Kwok Fai Lau

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi Promoter characterization and genomic organization of the human X11β gene APBA2
    Yan Hao
    Biochemistry Program, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Neuroreport 23:146-51. 2012
  2. ncbi Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription
    Kwok Fai Lau
    Department of Biochemistry and Molecular Biotechnology Programme, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    J Biol Chem 283:34728-37. 2008
  3. ncbi An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter
    Kwok Fai Lau
    Department of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Neuroreport 21:761-6. 2010
  4. ncbi CAG expansion induces nucleolar stress in polyglutamine diseases
    Ho Tsoi
    Laboratory of Drosophila Research, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Proc Natl Acad Sci U S A 109:13428-33. 2012
  5. ncbi GULP1 is a novel APP-interacting protein that alters APP processing
    Yan Hao
    Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Biochem J 436:631-9. 2011
  6. ncbi Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases
    Ho Tsoi
    Laboratory of Drosophila Research, Biochemistry Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, People s Republic of China
    Hum Mol Genet 20:3787-97. 2011
  7. ncbi Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1
    Hoi Tin Yu
    Department of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    J Cell Biochem 109:782-93. 2010
  8. ncbi DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells
    Ming Li
    State Key Laboratory of Phytochemistry and Plant Resources in West China CUHK, Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, P R China
    Chembiochem 13:1286-90. 2012
  9. ncbi Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627
    Andy Ka Leung Ng
    Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    PLoS ONE 7:e36415. 2012
  10. ncbi Genomic organization and promoter cloning of the human X11α gene APBA1
    Ka Ho Chai
    Biochemistry Program, School Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    DNA Cell Biol 31:651-9. 2012

Collaborators

Detail Information

Publications14

  1. ncbi Promoter characterization and genomic organization of the human X11β gene APBA2
    Yan Hao
    Biochemistry Program, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Neuroreport 23:146-51. 2012
    ..In addition, mutagenesis analysis revealed a putative Pax5-binding site within the promoter. Together, APBA2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and Pax5...
  2. ncbi Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription
    Kwok Fai Lau
    Department of Biochemistry and Molecular Biotechnology Programme, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    J Biol Chem 283:34728-37. 2008
    ..These findings reveal a novel regulatory mechanism for FE65-APP-mediated signaling...
  3. ncbi An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter
    Kwok Fai Lau
    Department of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Neuroreport 21:761-6. 2010
    ..Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis...
  4. ncbi CAG expansion induces nucleolar stress in polyglutamine diseases
    Ho Tsoi
    Laboratory of Drosophila Research, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Proc Natl Acad Sci U S A 109:13428-33. 2012
    ..Our work provides in vivo evidence that expanded CAG RNAs trigger nucleolar stress and induce apoptosis via p53 and describes a polyQ pathogenic mechanism that involves the nucleolus...
  5. ncbi GULP1 is a novel APP-interacting protein that alters APP processing
    Yan Hao
    Biochemistry Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    Biochem J 436:631-9. 2011
    ..The results of the present study reveal that GULP1 is a novel APP/APPc-interacting protein that influences APP processing and Aβ production...
  6. ncbi Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases
    Ho Tsoi
    Laboratory of Drosophila Research, Biochemistry Program, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, People s Republic of China
    Hum Mol Genet 20:3787-97. 2011
    ..We also provide a novel mechanistic explanation to how perturbation of RNA nuclear export would contribute to polyQ degeneration...
  7. ncbi Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1
    Hoi Tin Yu
    Department of Biochemistry Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    J Cell Biochem 109:782-93. 2010
    ..Furthermore, reduced levels of Sp1 resulted in downregulation of endogenous FE65 mRNA and protein. These findings reveal that Sp1 plays a crucial role in transcriptional control of the human FE65 gene...
  8. ncbi DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells
    Ming Li
    State Key Laboratory of Phytochemistry and Plant Resources in West China CUHK, Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, P R China
    Chembiochem 13:1286-90. 2012
    ..2 neural stem cells by using a DNA microarray followed by qPCR validation. The expression of 15 genes was significantly regulated among the 58 differentially expressed genes important for nervous system development and function...
  9. ncbi Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627
    Andy Ka Leung Ng
    Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    PLoS ONE 7:e36415. 2012
    ..In conclusion, our study provides new information on the NP-PB2 interaction and shows that the strength of NP-polymerase interaction and the resulting RNP activity are promoted by the positive charges at aa. 627 and 630 of PB2...
  10. ncbi Genomic organization and promoter cloning of the human X11α gene APBA1
    Ka Ho Chai
    Biochemistry Program, School Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    DNA Cell Biol 31:651-9. 2012
    ..Moreover, inhibition of Sp3 reduces endogenous X11α expression and promotes the generation of Aβ. Our findings reveal that Sp3 play an essential role in APBA1 transcription...
  11. ncbi Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65
    Wan Ning Vanessa Chow
    School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Biochem J 443:681-9. 2012
    ..These results suggest that FE65 facilitates the accumulation of mutant Htt in cells by preventing its degradation via the UPS, and thereby enhances the toxicity of mutant Htt...
  12. ncbi Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1
    Wing Man Chan
    Laboratory of Drosophila Research, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    Hum Mol Genet 20:1738-50. 2011
    ..Taken together, we first showed that Xpo1 is a nuclear export receptor for expanded polyQ domain, and our findings establish a direct link between protein nuclear export and the progressive nature of polyQ neurodegeneration...
  13. ncbi Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin
    Ming Li
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T Hong Kong, P R China
    Chembiochem 12:449-56. 2011
    ..2 neural stem cells and that this is mediated by activation of Erk1/2. Our work lays the foundation for exploring baicalin for the promotion of neural regeneration after injury or disease...
  14. ncbi Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task
    Kelvin Kin Kwan Wong
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, PR China
    Planta Med 76:228-34. 2010
    ..Our findings demonstrate the ability of CT to improve task learning in rats with scopolamine-induced cognitive impairment. These results suggest that CT has the potential as a therapeutic drug for treating AD...