K K H Lee

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc Silencing BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells accelerates osteogenic and chondrogenic differentiation
    Elve Chen
    Stem Cell and Regeneration Thematic Research Programme, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, People s Republic of China
    PLoS ONE 8:e67896. 2013
  2. ncbi Hepatocyte growth factor stimulates chemotactic response in mouse embryonic limb myogenic cells in vitro
    K K Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, People s Republic of China
    J Exp Zool 283:170-80. 1999
  3. ncbi gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb
    K K Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Dev Biol 207:14-25. 1999
  4. pmc Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells
    Winifred Wy Yau
    Stem Cell and Regeneration Thematic Research Programme, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, Hong Kong
    Proteome Sci 9:3. 2011
  5. ncbi Functions of the growth arrest specific 1 gene in the development of the mouse embryo
    K K Lee
    Department of Anatomy, The Chinese University of Hong Kong, Hong Kong, Shatin, People s Republic of China
    Dev Biol 234:188-203. 2001
  6. ncbi Growth arrest-specific 2 gene expression during patellar tendon healing
    K K H Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Cells Tissues Organs 173:138-46. 2003
  7. ncbi Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death
    S W Shan
    Department of Anatomy, Basic Medical Science Building, Chinese University of Hong Kong, Shatin, Hong Kong
    Dev Dyn 233:266-81. 2005
  8. ncbi Heart-type fatty acid binding proteins are upregulated during terminal differentiation of mouse cardiomyocytes, as revealed by proteomic analysis
    M K Tang
    Department of Anatomy, Faculty of Medicine, Basic Medical Science Building, The Chinese University of Hong Kong, Sha Tin, Hong Kong, People s Republic of China
    Cell Tissue Res 316:339-47. 2004
  9. ncbi Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong
    J H You
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Aliment Pharmacol Ther 15:1009-15. 2001
  10. ncbi Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation
    E K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
    Rheumatology (Oxford) 47:1358-63. 2008

Collaborators

Detail Information

Publications19

  1. pmc Silencing BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells accelerates osteogenic and chondrogenic differentiation
    Elve Chen
    Stem Cell and Regeneration Thematic Research Programme, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, People s Republic of China
    PLoS ONE 8:e67896. 2013
    ..In sum, we propose that BRE acts like an adaptor protein that promotes stemness and at the same time inhibits the differentiation of HUCPV cells. ..
  2. ncbi Hepatocyte growth factor stimulates chemotactic response in mouse embryonic limb myogenic cells in vitro
    K K Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, People s Republic of China
    J Exp Zool 283:170-80. 1999
    ..Positive staining was also obtained for the myogenic regions. However, the pattern was heterogeneous--punctuated with myogenic cells expressing and not expressing HGF...
  3. ncbi gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb
    K K Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Dev Biol 207:14-25. 1999
    ..This inhibition correlated with the absence of the Gas2 peptide and pro-caspase-3 cleavage. The data suggest that Gas2 might be involved in the execution of the apoptotic process...
  4. pmc Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells
    Winifred Wy Yau
    Stem Cell and Regeneration Thematic Research Programme, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, Hong Kong
    Proteome Sci 9:3. 2011
    ..abstract:..
  5. ncbi Functions of the growth arrest specific 1 gene in the development of the mouse embryo
    K K Lee
    Department of Anatomy, The Chinese University of Hong Kong, Hong Kong, Shatin, People s Republic of China
    Dev Biol 234:188-203. 2001
    ..We speculated that the reason gas1 was expressed outside the chondrogenic nodules was to restrict cells from being recruited into the nodules and thereby defining the boundary between chondrogenic and nonchondrogenic forming regions...
  6. ncbi Growth arrest-specific 2 gene expression during patellar tendon healing
    K K H Lee
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Cells Tissues Organs 173:138-46. 2003
    ..We speculate that the GAS2 gene might play a role in regulating tenocyte proliferation during tendon healing...
  7. ncbi Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death
    S W Shan
    Department of Anatomy, Basic Medical Science Building, Chinese University of Hong Kong, Shatin, Hong Kong
    Dev Dyn 233:266-81. 2005
    ..Taken together, our study identifies two new players in interdigital cell death and highlights that PCD is regulated by a delicate balance of proapoptotic and survival-promoting activities...
  8. ncbi Heart-type fatty acid binding proteins are upregulated during terminal differentiation of mouse cardiomyocytes, as revealed by proteomic analysis
    M K Tang
    Department of Anatomy, Faculty of Medicine, Basic Medical Science Building, The Chinese University of Hong Kong, Sha Tin, Hong Kong, People s Republic of China
    Cell Tissue Res 316:339-47. 2004
    ..Hence, we tentatively propose that H-FABP isoforms are involved in regulating cardiomyocyte growth and differentiation in mouse neonatal hearts...
  9. ncbi Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong
    J H You
    School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Aliment Pharmacol Ther 15:1009-15. 2001
    ..One-week triple regimens have been shown to be effective for the treatment of Helicobacter pylori-related peptic ulcer disease...
  10. ncbi Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation
    E K Li
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
    Rheumatology (Oxford) 47:1358-63. 2008
    ..To examine the short-term efficacy and safety of MTX in combination with infliximab compared with infliximab and placebo in the treatment of AS using MRI to monitor its effect...
  11. ncbi Identification and purification of an intrinsic human muscle myogenic factor that enhances muscle repair and regeneration
    M Li
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT
    Arch Biochem Biophys 384:263-8. 2000
    ..These newly regenerated fibers originated from the fusion of differentiated satellite cells as revealed by BrdU-labeling analysis. In contrast, the injury site of muscles treated with BSA control protein contained mainly fibroblasts...
  12. ncbi Costs and quality of life of patients with ankylosing spondylitis in Hong Kong
    T Y Zhu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Rheumatology (Oxford) 47:1422-5. 2008
    ..To assess the annual direct, indirect and total societal costs, quality of life (QoL) of AS in a Chinese population in Hong Kong and determine the cost determinants...
  13. ncbi Fibroblast growth factors 2 and 4 stimulate migration of mouse embryonic limb myogenic cells
    S E Webb
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Dev Dyn 209:206-16. 1997
    ..Finally, we used in situ hybridization and immunohistochemical techniques to determine the distribution of myogenic cells and FGF-2 protein in the day 11.5 mouse forelimbs...
  14. ncbi BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma
    B C L Chan
    Clinical Immunology Unit and Sir YK Pao Centre for Cancer, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Oncogene 27:1208-17. 2008
    ..Indeed, all cell lines analysed express high levels of BRE. In conclusion, BRE is antiapoptotic in vivo, and may promote tumorigenesis when overexpressed...
  15. ncbi Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities
    W Y Chan
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Hum Exp Toxicol 23:35-47. 2004
    ..It is also postulated that both formulations protect the liver through regulating signal transduction in the cell...
  16. ncbi Fibroblast growth factor-8b-stimulated myogenic cell proliferation is suppressed by the promyelocytic leukemia gene
    W H Kwong
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China
    Biol Signals Recept 10:285-93. 2001
    ..It also inhibited AP-1 and E-box transactivation. However, we believe that PML functions as a stress-response gene in G8 cells rather than as a gene normally involved in regulating muscle development...
  17. ncbi Parvalbumin expression is downregulated in rat fast-twitch skeletal muscles during aging
    D Q Cai
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, NT
    Arch Biochem Biophys 387:202-8. 2001
    ..Our results suggest that high-intensity training could be used to improve muscle functions during aging because parvalbumin play an important role in regulating skeletal muscle contraction and relaxation...
  18. ncbi Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues
    M K Tang
    Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Peoples Republic of China
    Dev Biol 218:89-98. 2000
    ..In sum, the results suggest that Bmp-4 is a multifunctional protein and its effect on the interdigital tissues is dependent on the modulating influence of the digits...
  19. ncbi Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma
    J Y H Chan
    Institute of Radiological Sciences, National Yang Ming University, 155 Sec 2, Li Nung St, Shi Pai, ROC, Taipei, Taiwan
    Eur J Cancer 38:1600-6. 2002
    ..This is, to our knowledge, the first report describing PML and CBP expression in NPC and our data strongly suggests that PML and CBP, but not Bax, may play a role in the transformed phenotypes of NPC...