Ui Soon Khoo

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc Localization of hRad9 in breast cancer
    Vivian Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    BMC Cancer 8:196. 2008
  2. doi request reprint DC-SIGN and L-SIGN: the SIGNs for infection
    Ui Soon Khoo
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, University Pathology Building, Hong Kong, SAR, China
    J Mol Med (Berl) 86:861-74. 2008
  3. ncbi request reprint Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections
    U S Khoo
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Hong Kong Med J 14:31-5. 2008
  4. doi request reprint CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
    Kelvin Yuen Kwong Chan
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Hum Immunol 71:702-7. 2010
  5. ncbi request reprint Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
    Vera S F Chan
    Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
    Nat Genet 38:38-46. 2006
  6. pmc Promoter methylation and differential expression of pi-class glutathione S-transferase in endometrial carcinoma
    Queeny K Y Chan
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Rd, Hong Kong
    J Mol Diagn 7:8-16. 2005
  7. ncbi request reprint Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome: a differential expression study
    Pui yee Fong
    Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 103:268-76. 2005
  8. ncbi request reprint Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization
    Caroline Y L Lai
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Mod Pathol 17:40-8. 2004
  9. ncbi request reprint Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer
    Kelvin Y K Chan
    Department of Pathology, Queen Mary Hospital and The University of Hong Kong, Hong Kong
    Cancer Res 62:4151-6. 2002
  10. ncbi request reprint Single nucleotide polymorphism of pi-class glutathione s-transferase and susceptibility to endometrial carcinoma
    Queeny K Y Chan
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 11:2981-5. 2005

Collaborators

Detail Information

Publications20

  1. pmc Localization of hRad9 in breast cancer
    Vivian Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong, China
    BMC Cancer 8:196. 2008
    ..We have previously shown that the mRNA up-regulation correlated with tumor size and local recurrence. Immunohistochemical studies were made to better define the role of hRad9 in breast carcinogenesis...
  2. doi request reprint DC-SIGN and L-SIGN: the SIGNs for infection
    Ui Soon Khoo
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, University Pathology Building, Hong Kong, SAR, China
    J Mol Med (Berl) 86:861-74. 2008
    ..These findings support the neck region as an excellent candidate acting as a functional target for selective pressures exerted by pathogens...
  3. ncbi request reprint Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections
    U S Khoo
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Hong Kong Med J 14:31-5. 2008
    ....
  4. doi request reprint CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese
    Kelvin Yuen Kwong Chan
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Hum Immunol 71:702-7. 2010
    ..This association is in keeping with the role of CD209 in modulating immune response to viral infection. The relevance of these findings for other infectious diseases and inflammatory conditions would be worth investigating...
  5. ncbi request reprint Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
    Vera S F Chan
    Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
    Nat Genet 38:38-46. 2006
    ..Thus, homozygosity for L-SIGN plays a protective role during SARS infection...
  6. pmc Promoter methylation and differential expression of pi-class glutathione S-transferase in endometrial carcinoma
    Queeny K Y Chan
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Pokfulam Rd, Hong Kong
    J Mol Diagn 7:8-16. 2005
    ....
  7. ncbi request reprint Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome: a differential expression study
    Pui yee Fong
    Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 103:268-76. 2005
    ..In previous studies, the authors demonstrated that low apoptotic activity was correlated with the progression of HM to GTN, and they hypothesized that some apoptosis-related genes may determine this progression...
  8. ncbi request reprint Analysis of gestational trophoblastic disease by genotyping and chromosome in situ hybridization
    Caroline Y L Lai
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Mod Pathol 17:40-8. 2004
    ..As a partial mole still carries a risk of developing gestational trophoblastic neoplasia, follow-up is considered necessary for both complete and partial moles...
  9. ncbi request reprint Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer
    Kelvin Y K Chan
    Department of Pathology, Queen Mary Hospital and The University of Hong Kong, Hong Kong
    Cancer Res 62:4151-6. 2002
    ..Our findings suggest that both genes may be involved in the development of sporadic ovarian cancer...
  10. ncbi request reprint Single nucleotide polymorphism of pi-class glutathione s-transferase and susceptibility to endometrial carcinoma
    Queeny K Y Chan
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 11:2981-5. 2005
    ..In this study, we aimed at determining the association between the GSTP1 polymorphism and the risk of endometrial carcinoma in a Chinese population...
  11. ncbi request reprint Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population
    Annie N Y Cheung
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Cancer 99:331-5. 2003
    ....
  12. ncbi request reprint Cervical and peritoneal fluid cytology of uterine sarcomas
    Xiao Wang
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Acta Cytol 46:465-9. 2002
    ..To study the cytologic features of uterine sarcoma...
  13. ncbi request reprint Association of ICAM3 genetic variant with severe acute respiratory syndrome
    Kelvin Y K Chan
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Rd, Hong Kong
    J Infect Dis 196:271-80. 2007
    ..31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS...
  14. ncbi request reprint Malignant placental site trophoblastic tumor: a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization
    Wei Cheng Xue
    Department of Pathology, People s Hospital, Peking University, Beijing, China
    Cancer 94:2288-94. 2002
    ..Most showed benign behavior whereas 10-15% of PSTTs were clinically malignant with later recurrence and metastasis. Currently, there are no reliable means to predict clinical outcome, and cytogenetic information is scanty...
  15. doi request reprint SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity
    Luduo Zhang
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Cancer Res 73:246-55. 2013
    ..Our findings highlight a novel splice variant of the ERα corepressor NCOR2 as a candidate biomarker in breast cancer that not only predicts tamoxifen response but may be targeted to overcome tamoxifen resistance...
  16. doi request reprint Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection
    Johannes Chi Yun Ching
    Department of Pathology, University of Hong Kong, Princess Margaret Hospital, Hong Kong
    J Infect Dis 201:1899-908. 2010
    ....
  17. ncbi request reprint Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix
    Tsin Wah Leung
    Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Gynecol Oncol 92:866-72. 2004
    ....
  18. ncbi request reprint Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population
    Ui Soon Khoo
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Hum Mutat 19:307-8. 2002
    ....
  19. ncbi request reprint Atypical squamous cells of undetermined significance on cervical smears: follow-up study of an Asian screening population
    Annie N Y Cheung
    Department of Pathology, The University of Hong Kong, Hong Kong, China
    Cancer 102:74-80. 2004
    ..The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date...
  20. pmc A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung
    Yongxiong Chen
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Exp Med 204:2529-36. 2007
    ..Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed...