Ting F Leung

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensate
    Ting F Leung
    Department of Pediatrics, Chinese University of Hong Kong, Hong Kong SAR, China
    Pediatr Pulmonol 41:87-94. 2006
  2. ncbi request reprint Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Pediatr Allergy Immunol 14:296-301. 2003
  3. ncbi request reprint Helper T-lymphocyte-related chemokines in healthy newborns
    Ting Fan Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6 F, Clinical Sciences Building, Shatin, Hong Kong
    Pediatr Res 55:334-8. 2004
  4. ncbi request reprint Infection control for SARS in a tertiary paediatric centre in Hong Kong
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Hosp Infect 56:215-22. 2004
  5. ncbi request reprint CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergy
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Curr Drug Targets Inflamm Allergy 4:169-75. 2005
  6. ncbi request reprint Immunogenicity of a two-dose regime of varicella vaccine in children with cancers
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Eur J Haematol 72:353-7. 2004
  7. ncbi request reprint Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma
    T F Leung
    Departments of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Exp Allergy 34:786-91. 2004
  8. ncbi request reprint The relation between obesity and asthmatic airway inflammation
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Allergy Immunol 15:344-50. 2004
  9. ncbi request reprint A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    Pediatr Allergy Immunol 15:558-61. 2004
  10. ncbi request reprint RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Respir Med 99:216-9. 2005

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensate
    Ting F Leung
    Department of Pediatrics, Chinese University of Hong Kong, Hong Kong SAR, China
    Pediatr Pulmonol 41:87-94. 2006
    ..In conclusion, our results suggest that pH in non-deaerated EBC is influenced by asthma severity in children. EBC pH measurement is reproducible, but is dependent on the collection devices used...
  2. ncbi request reprint Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Pediatr Allergy Immunol 14:296-301. 2003
    ..The other chemokines did not correlate with AD severity. In conclusion, our results suggest that serum MDC concentration may be a useful inflammatory marker for assessing AD severity in infants and young children...
  3. ncbi request reprint Helper T-lymphocyte-related chemokines in healthy newborns
    Ting Fan Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6 F, Clinical Sciences Building, Shatin, Hong Kong
    Pediatr Res 55:334-8. 2004
    ..010). This study provides reference ranges of Th-specific chemokines in UCB serum of singleton term neonates. Increased serum MDC concentrations at birth are associated with the occurrence of wheezing during infancy...
  4. ncbi request reprint Infection control for SARS in a tertiary paediatric centre in Hong Kong
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Hosp Infect 56:215-22. 2004
    ..In conclusion, stringent infection control precautions, appropriate triage and prompt isolation of potential SARS patients may have contributed to a lack of nosocomial spread and HCW acquisition of SARS in our unit...
  5. ncbi request reprint CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergy
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Curr Drug Targets Inflamm Allergy 4:169-75. 2005
    ..Lastly, the prospect of using immunomodulatory agents targeting on the innate immunity to treat or even prevent asthma and other allergic diseases will be discussed...
  6. ncbi request reprint Immunogenicity of a two-dose regime of varicella vaccine in children with cancers
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Eur J Haematol 72:353-7. 2004
    ..Live-attenuated varicella vaccine is effective and safe in immunocompetent children. In this study, we assess the immunogenicity and adverse events following varicella vaccination in immunosuppressed cancer children...
  7. ncbi request reprint Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma
    T F Leung
    Departments of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Exp Allergy 34:786-91. 2004
    ..Type 2 helper T lymphocyte-specific chemokines including macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) and eotaxin are important mediators for allergic airway inflammation...
  8. ncbi request reprint The relation between obesity and asthmatic airway inflammation
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Allergy Immunol 15:344-50. 2004
    ..In conclusion, ENO and LTB(4) concentration in EBC are increased in childhood asthma. However, these inflammatory markers did not differ between obese and non-obese children with asthma...
  9. ncbi request reprint A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    Pediatr Allergy Immunol 15:558-61. 2004
    ..05). Our results do not support the use of AA-based elemental milk formula in treating young children with AD irrespective of their food allergy status...
  10. ncbi request reprint RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Respir Med 99:216-9. 2005
    ..044). RANTES C-28G was not associated with any outcome in this study. In conclusion, the gain-of-function mutation at -401 of RANTES promoter is associated with sensitization to cat and mold allergens and FEV1 in Chinese children...
  11. ncbi request reprint Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int Arch Allergy Immunol 137:66-72. 2005
    ..This study investigates the relation between childhood asthma and levels of these mediators in exhaled breath condensate (EBC)...
  12. ncbi request reprint Bone mineral density in children with thalassaemia major: determining factors and effects of bone marrow transplantation
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Bone Marrow Transplant 36:331-6. 2005
    ..d.) osteocalcin levels in BMT and BT groups were 96.4 (72.7) microg and 68.9 (40.3) microg/l, respectively (P=0.037). In conclusion, severe BMD deficit is common in Chinese TM patients and BMT may reverse BMD deficit in these patients...
  13. ncbi request reprint The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Pediatr Allergy Immunol 14:255-60. 2003
    ..039). This polymorphic marker was not associated with asthma or aeroallergen sensitization in our cohort. Our results suggest that the C-159T of CD14 was associated with serum total IgE concentration in atopic Chinese children...
  14. ncbi request reprint Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children
    T F Leung
    Dept of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Eur Respir J 21:616-20. 2003
    ....
  15. ncbi request reprint A Chinese girl with Leigh syndrome: effect of botulinum toxin on dystonia
    T F Leung
    Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    J Paediatr Child Health 34:480-2. 1998
    ..Dystonia persisted despite treatments with muscle relaxants and a ketogenic diet. Intramuscular botulinum toxin resulted in significant relief of dystonia...
  16. ncbi request reprint Pneumocystis carinii pneumonia in an immunocompetent infant with congenital cytomegalovirus infection
    T F Leung
    Dept of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin
    Infection 28:184-6. 2000
    ..This case highlights the fact that PCP can occur in apparently immunocompetent term infants. Malnourished infants with zinc deficiency or congenital CMV infection are at increased risk of developing PCP...
  17. ncbi request reprint Severe chronic neutropenia in Chinese children in Hong Kong
    T F Leung
    Department of Paediatrics, Prince of Wales Hospital, Hong Kong SAR, China
    J Paediatr Child Health 37:137-41. 2001
    ..Severe chronic neutropenia (SCN) is a rare and heterogeneous disorder in children. The epidemiology, clinical features and outcomes of SCN in Chinese children were reviewed...
  18. ncbi request reprint A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Exp Allergy 31:1515-21. 2001
    ..Previous studies showed that polymorphisms in the IL-13 gene were associated with serum total IgE or allergic asthma. The relationship of this marker with sensitization to individual aeroallergens has not been evaluated...
  19. ncbi request reprint Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR, China
    Pediatr Allergy Immunol 13:10-7. 2002
    ..This marker is also associated with the extent of allergic sensitization to cat, as well as with reduced FEV1 and FVC values...
  20. ncbi request reprint Inhalant allergens as risk factors for the development and severity of mild-to-moderate asthma in Hong Kong Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
    J Asthma 39:323-30. 2002
    ..In conclusion, indoor aeroallergens are one of the risk factors for the development and severity of mild-to-moderate asthma in Chinese children in Hong Kong...
  21. ncbi request reprint Sociodemographic and atopic factors affecting breastfeeding intention in Chinese mothers
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    J Paediatr Child Health 39:460-4. 2003
    ..The objective of this survey was to study the intention and planned duration of breastfeeding in Chinese women in Hong Kong, and to investigate the sociodemographic and atopic factors affecting the intention to breastfeed...
  22. ncbi request reprint Sensitization to common food allergens is a risk factor for asthma in young Chinese children in Hong Kong
    Ting Fan Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR
    J Asthma 39:523-9. 2002
    ..In conclusion, a significant association was found between asthma and the presence of food-specific IgE antibodies in young Chinese children. Significant sensitization to common foods is rare in this cohort...
  23. doi request reprint Association of plasma soluble CTLA-4 with lung function and gene polymorphism in Chinese asthmatic children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
    Int Arch Allergy Immunol 152:113-21. 2010
    ..We investigated the effects of single nucleotide polymorphisms (SNPs) of CTLA-4 on asthma traits and plasma sCTLA-4 in 298 Chinese asthmatic children and 175 controls...
  24. doi request reprint Domestic exposure to aeroallergens in Hong Kong families with asthmatic children
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 46:632-9. 2011
    ..This study identifies determinants for cat, cockroach, and B. tropicalis levels in Hong Kong families with asthmatic children. These exposures are associated with severity of allergy symptoms...
  25. doi request reprint Determinants of, and reference equation for, exhaled nitric oxide in the Chinese population
    Fanny W S Ko
    Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Eur Respir J 42:767-75. 2013
    ..The FeNO of Chinese adults is higher than that of the Caucasian population, and is affected by age, sex, height and atopic status. This study provides useful references for the interpretation of FeNO. ..
  26. ncbi request reprint Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Allergy Clin Immunol 117:127-33. 2006
    ..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into asthma pathophysiology...
  27. doi request reprint Recent advances in asthma biomarker research
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong 6 F, Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Ther Adv Respir Dis 7:297-308. 2013
    ..Longitudinal studies with focused hypotheses and well-designed protocols are needed to establish the roles of these biomarkers in asthma management. The measurement of biomarkers in EBC remains a research tool. ..
  28. doi request reprint Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong
    Pediatr Allergy Immunol 20:142-50. 2009
    ..This is the first report to show significant association of Egr-1 polymorphisms with plasma total IgE and atopy in asthmatics. It may help to explore the pharmacogenetics of Egr-1 inhibitors...
  29. doi request reprint PHF11 is not a major candidate gene for asthma or eczema in Chinese children
    Hing Y Sy
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 45:890-7. 2010
    ..Our findings do not support PHF11 to be a major candidate gene for asthma, eczema and aeroallergen sensitization in Chinese children...
  30. doi request reprint Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children
    I H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Allergy 63:1031-9. 2008
    ..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into the pathophysiology of asthma...
  31. ncbi request reprint IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants
    Pak C Ng
    Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    Pediatr Res 61:93-8. 2007
    ..We conclude that preterm infants have the ability to induce a robust chemokine and cytokine response during sepsis, and IP-10 is a sensitive early marker of infection...
  32. ncbi request reprint Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentration
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Pediatr Pulmonol 41:649-55. 2006
    ..949), atopy (P = 0.305), IgE sensitization to aeroallergens (P > 0.2 for all), or FeNO (P = 0.847). These findings do not support NOS2 to be a major candidate gene for asthma or IgE-mediated allergic diseases in Chinese children...
  33. doi request reprint Predicting changes in clinical status of young asthmatics: clinical scores or objective parameters?
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 44:442-9. 2009
    ..203, P = 0.042). In conclusion, C-ACT is better than DSS and objective parameters in reflecting changes in asthma status and predicting asthma exacerbations in young children...
  34. ncbi request reprint Wheezing in Chinese schoolchildren: disease severity distribution and management practices, a community-based study in Hong Kong and Guangzhou
    F W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR
    Clin Exp Allergy 35:1449-56. 2005
    ..Asthma is a common chronic disease and information on its management practices at the community level is helpful in identifying problems and improving asthma care...
  35. ncbi request reprint Differences in asthma genetics between Chinese and other populations
    Ting F Leung
    Department of Pediatrics, Chinese University of Hong Kong, Hong Kong, China
    J Allergy Clin Immunol 133:42-8. 2014
    ..These sequence variations must be considered during the selection of tagging SNPs for replicating genetic associations between populations. ..
  36. ncbi request reprint Airway inflammatory and spirometric measurements in obese children
    Joyce S W Chow
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 15:346-52. 2009
    ..To investigate the association between obesity and airway inflammation and spirometric parameters in local children...
  37. ncbi request reprint Distribution in allele frequencies of predisposition-to-atopy genotypes in Chinese children
    T F Leung
    Department of Paediatrics, Chinese University of Hong Kong, Hong Kong, China
    Pediatr Pulmonol 34:419-24. 2002
    ..Additional studies involving larger samples are required to investigate the association between asthma or atopy and the genotypes studied to date in Chinese children...
  38. ncbi request reprint Relationship between passive smoking exposure and urinary heavy metals and lung functions in preschool children
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong Kong
    Pediatr Pulmonol 48:1089-97. 2013
    ..Urinary cotinine is more reliable than questionnaire for assessing ETS exposure in young children. Although high urinary Cd is common in Hong Kong preschoolers, such biomarker is not associated with any clinical or spirometric outcome...
  39. ncbi request reprint Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infants
    Pak C Ng
    Department of Pediatrics, Center of Epidemiology and Biostatistics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
    Clin Chem 52:1181-9. 2006
    ..We investigated the immunologic profiles of preterm infants with sepsis, using chemokine and cytokine measurements to predict the development of sepsis-induced DIC at the onset of infection...
  40. ncbi request reprint Rapid control of norovirus gastroenteritis outbreak in an acute paediatric ward
    Frankie W T Cheng
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Paediatr 95:581-6. 2006
    ..To provide a practical action plan for effective infection control of norovirus outbreak in acute paediatric wards...
  41. ncbi request reprint Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Respir Med 100:630-8. 2006
    ..8-isoprostane level, but not GROalpha and MCP-1, in EBC was increased in COPD patients with poorer lung function. This suggests an increased oxidative stress in the airway in patients with more severe COPD...
  42. ncbi request reprint Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children
    I H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Allergy 62:802-9. 2007
    ..Cyclooxygenase-2 (COX-2) plays essential roles in inflammation. Previous studies have suggested associations between prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and prostaglandins production in asthma...
  43. ncbi request reprint Reference standards for forced expiratory indices in Chinese preschool children
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 48:1119-26. 2013
    ..Their forced expiratory indices are determined by gender, age, weight and standing height, and standing height is the best anthropometric index to predict all spirometric indices...
  44. ncbi request reprint Inflammatory cytokine profile in children with severe acute respiratory syndrome
    Pak C Ng
    Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Pediatrics 113:e7-14. 2004
    ....
  45. doi request reprint Asthma and atopy are associated with chromosome 17q21 markers in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Allergy 64:621-8. 2009
    ..This study delineated the allele and genotype frequencies of 10 SNPs at chromosome 17q21, and investigated the relationship between these SNPs and asthma and plasma IgE in southern Chinese children...
  46. doi request reprint Cadmium and lead in Hong Kong school children
    Iris H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Pathology 44:626-31. 2012
    ..Cadmium (Cd) and lead (Pb) are toxic elements in our environment. This study is to determine the reference intervals of Cd and Pb in blood and urine from Hong Kong school children and to identify their determinants...
  47. ncbi request reprint Which aeroallergens are associated with eczema severity?
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Clin Exp Dermatol 32:401-4. 2007
    ..It is sensible to advise parents on specific avoidance strategies only in severely affected children who have a definitive history of eczema exacerbation by specific aeroallergens and who are not responsive to conventional treatment...
  48. ncbi request reprint Declining asthma prevalence in Hong Kong Chinese schoolchildren
    G W K Wong
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
    Clin Exp Allergy 34:1550-5. 2004
    ..Many studies have reported an increase in the prevalence of asthma and related atopic disorders. The lack of standardized methodologies and 'objective' measurements make reliable comparison and monitoring of trends of asthma very difficult...
  49. ncbi request reprint Pathophysiology of nocturnal scratching in childhood atopic dermatitis: the role of brain-derived neurotrophic factor and substance P
    K L E Hon
    Department of Pediatrics, The Chinese University of Hong Kong, 6 F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong
    Br J Dermatol 157:922-5. 2007
    ..Childhood atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. The pathophysiology of pruritus is complex and various neuropeptides may be involved...
  50. ncbi request reprint Clinical and virologic factors associated with reduced sensitivity of rapid influenza diagnostic tests in hospitalized elderly patients and young children
    Martin C W Chan
    Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Microbiol 52:497-501. 2014
    ..A negative RIDT result should be interpreted with caution. ..
  51. doi request reprint Clinical and virologic factors associated with reduced sensitivity of rapid influenza diagnostic tests in hospitalized elderly patients and young children
    Martin C W Chan
    Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Microbiol 52:497-501. 2014
    ..A negative RIDT result should be interpreted with caution. ..
  52. doi request reprint Influenza B lineage circulation and hospitalization rates in a subtropical city, Hong Kong, 2000-2010
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, 1 F Clinical Sciences Bldg, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SpecialAdministrative Region, People s Republic of China
    Clin Infect Dis 56:677-84. 2013
    ..This retrospective study revealed the situation in a subtropical city over a 10-year period...
  53. pmc Decreased T-bet expression and changes in chemokine levels in adults with asthma
    F W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Clin Exp Immunol 147:526-32. 2007
    ..This is in keeping with asthma being a predominantly Th2 disease and T-bet probably plays a role in the pathogenesis of asthma. Further studies are needed to explore the potential application of peripheral blood monitoring of T-bet...
  54. ncbi request reprint Symptoms of asthma and atopic disorders in preschool children: prevalence and risk factors
    G W K Wong
    Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Clin Exp Allergy 37:174-9. 2007
    ..This study was designed to measure the prevalence of, and risk factors for, asthma and atopic disorders in preschool children from Hong Kong...
  55. ncbi request reprint Intraventricular amphotericin for absidiomycosis in an immunocompetent child
    L L Y Tsung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 16:137-40. 2010
    ..The patient responded to surgical drainage with concomitant intravenous and intraventricular amphotericin B...
  56. ncbi request reprint Identifying uncontrolled asthma in young children: clinical scores or objective variables?
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Asthma 46:130-5. 2009
    ..This study investigated the ability of Chinese version of Childhood Asthma Control Test (C-ACT) and other disease-related factors in identifying uncontrolled asthma (UA) in young children...
  57. doi request reprint Filaggrin null mutations in childhood atopic dermatitis among the Chinese
    G K Ching
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int J Immunogenet 36:251-4. 2009
    ..Heterozygous carriage of R501X was only found in four male patients, and associated with long-term disease severity. FLG mutations prevalent in Caucasian and other Asian populations are rarely found in our series...
  58. ncbi request reprint Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study
    K L E Hon
    Department of Paediatrics, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Br J Dermatol 157:357-63. 2007
    ..A twice-daily concoction of an ancestral formula containing five herbs has been found to be beneficial in an open study...
  59. ncbi request reprint Are exhaled breath condensates useful in monitoring asthma?
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Curr Allergy Asthma Rep 7:65-71. 2007
    ..More studies are needed before this technique can be recommended for clinical use...
  60. ncbi request reprint Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptoms
    Martin C W Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Clin Virol 45:208-11. 2009
    ..In seasonal influenza, gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain are sometimes observed, especially among young children. However, fecal excretion of seasonal influenza virus has seldom been studied...
  61. ncbi request reprint Association between candidate genes and lung function growth in Chinese asthmatic children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Exp Allergy 37:1480-6. 2007
    ..However, there has not been any study that has addressed the genetic influences for longitudinal lung function growth...
  62. ncbi request reprint Haematopoietic stem cell transplantation for thalassaemia in Chinese patients
    C K Li
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Hong Kong Med J 15:39-41. 2009
    ..The survivors require iron depletion to remove excessive iron store and some may require hormonal replacement therapy. Most of the patients have good quality of life after successful HSCT...
  63. doi request reprint In vitro and clinical immunomodulatory effects of a novel Pentaherbs concoction for atopic dermatitis
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Br J Dermatol 158:1216-23. 2008
    ..Our group recently reported a randomized and placebo-controlled clinical trial on the efficacy of a twice-daily concoction of five herbal ingredients (Pentaherbs formulation, PHF) in treating children with atopic dermatitis (AD)...
  64. doi request reprint Quality-of-life assessment in Chinese families with food-allergic children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Exp Allergy 39:890-6. 2009
    ..Such data are limited in Asian children. Based on our recent questionnaire-based survey, 8.1% of young children recruited from local nurseries and kindergartens had parent-reported adverse food reactions (AFRs)...
  65. doi request reprint Estimating emollient usage in patients with eczema
    K L E Hon
    Department of Paediatrics and School of Pharmacy, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Clin Exp Dermatol 35:22-6. 2010
    ..Atopic eczema (AE) is characterized by reduced skin hydration (SH) and impaired integrity of the skin. Proper emollient usage is an important facet of AE management and patients are encouraged to use emollients liberally...
  66. ncbi request reprint Brief case series: montelukast, at doses recommended for asthma treatment, reduces disease severity and increases soluble CD14 in children with atopic dermatitis
    K L E Hon
    Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
    J Dermatolog Treat 16:15-8. 2005
    ..The choice of oral therapeutic agents for the treatment of atopic dermatitis (AD) in children is limited. Montelukast, a specific cysteinyl leukotriene (LT) receptor antagonist, may be useful in alleviating AD symptoms...
  67. ncbi request reprint Exhaled nitric oxide levels are not correlated with eczema severity in Chinese children with atopic dermatitis
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Shatin, SAR, China
    J Asthma 43:417-9. 2006
    ..ENO appears to be a noninvasive marker whose level is independent of the two atopic diseases of AD and AR in children old enough to perform exhalation maneuver...
  68. ncbi request reprint A longitudinal study of cardiac function in children with cancer over 40 months
    C K Li
    Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, China
    Pediatr Hematol Oncol 17:77-83. 2000
    ..Mildly abnormal cardiac indices detected in children after cessation of treatment with anthracycline did not deteriorate in 3 to 4 years follow-up. A longer cardiac follow-up study is indicated to assess the late outcome...
  69. ncbi request reprint High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren
    G W K Wong
    Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Clin Exp Allergy 35:889-93. 2005
    ..Exhaled nitric oxide (eNO) may represent a useful noninvasive marker of airway inflammation, but data on the reference population values in schoolchildren are limited. No reference eNO study in Asian children has been published...
  70. ncbi request reprint A survey of bathing and showering practices in children with atopic eczema
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Clin Exp Dermatol 30:351-4. 2005
    ..23% of review cases). It is important to determine whether this problem is due to inadequate patient education or whether other factors lead to poor compliance...
  71. ncbi request reprint Resting energy expenditure, oxygen consumption and carbon dioxide production during sleep in children with atopic dermatitis
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, China
    J Dermatolog Treat 16:22-5. 2005
    ..We evaluated whether resting energy expenditure (REE), oxygen consumption (VO2) and carbon dioxide production (VCO2) in various stages of sleep were influenced by the disease severity...
  72. ncbi request reprint Elevation of plasma soluble T cell costimulatory molecules CTLA-4, CD28 and CD80 in children with allergic asthma
    W K Ip
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Int Arch Allergy Immunol 137:45-52. 2005
    ..However, the role of their soluble forms in plasma has not yet been elucidated. In this study, we investigated whether expression is altered and whether soluble costimulatory molecules are clinically relevant in asthmatic patients...
  73. pmc Chemokine response in children with SARS
    P C Ng
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories
    Arch Dis Child 90:422-3. 2005
    ..High circulating IP-10 levels could facilitate viral clearance and might play a role in assisting the recovery of the patients...
  74. ncbi request reprint A survey of attitudes to Traditional Chinese Medicine in Hong Kong pharmacy students
    E K L Hon
    Department of Paediatrics, 6 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Complement Ther Med 12:51-6. 2004
    ..To study the attitudes and personal experiences with Traditional Chinese Medicine (TCM) use in pharmacy students...
  75. ncbi request reprint Snakebites in children in the densely populated city of Hong Kong: a 10-year survey
    K L Hon
    Department of Paediatrics, The Chinese University of Hong Kong, 6 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
    Acta Paediatr 93:270-2. 2004
    ..To review the pattern and characteristics of snakebites in children in rural Hong Kong...
  76. ncbi request reprint ISAAC and risk factors for asthma in the Asia-Pacific
    G W K Wong
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Paediatr Respir Rev 5:S163-9. 2004
  77. ncbi request reprint Severe acute respiratory syndrome: 'SARS' or 'not SARS'
    A M Li
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Paediatr Child Health 40:63-5. 2004
    ..We report five cases to illustrate the difficulties and dilemmas faced by clinicians in diagnosing SARS in children...
  78. pmc Infection control for SARS in a tertiary neonatal centre
    P C Ng
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
    Arch Dis Child Fetal Neonatal Ed 88:F405-9. 2003
    ..We hope this information is useful in helping other units to formulate their own infection control plans according to their own unit configuration and clinical needs...
  79. ncbi request reprint Haematopoietic stem cell transplantation for thalassaemia major in Hong Kong: prognostic factors and outcome
    C K Li
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Bone Marrow Transplant 29:101-5. 2002
    ..Patients aged more than 11 years were more inclined to develop VOD. In conclusion, haematopoietic stem cell transplantation should be performed early if an HLA identical sibling is available...
  80. ncbi request reprint Montelukast in the treatment of children with moderate-to-severe atopic dermatitis: a pilot study
    A Y Pei
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    Pediatr Allergy Immunol 12:154-8. 2001
    ..05). Our findings suggest that leukotriene receptor antagonist as an adjunct treatment has an anti-inflammatory effect on moderate-to-severe AD. A larger trial is needed to ascertain its efficacy fully...
  81. ncbi request reprint Sex differences in the growth of diabetic children
    G W Wong
    Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, Hong Kong
    Diabetes Res Clin Pract 50:187-93. 2000
    ..Diabetic boys were tall for age at presentation but they achieved average final heights while diabetic girls attained below average adult stature and they tended to become obese...
  82. pmc Clinical and atopic parameters and airway inflammatory markers in childhood asthma: a factor analysis
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Thorax 60:822-6. 2005
    ..A study was undertaken to determine, using factor analysis, whether the above features represent separate dimensions of childhood asthma...
  83. ncbi request reprint Dietary restriction and supplementation in children with atopic eczema
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Clin Exp Dermatol 31:187-91. 2006
    ..Management is suboptimal if children with food allergy and severe disease continue to consume the culprit food. Conversely, avoidance of common foods in children without food allergy could result in food faddism or malnutrition...
  84. ncbi request reprint Asthma and atopy are associated with DEFB1 polymorphisms in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Genes Immun 7:59-64. 2006
    ..The GCA haplotype of DEFB1 was significantly associated with asthma (odds ratio (95% confidence interval): 1.64 (1.05-2.57); P = 0.029). These results suggest that DEFB1 is a candidate gene for asthma and atopy in children...
  85. ncbi request reprint Snakebite in a child: could we avoid the anaphylaxis or the fasciotomies?
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong
    Ann Acad Med Singapore 34:454-6. 2005
    ..We report the unusual presentation and complications of a case of snakebite, involving a child and his mother, who were bitten by the same snake...
  86. ncbi request reprint Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Exp Allergy 35:1288-94. 2005
    ..We investigated the association between asthma traits and genetic polymorphisms in neuronal NO synthase (NOS1) and endothelial NO synthase (NOS3) in Chinese children...
  87. ncbi request reprint Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Ann Acad Med Singapore 34:602-5. 2005
    ..Staphylococcus aureus colonisation/infection is common in children with atopic dermatitis (AD)...
  88. ncbi request reprint Exhaled breath condensate levels of eotaxin and macrophage-derived chemokine in stable adult asthma patients
    F W S Ko
    Departments of Medicine and Therapeutics, Paediatrics and Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China
    Clin Exp Allergy 36:44-51. 2006
    ..Asthma is associated with esoinophilic airway inflammation and overproduction of T-helper type 2 (Th2) lymphocyte-related cytokines...
  89. ncbi request reprint Allogeneic peripheral blood stem cell transplant in children
    C K Li
    Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Med Pediatr Oncol 30:147-51. 1998
    ..Allogeneic PBSC transplant appears safe in pediatric patients and donors, and it seems not to be associated with increase of acute GVHD or chronic GVHD...
  90. ncbi request reprint Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Br J Dermatol 154:629-35. 2006
    ..Atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. Scratching due to pruritus is an important mechanism in the exacerbation of AD but is difficult to document in the home environment...
  91. doi request reprint Rotavirus activity and meteorological variations in an Asian subtropical city, Hong Kong, 1995-2009
    Martin C W Chan
    Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Med Virol 85:2026-33. 2013
    ..In summary, the current study provides evidence suggesting that local seasonal activity of rotavirus correlated strongly with air temperature, followed by atmospheric pressure but only minimally with relative humidity in pre-vaccine era...
  92. ncbi request reprint Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children
    Rainbow K Y Mak
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Pediatr Infect Dis J 30:749-53. 2011
    ..This study elucidated disease spectrum of HRV infections among Hong Kong children hospitalized with respiratory illnesses...
  93. ncbi request reprint Plasma concentrations of soluble CTLA-4, CD28, CD80 and CD86 costimulatory molecules reflect disease severity of acute asthma in children
    W K Ip
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 41:674-82. 2006
    ....
  94. doi request reprint The EuroPrevall-INCO surveys on the prevalence of food allergies in children from China, India and Russia: the study methodology
    G W K Wong
    Department of Paediatrics and School of Public Health, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Allergy 65:385-90. 2010
    ..The epidemiological surveys of the project were designed to estimate variations in the prevalence of food allergy and exposure to known or suspected risk factors for food allergy and to compare the data with different European countries...
  95. ncbi request reprint Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Clin Exp Dermatol 29:293-6. 2004
    ..618, P < 0.001, and r = 0.587, P = 0.001, respectively). Serum CTACK concentration appears to be a skin-specific objective marker that correlates with various clinical and laboratory parameters of AD...
  96. ncbi request reprint CDLQI, SCORAD and NESS: are they correlated?
    K L E Hon
    Department of Paediatrics, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Qual Life Res 15:1551-8. 2006
    ....
  97. doi request reprint Does age or gender influence quality of life in children with atopic dermatitis?
    K L E Hon
    Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, PR China
    Clin Exp Dermatol 33:705-9. 2008
    ..Quality of life (QoL) is impaired in children with atopic dermatitis (AD) but the various aspects of QoL may not be equally affected. Aim. To evaluate if age and gender affect some aspects of QoL in children with AD...
  98. ncbi request reprint Outdoor air pollution and asthma
    Gary W Wong
    Department of Pediatrics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    Pediatr Pulmonol Suppl 26:220-2. 2004
  99. ncbi request reprint Bird flu: lessons from SARS
    Gary W K Wong
    Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China
    Paediatr Respir Rev 8:171-6. 2007
    ..The availability of isolation facilities, the stockpiling of antiviral agents and effective and safe vaccination will be extremely important in minimising the damage of a new influenza pandemic...
  100. ncbi request reprint Chinese nursing students' attitudes toward traditional Chinese medicine
    Kam Lun Ellis Hon
    Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, China
    J Nurs Educ 45:182-5. 2006
    ....
  101. pmc Influenza or not influenza: analysis of a case of high fever that happened 2000 years ago in Biblical time
    Kam L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Virol J 7:169. 2010
    ..Infectious diseases continue to be a threat to humanity, and influenza has been with us since the dawn of human history. We analysed a case of high fever that happened 2000 years ago in Biblical time and discussed possible etiologies...