Po Sing Leung

Summary

Affiliation: The Chinese University of Hong Kong
Location: Hong Kong, China
URL: http://www.sbs.cuhk.edu.hk/TeachingStaffDetails.asp?TE_NAME=LEUNG%20Po%20Sing

Publications

  1. Leung P. The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus. Nutrients. 2016;8:147 pubmed publisher
    ....
  2. request reprint
    Cheng S, So W, Zhang D, Cheng Q, Boucher B, Leung P. Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus. Curr Mol Med. 2016;16:747-758 pubmed
    ..Our data indicate that calcitriol, at above-physiological serum concentrations, reduces hepatic triglyceride accumulation and glucose output, at least in part through activation of Ca2+/CaMKK?/AMPK under insulin-resistant condition. ..
  3. Chen L, So W, Li S, Cheng Q, Boucher B, Leung P. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Mol Cell Endocrinol. 2015;404:56-66 pubmed publisher
    ..Our data indicate that niacin-induced pancreatic islet dysfunction is probably modulated through activation of the islet beta-cell GPR109a-induced ROS-PPAR?-UCP2 pathways. ..
  4. Wong T, Chan L, Leung P. Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice. Nutrients. 2015;7:7543-61 pubmed publisher
    ..In conclusion, the enhanced GPR109a expression in jejunal enterocytes of T2DM mice and high-glucose treated Caco-2 cells suggests that GPR109a is involved in elevating intestinal glucose transport observed in diabetes. ..
  5. So W, Leung P. Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling. Int J Biochem Cell Biol. 2016;78:237-247 pubmed publisher
    ....
  6. Zhang D, So W, Wang Y, Wu S, Cheng Q, Leung P. Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states. Clin Sci (Lond). 2017;131:247-260 pubmed publisher
    ....
  7. Li S, Cheng S, Zhang D, Leung P. Identification and Functional Implications of Sodium/Myo-Inositol Cotransporter 1 in Pancreatic ?-Cells and Type 2 Diabetes. Diabetes. 2017;66:1258-1271 pubmed publisher
    ..On the basis of our results, we postulate that the MI transporter SMIT1 is required to maintain a stable PI pool in ?-cells in order that PI remains available despite its rapid turnover. ..

Detail Information

Publications7

  1. Leung P. The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus. Nutrients. 2016;8:147 pubmed publisher
    ....
  2. request reprint
    Cheng S, So W, Zhang D, Cheng Q, Boucher B, Leung P. Calcitriol Reduces Hepatic Triglyceride Accumulation and Glucose Output Through Ca2+/CaMKKβ/AMPK Activation Under Insulin-Resistant Conditions in Type 2 Diabetes Mellitus. Curr Mol Med. 2016;16:747-758 pubmed
    ..Our data indicate that calcitriol, at above-physiological serum concentrations, reduces hepatic triglyceride accumulation and glucose output, at least in part through activation of Ca2+/CaMKK?/AMPK under insulin-resistant condition. ..
  3. Chen L, So W, Li S, Cheng Q, Boucher B, Leung P. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Mol Cell Endocrinol. 2015;404:56-66 pubmed publisher
    ..Our data indicate that niacin-induced pancreatic islet dysfunction is probably modulated through activation of the islet beta-cell GPR109a-induced ROS-PPAR?-UCP2 pathways. ..
  4. Wong T, Chan L, Leung P. Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice. Nutrients. 2015;7:7543-61 pubmed publisher
    ..In conclusion, the enhanced GPR109a expression in jejunal enterocytes of T2DM mice and high-glucose treated Caco-2 cells suggests that GPR109a is involved in elevating intestinal glucose transport observed in diabetes. ..
  5. So W, Leung P. Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling. Int J Biochem Cell Biol. 2016;78:237-247 pubmed publisher
    ....
  6. Zhang D, So W, Wang Y, Wu S, Cheng Q, Leung P. Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states. Clin Sci (Lond). 2017;131:247-260 pubmed publisher
    ....
  7. Li S, Cheng S, Zhang D, Leung P. Identification and Functional Implications of Sodium/Myo-Inositol Cotransporter 1 in Pancreatic ?-Cells and Type 2 Diabetes. Diabetes. 2017;66:1258-1271 pubmed publisher
    ..On the basis of our results, we postulate that the MI transporter SMIT1 is required to maintain a stable PI pool in ?-cells in order that PI remains available despite its rapid turnover. ..