David S-C Hui

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. doi request reprint Adjunctive therapies and immunomodulatory agents in the management of severe influenza
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Antiviral Res 98:410-6. 2013
  2. pmc Exhaled air dispersion during coughing with and without wearing a surgical or N95 mask
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, The People s Republic of China
    PLoS ONE 7:e50845. 2012
  3. pmc A prospective cohort study of the long-term effects of CPAP on carotid artery intima-media thickness in obstructive sleep apnea syndrome
    David S Hui
    SH Ho Sleep Apnea Management Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong, China
    Respir Res 13:22. 2012
  4. pmc The unmasking of Pneumocystis jiroveci pneumonia during reversal of immunosuppression: case reports and literature review
    Alan K L Wu
    Division of Infectious Diseases, Centre of Infection, Queen Mary Hospital, The University of Hong Kong Hong Kong Special Administrative Region, China
    BMC Infect Dis 4:57. 2004
  5. doi request reprint Severe acute respiratory syndrome and coronavirus
    David S C Hui
    Division of Respiratory Medicine, Stanley Ho Center for Emerging Infectious Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Infect Dis Clin North Am 24:619-38. 2010
  6. pmc Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors
    D S Hui
    Center for Emerging Infectious Diseases, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Thorax 60:401-9. 2005
  7. ncbi request reprint The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors
    David S Hui
    Center for Emerging Infectious Diseases, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong
    Chest 128:2247-61. 2005
  8. ncbi request reprint An overview on severe acute respiratory syndrome (SARS)
    D S C Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Monaldi Arch Chest Dis 63:149-57. 2005
  9. pmc Nasal CPAP reduces systemic blood pressure in patients with obstructive sleep apnoea and mild sleepiness
    D S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Thorax 61:1083-90. 2006
  10. ncbi request reprint Noninvasive positive-pressure ventilation: An experimental model to assess air and particle dispersion
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong
    Chest 130:730-40. 2006

Detail Information

Publications76

  1. doi request reprint Adjunctive therapies and immunomodulatory agents in the management of severe influenza
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Antiviral Res 98:410-6. 2013
    ..g., secondary infections) and mortality in H1N1pdm09 influenza. This article forms part of a symposium in Antiviral Research on "Treatment of influenza: targeting the virus or the host."..
  2. pmc Exhaled air dispersion during coughing with and without wearing a surgical or N95 mask
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, The People s Republic of China
    PLoS ONE 7:e50845. 2012
    ..We compared the expelled air dispersion distances during coughing from a human patient simulator (HPS) lying at 45° with and without wearing a surgical mask or N95 mask in a negative pressure isolation room...
  3. pmc A prospective cohort study of the long-term effects of CPAP on carotid artery intima-media thickness in obstructive sleep apnea syndrome
    David S Hui
    SH Ho Sleep Apnea Management Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong, China
    Respir Res 13:22. 2012
    ..To examine the long-term effect of CPAP on carotid artery intima-media thickness (IMT) in patients with Obstructive sleep apnea syndrome(OSAS)...
  4. pmc The unmasking of Pneumocystis jiroveci pneumonia during reversal of immunosuppression: case reports and literature review
    Alan K L Wu
    Division of Infectious Diseases, Centre of Infection, Queen Mary Hospital, The University of Hong Kong Hong Kong Special Administrative Region, China
    BMC Infect Dis 4:57. 2004
    ....
  5. doi request reprint Severe acute respiratory syndrome and coronavirus
    David S C Hui
    Division of Respiratory Medicine, Stanley Ho Center for Emerging Infectious Diseases, Prince of Wales Hospital, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Infect Dis Clin North Am 24:619-38. 2010
    ..Horseshoe bats are implicated in the emergence of novel coronavirus infection in humans. Further studies are needed to examine host genetic markers that may predict clinical outcome...
  6. pmc Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors
    D S Hui
    Center for Emerging Infectious Diseases, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Thorax 60:401-9. 2005
    ..To examine the impact of severe acute respiratory syndrome (SARS) on pulmonary function, exercise capacity, and health-related quality of life (HRQoL) among survivors...
  7. ncbi request reprint The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors
    David S Hui
    Center for Emerging Infectious Diseases, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong
    Chest 128:2247-61. 2005
    ..To examine pulmonary function, exercise capacity, and health-related quality of life (HRQoL) among severe acute respiratory syndrome (SARS) survivors...
  8. ncbi request reprint An overview on severe acute respiratory syndrome (SARS)
    D S C Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Monaldi Arch Chest Dis 63:149-57. 2005
    ..Rapid diagnosis, early isolation, and good infection control measures are important in preventing spread of the infection...
  9. pmc Nasal CPAP reduces systemic blood pressure in patients with obstructive sleep apnoea and mild sleepiness
    D S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Thorax 61:1083-90. 2006
    ..A randomised controlled study was undertaken to examine the effect of nasal continuous positive airway pressure (CPAP) on 24 hour systemic blood pressure (BP) in patients with obstructive sleep apnoea (OSA)...
  10. ncbi request reprint Noninvasive positive-pressure ventilation: An experimental model to assess air and particle dispersion
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong
    Chest 130:730-40. 2006
    ..We studied exhaled air and particle dispersion through an oronasal mask attached to a human-patient simulator (HPS) during noninvasive positive-pressure ventilation (NPPV)...
  11. ncbi request reprint Sleep-disordered breathing and continuous positive airway pressure compliance in a group of commercial bus drivers in Hong Kong
    David S C Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Respirology 11:723-30. 2006
    ..Sleep-disordered breathing may predispose drivers to road traffic accidents. However, CPAP acceptance and compliance among commercial bus drivers is unknown...
  12. ncbi request reprint Exhaled air dispersion during oxygen delivery via a simple oxygen mask
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong, People s Republic of China
    Chest 132:540-6. 2007
    ..We studied the dispersion of exhaled air through a simple oxygen mask applied to a human patient simulator (HPS) during the delivery of different oxygen flow in a room free of air currents...
  13. doi request reprint Influenza-like illness in residential care homes: a study of the incidence, aetiological agents, natural history and health resource utilisation
    D S Hui
    Department of Medicine amd Therapeutics, The Chinese University of Hong Kong, 30 32 Ngan Shing St, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Thorax 63:690-7. 2008
    ..A study was undertaken to examine the incidence, underlying aetiology, natural history and associated healthcare resource utilisation related to ILI in the RCHE population...
  14. doi request reprint Review of clinical symptoms and spectrum in humans with influenza A/H5N1 infection
    David S C Hui
    Division of Respiratory Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Respirology 13:S10-3. 2008
    ....
  15. doi request reprint Exhaled air dispersion and removal is influenced by isolation room size and ventilation settings during oxygen delivery via nasal cannula
    David S Hui
    Stanley Ho Center for Emerging Infectious Diseases, Department Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 16:1005-13. 2011
    ..We compared the exhaled air dispersion distances during oxygen delivery via nasal cannula to a human-patient simulator (HPS) in two different isolation rooms...
  16. doi request reprint Clinical features, pathogenesis and immunobiology of severe acute respiratory syndrome
    David S Hui
    Division of Respiratory Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Curr Opin Pulm Med 14:241-7. 2008
    ..A better understanding of these issues may help prevent and control future outbreaks of severe acute respiratory syndrome...
  17. doi request reprint Exhaled air and aerosolized droplet dispersion during application of a jet nebulizer
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, NT, Hong Kong
    Chest 135:648-54. 2009
    ....
  18. doi request reprint A multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 16:532-9. 2011
    ..Antimicrobial resistance is a global problem and the prevalence is high in many Asian countries...
  19. doi request reprint Exhaled air dispersion distances during noninvasive ventilation via different Respironics face masks
    David S Hui
    David S Hui, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, People s Republic of China
    Chest 136:998-1005. 2009
    ....
  20. doi request reprint Clinical management of pandemic 2009 influenza A(H1N1) infection
    David S Hui
    Division of Respiratory Medicine, The Chinese University of Hong Kong, 9 F, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong
    Chest 137:916-25. 2010
    ..Nonpharmacologic measures, such as early case isolation, household quarantine, school/workplace closure, good community hygiene, and restrictions on travel are useful measures in controlling an influenza pandemic at its early phase...
  21. doi request reprint Influenza A/H5N1 infection: other treatment options and issues
    David S C Hui
    Division of Respiratory Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Respirology 13:S22-6. 2008
    ..Non-pharmacological measures such as early case isolation, household quarantine, school/workplace closure, good community hygiene and restrictions on travel are useful measures in controlling a pandemic...
  22. ncbi request reprint Prevalence of sleep-disordered breathing and continuous positive airway pressure compliance: results in chinese patients with first-ever ischemic stroke
    David S C Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Chest 122:852-60. 2002
    ..To assess the prevalence of sleep-disordered breathing (SDB), continuous positive airway pressure (CPAP) acceptance, and CPAP compliance in patients who have experienced ischemic stroke...
  23. pmc Severe acute respiratory syndrome (SARS): epidemiology and clinical features
    D S C Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Postgrad Med J 80:373-81. 2004
    ..Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%-80% in the first week of the illness...
  24. ncbi request reprint Prevalence of snoring and sleep-disordered breathing in a group of commercial bus drivers in Hong Kong
    D S C Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories
    Intern Med J 32:149-57. 2002
    ..To assess the prevalence of sleep-disordered breathing (SDB) and its associated symptoms in a group of commercial bus drivers in Hong Kong...
  25. ncbi request reprint Cephalometric assessment of craniofacial morphology in Chinese patients with obstructive sleep apnoea
    D S C Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Respir Med 97:640-6. 2003
    ..To compare the differences in craniofacial morphology in Chinese patients with and without obstructive sleep apnoea (OSA)...
  26. ncbi request reprint Determinants of continuous positive airway pressure compliance in a group of Chinese patients with obstructive sleep apnea
    D S Hui
    Department of Medicine and Therapeutics, Centre for Clinical Trials and Epidemiological Research, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Chest 120:170-6. 2001
    ..To assess continuous positive airway pressure (CPAP) compliance and factors associated with CPAP compliance among Chinese patients with obstructive sleep apnea (OSA)...
  27. ncbi request reprint The effects of nasal continuous positive airway pressure on platelet activation in obstructive sleep apnea syndrome
    David S Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Chest 125:1768-75. 2004
    ..A case-controlled study to assess the effects of nasal continuous positive airway pressure (CPAP) on platelet activation in patients with obstructive sleep apnea (OSAS) syndrome...
  28. ncbi request reprint Effects of augmented continuous positive airway pressure education and support on compliance and outcome in a Chinese population
    D S Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Chest 117:1410-6. 2000
    ..To study the effects of augmentation of continuous positive airway pressure (CPAP) education and support on compliance and outcome in patients with obstructive sleep apnea (OSA)...
  29. ncbi request reprint SARS: clinical features and diagnosis
    David Shu Cheong Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Respirology 8:S20-4. 2003
    ....
  30. ncbi request reprint Prevalence of snoring and sleep-disordered breathing in a student population
    D S Hui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Chest 116:1530-6. 1999
    ..We aim to determine the symptoms and prevalence of SDB in a university student population using a questionnaire survey followed by home sleep monitoring...
  31. ncbi request reprint ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome
    Rossa W K Chiu
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin
    Clin Chem 50:1683-6. 2004
  32. doi request reprint A one-year prospective study of infectious etiology in patients hospitalized with acute exacerbations of COPD and concomitant pneumonia
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Respir Med 102:1109-16. 2008
    ..This study assessed the infectious etiology of patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with concomitant pneumonia...
  33. ncbi request reprint Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: preliminary experience
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 228:810-5. 2003
    ..To report the initial experience regarding thin-section computed tomographic (CT) findings in patients with severe acute respiratory syndrome (SARS) who improved clinically after treatment...
  34. ncbi request reprint Viral etiology of acute exacerbations of COPD in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong
    Chest 132:900-8. 2007
    ..Viral respiratory infections may precipitate acute exacerbations of COPD (AECOPD). However, little is known about viral etiology related to AECOPD in Asia. We aimed to study the viral etiology of AECOPD in Hong Kong...
  35. ncbi request reprint Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period
    Ka Tak Wong
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong, China
    J Comput Assist Tomogr 28:790-5. 2004
    ..To evaluate thin-section computed tomography findings of patients with severe acute respiratory syndrome (SARS) in the convalescent period and to correlate the results with clinical parameters and lung function tests...
  36. ncbi request reprint Sputum bacteriology in patients with acute exacerbations of COPD in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Ngan Shing Street, Shatin, New Territories, Hong Kong
    Respir Med 99:454-60. 2005
    ..To study the demographics and sputum microbiology of patients admitted to a teaching hospital with acute exacerbations of chronic obstructive pulmonary disease (AECOPD)...
  37. ncbi request reprint Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
    Margaret Ip
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Diagn Microbiol Infect Dis 59:131-6. 2007
    ..857, whereas (CRP x PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI...
  38. pmc Human metapneumovirus detection in patients with severe acute respiratory syndrome
    Paul K S Chan
    Faculty of Medicine of the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Emerg Infect Dis 9:1058-63. 2003
    ..These widely available HEp-2 cells should be included in conjunction with a molecular method for cell culture followup to detect HMPV, particularly in patients with SARS...
  39. ncbi request reprint Imaging of severe acute respiratory syndrome in Hong Kong
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong, Republic of China
    AJR Am J Roentgenol 181:11-7. 2003
  40. ncbi request reprint Are exhaled breath condensates useful in monitoring asthma?
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Curr Allergy Asthma Rep 7:65-71. 2007
    ..More studies are needed before this technique can be recommended for clinical use...
  41. doi request reprint Outdoor air pollution: impact on chronic obstructive pulmonary disease patients
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong, PRC
    Curr Opin Pulm Med 15:150-7. 2009
    ..Recent publications (2007-2008) on the effects of outdoor air pollutants specifically on COPD patients are reviewed in this article...
  42. pmc Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Int J Chron Obstruct Pulmon Dis 4:79-86. 2009
    ..Assessment of airway inflammation in the clinical course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) may advance our understanding of the pathogenesis and treatment...
  43. doi request reprint Asthma Control Test correlates well with the treatment decisions made by asthma specialists
    Fanny W S Ko
    Department of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 14:559-66. 2009
    ....
  44. pmc Acute encephalopathy associated with influenza A infection in adults
    Nelson Lee
    Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 9 F Clinical Sciences Building, Department of Medicine and Therapeutics, Shatin, Hong Kong, People s Republic of China
    Emerg Infect Dis 16:139-42. 2010
    ..Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis...
  45. doi request reprint Predicting changes in clinical status of young asthmatics: clinical scores or objective parameters?
    Ting F Leung
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pediatr Pulmonol 44:442-9. 2009
    ..203, P = 0.042). In conclusion, C-ACT is better than DSS and objective parameters in reflecting changes in asthma status and predicting asthma exacerbations in young children...
  46. pmc Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
    K C Allen Chan
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 5:26. 2005
    ..Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requirement of intensive care in SARS patients...
  47. ncbi request reprint Factors associated with early hospital discharge of adult influenza patients
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Antivir Ther 12:501-8. 2007
    ..Understanding factors affecting length of hospital stay (LOS) in patients with severe influenza may improve their management...
  48. ncbi request reprint Prevalence of allergic rhinitis and its associated morbidity in adults with asthma: a multicentre study
    Fanny W S Ko
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Hong Kong Med J 16:354-61. 2010
    ..To assess the prevalence of allergic rhinitis in adult patients with asthma in Hong Kong, and to compare the morbidity endured by asthma patients with and without allergic rhinitis...
  49. ncbi request reprint SARS: clinical presentation, transmission, pathogenesis and treatment options
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Clin Sci (Lond) 110:193-204. 2006
    ..Although SARS led to more than 700 deaths worldwide, the lessons learnt have prepared healthcare systems worldwide to face future emerging and re-emerging infections...
  50. ncbi request reprint 12-year change in prevalence of respiratory symptoms in elderly Chinese living in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Respir Med 100:1598-607. 2006
    ..7% in 1991 and 7.7% in 2003). The prevalence of respiratory symptoms has increased over the past 12 years and this may be related to environmental factors especially increasing air pollution in Hong Kong...
  51. ncbi request reprint Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Respir Med 100:630-8. 2006
    ..8-isoprostane level, but not GROalpha and MCP-1, in EBC was increased in COPD patients with poorer lung function. This suggests an increased oxidative stress in the airway in patients with more severe COPD...
  52. pmc Laboratory diagnosis of SARS
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:825-31. 2004
    ..Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity...
  53. ncbi request reprint A community model of group therapy for the older patients with chronic obstructive pulmonary disease: a pilot study
    Jean Woo
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Eval Clin Pract 12:523-31. 2006
    ..A community-based programme for chronic obstructive pulmonary disease (COPD) patients in group sessions is designed, and the feasibility, acceptability and physical and psychosocial outcomes evaluated...
  54. ncbi request reprint Early results of endoscopic lung volume reduction for emphysema
    Anthony P C Yim
    Division of Cardiothoracic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Thorac Cardiovasc Surg 127:1564-73. 2004
    ..We determined the feasibility, safety, and short-term efficacy of bronchoscopic placement of a one-way endobronchial valve in selected bronchopulmonary segments as an alternative to surgical lung volume reduction...
  55. ncbi request reprint A 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong, Peoples Republic of China
    Chest 131:44-52. 2007
    ..Infection is a major cause of acute exacerbations of COPD (AECOPDs). We aimed to study the infectious etiology related to AECOPD...
  56. ncbi request reprint Long-term outcome of acute respiratory distress syndrome caused by severe acute respiratory syndrome (SARS): an observational study
    Thomas St Li
    Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Crit Care Resusc 8:302-8. 2006
    ..We examined long-term outcome of pulmonary function, exercise capacity and health-related quality of life (HRQoL) in patients with acute respiratory distress syndrome (ARDS) caused by severe acute respiratory syndrome (SARS)...
  57. pmc Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong
    Fanny W S Ko
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Thorax 62:780-5. 2007
    ..To assess any relationship between the levels of ambient air pollutants and hospital admissions for chronic obstructive pulmonary disease (COPD) in Hong Kong...
  58. doi request reprint Allele-specific conventional reverse-transcription polymerase chain reaction as a screening assay for discriminating influenza a H1N1 (H275Y) oseltamivir-resistant and wild-type viruses
    Karry L K Ngai
    Faculty of Medicine, Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administration Region, China
    J Med Virol 82:1295-8. 2010
    ..Further improvement in performance is expected when applied to cell culture isolates with a higher viral titer. These allele-specific cRT-PCR assays can be a simple, low-cost option for large-scale screening of influenza isolates...
  59. doi request reprint Viral loads and duration of viral shedding in adult patients hospitalized with influenza
    Nelson Lee
    Department of Medicine and Therapeutics, Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Infect Dis 200:492-500. 2009
    ..The goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza...
  60. doi request reprint Validation of Embletta portable diagnostic system for identifying patients with suspected obstructive sleep apnoea syndrome (OSAS)
    Susanna S S Ng
    Division of Respiratory Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, HK, China
    Respirology 15:336-42. 2010
    ..The simple device may be useful for screening and diagnostic purpose when access to PSG is limited...
  61. ncbi request reprint Advancements in the battle against severe acute respiratory syndrome
    David S C Hui
    Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Expert Opin Pharmacother 5:1687-93. 2004
    ..This paper provides a review of the epidemiology, clinical features and possible treatment strategies of SARS...
  62. doi request reprint Role of 'atypical pathogens' among adult hospitalized patients with community-acquired pneumonia
    Grace Lui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Respirology 14:1098-105. 2009
    ..This study examined the role of these 'atypical pathogens' (AP) among adult hospitalized patients with CAP...
  63. ncbi request reprint Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy
    Michael H M Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Pathology 38:229-35. 2006
    ....
  64. ncbi request reprint Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma
    Samantha W M Lun
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Immunol 27:430-7. 2007
    ..05). In conclusion, the aberrant expression of CD26 may contribute to the inflammatory process and Th2 predominance in the immunopathogenesis of allergic asthma...
  65. ncbi request reprint Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease
    K T Wong
    Department of Diagnostic Radiology, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 228:395-400. 2003
    ..To retrospectively analyze the thin-section computed tomographic (CT) features in patients with severe acute respiratory syndrome (SARS) at the authors' institution...
  66. ncbi request reprint Chest radiograph scores as potential prognostic indicators in severe acute respiratory syndrome (SARS)
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    AJR Am J Roentgenol 184:734-41. 2005
    ..We sought to establish the earliest radiographic scores sensitive as potential prognostic indicators of fatal outcomes...
  67. ncbi request reprint Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma
    Samantha W M Lun
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    J Clin Immunol 26:145-52. 2006
    ..05). In conclusion, plasma RANTES may be a surrogate marker for asthma and the diminished Th1 related CXC chemokine production may contribute to Th2 predominance in asthma...
  68. ncbi request reprint Prevalence of sleep disturbances in Chinese patients with end stage renal failure on maintenance hemodialysis
    David S C Hui
    Department of Medicine and Therapeutics, Division of Respiratory Medicine, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Med Sci Monit 8:CR331-6. 2002
    ..Sleep disorders, such as daytime sleepiness, insomnia, restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) have been reported as prevalent among patients with end stage renal failure(ESRF)...
  69. ncbi request reprint Airflow and droplet spreading around oxygen masks: a simulation model for infection control research
    Margaret Ip
    Centre for Emerging Infectious Diseases, School of Public Health, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Am J Infect Control 35:684-9. 2007
    ..Respiratory assist devices, such as oxygen masks, may enhance the potential to spread infectious aerosols from patients with respiratory infections...
  70. doi request reprint Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma
    Samantha W M Lun
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Immunol 29:330-42. 2009
    ..05). Therefore, the decreased activation of TLR4 and TLR5 in asthmatic patients might contribute to the immunopathological mechanisms of asthma by reducing the release of Th1 and anti-inflammatory cytokines...
  71. doi request reprint Development and comparison of molecular assays for the rapid detection of the pandemic influenza A (H1N1) 2009 virus
    Wai Yip Lam
    Faculty of Medicine, Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Med Virol 82:675-83. 2010
    ..The newly developed cRT-PCR assay targeting the HA gene allows rapid, specific, and sensitive screening of this novel agent, which can serve as an alternative for laboratories where a real-time PCR machine is not available...
  72. ncbi request reprint Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction
    Jeffrey W H Fung
    Division of Cardiology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Chest 121:422-9. 2002
    ..Therefore, we have assessed the prevalence of diastolic dysfunction in patients with OSA and the relationship between diastolic parameters and severity of OSA...
  73. ncbi request reprint A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome
    Herman Mun Cheung Lau
    Department of Physiotherapy, The Prince of Wales Hospital, Shatin, Hong Kong, China
    Aust J Physiother 51:213-9. 2005
    ..However, health-related quality of life was not affected by physical training...
  74. ncbi request reprint Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome
    Nelson Leung Sang Tang
    Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin
    Clin Chem 51:2333-40. 2005
    ..Previous studies on chemokines have included only small numbers of patients, and the utility of plasma chemokines as prognostic indicators is unclear...
  75. ncbi request reprint The impact of severe acute respiratory syndrome on the physical profile and quality of life
    Herman Mun Cheung Lau
    Physiotherapy Department, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, P R China
    Arch Phys Med Rehabil 86:1134-40. 2005
    ..To investigate the impact of severe acute respiratory syndrome (SARS) on the physical fitness and health-related quality of life (HRQOL) among SARS survivors...
  76. ncbi request reprint Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
    Nelson Leung Sang Tang
    Nat Genet 39:691-2; author reply 694-6. 2007