Research Topics
Genomes and Genes | K K H LeeSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
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Detail Information
Publications
Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like CellsWinifred Wy Yau
Stem Cell and Regeneration Thematic Research Programme, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, Hong Kong
Proteome Sci 9:3. 2011..abstract:..
Growth arrest-specific 2 gene expression during patellar tendon healingK K H Lee
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
Cells Tissues Organs 173:138-46. 2003..We speculate that the GAS2 gene might play a role in regulating tenocyte proliferation during tendon healing...- Functions of the growth arrest specific 1 gene in the development of the mouse embryoK K Lee
Department of Anatomy, The Chinese University of Hong Kong, Hong Kong, Shatin, People s Republic of China
Dev Biol 234:188-203. 2001..We speculated that the reason gas1 was expressed outside the chondrogenic nodules was to restrict cells from being recruited into the nodules and thereby defining the boundary between chondrogenic and nonchondrogenic forming regions... - gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limbK K Lee
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
Dev Biol 207:14-25. 1999..This inhibition correlated with the absence of the Gas2 peptide and pro-caspase-3 cleavage. The data suggest that Gas2 might be involved in the execution of the apoptotic process... - Hepatocyte growth factor stimulates chemotactic response in mouse embryonic limb myogenic cells in vitroK K Lee
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, People s Republic of China
J Exp Zool 283:170-80. 1999..Positive staining was also obtained for the myogenic regions. However, the pattern was heterogeneous--punctuated with myogenic cells expressing and not expressing HGF... - Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell deathS W Shan
Department of Anatomy, Basic Medical Science Building, Chinese University of Hong Kong, Shatin, Hong Kong
Dev Dyn 233:266-81. 2005..Taken together, our study identifies two new players in interdigital cell death and highlights that PCD is regulated by a delicate balance of proapoptotic and survival-promoting activities... - Heart-type fatty acid binding proteins are upregulated during terminal differentiation of mouse cardiomyocytes, as revealed by proteomic analysisM K Tang
Department of Anatomy, Faculty of Medicine, Basic Medical Science Building, The Chinese University of Hong Kong, Sha Tin, Hong Kong, People s Republic of China
Cell Tissue Res 316:339-47. 2004..Hence, we tentatively propose that H-FABP isoforms are involved in regulating cardiomyocyte growth and differentiation in mouse neonatal hearts... 
Costs and quality of life of patients with ankylosing spondylitis in Hong KongT Y Zhu
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
Rheumatology (Oxford) 47:1422-5. 2008..To assess the annual direct, indirect and total societal costs, quality of life (QoL) of AS in a Chinese population in Hong Kong and determine the cost determinants...- Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlationE K Li
Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
Rheumatology (Oxford) 47:1358-63. 2008..To examine the short-term efficacy and safety of MTX in combination with infliximab compared with infliximab and placebo in the treatment of AS using MRI to monitor its effect... - Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong KongJ H You
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Aliment Pharmacol Ther 15:1009-15. 2001..One-week triple regimens have been shown to be effective for the treatment of Helicobacter pylori-related peptic ulcer disease... - Identification and purification of an intrinsic human muscle myogenic factor that enhances muscle repair and regenerationM Li
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT
Arch Biochem Biophys 384:263-8. 2000..These newly regenerated fibers originated from the fusion of differentiated satellite cells as revealed by BrdU-labeling analysis. In contrast, the injury site of muscles treated with BSA control protein contained mainly fibroblasts... - Fibroblast growth factors 2 and 4 stimulate migration of mouse embryonic limb myogenic cellsS E Webb
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
Dev Dyn 209:206-16. 1997..Finally, we used in situ hybridization and immunohistochemical techniques to determine the distribution of myogenic cells and FGF-2 protein in the day 11.5 mouse forelimbs... - Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activitiesW Y Chan
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Hum Exp Toxicol 23:35-47. 2004..It is also postulated that both formulations protect the liver through regulating signal transduction in the cell... - Fibroblast growth factor-8b-stimulated myogenic cell proliferation is suppressed by the promyelocytic leukemia geneW H Kwong
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China
Biol Signals Recept 10:285-93. 2001..It also inhibited AP-1 and E-box transactivation. However, we believe that PML functions as a stress-response gene in G8 cells rather than as a gene normally involved in regulating muscle development... - BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinomaB C L Chan
Clinical Immunology Unit and Sir YK Pao Centre for Cancer, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
Oncogene 27:1208-17. 2008..Indeed, all cell lines analysed express high levels of BRE. In conclusion, BRE is antiapoptotic in vivo, and may promote tumorigenesis when overexpressed... - Parvalbumin expression is downregulated in rat fast-twitch skeletal muscles during agingD Q Cai
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, NT
Arch Biochem Biophys 387:202-8. 2001..Our results suggest that high-intensity training could be used to improve muscle functions during aging because parvalbumin play an important role in regulating skeletal muscle contraction and relaxation... - Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissuesM K Tang
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Peoples Republic of China
Dev Biol 218:89-98. 2000..In sum, the results suggest that Bmp-4 is a multifunctional protein and its effect on the interdigital tissues is dependent on the modulating influence of the digits... - Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinomaJ Y H Chan
Institute of Radiological Sciences, National Yang Ming University, 155 Sec 2, Li Nung St, Shi Pai, ROC, Taipei, Taiwan
Eur J Cancer 38:1600-6. 2002..This is, to our knowledge, the first report describing PML and CBP expression in NPC and our data strongly suggests that PML and CBP, but not Bax, may play a role in the transformed phenotypes of NPC...