Hui Yao Lan


Affiliation: The Chinese University of Hong Kong
Country: China


  1. Wang Y, Jiang H, Pan J, Huang X, Wang Y, Huang H, et al. Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury. J Am Soc Nephrol. 2017;28:2053-2067 pubmed publisher
    ..Moreover, the transition of bone marrow-derived M2-type macrophages to myofibroblasts in the renal allograft is regulated via a Smad3-dependent mechanism. ..
  2. Fu S, Tang Y, Huang X, Feng M, Xu A, Lan H. Smad7 protects against acute kidney injury by rescuing tubular epithelial cells from the G1 cell cycle arrest. Clin Sci (Lond). 2017;131:1955-1969 pubmed publisher
    ..In conclusion, Smad7 plays a protective role in AKI. Blockade of TGF-?/Smad3-p21/p27-induced G1 cell cycle arrest may be a key mechanism by which Smad7 treatment inhibits AKI. Thus, Smad7 may be a novel therapeutic agent for AKI. ..
  3. Tang P, Nikolic Paterson D, Lan H. Macrophages: versatile players in renal inflammation and fibrosis. Nat Rev Nephrol. 2019;: pubmed publisher
    ..MMT may serve as a key checkpoint for the progression of chronic inflammation into pathogenic fibrosis. ..
  4. Meng X, Lan H. [Transforming growth factor-β and renal fibrosis]. Sheng Li Xue Bao. 2018;70:612-622 pubmed
  5. Tang P, Zhang Y, Lan H. LncRNAs in TGF-β-Driven Tissue Fibrosis. Noncoding RNA. 2018;4: pubmed publisher
    ..In this review, we summarize the current updates of lncRNAs in TGF-β1-driven tissue fibrosis and discuss their therapeutic potential for the treatment of chronic fibrotic diseases. ..
  6. Li J, Tang Y, Tang P, Lv J, Huang X, Carlsson Skwirut C, et al. Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Mol Ther. 2018;: pubmed publisher
    ..In conclusion, MIF is pathogenic in cisplatin-induced AKI. Targeting MIF with an MIF inhibitor RPS19 could be a promising therapeutic potential for AKI. ..
  7. Lian G, Wang Q, Tang P, Zhou S, Huang X, Lan H. Combination of Asiatic Acid and Naringenin Modulates NK Cell Anti-cancer Immunity by Rebalancing Smad3/Smad7 Signaling. Mol Ther. 2018;26:2255-2266 pubmed publisher
  8. Duan W, Yu X, Huang X, Yu J, Lan H. Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro. Am J Pathol. 2014;184:2275-84 pubmed publisher
    ..These findings provide a mechanistic basis for future therapies targeting TGF-?/Smad signaling in peritoneal fibrosis. ..
  9. Zhou Q, Huang X, Yu J, Yu X, Lan H. Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation. Mol Ther. 2015;23:1034-1043 pubmed publisher
    ..Thus, Arid2-IR is a novel lncRNA that functions to promote NF-κB-dependent renal inflammation. Blockade of Arid2-IR may represent a novel and specific therapy for renal inflammatory disease. ..

More Information


  1. Wang Q, Tang P, Lian G, Li C, Li J, Huang X, et al. Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells. Cancer Immunol Res. 2018;6:965-977 pubmed publisher
    ..Thus, the NK-92-S3KD cell line may be useful for the clinical immunotherapy of cancer. Cancer Immunol Res; 6(8); 965-77. ©2018 AACR. ..
  2. Zhang Y, Meng X, Huang X, Lan H. The preventive and therapeutic implication for renal fibrosis by targetting TGF-?/Smad3 signaling. Clin Sci (Lond). 2018;132:1403-1415 pubmed publisher
    ..In conclusion, results from the present study suggest that targetting Smad3 may be a specific and effective therapy for renal fibrosis. ..
  3. Tang P, Tang P, Chung J, Hung J, Wang Q, Lian G, et al. A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro. J Vis Exp. 2018;: pubmed publisher
    ..Thus, this novel in vitro NK cell differentiating system is a biomaterial solution for immunity research. ..
  4. Liu B, Tang T, Lv L, Lan H. Renal tubule injury: a driving force toward chronic kidney disease. Kidney Int. 2018;93:568-579 pubmed publisher
    ..Thus, a better understanding the mechanisms by which tubular injury drives inflammation and fibrosis is necessary for the development of therapeutics to halt the progression of chronic kidney disease. ..
  5. Liu Z, Huang X, Chen H, Fung E, Liu J, Lan H. Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. Hypertension. 2017;70:822-830 pubmed publisher
    ..Overexpression of renal Smad7 protects against hypertensive nephropathy by inactivating angiotensin II-induced TGF-?/Smad3 and NF-?B pathways and by targeting the Smad3-dependent microRNA-21 axis. ..
  6. Sun S, Tang P, Feng M, Xiao J, Huang X, Li P, et al. Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b. Diabetes. 2018;67:731-744 pubmed publisher
    ..Collectively, we identify that Erbb4-IR is a Smad3-dependent lncRNA that promotes renal fibrosis in T2DN by suppressing miR-29b. Targeting Erbb4-IR may represent a novel therapy for T2DN. ..
  7. Tang P, Zhou S, Li C, Liao J, Xiao J, Wang Q, et al. The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney Int. 2018;93:173-187 pubmed publisher
    ..Thus, macrophage-myofibroblast transition contributes to Src-mediated tissue fibrosis. Hence, targeting Src may represent as a precision therapeutic strategy for macrophage-myofibroblast transition-driven fibrotic diseases. ..
  8. Lai W, Tang Y, Huang X, Ming Kuen Tang P, Xu A, Szalai A, et al. C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E. Kidney Int. 2016;90:610-26 pubmed publisher
    ..Thus, C-reactive protein may promote AKI by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex. Targeting Smad3 may offer a new treatment approach for AKI. ..
  9. Lan H. Transforming growth factor-?/Smad signalling in diabetic nephropathy. Clin Exp Pharmacol Physiol. 2012;39:731-8 pubmed publisher
    ..Targeting downstream TGF-?/Smad signalling by overexpressing Smad7- or Smad3-dependent microRNA related to fibrosis may represent a novel and effective strategy for the treatment of DN. ..
  10. Lan H, Chung A. Transforming growth factor-? and Smads. Contrib Nephrol. 2011;170:75-82 pubmed publisher
    ..In conclusion, TGF-?/Smad signaling plays a critical role in DN. A better understanding of the role of TGF-?/Smad signaling in the development of DN should provide an effective therapeutic strategy to combat DN. ..
  11. Yang C, Huang X, Fung E, Liu H, Lan H. The Regulatory T-cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis. Sci Rep. 2017;7:1481 pubmed publisher
    ..In conclusion, Foxp3 protects against kidney injury in crescentic GN through enhancement of Treg numbers and function, and suppression of Th1, Th2 and Th17 immune responses at the systemic and local tissue levels. ..
  12. Lv L, Tang P, Li C, You Y, Li J, Huang X, et al. The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017;91:587-602 pubmed publisher
    ..Hence, targeting Mincle may be a novel therapy for acute kidney injury associated with M1 macrophages. ..
  13. Feng M, Tang P, Huang X, Sun S, You Y, Xiao J, et al. TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis. Mol Ther. 2018;26:148-161 pubmed publisher
    ..Targeting Erbb4-IR may represent a precise therapeutic strategy for progressive renal fibrosis. ..
  14. Zhou Q, Chung A, Huang X, Dong Y, Yu X, Lan H. Identification of novel long noncoding RNAs associated with TGF-?/Smad3-mediated renal inflammation and fibrosis by RNA sequencing. Am J Pathol. 2014;184:409-17 pubmed publisher
  15. Lan H, Chung A. TGF-?/Smad signaling in kidney disease. Semin Nephrol. 2012;32:236-43 pubmed publisher
    ..Advances in understanding of the mechanisms of TGF-?/Smad signaling in renal fibrosis and inflammation during chronic kidney diseases should provide a better therapeutic strategy to combat kidney diseases. ..
  16. Tang Y, Chen J, Huang K, Luo D, Liang P, Feng M, et al. The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery. BMC Nephrol. 2017;18:184 pubmed publisher
  17. Lan H. Diverse roles of TGF-?/Smads in renal fibrosis and inflammation. Int J Biol Sci. 2011;7:1056-67 pubmed
    ..Thus, targeting the downstream TGF-?/Smad3 signaling pathway by gene transfer of either Smad7 or Smad3-dependent microRNAs may represent a specific and effective therapeutic strategy for kidney disease. ..