Research Topics
Genomes and GenesSpecies | Yin Bun CheungSummaryAffiliation: The University of Hong Kong Country: China Publications
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Detail Information
Publications
CYP3A5*3 and *6 single nucleotide polymorphisms in three distinct Asian populationsC Balram
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, 169610, Singapore
Eur J Clin Pharmacol 59:123-6. 2003..To determine the frequencies of two functional single nucleotide polymorphisms, CYP3A5*3 and CYP3A5*6, in the CYP3A5 gene in three distinct Asian ethnic groups, namely, the Chinese, Malays and Indians...
The impact of diabetes mellitus and other chronic medical conditions on health-related Quality of Life: is the whole greater than the sum of its parts?Hwee Lin Wee
Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore
Health Qual Life Outcomes 3:2. 2005....- Are Asians comfortable with discussing death in health valuation studies? A study in multi-ethnic SingaporeHwee Lin Wee
Department of Rheumatology and Immunology, Singapore General Hospital, Republic of Singapore
Health Qual Life Outcomes 4:93. 2006.... - A modified least-squares regression approach to the estimation of risk differenceYin Bun Cheung
MRC Tropical Epidemiology Group, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
Am J Epidemiol 166:1337-44. 2007..The method is illustrated with data from a patient survey in which the binomial regression fails to converge in the analyses of four out of five outcome variables... - The equivalence and difference between the English and Chinese versions of two major, cancer-specific, health-related quality-of-life questionnairesYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Cancer 101:2874-80. 2004.... - A longitudinal study of pediatric body mass index values predicted health in middle ageYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610
J Clin Epidemiol 57:1316-22. 2004..To characterize the use of pediatric body mass index (BMI) to predict obesity, overweight, and diseases in middle age... - Commentary: Fetal origins of social situations? Medicalization of social life?Yin Bun Cheung
Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610
Int J Epidemiol 33:856-7. 2004 - Variability and sample size requirements of quality-of-life measures: a randomized study of three major questionnairesYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610
J Clin Oncol 23:4936-44. 2005.... - Parametric modelling of neonatal mortality in relation to size at birthY B Cheung
Clinical Trials Centre, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, PR China
Stat Med 20:2455-66. 2001..We discuss the interpretability of the model and its potential use in neonatology and medical demography. We also compare the model to a Cox model with time-dependent covariates... - HIV incidence during a cluster-randomized trial of two strategies providing voluntary counselling and testing at the workplace, ZimbabweElizabeth L Corbett
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
AIDS 21:483-9. 2007..Counselling may promote beneficial behavioural change, although knowledge of negative status does not appear to contribute further benefit... 
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancerQingyu Zhou
Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610
Br J Clin Pharmacol 59:415-24. 2005....
The Singaporean English and Chinese versions of the EQ-5D achieved measurement equivalence in cancer patientsFei Gao
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
J Clin Epidemiol 62:206-13. 2009..To assess measurement equivalence of the Singaporean English and Chinese versions of the EuroQol Group's 5-domain questionnaire (EQ-5D) in cancer patients...- Does the 12-item General Health Questionnaire contain multiple factors and do we need them?Fei Gao
Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, 169610, Singapore
Health Qual Life Outcomes 2:63. 2004..Not much is known about the usefulness of the GHQ-12 factors, if they exist, in revealing between-patient differences in clinical states and health-related quality of life... - The English and Chinese versions of the five-level EuroQoL Group's five-dimension questionnaire (EQ-5D) were valid and reliable and provided comparable scores in Asian breast cancer patientsChun Fan Lee
Center for Quantitative Medicine, Office of Clinical Sciences, Duke NUS Graduate Medical School, Singapore, Singapore
Support Care Cancer 21:201-9. 2013..To examine the measurement properties of and comparability between the English and Chinese versions of the five-level EuroQoL Group's five-dimension questionnaire (EQ-5D) in breast cancer patients in Singapore... - Order effects: a randomised study of three major cancer-specific quality of life instrumentsYin Bun Cheung
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Health Qual Life Outcomes 3:37. 2005..Yet, information on the presence or absence of order effects on the assessment of HRQoL in cancer patients is limited... - Nursing and community rates of Mycobacterium tuberculosis infection among students in Harare, ZimbabweElizabeth L Corbett
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
Clin Infect Dis 44:317-23. 2007..We compared institutional rates and community rates of tuberculin skin test (TST) conversion in Harare, Zimbabwe... - Quality of life scores differed according to mode of administration in a review of three major oncology questionnairesYin Bun Cheung
MRC Tropical Epidemiology Group, Room 305A, IDEU, ITD, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
J Clin Epidemiol 59:185-91. 2006..To assess whether scores on the three major quality-of-life questionnaires in oncology (FACT-G, FLIC, and EORTC QLQ-C30) are associated with modes of administration in a realistic clinical research setting... - Difference in prevalence of common mental disorder as measured using four questionnaire delivery methods among young people in rural ZimbabweLisa F Langhaug
Royal Free and University College Medical School, London, United Kingdom
J Affect Disord 118:220-3. 2009..We report here on differences in prevalence of reporting mental health between four questionnaire delivery modes (QDM)... - EGFR Intron 1 polymorphism in Asian Populations and its correlation with EGFR gene expression and amplification in breast tumor tissuesQingyu Zhou
Laboratory of Clinical Pharmacology, National Cancer Centre, Singapore
Cancer Biol Ther 5:1445-9. 2006.... - Order effects in the assessment of quality of life in cancer patientsYin Bun Cheung
National Cancer Centre, Singapore
Qual Life Res 13:1217-23. 2004..The reasons and implications of the absence of an order effect are discussed. We conclude that presentation order is unlikely to alter the responses to the two HRQoL instruments... - Measurement properties of the English and Chinese versions of the Functional Assessment of Cancer Therapy-Breast (FACT-B) in Asian breast cancer patientsRaymond Ng
Department of Medical Oncology, National Cancer Center, Singapore, Singapore
Breast Cancer Res Treat 131:619-25. 2012..Data collected from the English and Chinese versions can be pooled and either version could be used for bilingual patients... - Estimation of intervention effects using first or multiple episodes in clinical trials: The Andersen-Gill model re-examinedYin Bun Cheung
Biostatistics, Singapore Clinical Research Institute, Singapore, Singapore
Stat Med 29:328-36. 2010..We maintain that a careful clarification of research purpose is needed before one can choose a statistical model, and that the AG model is useful in the estimation of the total effect of an intervention... - Developing health-related quality-of-life instruments for use in Asia: the issuesYin Bun Cheung
MRC Tropical Epidemiology Group, Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
Pharmacoeconomics 24:643-50. 2006..For instance, many important HR-QOL instruments are available in Japanese but not in Hindi or Tamil... - Epidemiology of tuberculosis in a high HIV prevalence population provided with enhanced diagnosis of symptomatic diseaseElizabeth L Corbett
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 4:e22. 2007..We investigated the epidemiology of prevalent and incident TB in a high HIV prevalence population provided with enhanced primary health care... - VKORC1 diplotype-derived dosing model to explain variability in warfarin dose requirements in Asian patientsEdwin Sandanaraj
Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore
Drug Metab Pharmacokinet 24:365-75. 2009..Translation of these findings into clinical guidelines for warfarin dosing may be required to assess its impact on the safety and efficacy of warfarin... - Quick-FLIC--a short questionnaire for assessing quality of life of cancer patientsYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Acta Oncol 42:36-42. 2003..It is concluded that the shortening of established health-related quality of life instruments is viable in oncology research... - Elicitation of prior distributions for a phase III randomized controlled trial of adjuvant therapy with surgery for hepatocellular carcinomaSay Beng Tan
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore, Singapore
Control Clin Trials 24:110-21. 2003..We illustrate these analyses, assuming that the data resulting from the new trial was the same as that obtained in the earlier trial when it was stopped... - A simple approach to test for interaction between intervention and an individual-level variable in community randomized trialsYin Bun Cheung
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 13:247-55. 2008..e. small number of communities but large number of subjects per community... - Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expressionBalram Chowbay
Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Br J Clin Pharmacol 60:159-71. 2005.... - Age at diagnosis and the choice of survival analysis methods in cancer epidemiologyYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore
J Clin Epidemiol 56:38-43. 2003..The relative survival approach agrees with the Cox model with age as the time scale. We maintain that a careful clarification of research purpose and a careful choice of methods are necessary... - Size at birth and neonatal and postneonatal mortalityY B Cheung
Clinical Trials Centre, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, PR China
Acta Paediatr 91:447-52. 2002..The findings are consistent with previous hypotheses about a transient effect of ponderal index and a persistent effect of birthlength... - Estimation and interpretation of incidence rate difference for recurrent events when the estimation model is misspecifiedYing Xu
Centre for Quantitative Medicine, Office of Clinical Sciences, Duke NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore Scientific Development Division, Singapore Clinical Research Institute, 31 Biopolis Way, Nanos 02 01, Singapore, 138669, Singapore
Biom J 54:750-65. 2012..We illustrate the method with data from a randomized vaccine trial... - Response and non-response to a quality-of-life question on sexual life: a case study of the simple mean imputation methodYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore, Singapore
Qual Life Res 15:1493-501. 2006.... - On the definition of gestational-age-specific mortalityYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Am J Epidemiol 160:207-10. 2004..All of the definitions are valid when used and interpreted correctly. The choice of which definition to adopt depends on the specific issues one attempts to address. Calls for abandoning the conventional definitions are not justified... - Benn Index at birth is associated with postnatal linear growthY B Cheung
Clinical Trials Centre, Department of Paediatrics, Faculty of Medicine, The University of Hong Kong, PR China
J Pediatr Endocrinol Metab 15:1161-6. 2002..05), and tall (p < 0.05) for gestational age newborns. Use of the Ponderal Index (kg/m3) would give similar results. The findings suggest that nutritional status at birth is related to linear growth velocity in newborns... - Social patterns of birth weight in Hong Kong, 1984-1997Y B Cheung
Clinical Trials Centre, , University of Hong Kong, Pokfulam
Soc Sci Med 52:1135-41. 2001..05). Type of living quarters and parental relation were also related to birth weight and low birth weight (each P<0.05). Continuous monitoring of the social patterns of birth weight is recommended... - C-reactive protein and procalcitonin in the evaluation of the efficacy of a pneumococcal conjugate vaccine in Gambian childrenYin Bun Cheung
London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 13:603-11. 2008..To determine the value of C-reactive protein (CRP) and procalcitonin in the evaluation of the efficacy of a pneumococcal conjugate vaccine in Gambian children... - Early origins and adult correlates of psychosomatic distressYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Soc Sci Med 55:937-48. 2002..The results support the hypothesis of a biological link between perinatal factors and psychological distress in adults. The strengths of the associations were compared with those between the outcome and adult correlates... - A nonparametric approach to QT interval correction for heart rateDuolao Wang
Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Biopharm Stat 20:508-22. 2010..The results show that the linear additive models provide the best fit for the vast majority of individual QT-RR profiles. Moreover, the QT correction formula derived from the linear additive model outperforms other correction methods... - Suicidal ideation and suicidal attempts in a population-based study of Chinese people: risk attributable to hopelessness, depression, and social factorsYin Bun Cheung
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, UK
J Affect Disord 90:193-9. 2006..Social support appeared to play little role as a buffer... - Bivariate poisson-poisson model of zero-inflated absenteeism dataYin Bun Cheung
MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Stat Med 25:3707-17. 2006..The findings do not support the existence of a critical window in infancy. There is some indication that childhood weight gain might affect health status... - Uptake of workplace HIV counselling and testing: a cluster-randomised trial in ZimbabweElizabeth L Corbett
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 3:e238. 2006..HIV counselling and testing is a key component of both HIV care and HIV prevention, but uptake is currently low. We investigated the impact of rapid HIV testing at the workplace on uptake of voluntary counselling and testing (VCT)... - Association between size at birth, paediatric diarrhoeal incidence and postnatal growthY B Cheung
Department of Paediatrics, Clinical Trials Centre, Faculty of Medicine, University of Hong Kong, Pokfulam, SAR, PR China
Acta Paediatr 90:1309-15. 2001..CONCLUSION: Prevention of low birthweight is unlikely to have an impact on diarrhoeal incidence in infants. Control of diarrhoeal incidence may not improve the growth of infants in developing countries... - Adjustment for selection bias in cohort studies: an application of a probit model with selectivity to life course epidemiologyY B Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
J Clin Epidemiol 54:1238-43. 2001..037) relation between birth weight and mental health than an ordinary probit regression model (P = 0.170). Interpretation and practical considerations are discussed... - Association between psychological symptoms in adults and growth in early life: longitudinal follow up studyY B Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610
BMJ 325:749. 2002..To test the hypothesis that birth weight for gestational age and weight gain in early childhood have a long term association with psychological distress in adults... - A confirmatory factor analysis of the 12-item General Health Questionnaire among older peopleYin Bun Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Int J Geriatr Psychiatry 17:739-44. 2002..Previous studies of its factor structure were often based on samples of young persons and on exploratory factor analysis techniques. The results varied from suggesting one to three factors... - Birthweight and psychological distress in adult twins: a longitudinal studyY B Cheung
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore
Acta Paediatr 93:965-8. 2004..To assess the relation between birthweight and psychological distress as measured by the Malaise Inventory in adult twins... - Can patients with early-stage diffuse large B-cell lymphoma be treated without bone marrow biopsy?S T Lim
Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, 169610 Singapore
Ann Oncol 16:215-8. 2005..Although BM biopsy is a safe procedure, it is often poorly tolerated. This analysis aims to assess the incidence of BM involvement and to identify parameters predicting BM involvement in early-stage DLBCL... - Quick assessment of hopelessness: a cross-sectional studyPaul S F Yip
The Hong Kong Jockey Club Centre for Suicide Research and Prevention, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR
Health Qual Life Outcomes 4:13. 2006..There is no clear indication of what BHS cutoff values are useful in identifying people with suicide tendency... - Growth in early life and its relation to pubertal growthZhong Cheng Luo
Clinical Trials Centre and Department of Pediatrics, University of Hong Kong, Pokfulam, The P R China
Epidemiology 14:65-73. 2003..Being small at birth is associated with early puberty and a reduced height gain during adolescence... - Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal studyPhilip C Hill
Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia
Clin Infect Dis 46:807-14. 2008..To prepare for national introduction of a pneumococcal conjugate vaccine of restricted valency, we studied nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants... - Performance of the CES-D and its short forms in screening suicidality and hopelessness in the communityYin Bun Cheung
Tropical Epidemiology Group, IDEU, London School of Hycidal Tropical Medicine
Suicide Life Threat Behav 37:79-88. 2007..Sensitivity, specificity, and predictive values in differentiating people with and without suicidal thought or attempt change almost linearly with the cut-offs... - Developmental potential in the first 5 years for children in developing countriesSally Grantham-McGregor
Centre for International Child Health, Institute of Child Health, University College London, UK
Lancet 369:60-70. 2007..These disadvantaged children are likely to do poorly in school and subsequently have low incomes, high fertility, and provide poor care for their children, thus contributing to the intergenerational transmission of poverty... - Semiparametric analysis of zero-inflated count dataK F Lam
Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam Road, Hong Kong
Biometrics 62:996-1003. 2006..For illustration purpose, the method is applied to a data set from a public health survey conducted in Indonesia where the variable of interest is the number of days of missed primary activities due to illness in a 4-week period... - Aflatoxin exposure in utero causes growth faltering in Gambian infantsPaul C Turner
Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK LS2 9JT
Int J Epidemiol 36:1119-25. 2007..However, in animal studies in utero exposure to low levels of aflatoxin also results in growth faltering...