Margaret Ip

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. doi request reprint Application of a target enrichment-based next-generation sequencing protocol for identification and sequence-based prediction of pneumococcal serotypes
    Veranja Liyanapathirana
    Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China
    BMC Microbiol 14:60. 2014
  2. doi request reprint Increased nasopharyngeal carriage of serotypes 6A, 6C, and 6D Streptococcus pneumoniae after introduction of childhood pneumococcal vaccination in Hong Kong
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 76:153-7. 2013
  3. pmc Evidence of clonal dissemination of multidrug-resistant Streptococcus pneumoniae in Hong Kong
    M Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 37:2834-9. 1999
  4. pmc Longitudinally tracking fluoroquinolone resistance and its determinants in penicillin-susceptible and -nonsusceptible Streptococcus pneumoniae isolates in Hong Kong, 2000 to 2005
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Antimicrob Agents Chemother 51:2192-4. 2007
  5. doi request reprint Pediatric hospitalization of acute respiratory tract infections with Human Bocavirus in Hong Kong
    Margaret I P
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Virol 42:72-4. 2008
  6. pmc Contemporary methicillin-resistant Staphylococcus aureus clones in Hong Kong
    Margaret Ip
    Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 43:5069-73. 2005
  7. ncbi request reprint Antimicrobial activities of silver dressings: an in vitro comparison
    Margaret Ip
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Med Microbiol 55:59-63. 2006
  8. pmc Rapid screening of fluoroquinolone resistance determinants in Streptococcus pneumoniae by PCR-restriction fragment length polymorphism and single-strand conformational polymorphism
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 44:970-5. 2006
  9. ncbi request reprint Use of the housekeeping genes, gdh (zwf) and gki, in multilocus sequence typing to differentiate Streptococcus pneumoniae from Streptococcus mitis and Streptococcus oralis
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 56:321-4. 2006
  10. ncbi request reprint Streptococcus suis in Hong Kong
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 57:15-20. 2007

Detail Information

Publications72

  1. doi request reprint Application of a target enrichment-based next-generation sequencing protocol for identification and sequence-based prediction of pneumococcal serotypes
    Veranja Liyanapathirana
    Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China
    BMC Microbiol 14:60. 2014
    ....
  2. doi request reprint Increased nasopharyngeal carriage of serotypes 6A, 6C, and 6D Streptococcus pneumoniae after introduction of childhood pneumococcal vaccination in Hong Kong
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 76:153-7. 2013
    ..0 μg/mL) was 9.1% and for cefotaxime (MIC ≥2.0 μg/mL) was 14.7%. A high prevalence of non-6B serotype, including 6A, 6C, and 6D was noted after the introduction of PCV7 conjugate pneumococcal vaccines in Hong Kong...
  3. pmc Evidence of clonal dissemination of multidrug-resistant Streptococcus pneumoniae in Hong Kong
    M Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 37:2834-9. 1999
    ..The results suggest that the rapid emergence of drug-resistant S. pneumoniae in Hong Kong has been due to the rapid dissemination of several successful clones...
  4. pmc Longitudinally tracking fluoroquinolone resistance and its determinants in penicillin-susceptible and -nonsusceptible Streptococcus pneumoniae isolates in Hong Kong, 2000 to 2005
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Antimicrob Agents Chemother 51:2192-4. 2007
    ..Rates of resistance to levofloxacin in S. pneumoniae have remained stable at a Hong Kong hospital...
  5. doi request reprint Pediatric hospitalization of acute respiratory tract infections with Human Bocavirus in Hong Kong
    Margaret I P
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Virol 42:72-4. 2008
    ..Respiratory tract infections are a leading cause of morbidity and mortality globally. Human Bocavirus (HBoV) has recently been identified and implicated as an aetiologic agent of lower respiratory tract infection in children...
  6. pmc Contemporary methicillin-resistant Staphylococcus aureus clones in Hong Kong
    Margaret Ip
    Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 43:5069-73. 2005
    ..The most prevalent MRSA clone in Hong Kong belongs to CC 239, with PFGE types A to E and H, SCCmec type III, ST 239, and a resistance profile of TEDGToCi...
  7. ncbi request reprint Antimicrobial activities of silver dressings: an in vitro comparison
    Margaret Ip
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Med Microbiol 55:59-63. 2006
    ....
  8. pmc Rapid screening of fluoroquinolone resistance determinants in Streptococcus pneumoniae by PCR-restriction fragment length polymorphism and single-strand conformational polymorphism
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 44:970-5. 2006
    ..This method provides a database of high resolution profiles on these mutations and allows rapid screening for new mutations of the fluoroquinolone resistance genes...
  9. ncbi request reprint Use of the housekeeping genes, gdh (zwf) and gki, in multilocus sequence typing to differentiate Streptococcus pneumoniae from Streptococcus mitis and Streptococcus oralis
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 56:321-4. 2006
    ....
  10. ncbi request reprint Streptococcus suis in Hong Kong
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Diagn Microbiol Infect Dis 57:15-20. 2007
    ..suis strains isolated from pork in this study. These methods may serve as useful tools in studying and enhancing our understanding of these infections in Hong Kong...
  11. pmc Identification of a Streptococcus agalactiae serotype III subtype 4 clone in association with adult invasive disease in Hong Kong
    Margaret Ip
    Dept of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 44:4252-4. 2006
    ..This clone was significantly associated with diseases caused by invasive strains from nonpregnant adults (P <or= 0.01, chi-square test) and was not present in the genital tracts of pregnant mothers...
  12. ncbi request reprint Seroprevalence of antibody to severe acute respiratory syndrome (SARS)-associated coronavirus among health care workers in SARS and non-SARS medical wards
    Margaret Ip
    Department of Microbiology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Clin Infect Dis 38:e116-8. 2004
    ..Rates for clinical SARS-CoV infection among 742 HCWs on these wards were highest among nurses (11.6%) and health care assistants (11.8%), indicating that these occupations are associated with the highest risks for exposure...
  13. pmc Serotype distribution and antimicrobial susceptibilities of nasopharyngeal isolates of Streptococcus pneumoniae from children hospitalized for acute respiratory illnesses in Hong Kong
    Margaret Ip
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 45:1969-71. 2007
    ..9% and 37.2% of the isolates were not susceptible to penicillin and cefotaxime, respectively. The rate of potential coverage by the seven-valent conjugate vaccine was 72.3%, and the rate increased to 74.6% for serogroup-specific types...
  14. pmc Fluoroquinolone resistance in atypical pneumococci and oral streptococci: evidence of horizontal gene transfer of fluoroquinolone resistance determinants from Streptococcus pneumoniae
    Margaret Ip
    Department of Microbiology, Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong
    Antimicrob Agents Chemother 51:2690-700. 2007
    ..Both recombinational events and de novo mutations play an important role in the development of fluoroquinolone resistance...
  15. ncbi request reprint Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
    Margaret Ip
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Diagn Microbiol Infect Dis 59:131-6. 2007
    ..857, whereas (CRP x PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI...
  16. pmc Characterization of isolates of methicillin-resistant Staphylococcus aureus from Hong Kong by phage typing, pulsed-field gel electrophoresis, and fluorescent amplified-fragment length polymorphism analysis
    M Ip
    Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Clin Microbiol 41:4980-5. 2003
    ..Thus, the predominant MRSA isolates frin the PWH in the last decade are closely related to early United Kingdom eMRSA clones 1, 4, and 11 and are members of a lineage that includes the Brazilian MRSA clone...
  17. ncbi request reprint A Hong Kong family with respiratory illness
    Margaret Ip
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Lancet 362:38. 2003
  18. ncbi request reprint Macrolide resistance and distribution of erm and mef genes among beta-haemolytic streptococci in Hong Kong
    M Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Eur J Clin Microbiol Infect Dis 21:238-40. 2002
  19. ncbi request reprint Patterns of antibiotic resistance, serotype distribution, and patient demographics of Streptococcus pneumoniae in Hong Kong
    M Ip
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Chemotherapy 47:110-6. 2001
    ..0001). A diverse range of serotypes was obtained in the penicillin-susceptible isolates whilst those of reduced susceptibility were confined to serotypes 23F, 19F, 6B, 14 and 9V...
  20. pmc Macrolide resistance in Streptococcus pneumoniae in Hong Kong
    M Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Antimicrob Agents Chemother 45:1578-80. 2001
    ..Extensive spread of clones of drug-resistant pneumococci has led to the widespread presence of macrolide resistance in S. pneumoniae in Hong Kong...
  21. pmc Introduction of new clones of penicillin-nonsusceptible Streptococcus pneumoniae in Hong Kong
    Margaret Ip
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Clin Microbiol 40:1522-5. 2002
    ..001) in 1999 and 2000, were noted to accompany the shift of clones...
  22. ncbi request reprint Airflow and droplet spreading around oxygen masks: a simulation model for infection control research
    Margaret Ip
    Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Am J Infect Control 35:684-9. 2007
    ..Respiratory assist devices, such as oxygen masks, may enhance the potential to spread infectious aerosols from patients with respiratory infections...
  23. doi request reprint Diagnostic utility of CRP to neopterin ratio in patients with acute respiratory tract infections
    Timothy H Rainer
    Accident and Emergency Academic Unit, Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong
    J Infect 58:123-30. 2009
    ....
  24. ncbi request reprint Viral etiology of acute exacerbations of COPD in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong
    Chest 132:900-8. 2007
    ..Viral respiratory infections may precipitate acute exacerbations of COPD (AECOPD). However, little is known about viral etiology related to AECOPD in Asia. We aimed to study the viral etiology of AECOPD in Hong Kong...
  25. pmc Epidemiology and clinical presentations of human coronavirus NL63 infections in hong kong children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Clin Microbiol 47:3486-92. 2009
    ..The majority of local HCoV-NL63 isolates were phylogenetically closely related to those found in Belgium and The Netherlands. In conclusion, HCoV-NL63 is an important yet uncommon virus among our hospitalized children with acute RTIs...
  26. doi request reprint A one-year prospective study of infectious etiology in patients hospitalized with acute exacerbations of COPD and concomitant pneumonia
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Respir Med 102:1109-16. 2008
    ..This study assessed the infectious etiology of patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with concomitant pneumonia...
  27. ncbi request reprint The spectrum of severe acute respiratory syndrome-associated coronavirus infection
    Timothy H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Ann Intern Med 140:614-9. 2004
    ..Objectives: To describe the spectrum of SARS coronavirus infection in a large outbreak and to compare diagnoses based on clinical judgment with the SARS coronavirus test...
  28. pmc Comparative study of nasopharyngeal aspirate and nasal swab specimens for diagnosis of acute viral respiratory infection
    Rita Y T Sung
    Department of Paediatrics, Centre for Epidemiology and Biostatistics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Microbiol 46:3073-6. 2008
    ..The overall sensitivity of viral detection with NPA specimens was higher than that obtained with NS specimens...
  29. doi request reprint Role of 'atypical pathogens' among adult hospitalized patients with community-acquired pneumonia
    Grace Lui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Respirology 14:1098-105. 2009
    ..This study examined the role of these 'atypical pathogens' (AP) among adult hospitalized patients with CAP...
  30. doi request reprint Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase
    Ben C L Chan
    Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Phytomedicine 20:611-4. 2013
    ..In conclusion, the inhibition of MRSA PK by diosmetin could lead to a deficiency of ATP and affect the bacterial efflux pump which might contribute to the antibacterial actions of diosmetin against MRSA...
  31. ncbi request reprint Characterizing 56 complete SARS-CoV S-gene sequences from Hong Kong
    Julian W Tang
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Virol 38:19-26. 2007
    ..The spike glycoprotein (S) gene of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) has been useful in analyzing the molecular epidemiology of the 2003 SARS outbreaks...
  32. pmc Rapid and simultaneous detection of Mycobacterium tuberculosis complex and Beijing/W genotype in sputum by an optimized DNA extraction protocol and a novel multiplex real-time PCR
    Eric T Y Leung
    Department of Microbiology1 and Department of Medicine and Therapeutics, 2 The Chinese University of Hong Kong, Hong Kong, China
    J Clin Microbiol 49:2509-15. 2011
    ..The combined procedure has the potential to compensate for the drawbacks of conventional mycobacterial culture in routine clinical laboratory setting, such as the lengthy incubation period and the limitation to viable organisms...
  33. pmc Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong Kong
    Shin Yan Man
    Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Thorax 62:348-53. 2007
    ..Community-acquired pneumonia (CAP) is a leading infectious cause of death throughout the world, including Hong Kong...
  34. pmc In vitro adsorption of gentamicin and netilmicin by polyacrylonitrile and polyamide hemofiltration filters
    Philip K N Lam
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Antimicrob Agents Chemother 54:963-5. 2010
    ..2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro. Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less...
  35. ncbi request reprint Change in prevalence of group B Streptococcus maternal colonisation in Hong Kong
    Michelle H Y Tsui
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 15:414-9. 2009
    ..To re-examine the prevalence of group B Streptococcus colonisation in our antenatal population, and identify demographic factors associated with carriage...
  36. pmc Severe acute respiratory syndrome-associated coronavirus infection
    Paul K S Chan
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Emerg Infect Dis 9:1453-4. 2003
    ..None of these healthcare workers had antibody to SARS CoV, indicating that subclinical or mild infection attributable to SARS-CoV in adults is rare...
  37. ncbi request reprint Airflows around oxygen masks: A potential source of infection?
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, Peoples Republic of China
    Chest 130:822-6. 2006
    ..An analysis of captured digital images showed that the exhaled air at the peak of simulated exhalation reached a distance of approximately 0.40 m...
  38. ncbi request reprint A longitudinal analysis of methicillin-resistant Staphylococcus aureus in a Hong Kong teaching hospital
    Margaret Ip
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Infect Control Hosp Epidemiol 25:126-9. 2004
    ..To review the incidence and trends of MRSA during a 12-year (1989-2000) period at a university teaching hospital and the relationship between strain distribution by antibiogram and molecular typing...
  39. ncbi request reprint Risk factors associated with life-threatening rickettsial infections
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Am J Trop Med Hyg 78:973-8. 2008
    ..014). Treatment with fluoroquinolone/clarithromycin did not correlate with clinical outcomes (P > 0.05). Early empirical doxycycline therapy should be considered if clinico-epidemiologic signs of rickettsial infections are present...
  40. doi request reprint InfectCheck CRP barcode-style lateral flow assay for semi-quantitative detection of C-reactive protein in distinguishing between bacterial and viral infections
    Wingman Leung
    Department of Chemistry, Biosensors and Bioelectronics Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Immunol Methods 336:30-6. 2008
    ..It is a one-step whole blood rapid test without any sample pre-treatment and the result is available within 20 min. This user friendly diagnostic tool can allow self-testing by interested individuals without any expensive reading device...
  41. doi request reprint Childhood pneumococcal diseases and serotypes: can vaccines protect?
    Kam Lun Hon
    Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, 6 F, Clinical Sciences Building, Shatin, Hong Kong
    Indian J Pediatr 77:1387-91. 2010
    ..To describe pneumococcal diseases in pediatric intensive care unit (PICU) and non-PICU patients...
  42. doi request reprint Role of atypical pathogens in nursing home-acquired pneumonia
    Hon Ming Ma
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, SAR, China
    J Am Med Dir Assoc 14:109-13. 2013
    ..This study aimed to investigate the prevalence and clinical characteristics of AP infections and review the need for empirical antibiotics with atypical coverage in NHAP...
  43. doi request reprint Active surveillance and decolonization of methicillin-resistant Staphylococcus aureus on admission to neonatal intensive care units in Hong Kong: a cost-effectiveness analysis
    Joyce H S You
    Center for Pharmacoeconomics Research, School of Pharmacy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong
    Infect Control Hosp Epidemiol 33:1024-30. 2012
    ....
  44. pmc A cost-effectiveness analysis of "test" versus "treat" patients hospitalized with suspected influenza in Hong Kong
    Joyce H S You
    School of Pharmacy, Faculty of Medicine, Centre for Pharmacoeconomics Research, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    PLoS ONE 7:e33123. 2012
    ..Early antiviral treatment may improve clinical outcomes. We examined potential outcomes and costs of test-guided versus empirical treatment in patients hospitalized for suspected influenza in Hong Kong...
  45. doi request reprint Quick identification of kuraridin, a noncytotoxic anti-MRSA (methicillin-resistant Staphylococcus aureus) agent from Sophora flavescens using high-speed counter-current chromatography
    Ben Chung Lap Chan
    State Key Laboratory of Phytochemistry and Plant Resources in West China CUHK, Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
    J Chromatogr B Analyt Technol Biomed Life Sci 880:157-62. 2012
    ..These data suggested that opening of ring A of the prenylated flavones might decrease the toxicity and remain the anti-MRSA effect, from a viewpoint of structure-activity relationship...
  46. ncbi request reprint Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, NT, Hong Kong, PR China
    J Clin Virol 35:179-84. 2006
    ..The association between a robust or depressed antibody response and clinical severity of SARS remains unknown...
  47. pmc Rapid multiplex nested PCR for detection of respiratory viruses
    W Y Lam
    Department of Microbiology, The Chinese University of Hong Kong, 1 F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Clin Microbiol 45:3631-40. 2007
    ..6%) in the overall positive rate. In conclusion, rapid multiplex nested PCR assays can improve the diagnostic yield for respiratory infections to allow prompt interventive actions to be taken...
  48. pmc Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan
    L Kristopher Siu
    Division of Infectious Diseases, National Health Research Institutes, Taichung, Taiwan
    J Clin Microbiol 49:3761-5. 2011
    ..Serotype K1 K. pneumoniae isolates with capsule expression leading to phagocytic resistance and with the aerobactin gene were associated with hypervirulence...
  49. doi request reprint Risk factors for drug-resistant bacterial pneumonia in older patients hospitalized with pneumonia in a Chinese population
    H M Ma
    Department of Medicine and Therapeutics, 9 F, Clinical Science Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 32 Ngan Shing Street, Shatin, NT, HKSAR
    QJM 106:823-9. 2013
    ..The relationship between healthcare-associated pneumonia (HCAP) and resistant bacteria is unclear. The aim of this study was to identify the risk factors for pneumonia caused by drug-resistant bacteria (DRB)...
  50. ncbi request reprint Combined antibiotic/corticosteroid cream in the empirical treatment of moderate to severe eczema: friend or foe?
    Kam Lun Hon
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Drugs Dermatol 11:861-4. 2012
    ..Eczema is a common atopic disease associated with pruritus, sleep disturbance, and impaired quality of life. Staphylococcus aureus colonization/infection is important in its pathophysiology...
  51. doi request reprint Humoral response to conjugate pneumococcal vaccine in paediatric oncology patients
    Frankie Wai Tsoi Cheng
    Department of Paediatrics, 6 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
    Arch Dis Child 97:358-60. 2012
    ..Pneumococcal conjugate vaccine (PCV) is an effective way to prevent invasive pneumococcal diseases in high risk populations. The efficacy of this vaccine in paediatric oncology patients remains unknown...
  52. doi request reprint A multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 16:532-9. 2011
    ..Antimicrobial resistance is a global problem and the prevalence is high in many Asian countries...
  53. ncbi request reprint A 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong, Peoples Republic of China
    Chest 131:44-52. 2007
    ..Infection is a major cause of acute exacerbations of COPD (AECOPDs). We aimed to study the infectious etiology related to AECOPD...
  54. doi request reprint Antibiotics-impregnated ventricular catheter versus systemic antibiotics for prevention of nosocomial CSF and non-CSF infections: a prospective randomised clinical trial
    George K C Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Neurol Neurosurg Psychiatry 81:1064-7. 2010
    ..This study aims to compare antibiotic impregnated catheters with conventional catheters coupled with systemic antibiotics...
  55. doi request reprint Preventing healthcare workers from acquiring influenza
    Tak Ching Ng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, and the Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong
    Infect Control Hosp Epidemiol 30:292-5. 2009
    ..56) during high-risk procedures, and failure to receive influenza vaccination (odds ratio, 4.82) were independent risk factors, adjusted for household contacts...
  56. ncbi request reprint Transmission of SARS to healthcare workers. The experience of a Hong Kong ICU
    Charles D Gomersall
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Intensive Care Med 32:564-9. 2006
    ..To describe the extent and temporal pattern of transmission of severe acute respiratory syndrome (SARS) to intensive care unit staff...
  57. doi request reprint Influenza-like illness in residential care homes: a study of the incidence, aetiological agents, natural history and health resource utilisation
    D S Hui
    Department of Medicine amd Therapeutics, The Chinese University of Hong Kong, 30 32 Ngan Shing St, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Thorax 63:690-7. 2008
    ..A study was undertaken to examine the incidence, underlying aetiology, natural history and associated healthcare resource utilisation related to ILI in the RCHE population...
  58. doi request reprint Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage
    G K Wong
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Clin Neurosci 15:654-5. 2008
    ..A CSF lactate level of above 4 mmol/L should prompt suspicion of CSF infection in intraventricular haemorrhage patients with an external ventricular drain...
  59. ncbi request reprint Rapid identification of medically important Candida to species level by polymerase chain reaction and single-strand conformational polymorphism
    M Hui
    Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China
    Diagn Microbiol Infect Dis 38:95-9. 2000
    ..This method of PCR-SSCP can provide a simple and specific method for the rapid identification of medically important Candida to species level...
  60. doi request reprint Cost-effectiveness analysis of influenza and pneumococcal vaccination for Hong Kong elderly in long-term care facilities
    J H S You
    Centre for Pharmacoeconomics Research, School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    J Epidemiol Community Health 63:906-11. 2009
    ..To compare cost and quality-adjusted life-years (QALYs) gained by influenza vaccination with or without pneumococcal vaccination in the elderly living in long-term care facilities (LTCFs)...
  61. ncbi request reprint Presence of human herpesviruses 6, 7, and 8 DNA sequences in normal brain tissue
    P K Chan
    Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    J Med Virol 59:491-5. 1999
    ..The results provide molecular evidence of the presence of the three newly identified herpesviruses in brain tissue. The pathogenic role for HHV-7 and HHV-8, as with HHV-6, in neurological diseases should not be overlooked...
  62. ncbi request reprint Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with moderate-to-severe atopic dermatitis
    K L E Hon
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Ann Acad Med Singapore 34:602-5. 2005
    ..Staphylococcus aureus colonisation/infection is common in children with atopic dermatitis (AD)...
  63. ncbi request reprint Features discriminating SARS from other severe viral respiratory tract infections
    T H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Rooms 107 113, 1st Floor, Shatin, NT, Hong Kong
    Eur J Clin Microbiol Infect Dis 26:121-9. 2007
    ..9-96.9). Certain clinical manifestations and laboratory changes may help to distinguish SARS from other influenza-like illnesses. Scoring systems may help identify patients who should receive more specific tests for influenza or SARS...
  64. ncbi request reprint Atopic dermatitis complicated by methicillin-resistant Staphylococcus aureus infection
    Kam Lun Ellis Hon
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    J Natl Med Assoc 100:797-800. 2008
    ..All specimens of MRSA had in-vitro sensitivity to vancomycin, with corresponding clinical correlates of disappearance of the erythema and fishy odor...
  65. pmc Adsorption of amikacin, a significant mechanism of elimination by hemofiltration
    Qi Tian
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Antimicrob Agents Chemother 52:1009-13. 2008
    ..Close monitoring of peak amikacin levels should be considered for patients receiving CVVH with PAN hemofilters...
  66. ncbi request reprint Role of laboratory variables in differentiating SARS-coronavirus from other causes of community-acquired pneumonia within the first 72 h of hospitalization
    N Lee
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Eur J Clin Microbiol Infect Dis 25:765-72. 2006
    ....
  67. doi request reprint Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase
    Ben C L Chan
    Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Ethnopharmacol 137:767-73. 2011
    ..The aim of the present study was to further investigate antibacterial activities of baicalein in association with various antibiotics against selected Staphylococcus aureus strains with known specific drug resistance mechanisms...
  68. ncbi request reprint Biases in human papillomavirus genotype prevalence assessment associated with commonly used consensus primers
    Paul K S Chan
    Department of Microbiology, School of Public Health, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Int J Cancer 118:243-5. 2006
    ..Biases in HPV type-specific sensitivity may result in misprioritization of vaccine candidates...
  69. ncbi request reprint The impact of ventricular catheter impregnated with antimicrobial agents on infections in patients with ventricular catheter: interim report
    George K C Wong
    Division of Neurosurgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Acta Neurochir Suppl 102:53-5. 2008
    ..Theoretically, these catheters provide antibiotic prophylaxis locally without the associated complications of systemic opportunistic infection...
  70. doi request reprint Successful treatment of multiple subdural empyemata caused by Mycoplasma hominis in a newborn
    Josephine S C Chong
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Neonatology 95:179-82. 2009
    ..This report illustrates the clinical presentation of this unusual infection and the crucial role of neurosurgical intervention and specific antimicrobial therapy for its successful management...
  71. pmc Megapneumonia Coinfection: pneumococcus, Mycoplasma pneumoniae, and Metapneumovirus
    Kam Lun Hon
    Department of Paediatrics, The Chinese University of Hong Kong, 6 F Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
    Case Report Med 2012:310104. 2012
    ..Also, the new policy in Hong Kong to use PCV13 may help prevent further cases of serotype 19A infections...
  72. ncbi request reprint Cryptococcosis in apparently immunocompetent patients
    G Lui
    Division of Infectious Diseases, Department of Medicine and Therapeutics, 9 F Clinical Sciences Building, Prince of Wales Hospital, Hong Kong
    QJM 99:143-51. 2006
    ..Few reports have described the clinical and microbiological features of cryptococcosis in immunocompetent patients...