COI) studies conducted to date...
  42. doi request reprint The perspective on psoriatic arthritis in Asia
    Ying Ying Leung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Curr Rheumatol Rep 13:369-75. 2011
    ....
  43. doi request reprint Psoriatic arthritis in Asia
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Rheumatology (Oxford) 48:1473-7. 2009
    ..Carotid intima-media thickness can identify PsA patients with subclinical atherosclerosis who may benefit from early intervention...
  44. ncbi request reprint Increased prevalence of squamous intraepithelial lesions in systemic lupus erythematosus: association with human papillomavirus infection
    Lai Shan Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Arthritis Rheum 50:3619-25. 2004
    ..The association of human papillomavirus (HPV) infection and the use of immunosuppressive agents with abnormal Pap smears in SLE was also assessed...
  45. doi request reprint Costs and quality of life of patients with ankylosing spondylitis in Hong Kong
    T Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Rheumatology (Oxford) 47:1422-5. 2008
    ..To assess the annual direct, indirect and total societal costs, quality of life (QoL) of AS in a Chinese population in Hong Kong and determine the cost determinants...
  46. doi request reprint ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin
    B Tomlinson
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Pharmacol Ther 87:558-62. 2010
    ..As compared with subjects with the c.421CC genotype, those with the c.421AA genotype showed a 6.9% greater reduction in LDL-C level, which would be equivalent to the effect obtained by doubling the dose of rosuvastatin...
  47. ncbi request reprint Patients with systemic lupus erythematosus show increased platelet activation and endothelial dysfunction induced by acute hyperhomocysteinemia
    Lai Shan Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    J Rheumatol 30:1479-84. 2003
    ..Systemic lupus erythematosus (SLE) is an inflammatory disease with a high atherothrombotic tendency. We examined whether acute hyperhomocysteinemia exacerbates endothelial and platelet dysfunction in patients with SLE...
  48. doi request reprint Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients
    Miao Hu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong SAR
    Pharmacogenet Genomics 20:634-7. 2010
    ..This study identified some genetic determinants of LDL-C response to rosuvastatin in Chinese patients, which need to be replicated in other populations...
  49. pmc Measuring disease activity in psoriatic arthritis
    Priscilla C H Wong
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Int J Rheumatol 2012:839425. 2012
    ..This paper reviews the currently available measures used in the assessment of the disease activity in PsA. The composite measures for PsA that are under development are also discussed...
  50. pmc Cardiovascular risk in patients with psoriatic arthritis
    Tracy Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Int J Rheumatol 2012:714321. 2012
    ..In this paper, we discuss the current literature indicating that patients with PsA are at risk of cardiovascular diseases...
  51. ncbi request reprint Risk of tuberculosis in patients with rheumatoid arthritis in Hong Kong--the role of TNF blockers in an area of high tuberculosis burden
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Clin Exp Rheumatol 28:679-85. 2010
    ....
  52. pmc Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis
    C Y Ho
    Department of Chemical Pathology and Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Clin Exp Immunol 133:132-8. 2003
    ..7 (55.9-28.4), respectively]. Combination therapy with leflunomide and MTX exhibits anti-inflammatory activity in the suppression of chemokine expression and subsequent recruitment of inflammatory cells into the inflammatory sites in RA...
  53. ncbi request reprint Decreased ex vivo production of TNF-alpha and IL-8 by peripheral blood cells of patients with rheumatoid arthritis after infliximab therapy
    S W M Lun
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int Immunopharmacol 7:1668-77. 2007
    ..Our study suggests that the reduction in synovial inflammation may be due to the decreased production of TNF-alpha and IL-8, and hence the number of neutrophils and other pro-inflammatory leukocytes infiltrating into the inflamed sites...
  54. ncbi request reprint Mesangial lupus nephritis in Chinese is associated with a high rate of transformation to higher grade nephritis
    L S Tam
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Lupus 12:665-71. 2003
    ..Our data highlight that renal biopsy should be repeated early in Chinese patients with mesangial nephritis who failed to respond to treatment in order to identify those who may require intense immunosuppressive therapy...
  55. doi request reprint Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Rheumatology (Oxford) 47:718-23. 2008
    ..To examine the distribution of traditional and novel risk factors of cardiovascular disease (CVD) in patients with PsA compared with healthy controls...
  56. ncbi request reprint Intravenous cyclophosphamide improves cardiac dysfunction in lupus myocarditis
    Y K Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PRC
    Scand J Rheumatol 32:306-8. 2003
    ..v.) 'pulse' cyclophosphamide. Three weeks after i.v. cyclophosphamide treatment, there was significant improvement of her heart failure symptoms with improvement in the ejection fraction from 19% to 63%...
  57. pmc Activation profile of Toll-like receptors of peripheral blood lymphocytes in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Exp Immunol 159:11-22. 2010
    ..These results suggest that the innate immune response for extracellular pathogens and self-originated DNA plays immunopathological roles via TLR activation in SLE...
  58. ncbi request reprint Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus
    L S Tam
    Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Lupus 13:601-4. 2004
    ..In summary, leflunomide was more effective than placebo in treating SLE patients with mild to moderate disease activity and was safe and well-tolerated...
  59. ncbi request reprint Hydroxychloroquine has no significant effect on lipids and apolipoproteins in Chinese systemic lupus erythematosus patients with mild or inactive disease
    L S Tam
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, tamls
    Lupus 9:413-6. 2000
    ..To investigate the effects of hydroxychloroquine (HCQ) in Chinese patients with systemic lupus erythematosus who were either on a low dose of prednisone or not on prednisone...
  60. ncbi request reprint Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Rheumatology (Oxford) 44:989-94. 2005
    ....
  61. ncbi request reprint Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Rheumatology (Oxford) 44:602-6. 2005
    ..Overexpression of OPN has been associated with the development of the autoimmune/lymphoproliferative syndrome...