Chor Sang Chim

Summary

Affiliation: The University of Hong Kong
Country: China

Publications

  1. pmc DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin's Lymphomas
    Rita Lok Hay Yim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong, China
    Front Genet 3:233. 2012
  2. pmc Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Transl Med 12:52. 2014
  3. pmc Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFκB pathway
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Mol Cancer 12:173. 2013
  4. pmc Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 5:28. 2012
  5. doi request reprint Epigenetic inactivation of the hsa-miR-203 in haematological malignancies
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Cell Mol Med 15:2760-7. 2011
  6. pmc Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Transl Med 9:197. 2011
  7. pmc Atypical Burkitt's lymphoma transforming from follicular lymphoma
    Yu Y Hwang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Diagn Pathol 6:63. 2011
  8. pmc Updated survivals and prognostic factor analysis in myeloma treated by a staged approach use of bortezomib/thalidomide/dexamethasone in transplant eligible patients
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Transl Med 8:124. 2010
  9. doi request reprint Restoration of chemosensitivity by bortezomib: implications for refractory myeloma
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Nat Rev Clin Oncol 6:237-40. 2009
  10. doi request reprint Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    J Clin Pathol 61:1214-9. 2008

Detail Information

Publications95

  1. pmc DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin's Lymphomas
    Rita Lok Hay Yim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong, China
    Front Genet 3:233. 2012
    ..Herein, we review the recent literature of methylation of tumor suppressive miRNAs in different histopathologic subtypes of lymphomas, and discuss its potential diagnostic, prognostic, and therapeutic significance...
  2. pmc Epigenetic inactivation of mir-34b/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Transl Med 12:52. 2014
    ..Moreover, we tested if miR-34b/c methylation might correlate with miR-203 or miR-124-1 methylation in CLL...
  3. pmc Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFκB pathway
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Mol Cancer 12:173. 2013
    ..The miR-9 family microRNAs have been identified as a tumor suppressor miRNA in cancers. We postulated that miR-9-1, miR-9-2 and miR-9-3 might be inactivated by DNA hypermethylation in chronic lymphocytic leukemia (CLL)...
  4. pmc Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 5:28. 2012
    ..Here we compared the outcomes of the staged approach with frontline PAD (bortezomib/doxorubicin/dexamethasone) or VTD (bortezomib/thalidomide/dexamethasone) induction, and analysed prognostic factors for outcome...
  5. doi request reprint Epigenetic inactivation of the hsa-miR-203 in haematological malignancies
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    J Cell Mol Med 15:2760-7. 2011
    ..In NHL, hsa-miR-203 methylation was associated with concomitant methylation of other tumour suppressor miRNAs. The frequent hsa-miR-203 methylation in lymphoid malignancies suggested a pathogenetic role of hsa-miR-203 methylation...
  6. pmc Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Transl Med 9:197. 2011
    ..MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis...
  7. pmc Atypical Burkitt's lymphoma transforming from follicular lymphoma
    Yu Y Hwang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
    Diagn Pathol 6:63. 2011
    ....
  8. pmc Updated survivals and prognostic factor analysis in myeloma treated by a staged approach use of bortezomib/thalidomide/dexamethasone in transplant eligible patients
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Transl Med 8:124. 2010
    ....
  9. doi request reprint Restoration of chemosensitivity by bortezomib: implications for refractory myeloma
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Nat Rev Clin Oncol 6:237-40. 2009
    ..The patient underwent autologous bone-marrow transplantation, and 14 months later she developed obstructive jaundice...
  10. doi request reprint Epigenetic dysregulation of the Wnt signalling pathway in chronic lymphocytic leukaemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    J Clin Pathol 61:1214-9. 2008
    ..Wnt signalling has recently been implicated in the pathogenesis of cancer...
  11. doi request reprint Epigenetic dysregulation of the DAP kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in acute leukaemias
    C S Chim
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    J Clin Pathol 61:844-7. 2008
    ..Dysregulation of apoptosis is important in carcinogenesis. Aim and..
  12. pmc A staged approach with vincristine, adriamycin, and dexamethasone followed by bortezomib, thalidomide, and dexamethasone before autologous hematopoietic stem cell transplantation in the treatment of newly diagnosed multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Ann Hematol 89:1019-27. 2010
    ..Our approach reduced the use of bortezomib without compromising the ultimate CR rate and is of financial significance for less affluent communities...
  13. ncbi request reprint Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leukemia 21:2527-36. 2007
    ..Methylation study of a panel of genes, regulating a cellular pathway instead of isolated genes, is important...
  14. ncbi request reprint Long-term results of allogeneic bone marrow transplantation for 108 adult patients with acute lymphoblastic leukemia: favorable outcome with BMT at first remission and HLA-matched unrelated donor
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Bone Marrow Transplant 40:339-47. 2007
    ..In summary, the adverse impact of Ph chromosome, B-cell phenotype and high leukocyte count was overcome by allogeneic BMT. Matched unrelated donor transplantation appears promising...
  15. ncbi request reprint Bulbar palsy in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 90:ECR42. 2005
  16. ncbi request reprint Primary large B-cell lymphoma of the ampulla of Vater
    C S Chim
    Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 91:ECR06. 2006
    ..Primary lymphoma of the ampulla of Vater is rare. The clinico-pathological and interesting endoscopic and radiological features of a patient with this disorder is presented...
  17. ncbi request reprint EBV-associated synovial lymphoma in a chronically inflamed joint in rheumatoid arthritis receiving prolonged methotrexate treatment
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 91:ECR31. 2006
    ..Biopsy confirmed high-grade B-cell lymphoma. He developed complete remission with rituximab plus CEOP. The role of chronic inflammation and methotrexate in the pathogenesis of lymphoma in RA was discussed...
  18. ncbi request reprint Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Hum Genet 51:832-8. 2006
    ..Moreover Chinese patients with CLL share a similarly indolent clinical course, and this is the first comprehensive study on p14, DAP kinase and Apaf-1 hypermethylation in CLL...
  19. pmc Aberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Pathol 60:104-6. 2007
    ..Methylation of DAP kinase and oestrogen receptor genes was comparable in multiple myeloma and MGUS. In conclusion, methylation of p16, SHP1 and E-cadherin genes might be involved in the progression of MGUS to multiple myeloma...
  20. pmc Epigenetic dysregulation of the death-associated protein kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma
    Chor Sang Chim
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong
    J Clin Pathol 60:664-9. 2007
    ..To study the role of gene promoter hypermethylation of the putative tumour suppressor genes involved in the death-associated protein (DAP) kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in multiple myeloma (MM)...
  21. doi request reprint Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Pathol 63:942-6. 2010
    ..In summary, methylation of TET2, CBL and CEBPA is infrequent in MPN at diagnosis. The role of methylation of these genes at the time of leukaemic transformation warrants further study...
  22. ncbi request reprint Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    Leuk Res 30:1135-9. 2006
    ..In conclusion, Wif-1 is infrequently methylated in CLL. Other factors leading to activation of the Wnt pathway warrant further study...
  23. ncbi request reprint Methylation of cyclin-dependent kinase inhibitors, XAF1, JUNB, CDH13 and soluble Wnt inhibitors in essential thrombocythaemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Pathol 63:518-21. 2010
    ....
  24. doi request reprint Epigenetic inactivation of the MIR34B/C in multiple myeloma
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, University of Hong King, Pokfulam, Hong Kong
    Blood 118:5901-4. 2011
    ..Hypermethylation of MIR34B/C is tumor-specific. Frequent MIR34B/C hypermethylation during relapse/progression but not at diagnosis implicated a role of MIR34B/C hypermethylation in myeloma relapse/progression...
  25. ncbi request reprint Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients
    Thomas S Y Chan
    Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, China
    Ann Hematol 93:493-8. 2014
    ..Breakthrough IFD during echinocandin treatment occurred infrequently (1.5 %), caused predominantly by Candida species. Clofarabine usage was an important risk factor. ..
  26. pmc Epigenetic inactivation of the miR-124-1 in haematological malignancies
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    PLoS ONE 6:e19027. 2011
    ..Amongst haematological cancers, miR-124-1 was more frequently hypermethylated in NHL, and hence warrants further study...
  27. pmc Epigenetic inactivation of the MIR129-2 in hematological malignancies
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong
    J Hematol Oncol 6:16. 2013
    ..MIR129-2 has been shown to be a tumor suppressor microRNA hypermethylated in epithelial cancers...
  28. ncbi request reprint Epigenetic silencing of MIR203 in multiple myeloma
    Kwan Yeung Wong
    Departments of Medicine Pathology Biochemistry, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China
    Br J Haematol 154:569-78. 2011
    ..Comparable occurrence of MIR203 methylation in MGUS and MM at diagnosis or relapse suggested that MIR203 methylation may be an early event in myelomagenesis instead of being acquired during disease progression...
  29. doi request reprint Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment
    Thomas S Y Chan
    Department of Medicine, Queen Mary Hospital Department of Pathology, Queen Mary Hospital, Hong Kong, China
    Clin Transplant 26:679-83. 2012
    ..EBV-positive PTLD occurred much later in Asian patients. Treatment results of PTLD were favorable...
  30. doi request reprint Primary treatment of leukemia relapses after allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning second transplantation from the original donor
    Anskar Y H Leung
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 88:485-91. 2013
    ..011) on CR/CRi. RIC-HSCT as primary treatment for acute leukemic relapses post-HSCT induced a high CR rate with low TRM. Optimal postremission treatment remains to be defined...
  31. ncbi request reprint Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia
    Wing Yan Au
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Leuk Res 29:1213-5. 2005
    ..There were no significant side effects, and normalization of erythropoiesis was durable. Alemtuzumab is active in PRCA that is idiopathic or secondary to T-cell lymphoproliferative diseases...
  32. ncbi request reprint Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients
    Wing Yan Au
    Department of Medicine, Queen Mary Hospital, University of Hong Kong
    Blood 104:243-9. 2004
    ..During treatment, patients with EBV DNA that showed further increases or failed to become undetectable had significantly inferior OS. In EBV-positive lymphomas, plasma EBV DNA is valuable as a tumor biomarker and for prognostication...
  33. ncbi request reprint Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 103:216-21. 2004
    ..4% versus 27.6%, P = 0.012), as well as for patients treated with chemotherapy/radiotherapy (IPI <or= 1 superior to IPI >or= 2 for CR: 76.7% versus 35.7%, P =.017; and 10-year OS: 63.8% versus 26.8%, P =.003)...
  34. doi request reprint Multiple myeloma with testicular involvement
    Yu Yan Hwang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong, China
    J Clin Oncol 26:1558-9. 2008
  35. ncbi request reprint SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Blood 103:4630-5. 2004
    ..SHP1 methylation leading to epigenetic activation of the Jak/STAT pathway might have a tentative role in the pathogenesis of myeloma, which should be further confirmed by functional studies in primary myeloma samples...
  36. ncbi request reprint Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide
    Wing Yan Au
    Department of Medicine, University of Hong Kong, Hong Kong
    Br J Haematol 131:632-5. 2005
    ..At first or subsequent relapses, owing to highly effective salvage by arsenic trioxide, CDKN2B methylation did not impact on event-free survival or overall survival...
  37. doi request reprint SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group
    Yok Lam Kwong
    Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China
    Blood 120:2973-80. 2012
    ..Multivariate analysis showed that international prognostic index was the most significant factor impacting on outcome and survivals...
  38. ncbi request reprint Mantle cell lymphoma in the Chinese: clinicopathological features and treatment outcome
    C S Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 59:295-301. 1998
    ..Clinicopathologic features and treatment outcome were similar to Caucasian patients, in that the disease combined the aggressive nature of DLC lymphoma and the incurability of low-grade lymphoma...
  39. doi request reprint Methylation of tumor suppressor microRNAs: lessons from lymphoid malignancies
    Lu Qian Wang
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Expert Rev Mol Diagn 12:755-65. 2012
    ..In this review, the authors will focus on the aberrant methylation of miRNAs in the pathogenesis of lymphoid malignancies including chronic lymphocytic leukemia, multiple myeloma and acute lymphoblastic leukemia...
  40. ncbi request reprint Long-term outcome of 231 patients with essential thrombocythemia: prognostic factors for thrombosis, bleeding, myelofibrosis, and leukemia
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong, ROC
    Arch Intern Med 165:2651-8. 2005
    ..Essential thrombocythemia (ET) is a clonal myeloproliferative disease associated with thrombohemorrhagic complications and myeloid transformation to diseases such as myelofibrosis and acute myeloid leukemia...
  41. doi request reprint DNA methylation of microRNA genes in multiple myeloma
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong Hong Kong, China
    Carcinogenesis 33:1629-38. 2012
    ....
  42. ncbi request reprint Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias
    C S Chim
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Ann Hematol 83:527-32. 2004
    ..Frequent methylation of SHP1, but not SOCS1, may be important in the pathogenesis, but not prognosis, of acute leukaemias...
  43. ncbi request reprint Side effects and good effects from new chemotherapeutic agents. Case 3. Bortezomib in primary refractory plasmacytoma
    C S Chim
    University Departments of Medicine, Radiology and Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 23:2426-8. 2005
  44. pmc Non-gastric marginal zone B cell lymphoma: clinicopathologic features and treatment results
    Harinder Gill
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol 90:1399-407. 2011
    ..Early stage, good performance status, and low international prognostic index risk scores significantly impacted on CR rate and survivals. Rituximab and fludarabine were safe for non-gastric MZL and resulted in more durable remissions...
  45. ncbi request reprint Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors
    Chee Kin Hui
    Division of Gastroenterology and Hepatology, The University of Hong Kong, China
    Am J Transplant 5:1437-45. 2005
    ..01, adjusted hazards ratio 7.27, 95%CI 1.62-32.58). Our data support the use of prophylactic therapy in preventing HBV-related hepatitis after allogeneic HSCT from HBsAg-positive donor...
  46. doi request reprint DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family
    Kwan Yeung Wong
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, China
    Epigenomics 3:83-92. 2011
    ..Finally, the potential role of miRNA methylation as a biomarker for diagnosis, prognosis (and hence the potential of developing a risk-stratified approach) and a therapeutic target is discussed...
  47. pmc Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients
    C S Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    J Clin Pathol 59:921-6. 2006
    ..INK4 (p15, p16, p18 and p19) and CIP/KIP (p21, p27 and p57) are two families of cyclin-dependent kinase inhibitors (CKI) targeting CDK4/6 and CDK2, respectively...
  48. doi request reprint Use of fludarabine-containing chemotherapeutic regimen results in durable complete remission of subcutaneous panniculitis-like T-cell lymphoma
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Clin Dermatol 9:396-8. 2008
    ..The patient achieved complete remission after one course of treatment. After completion of six courses of FND, the patient has remained in remission for more than 3 years. FND may be an effective treatment for aggressive SPTCL...
  49. ncbi request reprint Fine needle aspiration cytology in follicular dendritic cell sarcoma: a report of two cases
    Yuen Shan Fan
    Department of Pathology and Clinical Biochemistry, Queen Mary Hospital, Hong Kong SAR, China
    Acta Cytol 51:642-7. 2007
    ..However, difficulties persist in making cytologic diagnosis...
  50. ncbi request reprint Primary anaplastic large cell lymphoma of the pancreas
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 46:457-9. 2005
    ..The proper diagnosis was only derived later with CD30 immunohistochemical study. This carries important implications on the management, as radical surgery is indicated in resectable carcinoma but not for a chemosensitive lymphoma...
  51. ncbi request reprint Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma
    S Y Ma
    Division of Haematology and Oncology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Hong Kong Med J 10:77-83. 2004
    ..To present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among Chinese patients...
  52. ncbi request reprint Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 19:2033-40. 2001
    ..To investigate the frequency of p15 and p16 gene promoter methylation in acute promyelocytic leukemia (APL), and to define its value in the detection of minimal residual disease (MRD) and treatment prognostication...
  53. ncbi request reprint Arsenic trioxide- and idarubicin-induced remissions in relapsed acute promyelocytic leukaemia: clinicopathological and molecular features of a pilot study
    Y L Kwong
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 66:274-9. 2001
    ..This regimen avoids the possible long-term toxicities of As2O3 and mutagenicity of combination chemotherapy, a strategy that might be suitable for this potentially curable leukaemia...
  54. ncbi request reprint Methylation profiling in multiple myeloma
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, PR China
    Leuk Res 28:379-85. 2004
    ..We analysed the methylation status of a panel of 10 genes including p15, p16, DAPK, p73, VHL, E-CAD, MGMT, RARbeta, RIZ1, and ER...
  55. ncbi request reprint Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leukemia 19:2241-6. 2005
    ..RARA is the first myeloid-specific transcription factor shown to be dysregulated by both translocation and aberrant methylation...
  56. ncbi request reprint Outcome of Chinese patients with chronic myeloid leukaemia (CML) underwent allogeneic bone-marrow transplantation (BMT)
    C K Lee
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Am J Hematol 61:85-9. 1999
    ..Therefore, we followed a cohort of 81 Chinese patients who received allogeneic BMT...
  57. doi request reprint Epigenetic inactivation of the miR-34a in hematological malignancies
    C S Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Carcinogenesis 31:745-50. 2010
    ....
  58. ncbi request reprint Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Hematol 80:282-7. 2005
    ..A review of the literature showed a marked variation in the frequencies of methylation of these genes, which might be attributable to difference in methodologies used to detect gene methylation...
  59. ncbi request reprint Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Haematol 119:988-90. 2002
    ..Aberrant CEBPA methylation is infrequent in AML, but may occur preferentially in the M2 phenotype...
  60. ncbi request reprint Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia
    Ho Yin Ng
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Pathol 67:626-31. 2014
    ..We studied if DNA methylation might contribute to inactivation of gene/microRNA (miRNA) in the TP53 tumour suppressor network...
  61. ncbi request reprint Pathological bone fracture in non-Hodgkin's lymphoma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 25:3175-6. 2007
  62. ncbi request reprint Adverse prognostic impact of CDKN2B hyper-methylation in acute promyelocytic leukemia
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Hong Kong, PR China
    Leuk Lymphoma 47:815-25. 2006
    ..Therefore, CDKN2B methylation is a potential prognostic factor that may be incorporated into a risk-stratified therapeutic strategy, which aims at achieving a cure with optimal amounts of treatment...
  63. doi request reprint CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation
    Xiao Tong Hu
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 115:2458-61. 2010
    ..The ectopic expression of CD44DeltaEx1 in BJAB cells enhanced their proliferation rate and clonogenic ability, indicating a possible pathogenic role of the translocation...
  64. ncbi request reprint Treatment of de novo acute myeloid leukaemia in Hong Kong: a twenty-year experience (1975 to 1996)
    C S Chim
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Aust N Z J Med 29:726-30. 1999
    ..Small patient numbers and short follow-up are common in some acute myeloid leukaemia (AML) studies and data on secondary malignancies after treatment of AML are rare...
  65. ncbi request reprint Absence of p300 gene promoter methylation in acute leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Cancer Genet Cytogenet 150:164-7. 2004
    ..None of the cell lines and patient samples showed p300 gene methylation. Therefore, hypermethylation of p300 is not an important mechanism in leukemogenesis...
  66. ncbi request reprint Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma
    C S Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    Hum Pathol 38:1849-57. 2007
    ..There is more frequent p16 hypermethylation in mantle cell lymphoma and p15 or Rb1 hypermethylation in follicular lymphoma. The role of Rb methylation in disease or histologic transformation in follicular lymphoma warrants further study...
  67. doi request reprint Pulmonary interstitial amyloidosis complicating multiple myeloma
    Chor Sang Chim
    Department of Medicine, University of Hong Kong, Hong Kong
    J Clin Oncol 26:504-6. 2008
  68. ncbi request reprint GI manifestations of mantle cell lymphoma
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Gastrointest Endosc 58:931-3. 2003
  69. ncbi request reprint Primary extramedullary plasmacytoma of the lacrimal gland
    C S Chim
    University Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Leuk Lymphoma 42:831-4. 2001
    ..The usefulness of CD79a in the diagnosis of plasmacytoma and the good response of the tumor to combined surgery and radiotherapy are illustrated. Plamacytoma should be included in the differential diagnosis of lacrimal tumors...
  70. ncbi request reprint Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide
    W Y Au
    University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Haematol 117:130-2. 2002
    ..Our results suggest a synergistic therapeutic effect between As2O3 and ATRA in APL in advanced relapse...
  71. ncbi request reprint Clinicopathologic and prognostic features of chronic idiopathic thrombocytopenic purpura in adult Chinese patients: an analysis of 220 cases
    A Y Leung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China
    Ann Hematol 80:384-6. 2001
    ..In addition, primary steroid refractoriness and positive ANA were bad prognostic factors of the subsequent response to splenectomy...
  72. ncbi request reprint Plasma cell problems: Case 2. Extramedullary cardiac plasmacytoma presenting with cardiac tamponade
    C S Chim
    Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 23:3140-3. 2005
  73. ncbi request reprint Hypermethylation of gene promoters in hematological neoplasia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematol Oncol 20:167-76. 2002
    ..Emerging evidence suggests a possible prognostic value of gene promoter hypermethylation. Moreover, gene hypermethylation may also serve as a target for therapeutic invention by hypomethylating agents...
  74. ncbi request reprint An epidemiological study of motor neuron disease in Hong Kong
    G C Y Fong
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:164-8. 2005
    ..A territory-wide prospective epidemiological study is indicated...
  75. ncbi request reprint Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias
    C S Chim
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Ann Hematol 82:738-42. 2003
    ..In AML, p15 gene methylation was associated with the M2 subtype, but was not prognostic for CR, OS, or DFS...
  76. ncbi request reprint Primary CD30-positive anaplastic large cell lymphoma of the lip
    C S Chim
    Department of Medicine, Queen Mary Hospital, Hong Kong
    Oral Oncol 34:313-5. 1998
    ..The clinical features and clinical outcome in Ki-1 anaplastic large cell lymphoma are discussed...
  77. ncbi request reprint Isolated uterine relapse of nasal T/Nk cell lymphoma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 34:629-32. 1999
    ....
  78. ncbi request reprint Primary follicular lymphoma of the small intestine
    C S Chim
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Leuk Lymphoma 45:1463-6. 2004
    ..This is followed by the discussion on the frequency and staging systems for primary gastrointestinal lymphomas, and the relevance of monoclonal anti-CD20 antibody therapy...
  79. ncbi request reprint Radiologic manifestations of granulocytic sarcoma in adult leukemia
    G C Ooi
    Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, Rm. 405, Block K, Pokfulam Rd, Pokfulam, Hong Kong
    AJR Am J Roentgenol 176:1427-31. 2001
    ..The presence of peripheral rim enhancement with hypodense or hypointense centers on T1-weighted images may, however, mimic an abscess...
  80. ncbi request reprint Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong
    Leuk Lymphoma 33:385-8. 1999
    ..We describe a patient with chronic myeloid leukemia on interferon treatment, who developed BMN with symptoms and signs masquerading as interferon toxicity. This is followed by a literature review of BMN in CML...
  81. ncbi request reprint Der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematol Oncol 23:57-60. 2005
    ..We hypothesized that AML in this case resulted from a complex pre-disposition by the natural progression of ET, prolonged use of HU, and the prior evolution into MF. The leukemogenic risk of HU is critically appraised...
  82. ncbi request reprint Extramedullary sites of involvement in hematologic malignancies: case 3. Hemorrhagic gastric plasmacytoma as the primary presentation in multiple myeloma
    C S Chim
    Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 20:344-7. 2002
  83. ncbi request reprint Acute biphenotypic leukaemia
    C S Chim
    Honorary Clinical Associate Professor, Department of Medicine, Queen Mary Hospital, Hong Kong, ROC
    Haematologica 87:EIM03. 2002
  84. ncbi request reprint Cast nephropathy in multiple myeloma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 89:EIM08. 2004
  85. ncbi request reprint Common malignancies with uncommon sites of presentation: case 2. Mantle-cell lymphoma of the prostate
    C S Chim
    University Departments of Medicine, Pathology, and Radiology, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 21:4456-8. 2003
  86. ncbi request reprint Impact of JAK2V617F mutation on thrombosis and myeloid transformation in essential thrombocythemia: a multivariate analysis by Cox regression in 141 patients
    C S Chim
    Department of Medicine and Cancer Research Centre, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hematology 15:187-92. 2010
    ..To perform a multivariate analysis by Cox proportional hazard model of the impact of JAK2 V617F mutation on thrombosis and myeloid transformations in patients with essential thrombocythemia (ET)...
  87. ncbi request reprint Arsenic trioxide in comparison with chemotherapy and bone marrow transplantation for the treatment of relapsed acute promyelocytic leukaemia
    W Y Au
    Departments of Medicine and Pathology, Queen Mary Hospital, Hong Kong
    Ann Oncol 14:752-7. 2003
    ..The best overall treatment strategy for patients with acute promyelocytic leukaemia (APL) in relapse with chemotherapy, bone marrow transplantation (BMT) or arsenic trioxide (As(2)O(3)) based therapy remains undefined...
  88. ncbi request reprint Can defects in transferrin receptor 2 and hereditary hemochromatosis genes account for iron overload in HbH disease?
    Vivian Chan
    University Department of Medicine, Queen Mary Hospital, Hong Kong, SAR China
    Blood Cells Mol Dis 30:107-11. 2003
    ....
  89. ncbi request reprint Unusual abdominal tumors: case 3. Multiple lymphomatous polyposis in lymphoma of colon
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, People s Republic of China
    J Clin Oncol 21:953-5. 2003
  90. ncbi request reprint Electronic clinical practice guidelines: current status and future prospects in Hong Kong
    C S Chim
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Hong Kong Med J 9:299-301. 2003
  91. ncbi request reprint Unusual hematologic malignancies. Case 3. CNS involvement in CD56-positive intestinal gamma/delta T-cell lymphoma
    C S Chim
    Queen Mary Hospital, Hong Kong
    J Clin Oncol 20:3742-4. 2002
  92. ncbi request reprint Analysis of Clonality in Kimura's Disease
    C S Chim
    University Department of Medicine, Queen Mary Hospital, Hong Kong
    Am J Surg Pathol 26:1083-6. 2002
    ..Furthermore, the presence of identical T cell clones in different sites and at different times suggested that a clonal T cell population might have contributed to the pathogenesis in this case of Kimura's disease...
  93. ncbi request reprint Gut perforation in MALT lymphoma of colon
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Haematologica 87:EIM15. 2002
  94. ncbi request reprint Magnetic resonance imaging of leptomeningeal lymphoma
    C S Chim
    University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Br J Haematol 124:566. 2004