Yibin Feng


Affiliation: The University of Hong Kong
Country: China


  1. Feng Y, Siu K, Wang N, Ng K, Tsao S, Nagamatsu T, et al. Bear bile: dilemma of traditional medicinal use and animal protection. J Ethnobiol Ethnomed. 2009;5:2 pubmed publisher
    ..We then discussed the strategy for stopping the trading of bear bile and issues of bear bile related to potential alternative candidates, existing problems in alternative research and work to be done in the future...
  2. Qu Y, Dou B, Tan H, Feng Y, Wang N, Wang D. Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment. Mol Cancer. 2019;18:69 pubmed publisher
  3. Wang N, Tan H, Feng Y, Zhang C, Chen F, Feng Y. microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance. Cancers (Basel). 2018;11: pubmed publisher
    ..Several transcriptional and epigenetic factors may contribute to the dysregulation of miR-23a in cancer. This evidence highlights the essential role of miR-23a in the application of cancer diagnosis, prognosis, and treatment. ..
  4. Zhang C, Wang N, Xu Y, Tan H, Li S, Feng Y. Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study. Int J Mol Sci. 2018;19: pubmed publisher
    ..Furthermore, hepatic metabolic dysregulation may be the predominant pathological mechanism involved in TCM-induced hepatotoxic impairment. ..
  5. request reprint
    Feng Y, Luo W, Zhu S. [Explore new clinical application of Huanglian and corresponding compound prescriptions from their traditional use]. Zhongguo Zhong Yao Za Zhi. 2008;33:1221-5 pubmed
    ..Part of the effects has been proved by experimental research and it is worth carrying out more research in this area for development and clinical application. ..
  6. Li S, Wang N, Hong M, Tan H, Pan G, Feng Y. Hepatoprotective Effects of a Functional Formula of Three Chinese Medicinal Herbs: Experimental Evidence and Network Pharmacology-Based Identification of Mechanism of Action and Potential Bioactive Components. Molecules. 2018;23: pubmed publisher
  7. Wang X, Xiang L, Li H, Chen P, Feng Y, Zhang J, et al. The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review. Int J Mol Sci. 2015;16:22527-40 pubmed publisher
    ..HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study. ..
  8. Wang L, Wang N, Tan H, Zhang Y, Feng Y. Protective effect of a Chinese Medicine formula He-Ying-Qing-Re Formula on diabetic retinopathy. J Ethnopharmacol. 2015;169:295-304 pubmed publisher
    ..HF exhibits protective effect against diabetic retinopathy, which may be associated with inhibition on AGEs and recovery on endothelial dysfunction via modulation of tight junction and AGEs downstream signaling. ..
  9. Wang N, Feng Y, Tan H, Cheung F, Hong M, Lao L, et al. Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma. J Ethnopharmacol. 2015;164:309-18 pubmed publisher
    ..In nutrient deprived HCC cells with inactivated eEF2, the inhibitory effect of HLJDD in tumor cell expansion was interfered. Our results indicate that HLJDD has potential in blocking HCC progression with involvement of eEF2 inhibition. ..

More Information


  1. Tsang C, Cheung K, Cheung Y, Man K, Lui V, Tsao S, et al. Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. Biochim Biophys Acta. 2015;1852:541-51 pubmed publisher
    ..Lastly, berberine's anti-proliferative and anti-invasive activities could be partially rescued by Id-1 overexpression in HCC models, revealing a novel anti-cancer/anti-invasive mechanism of berberine via Id-1 suppression. ..
  2. Wang N, Feng Y, Cheung F, Wang X, Zhang Z, Feng Y. A Chinese medicine formula Gegen Qinlian decoction suppresses expansion of human renal carcinoma with inhibition of matrix metalloproteinase-2. Integr Cancer Ther. 2015;14:75-85 pubmed publisher
    ..The findings of this study provide experimental evidence of the inhibition of expansion and neoangiogenesis of renal carcinoma by Chinese medicine formula GQLD with involvement of MMP-2 suppression. ..
  3. Wang N, Tan H, Li L, Yuen M, Feng Y. Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives. J Ethnopharmacol. 2015;176:35-48 pubmed publisher
    ..Although more evidences on its specificity and clinical efficacy are necessary to support its clinical use, Coptidis Rhizoma and berberine are highly expected to be effective, safe and affordable treatments for cancer patients. ..
  4. Feng Y, Cheung K, Wang N, Liu P, Nagamatsu T, Tong Y. Chinese medicines as a resource for liver fibrosis treatment. Chin Med. 2009;4:16 pubmed publisher
    ..Further experiments and clinical trials should be carried out on the platforms that conform to international standards. ..
  5. Tan H, Wang N, Takahashi M, Feng Y, Li H, Feng Y. New Natural Pigment Fraction Isolated from Saw Palmetto: Potential for Adjuvant Therapy of Hepatocellular Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
    ..NYG suppressed tumor expansion of HCC via inhibiting neovascularization, and may be potential adjuvant treatment for HCC. ..
  6. Wang X, Wang N, Li H, Liu M, Cao F, Yu X, et al. Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. Int J Mol Sci. 2016;17:577 pubmed publisher
    ..In conclusion, our findings identified for the first time that inactivation of uPA receptor by up-regulation of PAI-1 and down-regulation of uPA is involved in the inhibitory effect of berberine on HCC cell invasion and migration. ..
  7. Lan J, Wang N, Huang L, Liu Y, Ma X, Lou H, et al. Design and synthesis of novel tetrandrine derivatives as potential anti-tumor agents against human hepatocellular carcinoma. Eur J Med Chem. 2017;127:554-566 pubmed publisher
    ..Our results suggest that compound 31, a new 14-position substituted amide tetrandrine derivative, might be a potential candidate for developing novel anti-HCC drugs in the coming future. ..
  8. Hong M, Wang N, Tan H, Tsao S, Feng Y. MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy. Cancers (Basel). 2015;7:1643-57 pubmed publisher
  9. Wang N, Wang X, Tan H, Li S, Tsang C, Tsao S, et al. Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells. Int J Mol Sci. 2016;17: pubmed
    ..Our results shed light on berberine's potential as an anti-tumor agent for clinical cancer therapy. ..
  10. Hong M, Tan H, Li S, Cheung F, Wang N, Nagamatsu T, et al. Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds. Int J Mol Sci. 2016;17: pubmed publisher
    ..However, further studies are needed to clarify the potential of clinical application of CMs and their active compounds as complementary and alternative therapy in this field. ..
  11. Hong M, Li S, Tan H, Wang N, Tsao S, Feng Y. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. Int J Mol Sci. 2015;16:28705-45 pubmed publisher
  12. Zhang C, Xu Y, Tan H, Li S, Wang N, Zhang Y, et al. Neuroprotective effect of He-Ying-Qing-Re formula on retinal ganglion cell in diabetic retinopathy. J Ethnopharmacol. 2018;214:179-189 pubmed publisher
    ..HF administration was a valid therapeutic approach for DR treatment, oriented at the blockade of endoplasmic reticulum- and mitochondria-dependent oxidative stress-induced retinal neurodegeneration including RGC apoptosis. ..
  13. Tan H, Wang N, Lam W, Guo W, Feng Y, Cheng Y. Targeting tumour microenvironment by tyrosine kinase inhibitor. Mol Cancer. 2018;17:43 pubmed publisher
    ..At last, the combination use of current TKIs with immunotherapy in the perspectives of efficacy and safety are discussed. ..
  14. Li H, Wang X, Liu Y, Pan D, Wang Y, Yang N, et al. Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: Context of the paradoxical effect. Food Chem Toxicol. 2017;108:407-418 pubmed publisher
    ..In conclusion, Heshouwu exhibited both hepatoprotection and hepatotoxicity. It is essential to evaluate the advantages and disadvantages when Heshouwu is in clinical use. ..
  15. Lam P, Cheung F, Tan H, Wang N, Yuen M, Feng Y. Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities. Int J Mol Sci. 2016;17:465 pubmed publisher
    ..This review aims to provide new insight into how Chinese medicinal herbs work in therapeutic strategies for liver diseases. ..
  16. Feng Y, Siu K, Ye X, Wang N, Yuen M, Leung C, et al. Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med. 2010;5:33 pubmed publisher
    ..Berberine should have potential for developing a new drug to treat liver toxicity. ..
  17. Wang N, Feng Y, Cheung F, Chow O, Wang X, Su W, et al. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats. BMC Complement Altern Med. 2012;12:239 pubmed publisher
  18. Tsang C, Cheung Y, Lui V, Yip Y, Zhang G, Lin V, et al. Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. BMC Cancer. 2013;13:619 pubmed publisher
    ..The effective inhibition of STAT3 activation in NPC cells by berberine supports its potential use in the treatment of NPC. ..
  19. Hong M, Li S, Wang N, Tan H, Cheung F, Feng Y. A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets. Int J Mol Sci. 2017;18: pubmed publisher
  20. Hong M, Li S, Tan H, Cheung F, Wang N, Huang J, et al. A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines. Molecules. 2017;22: pubmed publisher
    ..Based on the theoretical predictions, further experimental verification should be performed to validate the accuracy of the predicted interactions between herbal ingredients and protein targets in the future. ..
  21. Hong M, Zhang Y, Li S, Tan H, Wang N, Mu S, et al. A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae. Molecules. 2017;22: pubmed publisher
    ..The network pharmacology strategy used provides a forceful tool for searching the action mechanism of traditional herbal medicines and novel bioactive ingredients. ..
  22. Wang N, Zhu M, Tsao S, Man K, Zhang Z, Feng Y. MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. Mol Cancer. 2013;12:119 pubmed publisher
    ..Up-regulation of p53 induces mir-23a expression, while suppression of p53 inhibits miR-23a in HCC cells. Our study sheds light on the role of miR-23a as a potential target in regulating chemosensitivity of HCC cells. ..
  23. Wang N, Feng Y, Zhu M, Siu F, Ng K, Che C. A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma. Biochim Biophys Acta. 2013;1833:2890-2899 pubmed publisher
    ..Timosaponin AIII induces HCC cell apoptosis through a p53-independent mechanism involving XIAP degradation through autophagy-lysosomal pathway. The possibility of developing TAIII as a new anti-tumor agent is worth considering. ..
  24. Li S, Tan H, Wang N, Zhang Z, Lao L, Wong C, et al. The Role of Oxidative Stress and Antioxidants in Liver Diseases. Int J Mol Sci. 2015;16:26087-124 pubmed publisher
    ..Various factors that cause oxidative stress in liver and effects of antioxidants in the prevention and treatment of liver diseases were summarized, questioned, and discussed. ..
  25. Feng Y, Wang N, Ye X, Li H, Feng Y, Cheung F, et al. Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats. J Ethnopharmacol. 2011;138:683-90 pubmed publisher
    ..CRAE showed protective effect against CCl(4)-induced chronic liver damage in rats and its potential as an agent in the treatment of chronic liver diseases by protecting hepatocyte from injury. ..