Kwok Fai Lau
Affiliation: The Chinese University of Hong Kong
Li W, Tam K, Chan W, Koon A, Ngo J, Chan H, et al
. Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J Biol Chem. 2018;293:7674-7688 pubmed publisher
..Knockdown of DOCK180 reduces the stimulatory effect of FE65-ELMO1 on Rac1 activation and neurite outgrowth. Thus, we identify a novel mechanism by which FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. ..
Lau K, Chan W, Perkinton M, Tudor E, Chang R, Chan H, et al
. Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. J Biol Chem. 2008;283:34728-37 pubmed publisher
..These findings reveal a novel regulatory mechanism for FE65-APP-mediated signaling. ..
Lau K, Perkinton M, Rodriguez L, McLoughlin D, Miller C. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. Neuroreport. 2010;21:761-6 pubmed publisher
..Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis. ..
Cheung H, Dunbar C, MÃ³rotz G, Cheng W, Chan H, Miller C, et al
. FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J. 2014;28:337-49 pubmed publisher
..Thus, we identify FE65 as a novel regulator of neurite outgrowth via controlling ARF6-Rac1 signaling. ..
Chow W, Ngo J, Li W, Chen Y, Tam K, Chan H, et al
. Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing. Biochem J. 2015;470:303-17 pubmed publisher
..Thus FE65 influences APP degradation via the proteasome and phosphorylation of FE65 Ser(610) by SGK1 regulates binding of FE65 to APP, APP turnover and processing. ..
Lee Y, Chow W, Lau K. Phosphorylation of FE65 at threonine 579 by GSK3? stimulates amyloid precursor protein processing. Sci Rep. 2017;7:12456 pubmed publisher
..Hence, our findings reveal a novel mechanism that GSK3? stimulates amyloidogenic processing of APP by phosphorylation of FE65 at T579...