Yu Lung Lau

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. doi request reprint Efficacy, safety and immunogenicity of a human rotavirus vaccine (RIX4414) in Hong Kong children up to three years of age: a randomized, controlled trial
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong
    Vaccine 31:2253-9. 2013
  2. doi request reprint Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese
    Philip Hei Li
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Rheumatology (Oxford) 52:337-45. 2013
  3. pmc Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function
    Yuet Wu
    Department of Paediatrics, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    BMC Infect Dis 11:201. 2011
  4. doi request reprint ELF1 is associated with systemic lupus erythematosus in Asian populations
    Jing Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Hum Mol Genet 20:601-7. 2011
  5. pmc Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
    Man To Ling
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong
    J Infect Dis 205:44-53. 2012
  6. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
  7. ncbi request reprint BCG promotes cord blood monocyte-derived dendritic cell maturation with nuclear Rel-B up-regulation and cytosolic I kappa B alpha and beta degradation
    Enmei Liu
    Department of Pediatrics, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Pediatr Res 54:105-12. 2003
  8. doi request reprint Molecular diagnosis of severe combined immunodeficiency--identification of IL2RG, JAK3, IL7R, DCLRE1C, RAG1, and RAG2 mutations in a cohort of Chinese and Southeast Asian children
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Clin Immunol 31:281-96. 2011
  9. pmc Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia
    Yinping Liu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    J Clin Immunol 32:421-9. 2012
  10. doi request reprint Clinical characteristics and genotype-phenotype correlation in 62 patients with X-linked agammaglobulinemia
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    J Clin Immunol 30:121-31. 2010

Collaborators

Detail Information

Publications41

  1. doi request reprint Efficacy, safety and immunogenicity of a human rotavirus vaccine (RIX4414) in Hong Kong children up to three years of age: a randomized, controlled trial
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong
    Vaccine 31:2253-9. 2013
    ....
  2. doi request reprint Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese
    Philip Hei Li
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Rheumatology (Oxford) 52:337-45. 2013
    ..This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients...
  3. pmc Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function
    Yuet Wu
    Department of Paediatrics, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    BMC Infect Dis 11:201. 2011
    ..Dendritic cells are key antigen presenting cells but its role in such co-infection is unclear...
  4. doi request reprint ELF1 is associated with systemic lupus erythematosus in Asian populations
    Jing Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Hum Mol Genet 20:601-7. 2011
    ....
  5. pmc Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
    Man To Ling
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong
    J Infect Dis 205:44-53. 2012
    ..Avian influenza A H9N2 (H9N2/G1) virus has infected humans and has the potential to be the next pandemic virus. Antiviral function and immunomodulatory role of MBL in pdmH1N1 and H9N2/G1 virus infection have not been investigated...
  6. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
    ....
  7. ncbi request reprint BCG promotes cord blood monocyte-derived dendritic cell maturation with nuclear Rel-B up-regulation and cytosolic I kappa B alpha and beta degradation
    Enmei Liu
    Department of Pediatrics, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Pediatr Res 54:105-12. 2003
    ..These results suggest that BCG can promote cord blood monocyte-derived DC maturation, and that the mechanism is through the up-regulation of nuclear Rel-B secondary to the degradation of cytosolic IkappaB alpha and beta...
  8. doi request reprint Molecular diagnosis of severe combined immunodeficiency--identification of IL2RG, JAK3, IL7R, DCLRE1C, RAG1, and RAG2 mutations in a cohort of Chinese and Southeast Asian children
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Clin Immunol 31:281-96. 2011
    ..National management guidelines for SCID should be established, and research into an efficient platform for genetic diagnosis is needed...
  9. pmc Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia
    Yinping Liu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    J Clin Immunol 32:421-9. 2012
    ..Btk is expressed in both B and dendritic cells (DC). However, little is known about the immune response of DC and T cells to influenza virus in XLA patients...
  10. doi request reprint Clinical characteristics and genotype-phenotype correlation in 62 patients with X-linked agammaglobulinemia
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    J Clin Immunol 30:121-31. 2010
    ..Recent studies suggested genotype-phenotype correlation in XLA, but a definitive association remains controversial...
  11. pmc Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS Genet 6:e1000841. 2010
    ..These new genetic findings may help us to gain a better understanding of the disease and the functions of the genes involved...
  12. pmc The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Exp Med 208:1511-22. 2011
    ..As PAM has been commonly used to treat osteoporosis and Paget's disease, this new application of an old drug potentially offers a safe and readily available option for treating influenza...
  13. doi request reprint Penicilliosis in children without HIV infection--are they immunodeficient?
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
    Clin Infect Dis 54:e8-e19. 2012
    ..Majority of penicilliosis occurs in patients with AIDS, and less commonly with secondary immunodeficiencies. Penicilliosis is rare in otherwise healthy persons, but information on their immunological status is often lacking...
  14. ncbi request reprint Identification of five novel WASP mutations in Chinese families with Wiskott-Aldrich syndrome
    Koon Wing Chan
    Department of Paediatrics, The University of Hong Kong, Hong Kong
    Hum Mutat 20:151-2. 2002
    ..All of the mutations are predicted to lead to premature translational termination of WASP...
  15. doi request reprint Natural killer cells become tolerogenic after interaction with apoptotic cells
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, P R China
    Eur J Immunol 40:1718-27. 2010
    ..We report here a novel interaction between NK cells and AC, resulting in the tolerogenic properties of NK cells required for immune contraction...
  16. doi request reprint Phenotypic and functional characterization of human γδ T-cell subsets in response to influenza A viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong
    J Infect Dis 205:1646-53. 2012
    ..Our study provides further evidence for the phenotypic and functional characterization of human Vγ9Vδ2 T-cell subsets during fluA virus infection and may help improve the γδ T-cell-based immunotherapy for viral infection...
  17. doi request reprint Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 000000, China
    Sci Transl Med 5:168ra9. 2013
    ..These CD8(hi) T(regs) induced long-term tolerance effectively without compromising general immunity and graft-versus-tumor activity. Our results support testing of human CD8(hi) T(regs) in GVHD in clinical trials...
  18. pmc Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Am J Hum Genet 92:41-51. 2013
    ..For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases...
  19. ncbi request reprint Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with pediatric-onset systemic lupus erythematosus
    Pak Cheong Chow
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    J Rheumatol 34:1345-52. 2007
    ..We investigated the hypothesis that arterial stiffening is related to left ventricular (LV) structure and function in adolescents and young adults with pediatric-onset SLE...
  20. ncbi request reprint Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease
    Yiu Fai Cheung
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, China
    Pediatr Res 56:591-6. 2004
    ..20, p = 0.03) as significant determinants of arterial stiffness in the entire cohort. In conclusion, MBL genotype modulates arterial stiffness, an important cardiovascular risk factor, in children after KD...
  21. doi request reprint Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Carol Yu Centre for Infection and Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, PR China
    J Infect 64:500-6. 2012
    ..To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children...
  22. ncbi request reprint Severe acute respiratory syndrome among children
    Chi Wai Leung
    Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong
    Pediatrics 113:e535-43. 2004
    ....
  23. doi request reprint CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cell Mol Immunol 7:44-50. 2010
    ..Additionally, using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection, graft versus host disease (GVHD) and autoimmune diseases...
  24. pmc Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 85:11325-37. 2011
    ....
  25. pmc Is respiratory viral infection really an important trigger of asthma exacerbations in children?
    So Lun Lee
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Eur J Pediatr 170:1317-24. 2011
    ....
  26. doi request reprint PriVar: a toolkit for prioritizing SNVs and indels from next-generation sequencing data
    Lu Zhang
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Bioinformatics 29:124-5. 2013
    ....
  27. ncbi request reprint Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways
    Enmei Liu
    Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Pediatr Res 54:919-25. 2003
    ..We conclude that IGF-I has maturation and survival effects on CB DC. These effects are mediated through both MEK and PI 3-kinase pathways but not through the IGF-I induction of TNF-alpha production by the DC...
  28. pmc ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Hum Mol Genet 18:2063-70. 2009
    ..Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE...
  29. pmc Inhibition of human natural killer cell activity by influenza virions and hemagglutinin
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong
    J Virol 84:4148-57. 2010
    ..These findings suggest that influenza virus developed a novel strategy to evade NK cell innate immune defense that is likely to facilitate viral transmission and also contribute to virus pathogenesis...
  30. ncbi request reprint Prevalence of self-reported food allergy in Hong Kong children and teens--a population survey
    Marco H K Ho
    Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Asian Pac J Allergy Immunol 30:275-84. 2012
    ..There is a paucity of data on the prevalence, natural history and management of food allergy in most of the populous Asian countries, including China...
  31. doi request reprint Improving care, education, and research: the Asian primary immunodeficiency network
    Pamela Pui Wah Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Ann N Y Acad Sci 1238:33-41. 2011
    ..The network has a dynamic capacity to accommodate priorities and interests of collaborating units, from consultations and genetic testing to scientific research involving next-generation sequencing technologies...
  32. doi request reprint Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese
    Youling Guo
    Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
    Hum Mol Genet 21:1184-9. 2012
    ..Our results suggest that common genetic variants may increase the susceptibility to epilepsy in Chinese...
  33. doi request reprint The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
    Iris W Li
    Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, 4 F University Pathology Bldg, 102 Pokfulam Rd, Queen Mary Hospital, Hong Kong
    Chest 137:759-68. 2010
    ..The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain...
  34. pmc Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:1250-7. 2004
    ..5% from children < or = 5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine...
  35. doi request reprint Primary immunodeficiencies: "new" disease in an old country
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, HKSAR, China
    Cell Mol Immunol 6:397-406. 2009
    ..Future directions include establishment of a national PID registry, raising awareness of PIDs and securing sufficient resources for patient care and scientific research...
  36. ncbi request reprint Health consequences of breast-feeding: doctors' visits and hospitalizations during the first 18 months of life in Hong Kong Chinese infants
    Gabriel M Leung
    Departments of Community Medicine, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Epidemiology 16:328-35. 2005
    ..The evidence on whether breast-feeding reduces health services use in nonwhite infants is scant. We examined the effects of breast-feeding on health services utilization in Hong Kong Chinese infants...
  37. ncbi request reprint Review of the Varilrix varicella vaccine
    Susan S Chiu
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Expert Rev Vaccines 4:629-43. 2005
    ..Similar to the other Oka-strain vaccines, Varilrix is safe, immunogenic and efficacious in both immunocompromised and immunocompetent children and adults...
  38. ncbi request reprint Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis
    Min Zhang
    Department of Pathology, The University of Hong Kong, Pokfulam Road, Hong Kong, The People s Republic of China
    Int Immunol 17:1081-92. 2005
    ..These findings suggest that overproduction of BAFF by DCs and macrophages may play a crucial role in the pathogenesis of experimental arthritis...
  39. doi request reprint Susceptibility to mycobacterial infections in children with X-linked chronic granulomatous disease: a review of 17 patients living in a region endemic for tuberculosis
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, HKSAR, China
    Pediatr Infect Dis J 27:224-30. 2008
    ..Affected individuals are most prone to infections caused by staphylococci, Salmonella, Candida, and Aspergillus, but previously we observed a high incidence of Mycobacterium tuberculosis infection in Chinese children with CGD...
  40. doi request reprint Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    Eur J Hum Genet 16:1535-43. 2008
    ..We have made use of this feature in our program to allow evaluation of the identified IBD regions based on Bayesian probability calculation and simulation results...
  41. ncbi request reprint SARS: future research and vaccine
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Paediatr Respir Rev 5:300-3. 2004
    ..Lastly it is of utmost importance that international research collaboration should be strengthened to deal with SARS and any other emerging infectious disease that can seriously threaten our future...