Research Topics
Genomes and Genes
| Ting F LeungSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
| Collaborators
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Detail Information
Publications
Bone mineral density in children with thalassaemia major: determining factors and effects of bone marrow transplantationT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Bone Marrow Transplant 36:331-6. 2005..d.) osteocalcin levels in BMT and BT groups were 96.4 (72.7) microg and 68.9 (40.3) microg/l, respectively (P=0.037). In conclusion, severe BMD deficit is common in Chinese TM patients and BMT may reverse BMD deficit in these patients...- Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young childrenTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Pediatr Allergy Immunol 14:296-301. 2003..The other chemokines did not correlate with AD severity. In conclusion, our results suggest that serum MDC concentration may be a useful inflammatory marker for assessing AD severity in infants and young children... - Sociodemographic and atopic factors affecting breastfeeding intention in Chinese mothersT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
J Paediatr Child Health 39:460-4. 2003..The objective of this survey was to study the intention and planned duration of breastfeeding in Chinese women in Hong Kong, and to investigate the sociodemographic and atopic factors affecting the intention to breastfeed... - Helper T-lymphocyte-related chemokines in healthy newbornsTing Fan Leung
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6 F, Clinical Sciences Building, Shatin, Hong Kong
Pediatr Res 55:334-8. 2004..010). This study provides reference ranges of Th-specific chemokines in UCB serum of singleton term neonates. Increased serum MDC concentrations at birth are associated with the occurrence of wheezing during infancy... - RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
Respir Med 99:216-9. 2005..044). RANTES C-28G was not associated with any outcome in this study. In conclusion, the gain-of-function mutation at -401 of RANTES promoter is associated with sensitization to cat and mold allergens and FEV1 in Chinese children... - Immunogenicity of a two-dose regime of varicella vaccine in children with cancersTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Eur J Haematol 72:353-7. 2004..Live-attenuated varicella vaccine is effective and safe in immunocompetent children. In this study, we assess the immunogenicity and adverse events following varicella vaccination in immunosuppressed cancer children... - Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthmaT F Leung
Departments of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Clin Exp Allergy 34:786-91. 2004..Type 2 helper T lymphocyte-specific chemokines including macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) and eotaxin are important mediators for allergic airway inflammation... - The relation between obesity and asthmatic airway inflammationTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Pediatr Allergy Immunol 15:344-50. 2004..In conclusion, ENO and LTB(4) concentration in EBC are increased in childhood asthma. However, these inflammatory markers did not differ between obese and non-obese children with asthma... - Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensateTing F Leung
Department of Pediatrics, Chinese University of Hong Kong, Hong Kong SAR, China
Pediatr Pulmonol 41:87-94. 2006..In conclusion, our results suggest that pH in non-deaerated EBC is influenced by asthma severity in children. EBC pH measurement is reproducible, but is dependent on the collection devices used... - A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitisTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
Pediatr Allergy Immunol 15:558-61. 2004..05). Our results do not support the use of AA-based elemental milk formula in treating young children with AD irrespective of their food allergy status... - Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic childrenTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Int Arch Allergy Immunol 137:66-72. 2005..This study investigates the relation between childhood asthma and levels of these mediators in exhaled breath condensate (EBC)... - CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergyTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Curr Drug Targets Inflamm Allergy 4:169-75. 2005..Lastly, the prospect of using immunomodulatory agents targeting on the innate immunity to treat or even prevent asthma and other allergic diseases will be discussed... - The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese childrenTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
Pediatr Allergy Immunol 14:255-60. 2003..039). This polymorphic marker was not associated with asthma or aeroallergen sensitization in our cohort. Our results suggest that the C-159T of CD14 was associated with serum total IgE concentration in atopic Chinese children... - Plasma TARC concentration may be a useful marker for asthmatic exacerbation in childrenT F Leung
Dept of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Eur Respir J 21:616-20. 2003.... - Infection control for SARS in a tertiary paediatric centre in Hong KongT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
J Hosp Infect 56:215-22. 2004..In conclusion, stringent infection control precautions, appropriate triage and prompt isolation of potential SARS patients may have contributed to a lack of nosocomial spread and HCW acquisition of SARS in our unit... - A Chinese girl with Leigh syndrome: effect of botulinum toxin on dystoniaT F Leung
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
J Paediatr Child Health 34:480-2. 1998..Dystonia persisted despite treatments with muscle relaxants and a ketogenic diet. Intramuscular botulinum toxin resulted in significant relief of dystonia... - Pneumocystis carinii pneumonia in an immunocompetent infant with congenital cytomegalovirus infectionT F Leung
Dept of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
Infection 28:184-6. 2000..This case highlights the fact that PCP can occur in apparently immunocompetent term infants. Malnourished infants with zinc deficiency or congenital CMV infection are at increased risk of developing PCP... - Severe chronic neutropenia in Chinese children in Hong KongT F Leung
Department of Paediatrics, Prince of Wales Hospital, Hong Kong SAR, China
J Paediatr Child Health 37:137-41. 2001..Severe chronic neutropenia (SCN) is a rare and heterogeneous disorder in children. The epidemiology, clinical features and outcomes of SCN in Chinese children were reviewed... - A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Clin Exp Allergy 31:1515-21. 2001..Previous studies showed that polymorphisms in the IL-13 gene were associated with serum total IgE or allergic asthma. The relationship of this marker with sensitization to individual aeroallergens has not been evaluated... - Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese childrenTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR, China
Pediatr Allergy Immunol 13:10-7. 2002..This marker is also associated with the extent of allergic sensitization to cat, as well as with reduced FEV1 and FVC values... - Sensitization to common food allergens is a risk factor for asthma in young Chinese children in Hong KongTing Fan Leung
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
J Asthma 39:523-9. 2002..In conclusion, a significant association was found between asthma and the presence of food-specific IgE antibodies in young Chinese children. Significant sensitization to common foods is rare in this cohort... - Inhalant allergens as risk factors for the development and severity of mild-to-moderate asthma in Hong Kong Chinese childrenTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
J Asthma 39:323-30. 2002..In conclusion, indoor aeroallergens are one of the risk factors for the development and severity of mild-to-moderate asthma in Chinese children in Hong Kong... 
Domestic exposure to aeroallergens in Hong Kong families with asthmatic childrenTing F Leung
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Pediatr Pulmonol 46:632-9. 2011..This study identifies determinants for cat, cockroach, and B. tropicalis levels in Hong Kong families with asthmatic children. These exposures are associated with severity of allergy symptoms...- Association of plasma soluble CTLA-4 with lung function and gene polymorphism in Chinese asthmatic childrenIris H S Chan
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
Int Arch Allergy Immunol 152:113-21. 2010..We investigated the effects of single nucleotide polymorphisms (SNPs) of CTLA-4 on asthma traits and plasma sCTLA-4 in 298 Chinese asthmatic children and 175 controls... - Gene-gene interactions for asthma and plasma total IgE concentration in Chinese childrenIris H S Chan
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
J Allergy Clin Immunol 117:127-33. 2006..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into asthma pathophysiology... - Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic childrenIris H S Chan
Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong
Pediatr Allergy Immunol 20:142-50. 2009..This is the first report to show significant association of Egr-1 polymorphisms with plasma total IgE and atopy in asthmatics. It may help to explore the pharmacogenetics of Egr-1 inhibitors... - PHF11 is not a major candidate gene for asthma or eczema in Chinese childrenHing Y Sy
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Pediatr Pulmonol 45:890-7. 2010..Our findings do not support PHF11 to be a major candidate gene for asthma, eczema and aeroallergen sensitization in Chinese children... - Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic childrenI H S Chan
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Allergy 63:1031-9. 2008..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into the pathophysiology of asthma... - Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentrationTing F Leung
Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Pediatr Pulmonol 41:649-55. 2006..949), atopy (P = 0.305), IgE sensitization to aeroallergens (P > 0.2 for all), or FeNO (P = 0.847). These findings do not support NOS2 to be a major candidate gene for asthma or IgE-mediated allergic diseases in Chinese children... - IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infantsPak C Ng
Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
Pediatr Res 61:93-8. 2007..We conclude that preterm infants have the ability to induce a robust chemokine and cytokine response during sepsis, and IP-10 is a sensitive early marker of infection... - Predicting changes in clinical status of young asthmatics: clinical scores or objective parameters?Ting F Leung
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Pediatr Pulmonol 44:442-9. 2009..203, P = 0.042). In conclusion, C-ACT is better than DSS and objective parameters in reflecting changes in asthma status and predicting asthma exacerbations in young children... - Wheezing in Chinese schoolchildren: disease severity distribution and management practices, a community-based study in Hong Kong and GuangzhouF W S Ko
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR
Clin Exp Allergy 35:1449-56. 2005..Significant morbidity was seen even in this group of children with mostly intermittent and mild persistent asthma... - Airway inflammatory and spirometric measurements in obese childrenJoyce S W Chow
The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 15:346-52. 2009..To investigate the association between obesity and airway inflammation and spirometric parameters in local children... - Distribution in allele frequencies of predisposition-to-atopy genotypes in Chinese childrenT F Leung
Department of Paediatrics, Chinese University of Hong Kong, Hong Kong, China
Pediatr Pulmonol 34:419-24. 2002..Additional studies involving larger samples are required to investigate the association between asthma or atopy and the genotypes studied to date in Chinese children... - Rapid control of norovirus gastroenteritis outbreak in an acute paediatric wardFrankie W T Cheng
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Acta Paediatr 95:581-6. 2006..Children with unexplained vomiting and those with contact history of gastroenteritis should be properly triaged, isolated, and investigated for possible infective causes, including norovirus-induced gastroenteritis... - Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infantsPak C Ng
Department of Pediatrics, Center of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
Clin Chem 52:1181-9. 2006..We investigated the immunologic profiles of preterm infants with sepsis, using chemokine and cytokine measurements to predict the development of sepsis-induced DIC at the onset of infection... - Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary diseaseFanny W S Ko
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Respir Med 100:630-8. 2006..8-isoprostane level, but not GROalpha and MCP-1, in EBC was increased in COPD patients with poorer lung function. This suggests an increased oxidative stress in the airway in patients with more severe COPD... - Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese childrenI H S Chan
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Allergy 62:802-9. 2007..Cyclooxygenase-2 (COX-2) plays essential roles in inflammation. Previous studies have suggested associations between prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and prostaglandins production in asthma... - Inflammatory cytokine profile in children with severe acute respiratory syndromePak C Ng
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Pediatrics 113:e7-14. 2004.... - Asthma and atopy are associated with chromosome 17q21 markers in Chinese childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Allergy 64:621-8. 2009..This study delineated the allele and genotype frequencies of 10 SNPs at chromosome 17q21, and investigated the relationship between these SNPs and asthma and plasma IgE in southern Chinese children... - Cadmium and lead in Hong Kong school childrenIris H S Chan
Departments of Chemical Pathology Medicine and Therapeutics Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau these authors contributed equally to this manuscript
Pathology 44:626-31. 2012..Cadmium (Cd) and lead (Pb) are toxic elements in our environment. This study is to determine the reference intervals of Cd and Pb in blood and urine from Hong Kong school children and to identify their determinants... - Pathophysiology of nocturnal scratching in childhood atopic dermatitis: the role of brain-derived neurotrophic factor and substance PK L E Hon
Department of Pediatrics, The Chinese University of Hong Kong, 6 F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong
Br J Dermatol 157:922-5. 2007..Childhood atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. The pathophysiology of pruritus is complex and various neuropeptides may be involved... - Which aeroallergens are associated with eczema severity?K L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Clin Exp Dermatol 32:401-4. 2007..It is sensible to advise parents on specific avoidance strategies only in severely affected children who have a definitive history of eczema exacerbation by specific aeroallergens and who are not responsive to conventional treatment... - Declining asthma prevalence in Hong Kong Chinese schoolchildrenG W K Wong
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
Clin Exp Allergy 34:1550-5. 2004..CONCLUSION: Using the same standardized and validated ISAAC questionnaire, the prevalence rates of asthma symptoms in Hong Kong Chinese schoolchildren have decreased since 1994. The exact reasons for such trend remain to be explored... - A longitudinal study of cardiac function in children with cancer over 40 monthsC K Li
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, China
Pediatr Hematol Oncol 17:77-83. 2000..Mildly abnormal cardiac indices detected in children after cessation of treatment with anthracycline did not deteriorate in 3 to 4 years follow-up. A longer cardiac follow-up study is indicated to assess the late outcome... - Quality-of-life assessment in Chinese families with food-allergic childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Clin Exp Allergy 39:890-6. 2009..Such data are limited in Asian children. Based on our recent questionnaire-based survey, 8.1% of young children recruited from local nurseries and kindergartens had parent-reported adverse food reactions (AFRs)... - Severe acute respiratory syndrome: 'SARS' or 'not SARS'A M Li
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
J Paediatr Child Health 40:63-5. 2004..We report five cases to illustrate the difficulties and dilemmas faced by clinicians in diagnosing SARS in children... - Association between candidate genes and lung function growth in Chinese asthmatic childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Clin Exp Allergy 37:1480-6. 2007..However, there has not been any study that has addressed the genetic influences for longitudinal lung function growth... - ISAAC and risk factors for asthma in the Asia-PacificG W K Wong
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China
Paediatr Respir Rev 5:S163-9. 2004 - Allogeneic peripheral blood stem cell transplant in childrenC K Li
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Med Pediatr Oncol 30:147-51. 1998..Allogeneic PBSC transplant appears safe in pediatric patients and donors, and it seems not to be associated with increase of acute GVHD or chronic GVHD... - Are exhaled breath condensates useful in monitoring asthma?Fanny W S Ko
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
Curr Allergy Asthma Rep 7:65-71. 2007..More studies are needed before this technique can be recommended for clinical use... - Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled studyK L E Hon
Department of Paediatrics, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Br J Dermatol 157:357-63. 2007..A twice-daily concoction of an ancestral formula containing five herbs has been found to be beneficial in an open study... 
Decreased T-bet expression and changes in chemokine levels in adults with asthmaF W S Ko
Department of Medicine and Therapeutics, The Chinese University of Hong Kong
Clin Exp Immunol 147:526-32. 2007..This is in keeping with asthma being a predominantly Th2 disease and T-bet probably plays a role in the pathogenesis of asthma. Further studies are needed to explore the potential application of peripheral blood monitoring of T-bet...- Symptoms of asthma and atopic disorders in preschool children: prevalence and risk factorsG W K Wong
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong
Clin Exp Allergy 37:174-9. 2007..This study was designed to measure the prevalence of, and risk factors for, asthma and atopic disorders in preschool children from Hong Kong... - Identifying uncontrolled asthma in young children: clinical scores or objective variables?T F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
J Asthma 46:130-5. 2009..This study investigated the ability of Chinese version of Childhood Asthma Control Test (C-ACT) and other disease-related factors in identifying uncontrolled asthma (UA) in young children... - Infection control for SARS in a tertiary neonatal centreP C Ng
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
Arch Dis Child Fetal Neonatal Ed 88:F405-9. 2003..We hope this information is useful in helping other units to formulate their own infection control plans according to their own unit configuration and clinical needs... - Sex differences in the growth of diabetic childrenG W Wong
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, Hong Kong
Diabetes Res Clin Pract 50:187-93. 2000..Diabetic boys were tall for age at presentation but they achieved average final heights while diabetic girls attained below average adult stature and they tended to become obese... - Intraventricular amphotericin for absidiomycosis in an immunocompetent childL L Y Tsung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 16:137-40. 2010..The patient responded to surgical drainage with concomitant intravenous and intraventricular amphotericin B... - Montelukast in the treatment of children with moderate-to-severe atopic dermatitis: a pilot studyA Y Pei
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
Pediatr Allergy Immunol 12:154-8. 2001..05). Our findings suggest that leukotriene receptor antagonist as an adjunct treatment has an anti-inflammatory effect on moderate-to-severe AD. A larger trial is needed to ascertain its efficacy fully... - Estimating emollient usage in patients with eczemaK L E Hon
Department of Paediatrics and School of Pharmacy, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Clin Exp Dermatol 35:22-6. 2010..Atopic eczema (AE) is characterized by reduced skin hydration (SH) and impaired integrity of the skin. Proper emollient usage is an important facet of AE management and patients are encouraged to use emollients liberally... - Haematopoietic stem cell transplantation for thalassaemia major in Hong Kong: prognostic factors and outcomeC K Li
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Bone Marrow Transplant 29:101-5. 2002..Patients aged more than 11 years were more inclined to develop VOD. In conclusion, haematopoietic stem cell transplantation should be performed early if an HLA identical sibling is available... - Filaggrin null mutations in childhood atopic dermatitis among the ChineseG K Ching
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Int J Immunogenet 36:251-4. 2009..Heterozygous carriage of R501X was only found in four male patients, and associated with long-term disease severity. FLG mutations prevalent in Caucasian and other Asian populations are rarely found in our series... - Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptomsMartin C W Chan
Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
J Clin Virol 45:208-11. 2009..In seasonal influenza, gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain are sometimes observed, especially among young children. However, fecal excretion of seasonal influenza virus has seldom been studied... - Haematopoietic stem cell transplantation for thalassaemia in Chinese patientsC K Li
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Hong Kong Med J 15:39-41. 2009..The survivors require iron depletion to remove excessive iron store and some may require hormonal replacement therapy. Most of the patients have good quality of life after successful HSCT... - Chemokine response in children with SARSP C Ng
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories
Arch Dis Child 90:422-3. 2005..High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients... - Exhaled nitric oxide levels are not correlated with eczema severity in Chinese children with atopic dermatitisK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Shatin, SAR, China
J Asthma 43:417-9. 2006..ENO appears to be a noninvasive marker whose level is independent of the two atopic diseases of AD and AR in children old enough to perform exhalation maneuver... - In vitro and clinical immunomodulatory effects of a novel Pentaherbs concoction for atopic dermatitisT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Br J Dermatol 158:1216-23. 2008..Our group recently reported a randomized and placebo-controlled clinical trial on the efficacy of a twice-daily concoction of five herbal ingredients (Pentaherbs formulation, PHF) in treating children with atopic dermatitis (AD)... - A survey of attitudes to Traditional Chinese Medicine in Hong Kong pharmacy studentsE K L Hon
Department of Paediatrics, 6 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Complement Ther Med 12:51-6. 2004..To study the attitudes and personal experiences with Traditional Chinese Medicine (TCM) use in pharmacy students... - Asthma and atopy are associated with DEFB1 polymorphisms in Chinese childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Genes Immun 7:59-64. 2006..The GCA haplotype of DEFB1 was significantly associated with asthma (odds ratio (95% confidence interval): 1.64 (1.05-2.57); P = 0.029). These results suggest that DEFB1 is a candidate gene for asthma and atopy in children... - Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitisK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
Ann Acad Med Singapore 34:602-5. 2005..Staphylococcus aureus colonisation/infection is common in children with atopic dermatitis (AD)... - Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese childrenT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Clin Exp Allergy 35:1288-94. 2005..We investigated the association between asthma traits and genetic polymorphisms in neuronal NO synthase (NOS1) and endothelial NO synthase (NOS3) in Chinese children... - Dietary restriction and supplementation in children with atopic eczemaK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Clin Exp Dermatol 31:187-91. 2006..Management is suboptimal if children with food allergy and severe disease continue to consume the culprit food. Conversely, avoidance of common foods in children without food allergy could result in food faddism or malnutrition... - Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitisK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Br J Dermatol 154:629-35. 2006..Atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. Scratching due to pruritus is an important mechanism in the exacerbation of AD but is difficult to document in the home environment... - Elevation of plasma soluble T cell costimulatory molecules CTLA-4, CD28 and CD80 in children with allergic asthmaW K Ip
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
Int Arch Allergy Immunol 137:45-52. 2005..The increased expression of these soluble proteins may reflect the dysregulation of T cell activation, contributing to the immunopathogenesis of allergic asthma... - Snakebite in a child: could we avoid the anaphylaxis or the fasciotomies?K L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
Ann Acad Med Singapore 34:454-6. 2005..We report the unusual presentation and complications of a case of snakebite, involving a child and his mother, who were bitten by the same snake... - Clinical and atopic parameters and airway inflammatory markers in childhood asthma: a factor analysisT F Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
Thorax 60:822-6. 2005..A study was undertaken to determine, using factor analysis, whether the above features represent separate dimensions of childhood asthma... - High levels and gender difference of exhaled nitric oxide in Chinese schoolchildrenG W K Wong
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
Clin Exp Allergy 35:889-93. 2005..CONCLUSIONS: This study demonstrates a gender difference of eNO level in healthy Chinese schoolchildren. When compared with Caucasians, Chinese children have significantly higher eNO levels... - Brief case series: montelukast, at doses recommended for asthma treatment, reduces disease severity and increases soluble CD14 in children with atopic dermatitisK L E Hon
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
J Dermatolog Treat 16:15-8. 2005..The choice of oral therapeutic agents for the treatment of atopic dermatitis (AD) in children is limited. Montelukast, a specific cysteinyl leukotriene (LT) receptor antagonist, may be useful in alleviating AD symptoms... - A survey of bathing and showering practices in children with atopic eczemaK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
Clin Exp Dermatol 30:351-4. 2005..23% of review cases). It is important to determine whether this problem is due to inadequate patient education or whether other factors lead to poor compliance... - Snakebites in children in the densely populated city of Hong Kong: a 10-year surveyK L Hon
Department of Paediatrics, The Chinese University of Hong Kong, 6 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
Acta Paediatr 93:270-2. 2004..To review the pattern and characteristics of snakebites in children in rural Hong Kong... - Resting energy expenditure, oxygen consumption and carbon dioxide production during sleep in children with atopic dermatitisK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
J Dermatolog Treat 16:22-5. 2005..We evaluated whether resting energy expenditure (REE), oxygen consumption (VO2) and carbon dioxide production (VCO2) in various stages of sleep were influenced by the disease severity... - Exhaled breath condensate levels of eotaxin and macrophage-derived chemokine in stable adult asthma patientsF W S Ko
Departments of Medicine and Therapeutics, Paediatrics and Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China
Clin Exp Allergy 36:44-51. 2006..Asthma is associated with esoinophilic airway inflammation and overproduction of T-helper type 2 (Th2) lymphocyte-related cytokines... - Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong childrenRainbow K Y Mak
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Pediatr Infect Dis J 30:749-53. 2011..This study elucidated disease spectrum of HRV infections among Hong Kong children hospitalized with respiratory illnesses... - The EuroPrevall-INCO surveys on the prevalence of food allergies in children from China, India and Russia: the study methodologyG W K Wong
Department of Paediatrics and School of Public Health, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Allergy 65:385-90. 2010..The epidemiological surveys of the project were designed to estimate variations in the prevalence of food allergy and exposure to known or suspected risk factors for food allergy and to compare the data with different European countries... - Plasma concentrations of soluble CTLA-4, CD28, CD80 and CD86 costimulatory molecules reflect disease severity of acute asthma in childrenW K Ip
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Pediatr Pulmonol 41:674-82. 2006.... - Does age or gender influence quality of life in children with atopic dermatitis?K L E Hon
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, PR China
Clin Exp Dermatol 33:705-9. 2008..Quality of life (QoL) is impaired in children with atopic dermatitis (AD) but the various aspects of QoL may not be equally affected. Aim. To evaluate if age and gender affect some aspects of QoL in children with AD... - CDLQI, SCORAD and NESS: are they correlated?K L E Hon
Department of Paediatrics, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Qual Life Res 15:1551-8. 2006.... - Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in childrenK L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Clin Exp Dermatol 29:293-6. 2004..618, P < 0.001, and r = 0.587, P = 0.001, respectively). Serum CTACK concentration appears to be a skin-specific objective marker that correlates with various clinical and laboratory parameters of AD... - Influenza or not influenza: analysis of a case of high fever that happened 2000 years ago in Biblical timeKam L E Hon
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Virol J 7:169. 2010..Infectious diseases continue to be a threat to humanity, and influenza has been with us since the dawn of human history. We analysed a case of high fever that happened 2000 years ago in Biblical time and discussed possible etiologies... - Bird flu: lessons from SARSGary W K Wong
Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China
Paediatr Respir Rev 8:171-6. 2007..The availability of isolation facilities, the stockpiling of antiviral agents and effective and safe vaccination will be extremely important in minimising the damage of a new influenza pandemic... - Chinese nursing students' attitudes toward traditional Chinese medicineKam Lun Ellis Hon
Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, China
J Nurs Educ 45:182-5. 2006.... - Outdoor air pollution and asthmaGary W Wong
Department of Pediatrics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
Pediatr Pulmonol Suppl 26:220-2. 2004 - Genetic association study between mbl2 and asthma phenotypes in Chinese childrenTing Fan Leung
Department of Paediatrics, The Chinese Univesity of Hong Kong, Prince of Wales Hospital, Hong Kong
Pediatr Allergy Immunol 17:501-7. 2006..047). The latter three associations became insignificant when adjusted for multiple comparisons. Despite the importance of MBL in innate immunity, our mbl2 polymorphisms only show weak association with asthma and atopy in children... - The Asian side of asthma and allergyTing Fan Leung
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China
Curr Opin Allergy Clin Immunol 8:384-90. 2008..This review summarizes important lessons learnt from research findings from Asia on asthma and allergy... - A survey of traditional Chinese medicine use in children with atopic dermatitis attending a paediatric dermatology clinicKam Lun Ellis Hon
Department of Pediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
J Dermatolog Treat 16:154-7. 2005..TCM use was not associated with parental ages or 'grandparent as caregiver' but 'severe AD' was an independent factor for TCM use (OR 3.24, 95% CI 1.67-6.31; p = 0.0003)... - Serum concentration of IL-18 correlates with disease extent in young children with atopic dermatitisKam Lun Ellis Hon
Department of Pediatrics, 6 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Pediatr Dermatol 21:619-22. 2004..It may be a useful inflammatory marker that correlates with the extent component of AD in particular, and differentiates mild disease from more severe disease when used for assessing AD severity in young children... - Validation of a self-administered questionnaire in Chinese in the assessment of eczema severityKam Lun Hon
Department of Pediatrics, Chinese University of Hong Kong, Shatin, Hong Kong
Pediatr Dermatol 20:465-9. 2003..The self-administered questionnaire appears to be useful in assessing AD severity in Chinese children... - Skin diseases in Chinese children at a pediatric dermatology centerKam Lun Hon
Department of Pediatrics, Chinese University of Hong Kong, 6 F Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, ROC
Pediatr Dermatol 21:109-12. 2004..Since chronic skin disorders prevailed in the referrals, repeated follow-up appointments were required... - Ribavirin for SARS in childrenWai Tsoi Frankie Cheng
Department of Pediatrics, 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
Clin Pediatr (Phila) 43:193-6. 2004 - Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unitKam Lun Hon
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Pediatr Pulmonol 43:275-80. 2008..The purpose of this study was to report the clinical features and outcome of all children with a laboratory proven diagnosis of respiratory virus infection admitted to a university Pediatric Intensive Care Unit (PICU)... - Immunological reconstitution in long-term survivors of thalassemia major patients after hematopoietic stem cell transplantationChi Kong Li
Haematologica 88:1194-6. 2003..Five and seven patients had suboptimal antibody response at 4 week after pneumococcal and hepatitis B vaccine, respectively, but this response returned to normal by 6 months...