Dong Yan Jin


Affiliation: The University of Hong Kong
Country: China


  1. Ho T, Kew C, Lui P, Chan C, Satoh T, Akira S, et al. PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine. J Virol. 2016;90:1557-68 pubmed publisher
    ..They are potentially useful as chemically defined vaccine adjuvants, antivirals, and immunostimulatory agents. ..
  2. Yuen C, Chan C, Fung S, Wang P, Wong W, Tang H, et al. Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation. J Virol. 2016;90:3902-3912 pubmed publisher
    ..Our work sheds light on the mechanism of action for the inhibition of interferon production by an HTLV-1 oncogenic protein called Tax. Our findings might help to improve interferon-based anti-HTLV-1 and anti-ATL therapy. ..
  3. Yuan S, Chan J, Ye Z, Wen L, Tsang T, Cao J, et al. Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. Viruses. 2019;11: pubmed publisher
    ..The novel antiviral activity and mechanism of hexachlorophene in this study would facilitate the use of hexachlorophene as a lead compound to develop more entry inhibitors with higher anti-SFTSV potency and lower toxicity. ..
  4. Zhu Z, Chu H, Wen L, Yuan S, Chik K, Yuen T, et al. Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy. Int J Mol Sci. 2019;20: pubmed publisher
  5. Wang P, Ye Z, Deng J, Siu K, Gao W, Chaudhary V, et al. Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. EMBO Rep. 2018;19: pubmed publisher
  6. Tang H, Gao W, Chan C, Cheng Y, Chaudhary V, Deng J, et al. Requirement of CRTC1 coactivator for hepatitis B virus transcription. Nucleic Acids Res. 2014;42:12455-68 pubmed publisher
    ..In addition, HBV transactivator protein HBx stabilized CRTC1 and promoted its activity on HBV transcription. Our work reveals an essential role of CRTC1 coactivator in facilitating and supporting HBV transcription and replication. ..
  7. Tang H, Gao W, Chan C, Cheng Y, Deng J, Yuen K, et al. SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription. J Virol. 2015;89:8623-31 pubmed publisher
    ..Our findings not only provide new knowledge of the host control of HTLV-1 gene expression but also suggest a new strategy of using natural compounds for prevention and treatment of HTLV-1-associated diseases. ..
  8. Wong L, Lui P, Jin D. A molecular arms race between host innate antiviral response and emerging human coronaviruses. Virol Sin. 2016;31:12-23 pubmed publisher
  9. request reprint
    Yuen K, Chan C, Kok K, Jin D. Mutagenesis and Genome Engineering of Epstein-Barr Virus in Cultured Human Cells by CRISPR/Cas9. Methods Mol Biol. 2017;1498:23-31 pubmed
    ..This approach might also prove useful in the cure of EBV infection. In this chapter, we use the knockout of the BART promoter as an example to detail the experimental procedures for construction of recombinant EBV in human cells. ..

More Information


  1. Gao W, Tang H, Cheng Y, Chan C, Chan C, Jin D. Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1. Biochim Biophys Acta Gene Regul Mech. 2018;1861:211-223 pubmed publisher
    ..Our findings have implications in the development of new antihyperglycemic agents. ..
  2. Deng J, Kong K, Gao W, Tang H, Chaudhary V, Cheng Y, et al. Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription. Biochim Biophys Acta Gene Regul Mech. 2017;1860:491-501 pubmed publisher
    ..Taken together, our findings revealed not only the interplay between SIRT1 and HBx in the activation of HBV transcription but also new strategies and compounds for developing antivirals against HBV. ..
  3. Yuen K, Wang Z, Wong N, Zhang Z, Cheng T, Lui W, et al. Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9. Virus Res. 2018;244:296-303 pubmed publisher
    ..Our work provides the proof-of-principle for suppressing EBV DNA load with CRISPR/Cas9 and a potential new strategy to sensitize EBV-infected NPC cells to chemotherapy. ..
  4. Chan C, Kok K, Jin D. Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. Adv Exp Med Biol. 2017;1018:147-166 pubmed publisher
    ..A better understanding of HTLV-1 biology and leukemogenesis will reveal new strategies and modalities for ATL prevention and treatment. ..
  5. Chaudhary V, Yuen K, Chan J, Chan C, Wang P, Cai J, et al. Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein. J Virol. 2017;91: pubmed publisher
    ..A drug that specifically inhibits the IFN-γ receptor or STAT1 shows an anti-ZIKV effect and might also have anti-inflammatory activity. ..