Billy K C Chow

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. ncbi Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption
    Jessica Y S Chu
    Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Cell Biol 27:2499-511. 2007
  2. ncbi Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP)
    Ian P Y Lam
    School of Biological Sciences, The Univerity of Hong Kong, Pokfulam Rd, Hong Kong
    Am J Physiol Gastrointest Liver Physiol 297:G90-7. 2009
  3. ncbi An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    FASEB J 24:5024-32. 2010
  4. ncbi Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates
    Leo T O Lee
    Department of Zoology, University of Hong Kong, Pokfulam Road, Hong Kong, China
    Proc Natl Acad Sci U S A 104:2133-8. 2007
  5. ncbi Agnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified forms
    Stephanie Y L Ng
    School of Biological Sciences, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    PLoS ONE 7:e44691. 2012
  6. ncbi Secretin as a neurohypophysial factor regulating body water homeostasis
    Jessica Y S Chu
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 106:15961-6. 2009
  7. ncbi Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells
    Ian P Y Lam
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PRC
    Ann N Y Acad Sci 1070:371-5. 2006
  8. ncbi The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 7:e39913. 2012
  9. ncbi Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin
    Janice K V Tam
    School of Biological Sciences, Research Centre of Heart, Brain, Hormone and Healthy Ageing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 6:e19384. 2011
  10. ncbi Identification and characterization of a glucagon receptor from the goldfish Carassius auratus: implications for the evolution of the ligand specificity of glucagon receptors in vertebrates
    Billy K C Chow
    Department of Zoology, University of Hong Kong, Hong Kong
    Endocrinology 145:3273-88. 2004

Collaborators

Detail Information

Publications43

  1. ncbi Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption
    Jessica Y S Chu
    Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Mol Cell Biol 27:2499-511. 2007
    ..Future investigations in this direction should be important in developing therapeutic means for treating NDI patients...
  2. ncbi Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP)
    Ian P Y Lam
    School of Biological Sciences, The Univerity of Hong Kong, Pokfulam Rd, Hong Kong
    Am J Physiol Gastrointest Liver Physiol 297:G90-7. 2009
    ..Because secretin is a key hormone that stimulates bile flow in cholangiocytes, this pathway thus provides a novel means to modulate secretin-stimulated choleresis in response to intraduodenal bile acids...
  3. ncbi An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    FASEB J 24:5024-32. 2010
    ..In summary, our findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body...
  4. ncbi Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates
    Leo T O Lee
    Department of Zoology, University of Hong Kong, Pokfulam Road, Hong Kong, China
    Proc Natl Acad Sci U S A 104:2133-8. 2007
    ..These GHRHs, also found in flounder, Fugu, medaka, stickleback, Tetraodon, and rainbow trout, provide research directions regarding the neuroendocrine control of growth in vertebrates...
  5. ncbi Agnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified forms
    Stephanie Y L Ng
    School of Biological Sciences, The University of Hong Kong, Hong Kong, Special Administrative Region, China
    PLoS ONE 7:e44691. 2012
    ..We also propose VIP and PACAP's first functions to predominate in the brain, evolving alongside the central nervous system, subsequently establishing peripheral functions...
  6. ncbi Secretin as a neurohypophysial factor regulating body water homeostasis
    Jessica Y S Chu
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 106:15961-6. 2009
    ..Findings presented here challenge previous understanding regarding the neurohypophysis and could provide new concepts in treating disorders related to osmoregulation...
  7. ncbi Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells
    Ian P Y Lam
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PRC
    Ann N Y Acad Sci 1070:371-5. 2006
    ..These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene...
  8. ncbi The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 7:e39913. 2012
    ....
  9. ncbi Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin
    Janice K V Tam
    School of Biological Sciences, Research Centre of Heart, Brain, Hormone and Healthy Ageing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    PLoS ONE 6:e19384. 2011
    ..We therefore hypothesize that secretin and orexin are of different ancestral origins early in the vertebrate lineage...
  10. ncbi Identification and characterization of a glucagon receptor from the goldfish Carassius auratus: implications for the evolution of the ligand specificity of glucagon receptors in vertebrates
    Billy K C Chow
    Department of Zoology, University of Hong Kong, Hong Kong
    Endocrinology 145:3273-88. 2004
    ..Our results demonstrate that the binding pocket of gfGlucR can accommodate a broad range of glucagon structures and that in the frogs and mammals, there is a structural switch to a more restrictive conformation of glucagon receptors...
  11. ncbi Secretin and body fluid homeostasis
    Jessica Y S Chu
    School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Kidney Int 79:280-7. 2011
    ....
  12. ncbi Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
    Fang Yu
    Brain Tumour Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Neurooncol 103:187-95. 2011
    ..Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas...
  13. ncbi Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene
    Ruby L C Hoo
    School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong, China
    FEBS J 274:2695-706. 2007
    ..Taken together, these data demonstrate the differential roles of NF-kappaB p65 and RARalpha/RXRalpha, interacting with the same sequence in the promoter of the human GnRH II gene to influence gene expression in a cell-specific manner...
  14. ncbi Functional identification of an intronic promoter of the human glucose-dependent insulinotropic polypeptide gene
    Ruby L C Hoo
    School of Biological Sciences, The University of Hong Kong, Hong Kong SAR, PR China
    Gene 463:29-40. 2010
    ..Taken together, our results suggest that the proximal intronic sequences contain essential cis-acting elements for the cell-specific expression of the hGIP gene...
  15. ncbi Aspartic acid scanning mutation analysis of a goldfish growth hormone-releasing hormone (GHRH) receptor specific to the GHRHsalmon-like peptide
    Francis Kee
    Department of Zoology, University of Hong Kong, Hong Kong, PR China
    Gen Comp Endocrinol 140:41-51. 2005
    ..Collectively, these results suggest that aspartic acid residues at positions 66 and 122 are critical for the interaction between the goldfish GHRH receptor and its endogenous ligands...
  16. ncbi A functional variable number of tandem repeats is located at the 5' flanking region of the human secretin gene plays a downregulatory role in expression
    Leo T O Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Mol Neurosci 36:125-31. 2008
    ..These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals...
  17. ncbi PACAP-related peptide (PRP)--molecular evolution and potential functions
    Janice K V Tam
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Peptides 28:1920-9. 2007
    ..This information may provide clues to elucidate functions of PRP in the future...
  18. ncbi Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus
    Janice K V Tam
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS ONE 8:e53482. 2013
    ..GHRHR(2), which has only been found in xenopus, zebrafish and chicken hitherto, accommodates both GHRH and PRP...
  19. ncbi Multiple actions of secretin in the human body
    Ian P Y Lam
    Department of Zoology, University of Hong Kong, Hong Kong, China
    Int Rev Cytol 265:159-90. 2008
    ..This chapter reviews our current understanding of the pleiotropic actions of secretin with a special focus on the hormonal and neural interdependent pathways that mediate these actions...
  20. ncbi Southwestern blotting in investigating transcriptional regulation
    Francis K Y Siu
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, HKSAR, China
    Nat Protoc 3:51-8. 2008
    ..The whole Southwestern blotting procedure takes approximately 4 d to complete. In this article, a commonly used protocol and expected results are described and discussed...
  21. ncbi Signaling mechanisms of secretin receptor
    Francis K Y Siu
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China
    Regul Pept 137:95-104. 2006
    ..The structural features and signal transduction pathways of the secretin receptor in various tissues are reviewed in this article...
  22. ncbi The prenatal expression of secretin receptor
    Francis K Y Siu
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PRC
    Ann N Y Acad Sci 1070:561-5. 2006
    ..Taken together, our data suggest a potential pleiotrophic role of secretin during embryonic development...
  23. ncbi Neuron-restrictive silencer factor functions to suppress Sp1-mediated transactivation of human secretin receptor gene
    Yuan Yuan
    The School of Biological Sciences, The University of Hong Kong, Hong Kong, China
    Biochim Biophys Acta 1829:231-8. 2013
    ..Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation...
  24. ncbi Gonadotropin-releasing hormone: regulation of the GnRH gene
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, China
    FEBS J 275:5458-78. 2008
    ..Other physiological stimuli, e.g. insulin and melatonin, will also be discussed...
  25. ncbi Orexins and their receptors from fish to mammals: a comparative approach
    Kari K Y Wong
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Gen Comp Endocrinol 171:124-30. 2011
    ..To allow better understanding of the evolution of orexins and their receptors, this review will provide a comparative approach to their structures and functions in vertebrates...
  26. ncbi Regulation of RASSF1A in nasopharyngeal cells and its response to UV irradiation
    Vien H Y Lee
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Gene 443:55-63. 2009
    ..In summary, our data provided a simple model to explain the potential development of NPC, via silencing of the tumor suppressor RASSF1A by reduced bindings of activators Sp1 and Sp3 onto the GC-boxes in the core promoter of the gene...
  27. ncbi Discovery of a new reproductive hormone in teleosts: pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)
    Janice K V Tam
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong
    Gen Comp Endocrinol 173:405-10. 2011
    ....
  28. ncbi Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein
    Wo Shing Au
    Department of Chemistry, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Kadoorie Biological Science Building, Hong Kong, China
    World J Gastroenterol 15:2987-94. 2009
    ..To test whether oral L-81 treatment could improve the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver...
  29. ncbi The human secretin gene in children with autistic spectrum disorder: screening for polymorphisms and mutations
    Samuel S M Ng
    Institute of Molecular Biology, The University of Hong Kong, Hong Kong
    J Child Neurol 20:701-4. 2005
    ..We did not find evidence of a relationship between human secretin gene mutation and autism...
  30. ncbi Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1
    Leo T O Lee
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PRC
    Ann N Y Acad Sci 1070:393-8. 2006
    ..The first pathway is by changing the expression levels of NFI-C and Sp proteins while the second pathway is by modifying the phosphorylation status of both NFI-C and Sp proteins via Cdk1...
  31. ncbi Extragastrointestinal functions and transcriptional regulation of secretin and secretin receptors
    Yuan Yuan
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Ann N Y Acad Sci 1220:23-33. 2011
    ....
  32. ncbi Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis
    Xiaomeng An
    Integrative Chemical Biology Laboratory, Department of Chemistry, The University of Hong Kong, China
    Eur J Cancer 46:1752-61. 2010
    ..These results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb...
  33. ncbi Secretin, a known gastrointestinal peptide, is widely expressed during mouse embryonic development
    Francis K Y Siu
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, People s Republic of China
    Gene Expr Patterns 5:445-51. 2005
    ..These observations strongly suggest for a functional role of secretin during mouse embryonic development...
  34. ncbi Identification of repressor element 1 in secretin/PACAP/VIP genes
    Leo T O Lee
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PRC
    Ann N Y Acad Sci 1070:388-92. 2006
    ..This observation suggests that RE-1/REST is a common negative regulatory pathway of this peptide family...
  35. ncbi Vasopressin-independent mechanisms in controlling water homeostasis
    Carrie Y Y Cheng
    School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, People s Republic of China
    J Mol Endocrinol 43:81-92. 2009
    ..This review focuses on how these two hormones are potentially involved as Vp-independent mechanisms in controlling water homeostasis...
  36. ncbi Secretin as a neuropeptide
    Samuel S M Ng
    Department of Zoology, University of Hong Kong, Hong Kong, PRC
    Mol Neurobiol 26:97-107. 2002
    ..In summary, the recent data support strongly the neuropeptide role of secretin, although the secretin-autism link remains to be clarified in the future...
  37. ncbi Receptor oligomerization: from early evidence to current understanding in class B GPCRs
    Stephanie Y L Ng
    Endocrinology, School of Biological Sciences, The University of Hong Kong Hong Kong, China
    Front Endocrinol (Lausanne) 3:175. 2012
    ..This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs...
  38. ncbi Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians
    Stephanie Y L Ng
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
    Ann N Y Acad Sci 1200:15-32. 2010
    ..This review will provide a comprehensive overview of current knowledge of proglucagon-derived peptides and receptors, with particular focus on fish and amphibian species...
  39. ncbi Organization of the shrimp vitellogenin gene: evidence of multiple genes and tissue specific expression by the ovary and hepatopancreas
    Wing-Sze Tsang
    Department of Zoology, University of Hong Kong, Pokfulam Road, Hong Kong
    Gene 303:99-109. 2003
    ....
  40. ncbi Serotonin increases the excitability of the hypothalamic paraventricular nucleus magnocellular neurons
    Sara S N Ho
    Department of Zoology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Eur J Neurosci 25:2991-3000. 2007
    ..This may help understanding the regulation of 5-HT-induced hormone release and feeding behavior in the PVN...
  41. ncbi Two Inr elements are important for mediating the activity of the proximal promoter of the human gonadotropin-releasing hormone receptor gene
    Ruby L C Hoo
    Department of Zoology, The University of Hong Kong, Hong Kong, Hong Kong
    Endocrinology 144:518-27. 2003
    ..Additional mechanisms are needed to modulate the efficiencies of individual promoters for developmental and/or tissue-specific regulations...
  42. ncbi Isolation and structure-function studies of a glucagon-like peptide 1 receptor from goldfish Carassius auratus: identification of three charged residues in extracellular domains critical for receptor function
    Chung-Man Yeung
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Endocrinology 143:4646-54. 2002
    ..Our results demonstrated that three charged residues (D(113), R(197), and D(205)) present in the extracellular domains are critical for receptor function...
  43. ncbi The role of secretin in the cerebellum
    Wing Ho Yung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Cerebellum 5:43-8. 2006
    ..In addition, we would like to propose other possible, but still to be confirmed, functions of secretin in the cerebellum....