Yu Lung Lau

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc Foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema
    S L Lee
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    ScientificWorldJournal 2012:542983. 2012
  2. pmc Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice
    Yan Han
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    PLoS ONE 9:e86166. 2014
  3. doi request reprint Efficacy, safety and immunogenicity of a human rotavirus vaccine (RIX4414) in Hong Kong children up to three years of age: a randomized, controlled trial
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong
    Vaccine 31:2253-9. 2013
  4. pmc Coronavirus HKU1 and other coronavirus infections in Hong Kong
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 44:2063-71. 2006
  5. ncbi request reprint Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
    J Infect Dis 196:986-93. 2007
  6. ncbi request reprint Distinct maturation of, but not migration between, human monocyte-derived dendritic cells upon ingestion of apoptotic cells of early or late phases
    Wai Kee Ip
    Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    J Immunol 173:189-96. 2004
  7. pmc Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
    Man To Ling
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong
    J Infect Dis 205:44-53. 2012
  8. doi request reprint Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 000000, China
    Sci Transl Med 5:168ra9. 2013
  9. doi request reprint ELF1 is associated with systemic lupus erythematosus in Asian populations
    Jing Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Hum Mol Genet 20:601-7. 2011
  10. pmc Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 85:11325-37. 2011

Collaborators

Detail Information

Publications73

  1. pmc Foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema
    S L Lee
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    ScientificWorldJournal 2012:542983. 2012
    ..Further studies are warranted to explore the potential causal relationship...
  2. pmc Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice
    Yan Han
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    PLoS ONE 9:e86166. 2014
    ..Our study provided the first evidence that the pathogenicity of both pdmH1N1 and H9N2 viruses was alleviated in cigarette smoke exposed mice, which might partially be attributed to the immunosuppressive effect of nicotine...
  3. doi request reprint Efficacy, safety and immunogenicity of a human rotavirus vaccine (RIX4414) in Hong Kong children up to three years of age: a randomized, controlled trial
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong
    Vaccine 31:2253-9. 2013
    ....
  4. pmc Coronavirus HKU1 and other coronavirus infections in Hong Kong
    Susanna K P Lau
    Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 44:2063-71. 2006
    ..Similar studies in other countries are required to better determine the epidemiology and genetic diversity of CoV-HKU1...
  5. ncbi request reprint Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
    J Infect Dis 196:986-93. 2007
    ..We conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (NPAs) and fecal samples...
  6. ncbi request reprint Distinct maturation of, but not migration between, human monocyte-derived dendritic cells upon ingestion of apoptotic cells of early or late phases
    Wai Kee Ip
    Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    J Immunol 173:189-96. 2004
    ....
  7. pmc Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection
    Man To Ling
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong
    J Infect Dis 205:44-53. 2012
    ..Avian influenza A H9N2 (H9N2/G1) virus has infected humans and has the potential to be the next pandemic virus. Antiviral function and immunomodulatory role of MBL in pdmH1N1 and H9N2/G1 virus infection have not been investigated...
  8. doi request reprint Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 000000, China
    Sci Transl Med 5:168ra9. 2013
    ..These CD8(hi) T(regs) induced long-term tolerance effectively without compromising general immunity and graft-versus-tumor activity. Our results support testing of human CD8(hi) T(regs) in GVHD in clinical trials...
  9. doi request reprint ELF1 is associated with systemic lupus erythematosus in Asian populations
    Jing Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Hum Mol Genet 20:601-7. 2011
    ....
  10. pmc Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Virol 85:11325-37. 2011
    ....
  11. pmc Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, PR China
    Blood 112:2554-62. 2008
    ..This approach may accelerate the clinical application of Treg-based immunotherapy in transplantation and autoimmune diseases...
  12. ncbi request reprint Risk-stratified seroprevalence of severe acute respiratory syndrome coronavirus among children in Hong Kong
    Pamela P W Lee
    Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Pediatrics 117:e1156-62. 2006
    ....
  13. pmc TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells
    Ping Lung Chan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong Hong Kong SAR, China
    PLoS ONE 8:e67969. 2013
    ....
  14. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
    ....
  15. ncbi request reprint BCG promotes cord blood monocyte-derived dendritic cell maturation with nuclear Rel-B up-regulation and cytosolic I kappa B alpha and beta degradation
    Enmei Liu
    Department of Pediatrics, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Pediatr Res 54:105-12. 2003
    ..These results suggest that BCG can promote cord blood monocyte-derived DC maturation, and that the mechanism is through the up-regulation of nuclear Rel-B secondary to the degradation of cytosolic IkappaB alpha and beta...
  16. pmc Type 1 responses of human Vγ9Vδ2 T cells to influenza A viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China
    J Virol 85:10109-16. 2011
    ..Our findings suggest a novel therapeutic strategy of using phosphoantigens to boost the antiviral activities of human Vγ9Vδ2 T cells against influenza virus infection...
  17. pmc Clinical and molecular epidemiology of human parainfluenza virus 4 infections in hong kong: subtype 4B as common as subtype 4A
    Susanna K P Lau
    Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 47:1549-52. 2009
    ..Patients with HPIV4 infection were mainly young children and immunocompromised adults. In contrast to the reported predominance of HPIV4A infection, molecular subtyping revealed that 15 (44%) cases were caused by HPIV4B...
  18. pmc Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia
    Yinping Liu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    J Clin Immunol 32:421-9. 2012
    ..Btk is expressed in both B and dendritic cells (DC). However, little is known about the immune response of DC and T cells to influenza virus in XLA patients...
  19. pmc Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS Genet 6:e1000841. 2010
    ..These new genetic findings may help us to gain a better understanding of the disease and the functions of the genes involved...
  20. doi request reprint Penicilliosis in children without HIV infection--are they immunodeficient?
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
    Clin Infect Dis 54:e8-e19. 2012
    ..Majority of penicilliosis occurs in patients with AIDS, and less commonly with secondary immunodeficiencies. Penicilliosis is rare in otherwise healthy persons, but information on their immunological status is often lacking...
  21. pmc Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function
    Yuet Wu
    Department of Paediatrics, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    BMC Infect Dis 11:201. 2011
    ..Dendritic cells are key antigen presenting cells but its role in such co-infection is unclear...
  22. ncbi request reprint Natural killer cells become tolerogenic after interaction with apoptotic cells
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, P R China
    Eur J Immunol 40:1718-27. 2010
    ..We report here a novel interaction between NK cells and AC, resulting in the tolerogenic properties of NK cells required for immune contraction...
  23. pmc Inhibition of human natural killer cell activity by influenza virions and hemagglutinin
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong
    J Virol 84:4148-57. 2010
    ..These findings suggest that influenza virus developed a novel strategy to evade NK cell innate immune defense that is likely to facilitate viral transmission and also contribute to virus pathogenesis...
  24. pmc Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Am J Hum Genet 92:41-51. 2013
    ..For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases...
  25. doi request reprint CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cell Mol Immunol 7:44-50. 2010
    ..Additionally, using CD40-B to generate Tregs may accelerate the clinical use of Treg-based immunotherapy in the treatment of allograft rejection, graft versus host disease (GVHD) and autoimmune diseases...
  26. doi request reprint Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong
    Pak Leung Ho
    Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Diagn Microbiol Infect Dis 71:327-34. 2011
    ..5; P = 0.001). In period 2, high rates of dual penicillin/erythromycin nonsusceptibility were found in serotypes 6B (77.3%), 14 (100%), 19F (100%), 23F (78%), 19A (75%), 6A (87.8%), 6C (59.3%), and 23A (78.9%)...
  27. doi request reprint Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Special Administrative Region, Hong Kong, China
    J Infect Dis 200:858-65. 2009
    ..gammadelta T cells have potent antiviral activities against different viruses, but no data are available concerning their antiviral activity against influenza viruses...
  28. pmc Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong
    J Clin Microbiol 45:3655-64. 2007
    ..A newly identified HRV species, HRV-C, is circulating worldwide and is an important cause of febrile wheeze and asthmatic exacerbations in children requiring hospitalization...
  29. pmc The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Exp Med 208:1511-22. 2011
    ..As PAM has been commonly used to treat osteoporosis and Paget's disease, this new application of an old drug potentially offers a safe and readily available option for treating influenza...
  30. pmc Homozygosity mapping on a single patient: identification of homozygous regions of recent common ancestry by using population data
    Lu Zhang
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, USA
    Hum Mutat 32:345-53. 2011
    ..Testing of the method on both real cases (singleton affected) and simulated data demonstrated its superb sensitivity and robustness under genetic heterogeneity...
  31. ncbi request reprint Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways
    Enmei Liu
    Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Pediatr Res 54:919-25. 2003
    ..We conclude that IGF-I has maturation and survival effects on CB DC. These effects are mediated through both MEK and PI 3-kinase pathways but not through the IGF-I induction of TNF-alpha production by the DC...
  32. doi request reprint Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese
    Philip Hei Li
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Rheumatology (Oxford) 52:337-45. 2013
    ..This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients...
  33. doi request reprint Molecular diagnosis of severe combined immunodeficiency--identification of IL2RG, JAK3, IL7R, DCLRE1C, RAG1, and RAG2 mutations in a cohort of Chinese and Southeast Asian children
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    J Clin Immunol 31:281-96. 2011
    ..National management guidelines for SCID should be established, and research into an efficient platform for genetic diagnosis is needed...
  34. doi request reprint Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells
    Gloria Hoi Wan Tso
    Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, HKSAR, China
    Stem Cells 28:939-54. 2010
    ..This data provide a novel insight on the role of AC in modulating MSC osteogenic differentiation and function in inflammatory bone diseases...
  35. ncbi request reprint Severe acute respiratory syndrome among children
    Chi Wai Leung
    Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong
    Pediatrics 113:e535-43. 2004
    ....
  36. pmc Is respiratory viral infection really an important trigger of asthma exacerbations in children?
    So Lun Lee
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Eur J Pediatr 170:1317-24. 2011
    ....
  37. ncbi request reprint Identification of five novel WASP mutations in Chinese families with Wiskott-Aldrich syndrome
    Koon Wing Chan
    Department of Paediatrics, The University of Hong Kong, Hong Kong
    Hum Mutat 20:151-2. 2002
    ..All of the mutations are predicted to lead to premature translational termination of WASP...
  38. ncbi request reprint Herpes zoster in juvenile-onset systemic lupus erythematosus: incidence, clinical characteristics and risk factors
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Pediatr Infect Dis J 25:728-32. 2006
    ..Herpes zoster (HZ) is common in systemic lupus erythematosus (SLE) patients, but its clinical features and risk factors in juvenile-onset SLE have not been well described before...
  39. doi request reprint Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
    Pak Leung Ho
    Division of Infectious Diseases, Carol Yu Centre for Infection and Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, PR China
    J Infect 64:500-6. 2012
    ..To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children...
  40. pmc Insulin-like growth factor I promotes cord blood T cell maturation through monocytes and inhibits their apoptosis in part through interleukin-6
    Helen K W Law
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, PR China
    BMC Immunol 9:74. 2008
    ..We hypothesized that the effects of IGF-I may be mediated by accessory cells and soluble factors...
  41. pmc Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data
    Joseph T Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    PLoS Med 8:e1001103. 2011
    ..As many influenza infections are subclinical, sero-surveillance is needed to allow reliable real-time estimates of infection attack rate (IAR) and severity...
  42. doi request reprint Clinical characteristics and genotype-phenotype correlation in 62 patients with X-linked agammaglobulinemia
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    J Clin Immunol 30:121-31. 2010
    ..Recent studies suggested genotype-phenotype correlation in XLA, but a definitive association remains controversial...
  43. pmc Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function
    Wing Keung Chan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    J Hematol Oncol 1:9. 2008
    ..The question of how leukemic cells especially in monocytic lineage respond to GL-PS stimuli remains unclear...
  44. ncbi request reprint Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis
    Min Zhang
    Department of Pathology, The University of Hong Kong, Pokfulam Road, Hong Kong, The People s Republic of China
    Int Immunol 17:1081-92. 2005
    ..These findings suggest that overproduction of BAFF by DCs and macrophages may play a crucial role in the pathogenesis of experimental arthritis...
  45. doi request reprint Phenotypic and functional characterization of human γδ T-cell subsets in response to influenza A viruses
    Gang Qin
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong
    J Infect Dis 205:1646-53. 2012
    ..Our study provides further evidence for the phenotypic and functional characterization of human Vγ9Vδ2 T-cell subsets during fluA virus infection and may help improve the γδ T-cell-based immunotherapy for viral infection...
  46. doi request reprint The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment
    Iris W Li
    Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, 4 F University Pathology Bldg, 102 Pokfulam Rd, Queen Mary Hospital, Hong Kong
    Chest 137:759-68. 2010
    ..The natural history of viral shedding from the upper respiratory tract of the new pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment were uncertain...
  47. pmc Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001
    Pak Leung Ho
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:1250-7. 2004
    ..5% from children < or = 5 years of age and 93% from persons of all ages were of serotypes that are included in the 23-valent polysaccharide vaccine...
  48. pmc Influenza virus directly infects human natural killer cells and induces cell apoptosis
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Virol 83:9215-22. 2009
    ....
  49. pmc Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 8:e60862. 2013
    ..To our knowledge, we identified for the first time the critical role of NK cells in the mechanism of IgG-induced induction of Treg cells in treatment of autoimmunity...
  50. pmc Inferring influenza infection attack rate from seroprevalence data
    Joseph T Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    PLoS Pathog 10:e1004054. 2014
    ..The same principles are broadly applicable for seroprevalence studies of other infectious disease outbreaks. ..
  51. ncbi request reprint Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease
    Yiu Fai Cheung
    Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong, China
    Pediatr Res 56:591-6. 2004
    ..20, p = 0.03) as significant determinants of arterial stiffness in the entire cohort. In conclusion, MBL genotype modulates arterial stiffness, an important cardiovascular risk factor, in children after KD...
  52. ncbi request reprint Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with pediatric-onset systemic lupus erythematosus
    Pak Cheong Chow
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    J Rheumatol 34:1345-52. 2007
    ..We investigated the hypothesis that arterial stiffening is related to left ventricular (LV) structure and function in adolescents and young adults with pediatric-onset SLE...
  53. doi request reprint Viral load in patients infected with pandemic H1N1 2009 influenza A virus
    Kelvin K W To
    Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    J Med Virol 82:1-7. 2010
    ..Younger age was associated with prolonged shedding in the respiratory tract and higher viral load in the stool. Data from this quantitative analysis of viral shedding may have implications for formulating infection control measures...
  54. pmc Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells
    Helen K W Law
    Department of Paediatrics and Adolescent Medicine, Hong Kong Jockey Club Clinical Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, PR China
    BMC Immunol 10:35. 2009
    ..We also compared adult and cord blood (CB) DCs to find a possible explanation for the age-dependent severity of SARS...
  55. doi request reprint Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong
    Susan S Chiu
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong
    Clin Infect Dis 49:1016-21. 2009
    ..We sought to determine the virologically confirmed hospitalization rates associated with influenza virus infection among Hong Kong children...
  56. doi request reprint Inflammatory gene polymorphisms and susceptibility to kawasaki disease and its arterial sequelae
    Yiu Fai Cheung
    Grantham Hospital, University of Hong Kong, Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, 125 Wong Chuk Hang Rd, Hong Kong, China
    Pediatrics 122:e608-14. 2008
    ..We tested the hypothesis that single-nucleotide polymorphisms of inflammatory genes C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha) may exert influence on susceptibility to Kawasaki disease and its arterial sequelae...
  57. doi request reprint MHC expression kinetics and immunogenicity of mesenchymal stromal cells after short-term IFN-gamma challenge
    Wing Keung Chan
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Exp Hematol 36:1545-55. 2008
    ..This information is helpful to delineate how human MSCs can be modulated by IFN-gamma in different clinical scenarios...
  58. doi request reprint H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades
    Kenrie P Y Hui
    Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
    J Infect Dis 204:1866-78. 2011
    ..Thus, sensitizing neighboring cells by upregulation of RIG-I contributes to the amplified cytokine cascades during H5N1 infection...
  59. doi request reprint Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells
    Jian Zheng
    Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Immunol 183:3742-50. 2009
    ..This approach may facilitate the clinical application of CD8(+) Treg-based immunotherapy in transplantation and autoimmune diseases...
  60. doi request reprint Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: a randomized controlled trial
    Susan S Chiu
    Department of Pediatric and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    Vaccine 27:4834-9. 2009
    ..We documented maintenance of HAI titers above seroprotective levels against all three vaccine antigens in 97.6% of subjects regardless of vaccination methods over a time of waning maternal antibodies...
  61. ncbi request reprint Role of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells
    Wai Kee Ip
    Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    J Infect Dis 190:632-40. 2004
    ..albicans without the need for opsonophagocytosis by DCs, in which a direct interaction of MBL with C. albicans results in agglutination and accelerated complement activation via the lectin pathway, leading to inhibition of growth...
  62. ncbi request reprint Prevalence of self-reported food allergy in Hong Kong children and teens--a population survey
    Marco H K Ho
    Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Asian Pac J Allergy Immunol 30:275-84. 2012
    ..There is a paucity of data on the prevalence, natural history and management of food allergy in most of the populous Asian countries, including China...
  63. doi request reprint PriVar: a toolkit for prioritizing SNVs and indels from next-generation sequencing data
    Lu Zhang
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Bioinformatics 29:124-5. 2013
    ....
  64. pmc ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Hum Mol Genet 18:2063-70. 2009
    ..Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE...
  65. ncbi request reprint Health consequences of breast-feeding: doctors' visits and hospitalizations during the first 18 months of life in Hong Kong Chinese infants
    Gabriel M Leung
    Departments of Community Medicine, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Epidemiology 16:328-35. 2005
    ..The evidence on whether breast-feeding reduces health services use in nonwhite infants is scant. We examined the effects of breast-feeding on health services utilization in Hong Kong Chinese infants...
  66. doi request reprint Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese
    Youling Guo
    Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
    Hum Mol Genet 21:1184-9. 2012
    ..Our results suggest that common genetic variants may increase the susceptibility to epilepsy in Chinese...
  67. doi request reprint Improving care, education, and research: the Asian primary immunodeficiency network
    Pamela Pui Wah Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, China
    Ann N Y Acad Sci 1238:33-41. 2011
    ..The network has a dynamic capacity to accommodate priorities and interests of collaborating units, from consultations and genetic testing to scientific research involving next-generation sequencing technologies...
  68. doi request reprint Primary immunodeficiencies: "new" disease in an old country
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, HKSAR, China
    Cell Mol Immunol 6:397-406. 2009
    ..Future directions include establishment of a national PID registry, raising awareness of PIDs and securing sufficient resources for patient care and scientific research...
  69. doi request reprint Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China
    Eur J Hum Genet 16:1535-43. 2008
    ..We have made use of this feature in our program to allow evaluation of the identified IBD regions based on Bayesian probability calculation and simulation results...
  70. ncbi request reprint Review of the Varilrix varicella vaccine
    Susan S Chiu
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Expert Rev Vaccines 4:629-43. 2005
    ..Similar to the other Oka-strain vaccines, Varilrix is safe, immunogenic and efficacious in both immunocompromised and immunocompetent children and adults...
  71. ncbi request reprint SARS: future research and vaccine
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Paediatr Respir Rev 5:300-3. 2004
    ..Lastly it is of utmost importance that international research collaboration should be strengthened to deal with SARS and any other emerging infectious disease that can seriously threaten our future...
  72. doi request reprint Susceptibility to mycobacterial infections in children with X-linked chronic granulomatous disease: a review of 17 patients living in a region endemic for tuberculosis
    Pamela P W Lee
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, HKSAR, China
    Pediatr Infect Dis J 27:224-30. 2008
    ..Affected individuals are most prone to infections caused by staphylococci, Salmonella, Candida, and Aspergillus, but previously we observed a high incidence of Mycobacterium tuberculosis infection in Chinese children with CGD...