Research Topics
Genomes and GenesSpecies | Patrick KwanSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
| Collaborators
|
Detail Information
Publications
Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han ChinesePatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsy Behav 11:112-7. 2007..5, 95% confidence interval=1.4-4.6, P=0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations...
Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expressionPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
Pharmacogenet Genomics 18:989-98. 2008..We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium channels...- Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized studyPatrick Kwan
Department of Medicine and Therapeutics, Division of Neurology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Epilepsy Behav 14:610-6. 2009..Greater attention should be paid to investigate the potential impact of valproate on reproductive function in men... - Refractory epilepsy: mechanisms and solutionsPatrick Kwan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
Expert Rev Neurother 6:397-406. 2006.... - Refractory seizures: try additional antiepileptic drugs (after two have failed) or go directly to early surgery evaluation?Patrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
Epilepsia 50:57-62. 2009.... 
A systematic evaluation of payback of publicly funded health and health services research in Hong KongPatrick Kwan
Research Office, Health, Welfare and Food Bureau, Government of the Hong Kong Special Administrative Region, Hong Kong, China
BMC Health Serv Res 7:121. 2007..We evaluated the fund's outcomes and explored factors associated with the translation of research findings to changes in health policy and provider behaviour...- Emerging drugs for epilepsyPatrick Kwan
The Chinese University of Hong Kong, Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
Expert Opin Emerg Drugs 12:407-22. 2007..The ultimate goal is to develop novel agents that can prevent the occurrence of seizures and the progression of epilepsy in at risk individuals... - Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic StrategiesPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 51:1069-77. 2010..The rationale behind the definition and the principles governing its proper use are discussed, and examples to illustrate its application in clinical practice are provided... - Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han ChinesePatrick Kwan
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China
Pharmacogenomics 10:723-32. 2009..To further study the potential association, we genotyped a broad set of tagging SNPs, and explored whether any associations were affected by other host factors. We correlated any association with cerebral mRNA expression of ABCB1... - Association of subjective anxiety, depression, and sleep disturbance with quality-of-life ratings in adults with epilepsyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 50:1059-66. 2009..To determine the relative contributions of subjective anxiety, depression, sleep disturbance, and seizure-related variables to quality-of-life scores in adults with epilepsy, and the interrelationships among these factors... - Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Neurobiol Dis 39:192-7. 2010..002 and 0.006, respectively). The results suggest that P-glycoprotein expression in temporal lobe may be associated with seizure recurrence after surgery for pharmacoresistant TLE... - Headache in patients with epilepsy: a prospective incidence studyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 49:1099-102. 2008..A formal headache diagnosis was not made in any of the patients prior to the survey. Although the incidence of headache in epilepsy patients appeared to be low, it was underdiagnosed and associated with substantial negative impact... - Efficacy and safety of levetiracetam as adjunctive therapy in adult patients with uncontrolled partial epilepsy: the Asia SKATE II StudyPatrick Kwan
The Chinese University of Hong Kong, Hong Kong, China
Epilepsy Behav 18:100-5. 2010..4%, and 17.7% became seizure free during the treatment period. Levetiracetam was well tolerated and efficacious as adjunctive therapy for partial epilepsy in clinical practice among Asian populations... - Potential role of drug transporters in the pathogenesis of medically intractable epilepsyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Epilepsia 46:224-35. 2005..Further studies to delineate the exact role, if any, of P-gp and other efflux transporters in drug-resistant epilepsy are warranted... - Efficacy and safety of pregabalin versus lamotrigine in patients with newly diagnosed partial seizures: a phase 3, double-blind, randomised, parallel-group trialPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Lancet Neurol 10:881-90. 2011..We studied the efficacy and safety of pregabalin as monotherapy, using a design that complied with European regulatory requirements and International League Against Epilepsy guidelines... - Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Pharmacogenomics 12:319-25. 2011..To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs... - Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsyChunbo Zhang
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China
Epilepsia 51:1878-81. 2010..The results do not suggest that SCN1A SNPs are susceptibility factors for FS in Han Chinese... - Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han ChineseCeleste B L Man
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 48:1015-8. 2007..Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals... - Prognosticating acute symptomatic seizures using two different seizure outcomesHowan Leung
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Epilepsia 51:1570-9. 2010.... - Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in ChineseYouling Guo
Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
Hum Mol Genet 21:1184-9. 2012..Our results suggest that common genetic variants may increase the susceptibility to epilepsy in Chinese... - In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoproteinChunbo Zhang
School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Epilepsia 52:1894-904. 2011..For most AEDs, conflicting evidence precludes consensus on whether they are substrates of Pgp. The objective of this study was to evaluate whether analogs and metabolites of the AED carbamazepine are substrates of human Pgp... - In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoproteinChunbo Zhang
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Life Sci 86:899-905. 2010..We evaluated AEDs as P-gp substrates using cell monolayers... - Phenobarbital for the treatment of epilepsy in the 21st century: a critical reviewPatrick Kwan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Epilepsia 45:1141-9. 2004.... - The transport of antiepileptic drugs by P-glycoproteinChunbo Zhang
School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
Adv Drug Deliv Rev 64:930-42. 2012..We discuss criteria for identifying the substrate status of AEDs and use structure-activity relationship (SAR) models to predict which AEDs act as P-gp substrates... - Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot studyXiao Ting Hao
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsy Behav 22:388-90. 2011..91 (P<0.001). The definition appeared to have a high degree of interrater reliability in this setting... - Diagnostic value and safety of long-term video-EEG monitoringAndrew C F Hui
Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
Hong Kong Med J 13:228-30. 2007..Major injuries and status epilepticus did not occur during monitoring. In our experience video-EEG is safe and provides important clinical information in over 80% of patients... - Combination therapy in epilepsy: when and what to usePatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Drugs 66:1817-29. 2006..Care should be taken to avoid excessive drug load, which is associated with increased toxicity.Bigger and better randomised, controlled studies are needed to determine the optimal time and way to combine AEDs... - Drug treatment of epilepsy: when does it fail and how to optimize its use?Patrick Kwan
Department of Medicine and Therapeutics, Division of Neurology, Prince of Whales Hospital, Chinese University of Hong Kong, China
CNS Spectr 9:110-9. 2004..An orderly approach to each epilepsy syndrome will optimize the chance of perfect seizure control and help more patients achieve a fulfilling life... - Simple partial status epilepticus in Chinese adultsAndrew C F Hui
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
J Clin Neurosci 12:902-4. 2005..6%), metabolic derangement (12.5%) and tumor (12.5%). At 30 days from the onset of seizures, 13(40.5%) patients had recovered fully and seven (21.9%) had died. Poor outcome was associated with the presence of an acute symptomatic injury... - Mesial frontal epilepsy and ictal body turning along the horizontal body axisHowan Leung
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong SAR, The People s Republic of China
Arch Neurol 65:71-7. 2008..To evaluate the clinical utility of mesial frontal semiology... - Epidemiology and management of epilepsy in Hong Kong: an overviewAndrew C F Hui
Division of Neurology, Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Seizure 13:244-6. 2004..In this article, we summarise some of the main problems faced by patients and the current treatment options available in an urban area of China... - Intracranial electroencephalogram to evaluate refractory temporal and frontal lobe epilepsyLisa Au
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Hong Kong Med J 17:453-9. 2011..We undertook a collaborative study in a multidisciplinary team to channel refractory epilepsy patients to test a hypothesis about placement of intracranial electroencephalography arrays... - ELF1 is associated with systemic lupus erythematosus in Asian populationsJing Yang
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
Hum Mol Genet 20:601-7. 2011.... - Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsyPatrick Kwan
Division of Neurology, Department of Medicine, United Christian Hospital, Kwun Tong, Hong Kong
Neurology 60:S2-12. 2003.... - Topiramate for migraine prophylaxis among Chinese populationHo Lun Li
Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China
Headache 47:616-9. 2007..There was no difference in baseline headache frequency or intensity between responders and nonresponders... - Refractory epilepsy: a progressive, intractable but preventable condition?Patrick Kwan
Division of Neurology, Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong Kong, China
Seizure 11:77-84. 2002..This strategy has the potential to improve outcome by preventing the insidious progression to intractable 'refractoriness' and a downward spiraling quality of life... - Current position of phenobarbital in epilepsy and its futureMartin J Brodie
Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom Department of Medicine and Neurology, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China
Epilepsia 53:40-6. 2012..All these data predict a healthy future for phenobarbital, particularly in helping to close the treatment gap in low- and middle-income countries during its second century of clinical use... - Effect of dosage failed of first antiepileptic drug on subsequent outcomeMartin J Brodie
Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom Departments of Medicine and Neurology, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
Epilepsia 54:194-8. 2013..This methodology could be used to refine further the ILAE definition of drug-resistant epilepsy by exploring the doses need to fail to provide an adequate AED trial... - Anxiety symptoms in patients with frontal lobe epilepsy versus generalized epilepsyW K Tang
Department of Psychiatry, Shatin Hospital, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
Seizure 21:457-60. 2012..The aim of this study was to compare the frequency of anxiety symptoms between patients with frontal lobe epilepsy (FLE) and generalized epilepsy (GE)... 
Epilepsy in elderly peopleMartin J Brodie
Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT
BMJ 331:1317-22. 2005- Staged approach to epilepsy managementMartin J Brodie
Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
Neurology 58:S2-8. 2002..A staged approach to the pharmacologic management and, when appropriate, surgical work-up for each epilepsy syndrome will optimize the chance of perfect seizure control and help more patients achieve a fulfilling life... - Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizurePatrick Kwan
Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
Epilepsia 43:1318-23. 2002..Further studies are required to investigate the effects of recurrent seizure activity and to characterise mdr expression in other experimental seizure models... - An epidemiological study of epilepsy in Hong Kong SAR, ChinaGardian C Y Fong
University Department of Medicine, The University of Hong Kong, China
Seizure 17:457-64. 2008..Population-based epidemiological data for epilepsy is not available. We performed the first population-based epidemiological survey of epilepsy in this locality... - Differential expression of multidrug resistance genes in naïve rat brainPatrick Kwan
Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, G11 6NT, Scotland, Glasgow, United Kingdom
Neurosci Lett 339:33-6. 2003..These findings reveal a differential expression of mdr1 genes in normal rodent brain tissue and suggest that P-gp may afford a broader protection of the hippocampus than other brain structures... - Overtreatment in epilepsy: how it occurs and how it can be avoidedEmilio Perucca
Institute of Neurology IRCCS, C. Mondino Foundation, Pavia, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
CNS Drugs 19:897-908. 2005..Even though the importance of complete seizure control cannot be overemphasised, no patient should be made to suffer more from the adverse effects of treatment than from the manifestations of the seizure disorder... - Phenobarbital: a drug for the 21st century?Martin J Brodie
Epilepsy Behav 5:802-3. 2004