Sheung-Tat Fan

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization
    Barbara H Chik
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    Arch Surg 142:63-9; discussion 69. 2007
  2. pmc Gene expression profiling of liver cancer stem cells by RNA-sequencing
    David W Y Ho
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 7:e37159. 2012
  3. pmc Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines
    Xiao Qi Wang
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 8:e72435. 2013
  4. ncbi request reprint Technical note on complete excision of choledochal cysts
    Tan To Cheung
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 12:218-21. 2013
  5. doi request reprint Hepatocellular carcinoma--resection or transplant?
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong
    Nat Rev Gastroenterol Hepatol 9:732-7. 2012
  6. ncbi request reprint The impact of family history of hepatocellular carcinoma on its patients' survival
    Wing Chiu Dai
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 11:160-4. 2012
  7. pmc Biliary complications in liver transplantation
    See Ching Chan
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    Hepatol Int 2:399-404. 2008
  8. pmc Liver transplantation for acute-on-chronic liver failure
    Albert C Chan
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China
    Hepatol Int 3:571-81. 2009
  9. doi request reprint Outcome after partial hepatectomy for hepatocellular cancer within the Milan criteria
    S T Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, 102 Pok Fu Lam Road, Hong Kong, China
    Br J Surg 98:1292-300. 2011
  10. ncbi request reprint Live donor liver transplantation in adults
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Transplantation 82:723-32. 2006

Collaborators

Detail Information

Publications176 found, 100 shown here

  1. ncbi request reprint Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization
    Barbara H Chik
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    Arch Surg 142:63-9; discussion 69. 2007
    ..The present study evaluated the factors associated with increased operative risks in patients who underwent extended right-sided hepatic resection for HCC...
  2. pmc Gene expression profiling of liver cancer stem cells by RNA-sequencing
    David W Y Ho
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 7:e37159. 2012
    ....
  3. pmc Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines
    Xiao Qi Wang
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    PLoS ONE 8:e72435. 2013
    ..These results underscore the restoration of pluripotency circuits in cancer cells as a potential mechanism for cancer progression. ..
  4. ncbi request reprint Technical note on complete excision of choledochal cysts
    Tan To Cheung
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 12:218-21. 2013
    ..However, incomplete excision of choledochal cysts may also cause problems...
  5. doi request reprint Hepatocellular carcinoma--resection or transplant?
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pok Fu Lam Road, Hong Kong
    Nat Rev Gastroenterol Hepatol 9:732-7. 2012
    ..Currently, resection and transplantation are considered complementary in the management of HCC. Expanding the transplantation and resection criteria of HCC needs to be investigated...
  6. ncbi request reprint The impact of family history of hepatocellular carcinoma on its patients' survival
    Wing Chiu Dai
    Department of Surgery, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 11:160-4. 2012
    ..Family history of hepatocellular carcinoma (HCC) has been identified as a risk factor for the development of the disease. The aim of this study is to evaluate the impact of such a history on HCC patients' survival...
  7. pmc Biliary complications in liver transplantation
    See Ching Chan
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    Hepatol Int 2:399-404. 2008
    ..Contingent measures of percutaneous transhepatic dilatation and stenting, and revision hepaticojejunostomy have to be exercised with utmost care to avoid hepatic artery injury which may results in graft loss...
  8. pmc Liver transplantation for acute-on-chronic liver failure
    Albert C Chan
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China
    Hepatol Int 3:571-81. 2009
    ..To evaluate the outcome of liver transplantation for acute-on-chronic liver failure...
  9. doi request reprint Outcome after partial hepatectomy for hepatocellular cancer within the Milan criteria
    S T Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, 102 Pok Fu Lam Road, Hong Kong, China
    Br J Surg 98:1292-300. 2011
    ..This study aimed to evaluate the outcome of such patients following partial hepatectomy as primary treatment...
  10. ncbi request reprint Live donor liver transplantation in adults
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Transplantation 82:723-32. 2006
    ..The outcome of LDLT is equivalent to deceased donor liver transplantation despite a smaller graft size and higher technical complexity...
  11. doi request reprint Liver functional reserve estimation: state of the art and relevance for local treatments: the Eastern perspective
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    J Hepatobiliary Pancreat Sci 17:380-4. 2010
    ..Yet, ICGR-15 values can differentiate patients with or without hospital mortality. The cutoff values of ICGR-15 for a safe major and minor hepatectomy are 14 and 22%, respectively...
  12. ncbi request reprint Caudal shifting of hepatic vein anastomosis in right liver living donor liver transplantation
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 7:654-7. 2008
    ..There may be situations that the portal vein is short or the right liver graft is small, leading to difficulty in portal vein, hepatic artery or duct-to-duct anastomosis...
  13. doi request reprint Continuous improvement of survival outcomes of resection of hepatocellular carcinoma: a 20-year experience
    Sheung Tat Fan
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong
    Ann Surg 253:745-58. 2011
    ..To investigate the trend of the posthepatectomy survival outcomes of hepatocellular carcinoma (HCC) patients by analysis of a prospective cohort of 1198 patients over a 20-year period...
  14. doi request reprint Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective study
    Sheung Tat Fan
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 254:569-76. 2011
    ..To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy...
  15. doi request reprint Follow-up of Chinese liver transplant recipients in Hong Kong
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Liver Transpl 15:544-50. 2009
    ..For non-HCC patients, however, the 5-year survival rate of 66.3% was comparable to that of recent reports from the Western world...
  16. ncbi request reprint Absent middle hepatic vein in a right liver graft donor
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Hepatobiliary Pancreat Dis Int 7:430-2. 2008
    ..An anomaly in form of two separate trunks, each draining segment V/VIII and segment IV, has been described by Couinaud but not been well documented in the literature...
  17. ncbi request reprint Commentary on living donor liver transplantation with reduced monosegments for neonates and small infants
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Transplantation 83:1299-300. 2007
  18. ncbi request reprint Precise hepatectomy guided by the middle hepatic vein
    Sheung Tat Fan
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 6:430-4. 2007
    ..Such technique has the potential of achieving adequate tumor-free resection margin, avoiding damage to intrahepatic portal pedicles, preserving venous drainage and functional liver tissue, and less postoperative infection...
  19. doi request reprint Changes in liver histology as a "surrogate" end point of antiviral therapy for chronic HBV can predict progression to liver complications
    Chee Kin Hui
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    J Clin Gastroenterol 42:533-8. 2008
    ..Improvement in modified HAI after antiviral therapy has usually been defined as a 2-point reduction in modified HAI score...
  20. ncbi request reprint Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin
    Chung Mau Lo
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:557-63. 2004
    ..With combination of adefovir and high-dose HBIG, however, long-term survival can be achieved after retransplantation...
  21. ncbi request reprint Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure
    Chi Leung Liu
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Transplantation 76:1174-9. 2003
    ..This study evaluates the survival outcomes of patients who underwent LDLT using right-lobe liver grafts for acute-on-chronic hepatitis B liver failure...
  22. ncbi request reprint Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence
    Xin Yi
    Department of Surgery, Peking University People s Hospital, Beijing, China
    Mol Cell Proteomics 7:315-25. 2008
    ..Mortalin (HSPA9) is associated with HCC metastasis and thus suggested as a tumor marker for predicting early recurrence, which may have immediate clinical applications for cancer surveillance after curative surgery...
  23. ncbi request reprint Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma
    Kelvin K Ng
    Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    J Gastrointest Surg 12:183-91. 2008
    ..There is no data on the analysis of recurrence pattern and its influence on long-term survival outcome after RFA in HCC patients...
  24. ncbi request reprint The role and limitation of living donor liver transplantation for hepatocellular carcinoma
    Chung Mau Lo
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:440-7. 2004
    ..14 to 0.90; P =.029). In conclusion, although complicated factors such as donor voluntarism and selection criteria limit the role of LDLT for HCC, LDLT allows more patients to undergo early transplantation and results in a better outcome...
  25. doi request reprint Risk factors and prognostic factors of local recurrence after radiofrequency ablation of hepatocellular carcinoma
    Vincent Wai To Lam
    Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China Cancer Institute, New South Wales, Australia
    J Am Coll Surg 207:20-9. 2008
    ..Local recurrence rates after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 2% to 36% in the literature. Limited data were available about the prognostic significance of local recurrence...
  26. ncbi request reprint Impact of preoperative fine-needle aspiration cytologic examination on clinical outcome in patients with hepatocellular carcinoma in a tertiary referral center
    Kelvin Kwok Chai Ng
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Arch Surg 139:193-200. 2004
    ..Preoperative fine-needle aspiration cytologic examination (FNAC) exerts a statistically significant adverse effect on long-term clinical outcome in patients with hepatocellular carcinoma (HCC)...
  27. pmc Abdominal drainage after hepatic resection is contraindicated in patients with chronic liver diseases
    Chi Leung Liu
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 239:194-201. 2004
    ..The aim of this study was to determine whether abdominal drainage is beneficial after elective hepatic resection in patients with underlying chronic liver diseases...
  28. ncbi request reprint Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis
    Yi Ren
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong Medical Centre, Hong Kong SAR, China
    Clin Cancer Res 9:5996-6001. 2003
    ..In this study, we measured the serum interleukin-8 (IL-8) levels in patients with hepatocellular carcinoma (HCC) to evaluate its correlation with clinicopathological features and prognosis...
  29. ncbi request reprint Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 9:5339-45. 2003
    ..This study evaluated whether TF expression correlates with microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, tumor invasiveness, and prognosis in human HCC...
  30. ncbi request reprint Hepatic resection for bilobar hepatocellular carcinoma: is it justified?
    Chi Leung Liu
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Arch Surg 138:100-4. 2003
    ..The aim of the present study was to evaluate the operative outcome and survival benefits of hepatic resection for patients with bilobar HCC...
  31. ncbi request reprint Value of live donor liver transplantation experience in major hepatectomy for hepatocellular carcinoma
    See Ching Chan
    Department of Surgery, The University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, People s Republic of China
    Arch Surg 138:265-71. 2003
    ..Live donor liver transplantation (LDLT) mandates conversance in liver anatomy and major hepatectomy. Hepatocellular carcinoma is most reliably treated by hepatectomy...
  32. ncbi request reprint Radiofrequency ablation for subcapsular hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and the Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg Oncol 11:281-9. 2004
    ..Limited data from recent studies suggested an increased risk of bleeding complications, needle-track seeding, and local recurrence after radiofrequency ablation (RFA) of subcapsular hepatocellular carcinoma (HCC)...
  33. ncbi request reprint Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation
    Xian Liang Li
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Transplantation 76:44-9. 2003
    ..However, organ preservation aims to decrease the metabolic rate. The objective of this study was to clarify the effect of insulin used in University of Wisconsin (UW) preservation solution on the liver graft...
  34. ncbi request reprint Disruption of p53-p21/WAF1 cell cycle pathway contributes to progression and worse clinical outcome of hepatocellular carcinoma
    Terence Kin Wah Lee
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, PR China
    Oncol Rep 12:25-31. 2004
    ..001, r=0.776) and apoptosis (p=0.003, r=0.639). Our findings suggest that disruption of p53-p21/WAF1 cell cycle pathways contributes to tumor progression and worse clinical outcome of HCC...
  35. ncbi request reprint Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver
    Joanna W Ho
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    World J Gastroenterol 11:176-81. 2005
    ....
  36. ncbi request reprint Heme oxygenase-1 potentiates the survival of small-for-size liver graft
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Hong Kong, China
    Liver Transpl 10:784-93. 2004
    ..These findings support the beneficial effects of HO-1 on allograft survival. In conclusion, the ability of small-for-size grafts in the induction of HO-1 expression might facilitate their own survival in liver transplantation...
  37. ncbi request reprint Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma
    Yi Ren
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Hong Kong SAR, China
    Int J Cancer 107:22-9. 2003
    ..A more detailed understanding of the MIF regulatory mechanisms involved may provide insight into new direction in the treatment of HCC...
  38. ncbi request reprint Safety and outcome of hepatitis B core antibody-positive donors in right-lobe living donor liver transplantation
    Chung Mau Lo
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Hong Kong, China
    Liver Transpl 9:827-32. 2003
    ..All donors had completely normal liver function at a median follow-up of 31 months (range, 21 to 76 months). A positive serological test result for anti-HBc should not be regarded as a contraindication for right-lobe liver donation...
  39. ncbi request reprint Hepatic resection for combined hepatocellular and cholangiocarcinoma
    Chi Leung Liu
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong
    Arch Surg 138:86-90. 2003
    ..The clinical significance of this disease entity is poorly understood. The aim of the present study was to determine the operative and survival outcomes of patients with HCC-CC who underwent hepatic resection...
  40. ncbi request reprint Significance of HBV DNA levels in liver histology of HBeAg and Anti-HBe positive patients with chronic hepatitis B
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Am J Gastroenterol 99:2032-7. 2004
    ..To determine the relationship between hepatitis B virus (HBV) DNA levels and total histologic activity index (HAI), necroinflammation (HAI-NI), and fibrosis (HAI-F) scores...
  41. pmc Determinants of hospital mortality of adult recipients of right lobe live donor liver transplantation
    Sheung Tat Fan
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Ann Surg 238:864-69; discussion 869-70. 2003
    ..To define the technical factors that might contribute to hospital mortality of recipients of right lobe live donor liver transplantation (LDLT) so as to perfect the design of the operation...
  42. ncbi request reprint High serum levels of vascular endothelial growth factor predict poor response to transarterial chemoembolization in hepatocellular carcinoma: a prospective study
    Ronnie Tung Ping Poon
    Department of Surgery, Queen Mary Hospital, Hong Kong, China
    Oncol Rep 11:1077-84. 2004
    ..In conclusion, the results of this study suggest that serum VEGF level may be useful as a novel prognostic predictor of tumor response and survival of patients with inoperable HCC undergoing TACE treatment...
  43. ncbi request reprint Pseudo pseudocyst after right lobe live donor liver transplantation
    Chi Leung Liu
    Centre for the Study of Liver Disease, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:571-2. 2004
  44. ncbi request reprint Thermal ablative therapy for malignant liver tumors: a critical appraisal
    Kelvin Kwok Chai Ng
    Departments of Surgery, Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    J Gastroenterol Hepatol 18:616-29. 2003
    ..As each of the loco-regional therapies has its own advantages and limitations, a multidisciplinary approach using a combination of therapies will be the future trend for the management of malignant liver tumors...
  45. ncbi request reprint Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B
    Chee Kin Hui
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    J Hepatol 47:191-202. 2007
    ..We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts...
  46. ncbi request reprint Safety of duct-to-duct biliary reconstruction in right-lobe live-donor liver transplantation without biliary drainage
    Chi Leung Liu
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Transplantation 77:726-32. 2004
    ..The aim of the present study was to evaluate the safety and operative outcomes of duct-to-duct biliary reconstruction after RLDLT without biliary drainage...
  47. doi request reprint Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection
    Ivan F N Hung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 103:1663-73. 2008
    ..To identify the risk factors for recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after resection...
  48. ncbi request reprint HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing
    Tai On Yau
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Oncogene 24:1607-14. 2005
    ..To conclude, downregulation of HDPR1 is common in HCCs, frequently involves hypermethylation of the promoter region, and allelic loss of the HDPR1 locus may also play a role...
  49. ncbi request reprint Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values
    John M Luk
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Hong Kong SAR, P R China
    Proteomics 6:1049-57. 2006
    ....
  50. ncbi request reprint rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats
    Tung Yu Tsui
    Center for the Study of Liver Disease, University of Hong Kong, Pokfulam, Hong Kong, China
    Hepatology 42:335-42. 2005
    ..With this approach, the severity of established micronodular cirrhosis was markedly reduced. In conclusion, these findings suggest a new approach for the treatment of liver fibrosis using adeno-associated virus-mediated gene transfer...
  51. ncbi request reprint Determination of the molecular relationship between multiple tumour nodules in hepatocellular carcinoma differentiates multicentric origin from intrahepatic metastasis
    Irene Oi Lin Ng
    Department of Pathology, The University of Hong Kong, Faculty of Medicine, Queen Mary Hospital, Hong Kong
    J Pathol 199:345-53. 2003
    ..Of these molecular methods, LOH analysis can be used to evaluate tumour clonality in most patients even before surgical resection, since this assay can be readily applied routinely to either liver biopsies or fine needle aspirates...
  52. ncbi request reprint Artificial neural networks and decision tree model analysis of liver cancer proteomes
    John M Luk
    Department of Surgery and Center for Cancer Research, Faculty of Medicine Building, 9 F, 21 Sassoon Road, University of Hong Kong, Pokfulam, Hong Kong
    Biochem Biophys Res Commun 361:68-73. 2007
    ..The 2-DE-based proteomic profiling approach combined with the ANN or CART algorithm yielded satisfactory performance on identifying HCC and revealed potential candidate cancer biomarkers...
  53. ncbi request reprint Distinct intragraft response pattern in relation to graft size in liver transplantation
    Ting Bo Liang
    Centre for the Study of Liver Disease, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Transplantation 75:673-8. 2003
    ..The molecular mechanism of small-for-size graft injury remains unclear. The aim of this study is to investigate the gene expression pattern of acute phase response in relation to graft size in a rat-liver transplantation model...
  54. ncbi request reprint Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property
    Kwong Fai Wong
    Department of Surgery, University of Hong Kong, Jockey Club Clinical Research Center, Pokfulam, Hong Kong
    Clin Exp Pharmacol Physiol 35:55-9. 2008
    ....
  55. ncbi request reprint Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations
    Man Fung Yuen
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR, China
    J Hepatol 39:850-5. 2003
    ..To study the outcome and the virologic profiles of severe hepatitis exacerbations due to YMDD mutants in lamivudine-treated patients...
  56. ncbi request reprint Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats
    Tung Yu Tsui
    Department of Surgery, Center for the Study of Liver Disease, The University of Hong Kong, Pokfulam, Hong Kong
    World J Gastroenterol 12:2016-23. 2006
    ....
  57. pmc Biliary reconstruction and complications of right lobe live donor liver transplantation
    Sheung Tat Fan
    Centre for the Study of Liver Disease, Department of Surgery and Diagnostic Radiology, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 236:676-83. 2002
    ..To identify the possible reasons of failure of biliary reconstruction in right lobe live donor liver transplantation (LDLT) and to devise the best method of reconstruction and treatment strategy for the complications...
  58. doi request reprint Safety and efficacy of radiofrequency ablation for periductal hepatocellular carcinoma with intraductal cooling of the central bile duct
    Vincent Wai To Lam
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    J Am Coll Surg 207:e1-5. 2008
  59. ncbi request reprint Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 63:3121-6. 2003
    ..This study provides strong evidence that supports the use of serum VEGF level as an indirect estimate of tumor VEGF expression...
  60. pmc Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation
    Sheung Tat Fan
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Ann Surg 238:137-48. 2003
    ..To evaluate the safety of donors who have donated the middle hepatic vein in right lobe live donor liver transplantation (LDLT) and to determine whether such inclusion is necessary for optimum graft function...
  61. ncbi request reprint Hepatic stress gene expression and ultrastructural features under intermittent Pringle manoeuvre
    Kwan Man
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 1:249-57. 2002
    ..The aim of the study is to investigate the expression of stress genes and ultrastructural change of the liver under intermittent Pringle manoeuvre...
  62. pmc Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches
    Ronnie Tung Ping Poon
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Ann Surg 238:9-28. 2003
    ..To review the current data on the prognostic and therapeutic implications of tumor angiogenesis in gastrointestinal cancers...
  63. ncbi request reprint Effectiveness of radiofrequency ablation for hepatocellular carcinomas larger than 3 cm in diameter
    Ronnie T P Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong, People s Republic of China
    Arch Surg 139:281-7. 2004
    ..Radiofrequency ablation is a safe and effective treatment for hepatocellular carcinomas 3.1 to 8.0 cm in diameter...
  64. ncbi request reprint Recombinant adeno-associated virus vector: Is it ideal for gene delivery in liver transplantation?
    Zhen Fan Yang
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    Liver Transpl 9:411-20. 2003
    ..Anti-hCTLA4Ig antibodies could be detected in long-term surviving animals, but the extent of humoral response was not severe. This study shows that rAAV can be an effective and safe vector for gene delivery in liver transplantation...
  65. ncbi request reprint Does diabetes mellitus influence the perioperative outcome or long term prognosis after resection of hepatocellular carcinoma?
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    Am J Gastroenterol 97:1480-8. 2002
    ..This study aims to evaluate whether diabetes mellitus has a significant influence on the perioperative outcome or long term prognosis after resection of hepatocellular carcinoma (HCC)...
  66. ncbi request reprint Oncoproteomics of hepatocellular carcinoma: from cancer markers' discovery to functional pathways
    Stella Sun
    Department of Surgery, LKS Faculty of Medicine, Jockey Club Clinical Research Center, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Int 27:1021-38. 2007
    ..The present article reviews the latest proteomic development and discovery of biomarkers in HCC that may provide insights into the underlying mechanisms of hepatocarcinogenesis and the readiness of biomarkers for clinical uses...
  67. ncbi request reprint Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway
    Terence Kin Wah Lee
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Carcinogenesis 24:1729-36. 2003
    ..In conclusion, the results provided an insight for the understanding of the role of Id-1 in functional inactivation of p16INK4a in HCC...
  68. ncbi request reprint Portal hyperperfusion injury as the cause of primary nonfunction in a small-for-size liver graft-successful treatment with splenic artery ligation
    Chung Mau Lo
    Department of Surgery, and Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Hong Kong
    Liver Transpl 9:626-8. 2003
    ..Splenic artery ligation is a technically simple procedure that can be applied for the prevention or treatment of such injury...
  69. ncbi request reprint Sustained disease remission after spontaneous HBeAg seroconversion is associated with reduction in fibrosis progression in chronic hepatitis B Chinese patients
    Chee Kin Hui
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region SAR, China
    Hepatology 46:690-8. 2007
    ..00 to -0.70 fibrosis units/year, versus median 0.51 fibrosis units/year, range 0 to +2.03 fibrosis units/year, P = 0.02)...
  70. ncbi request reprint Hepatic venoplasty in living-donor liver transplantation using right lobe graft with middle hepatic vein
    Chung Mau Lo
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Transplantation 75:358-60. 2003
    ..This hepatic venoplasty technique can be applied systemically as a standard one in right lobe liver graft with the middle hepatic vein to simplify the recipient hepatectomy and to obviate venous outflow obstruction...
  71. ncbi request reprint Internal hernia of the small bowel after right-lobe live donor liver transplantation
    Chi Leung Liu
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Clin Transplant 18:211-3. 2004
    ..The complication can be avoided with duct-to-duct biliary reconstruction or meticulous closure of all mesenteric defects with non-absorbable suture materials after hepaticojejunostomy in patients undergoing right-lobe LDLT...
  72. ncbi request reprint Evaluation of the new AJCC/UICC staging system for hepatocellular carcinoma after hepatic resection in Chinese patients
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Surg Oncol Clin N Am 12:35-50, viii. 2003
    ..This article evaluates the prognostic value of the new AJCC/UICC TNM staging and the new Japanese staging in a large cohort of Chinese patients who underwent hepatectomy for HCC in a single institution...
  73. ncbi request reprint Live donor liver transplantation for fulminant hepatic failure in children
    Chi Leung Liu
    Centre for the Study of Liver Disease, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Liver Transpl 9:1185-90. 2003
    ..051; patient survival, 89%; P =.281). Although survival outcomes are inferior to those in elective situations, LDLT is a timely and lifesaving procedure for children with FHF...
  74. ncbi request reprint De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report
    See Ching Chan
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:320-3. 2004
    ..The patient underwent successful right hepatectomy of the tumor that proved to be sarcoma. The patient is doing well without recurrence 1.5 years after resection and 5 years post transplant...
  75. ncbi request reprint Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation
    See Ching Chan
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 12:259-63. 2006
    ..In conclusion, donor right hepatectomy including the middle hepatic vein is biologically acceptable to the live donor...
  76. ncbi request reprint Tailoring donor hepatectomy per segment 4 venous drainage in right lobe live donor liver transplantation
    See Ching Chan
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 10:755-62. 2004
    ..In conclusion, unfavorable venous drainage patterns were one of the independent factors compromising postoperative donor liver function, but was circumvented by preservation of V4b...
  77. ncbi request reprint Clinicopathological significance of loss of heterozygosity on chromosome 13q in hepatocellular carcinoma
    Chun Ming Wong
    Departments of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Clin Cancer Res 8:2266-72. 2002
    ..Previous genome-wide studies have indicated that chromosome 13q is one of the most frequently affected chromosomes. However, reports on detailed deletion mapping as well as detailed clinicopathological correlation are scanty...
  78. doi request reprint Simplifying hepatic venous outflow reconstruction in sequential living donor liver transplantation
    See Ching Chan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Liver Transpl 15:1514-8. 2009
    ..Satisfactory venous outflow is reliably achieved because this is the most direct outflow tract...
  79. ncbi request reprint Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor
    Siu Tim Cheung
    Department of Surgery, Centre for the Study of Liver Disease, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Cancer Res 62:4711-21. 2002
    ..These metastasis-associated genes may provide clues to reveal patients with increased risk of developing metastasis, and to identify novel therapeutic targets for the treatment of metastasis...
  80. ncbi request reprint Effect of side and size of graft on surgical outcomes of adult-to-adult live donor liver transplantation
    See Ching Chan
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Liver Transpl 13:91-8. 2007
    ..However, despite similar GW/ESLV, the more arduous recovery and higher mortality rate of left liver recipients raise the caution of assuming the gram-to-gram equivalence of right and left liver grafts...
  81. pmc Lessons learned from one hundred right lobe living donor liver transplants
    Chung Mau Lo
    Centre for the Study of Liver Disease, and Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 240:151-8. 2004
    ..To evaluate the first 100 adult right lobe living donor liver transplants (LDLT) in a single center to determine whether the results have improved with technical modifications and better experience...
  82. ncbi request reprint Assessment of hepatic reserve for indication of hepatic resection: how I do it
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Hepatobiliary Pancreat Surg 12:31-7. 2005
    ....
  83. doi request reprint Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: implications for salvage liver transplant
    Kelvin K Ng
    FRCS Glasg, FRCS Edin, FACS, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong
    Arch Surg 143:68-74; discussion 74. 2008
    ..There is no difference in the survival benefit between salvage liver transplant and nontransplant therapies for recurrent hepatocellular carcinoma (HCC)...
  84. doi request reprint A decade of right liver adult-to-adult living donor liver transplantation: the recipient mid-term outcomes
    See Ching Chan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Ann Surg 248:411-9. 2008
    ..We analyzed a single center's experience over a decade of right liver living donor liver transplantation (RLDLT)...
  85. ncbi request reprint High frequency of chimerism in transplanted livers
    Irene Oi Lin Ng
    Department of Pathology, Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Hepatology 38:989-98. 2003
    ..However, with regard to recipient-derived hepatocytes, our data cannot distinguish between transdifferentiation and cell fusion...
  86. ncbi request reprint Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation
    John M Luk
    Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong
    Liver Int 27:879-90. 2007
    ..In this article, we discuss the laboratory findings and clinical trial studies of Chinese herbal medicines (particularly small molecule compounds) for the treatment of liver disease ranging from fibrosis to liver cancer...
  87. ncbi request reprint Methods and related drawbacks in the estimation of surgical risks in cirrhotic patients undergoing hepatectomy
    Sheung Tat Fan
    Department of Surgery, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Hepatogastroenterology 49:17-20. 2002
    ..In conclusion, preoperative risk assessment involves evaluation of hepatic function reserve, remnant liver volume, liver status, age and the medical condition of the patient. A 0% hospital mortality rate is considered the objective...
  88. ncbi request reprint Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma
    John M Luk
    Department of Surgery, The University of Hong Kong, Pokfulam
    Proteomics 5:1980-6. 2005
    ....
  89. ncbi request reprint Anterior approach for major right hepatic resection
    Sheung Tat Fan
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Hepatobiliary Pancreat Surg 12:356-61. 2005
    ..The anterior approach provides a "no-touch" technique in resecting large right-lobe tumors, reduces bleeding volume, decreases the chance of iatrogenic rupture of tumors, and probably prolongs survival...
  90. ncbi request reprint What is the best technique for right hemiliver living donor liver transplantation? With or without the middle hepatic vein? Duct-to-duct biliary anastomosis or Roux-en-Y hepaticojejunostomy?
    Chi Leung Liu
    Department of Surgery, Centre for the Study of Liver Disease, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong, China
    J Hepatol 43:17-22. 2005
  91. pmc Difference in tumor invasiveness in cirrhotic patients with hepatocellular carcinoma fulfilling the Milan criteria treated by resection and transplantation: impact on long-term survival
    Ronnie T P Poon
    Centre for the Study of Liver Disease and Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 245:51-8. 2007
    ..This study compared the tumor characteristics of patients with HCC within the Milan criteria treated by resection or transplantation, and elucidated their impact on long-term survival...
  92. pmc Prognosis after hepatic resection for stage IVA hepatocellular carcinoma: a need for reclassification
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Ann Surg 237:376-83. 2003
    ....
  93. doi request reprint Paired donor interchange to avoid ABO-incompatible living donor liver transplantation
    See Ching Chan
    Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Liver Transpl 16:478-81. 2010
    ..Approaches adopted in anticipation of potential adverse outcomes are explained in view of the higher donor and recipient mortality and morbidity rates in comparison with kidney transplantation...
  94. ncbi request reprint Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter
    Ronnie Tung Ping Poon
    Centre for the Study of Liver Disease and the Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China
    J Am Coll Surg 194:592-602. 2002
    ..The role of hepatic resection for large hepatocellular carcinoma (HCC) larger than 10 cm remains unclear...
  95. ncbi request reprint Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma
    Siu Tim Cheung
    Centre for the Study of Liver Disease and Departments of Surgery and Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 10:7629-36. 2004
    ..The aim of this study was to investigate the clinical significance of GEP expression and its potential as a therapeutic target in HCC...
  96. doi request reprint The significance of acute phase small-for-size graft injury on tumor growth and invasiveness after liver transplantation
    Kwan Man
    Departments of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 247:1049-57. 2008
    ..To test the hypothesis that acute phase small-for-size graft injury may promote late phase tumor recurrence after liver transplantation...
  97. doi request reprint Flowmetry-based portal inflow manipulation for a small-for-size liver graft in a recipient with spontaneous splenorenal shunt
    See Ching Chan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
    Clin Transplant 24:410-4. 2010
    ..Despite an SFSG, the graft was underperfused. This was recognized by flowmetry and was rectified by ligation of the splenorenal shunt...
  98. doi request reprint Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening
    Albert C Y Chan
    Department of Surgery, University of Hong Kong Medical Centre, Hong Kong, China
    Ann Surg 247:666-73. 2008
    ..To evaluate the impact of improved surgical management of hepatocellular carcinoma (HCC) on the survival of patients with screened HCC...
  99. pmc Improving perioperative outcome expands the role of hepatectomy in management of benign and malignant hepatobiliary diseases: analysis of 1222 consecutive patients from a prospective database
    Ronnie T Poon
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 240:698-708; discussion 708-10. 2004
    ..To assess the trends in perioperative outcome of hepatectomy for hepatobiliary diseases...