Lawrence Chi Ming Chiu

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint Induction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation
    L C Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P R China
    Int J Oncol 17:789-96. 2000
  2. ncbi request reprint Induction of apoptosis by a ribosome-inactivating protein from Agrostemma githago is associated with down-regulation of anti-apoptotic bcl-2 protein expression
    L C Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P R China
    Int J Oncol 19:137-41. 2001
  3. ncbi request reprint Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells
    L C Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P R China
    Int J Oncol 19:845-9. 2001
  4. ncbi request reprint Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
    Lawrence Chi Ming Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P R China
    Int J Oncol 23:729-35. 2003
  5. ncbi request reprint Synergistic action of piroxicam on the eicosapentaenoic acid-induced apoptosis is associated with enhanced down-regulation of anti-apoptotic Bcl-2 expression but not promoted activation of pro-apoptotic Bid protein
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Oncol Rep 11:225-30. 2004
  6. ncbi request reprint A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells
    Lawrence Chi Ming Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Ethnopharmacol 93:63-8. 2004
  7. ncbi request reprint The plant mannose-binding lectin NTL preserves cord blood haematopoietic stem/progenitor cells in long-term culture and enhances their ex vivo expansion
    Karen Li
    Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese Uinversity of Hong Kong, Hong Kong, China
    Br J Haematol 140:90-8. 2008
  8. ncbi request reprint Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction
    Mei Zhang
    Department of Biology, The Chinese University of Hong Kong, Hong Kong, P R China
    Oncol Rep 15:637-43. 2006
  9. ncbi request reprint Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma MCF-7 cells
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Ann N Y Acad Sci 1030:361-8. 2004
  10. doi request reprint Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia
    Kam Tong Leung
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Carcinogenesis 29:544-51. 2008

Collaborators

  • V E Ooi
  • Chi Kong Li
  • Karen Li
  • Kam Tong Leung
  • Mei Zhang
  • Samuel Sai ming Sun
  • Carmen Ka Yee Chuen
  • Pak Cheung Ng
  • Kam Sze Tsang
  • Tai Fai Fok
  • Kathy Yuen Yee Chan
  • Xiao Bing Zhang
  • Audrey Carmen Lam
  • Paul Kay Sheung Chan
  • Patrick Man Pan Yuen
  • Linda Shiou Mei Ooi
  • Karen Kwai Har Li
  • Peter C K Cheung

Detail Information

Publications12

  1. ncbi request reprint Induction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation
    L C Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P R China
    Int J Oncol 17:789-96. 2000
    ..These findings suggested that the AA- and EPA-induced apoptosis might not associate with endonucleases activation, and DNA fragmentation could not be used as a sole criterion to identify apoptotic cells...
  2. ncbi request reprint Induction of apoptosis by a ribosome-inactivating protein from Agrostemma githago is associated with down-regulation of anti-apoptotic bcl-2 protein expression
    L C Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P R China
    Int J Oncol 19:137-41. 2001
    ..Anti-apoptotic bcl-2 protein level was also reduced by agrostin showing that the associated apoptotic pathway might involve down-regulation of the intracellular bcl-2 protein level...
  3. ncbi request reprint Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells
    L C Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P R China
    Int J Oncol 19:845-9. 2001
    ..Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA...
  4. ncbi request reprint Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
    Lawrence Chi Ming Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P R China
    Int J Oncol 23:729-35. 2003
    ....
  5. ncbi request reprint Synergistic action of piroxicam on the eicosapentaenoic acid-induced apoptosis is associated with enhanced down-regulation of anti-apoptotic Bcl-2 expression but not promoted activation of pro-apoptotic Bid protein
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Oncol Rep 11:225-30. 2004
    ..This synergistic action of PRX on the EPA-induced apoptosis was associated with enhanced down-regulation of anti-apoptotic Bcl-2 protein expression, but not promoted activation of pro-apoptotic Bid protein...
  6. ncbi request reprint A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells
    Lawrence Chi Ming Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Ethnopharmacol 93:63-8. 2004
    ..Results from this study show that PPV is effective against both the HSV-1 and HSV-2 infections, and flow cytometry offers a quantitative and highly reproducible anti-HSV drug-susceptibility assay...
  7. ncbi request reprint The plant mannose-binding lectin NTL preserves cord blood haematopoietic stem/progenitor cells in long-term culture and enhances their ex vivo expansion
    Karen Li
    Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese Uinversity of Hong Kong, Hong Kong, China
    Br J Haematol 140:90-8. 2008
    ....
  8. ncbi request reprint Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction
    Mei Zhang
    Department of Biology, The Chinese University of Hong Kong, Hong Kong, P R China
    Oncol Rep 15:637-43. 2006
    ..cocos beta-glucan still needs further investigation, this study provides preliminary insights into its mode of action and perspectives of its development as a water-soluble anti-tumor agent...
  9. ncbi request reprint Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma MCF-7 cells
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Ann N Y Acad Sci 1030:361-8. 2004
    ..Results from this study suggest that DHA from the cultured microalga is also effective in controlling cancer cell growth and that downregulation of antiapoptotic Bcl-2 is an important step in the induced apoptosis...
  10. doi request reprint Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia
    Kam Tong Leung
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Carcinogenesis 29:544-51. 2008
    ..Together, our findings suggest that the JNK activation status may correlate with the Bim(EL) level and in turn can control the sensitivity of T-ALL cells to chemotherapeutic agents...
  11. ncbi request reprint Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation
    Lawrence C M Chiu
    Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Ethnopharmacol 105:263-8. 2006
    ....
  12. ncbi request reprint The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion
    Lawrence C M Chiu
    Natural Product Research Laboratory, Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Int J Mol Med 16:735-40. 2005
    ..Results from this study support further research on CHL for preventing and treating those tumors with deregulated ERK activations...