Research Topics
Genomes and Genes
Species | Alfred S L ChengSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
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Detail Information
Publications
Epigenetic Deregulation of MicroRNAs: New Opportunities to Target Oncogenic Signaling Pathways in Hepatocellular CarcinomaZhuo Yu
Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, PR China
Curr Pharm Des 19:1192-200. 2013..Better understanding of the epigenetics-miRNA regulatory cascades in the control of the functionally significant pathways will provide new opportunities for the development of more effective therapeutic modality for HCC...
Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesisAlfred S L Cheng
Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
Gastroenterology 144:122-133.e9. 2013..Promoter hypermethylation occurs during Helicobacter pylori-induced gastritis. We investigated whether the deregulated genes contribute to gastric tumorigenesis...
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modulesHuaxia Qin
Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
BMC Syst Biol 3:73. 2009..The regulatory effect of SMAD complex likely depends on transcriptional modules, in which the SMAD binding elements and partner transcription factor binding sites (SMAD modules) are present in specific context...- Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cellsAlfred S L Cheng
Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
Int J Oncol 23:113-9. 2003..In conclusion, specific COX-2 inhibitor suppresses cell proliferation and induces apoptosis in HCC cell lines that express COX-2. Our finding suggests that COX-2 inhibition may offer a new approach for HCC chemoprevention... - EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesisAlfred S L Cheng
Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
Cancer Res 71:4028-39. 2011.... - Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinomaAlfred S L Cheng
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
Int J Oncol 24:853-60. 2004..Moreover, COX-2 up-regulates VEGF expression in HCC cells, possibly via PGs production. Selective inhibition of COX-2 may block HCC associated angiogenesis and thus provides a rational approach for treatment of this malignancy... - Elucidation of the role of COX-2 in liver fibrogenesis using transgenic miceJun Yu
Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
Biochem Biophys Res Commun 372:571-7. 2008..This is the first report on the effect of COX-2 in liver fibrosis based on genetic mouse models. The results suggest that COX-2 does not appear to mediate the development of liver fibrosis... - Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cellsMichael W Y Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China
Oncol Rep 18:1557-62. 2007..RNA interference may be a promising alternative to specific COX-2 inhibitors in the prevention and treatment of gastric cancer... - Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancerWei Kang
Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Sir Y K Pao Center for Cancer, The Chinese University of Hong Kong, Hong Kong, China
PLoS ONE 7:e33919. 2012..Our findings supported an oncogenic role of STMN1 in gastric cancer. STMN1 might serve as a prognostic marker and a potential therapeutic target for gastric cancer... - Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancerKin Fai Cheung
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
Cancer 118:947-59. 2012..By using genome-wide methylation screening, the authors identified ring finger protein 180 (RNF180) as preferentially methylated in cancer. This study was undertaken to clarify its structure and functional role in gastric cancer... - Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in miceWai K Leung
Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Carcinogenesis 29:1648-54. 2008..In conclusion, both high salt and COX-2 overexpression promote chemical-induced gastric carcinogenesis, possibly related to chronic inflammation, induction of PGE(2), disruption of cell kinetics and induction of inflammatory cytokines... - COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosisAlfred S L Cheng
Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
Biochem Biophys Res Commun 374:175-80. 2008..Over-expression of HBx and COX-2 may provide a selective clonal advantage for preneoplastic or neoplastic hepatocytes and contribute to the initiation and progression of HCC... - Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesisHai Feng
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
J Clin Invest 121:3159-75. 2011..Our results reveal a direct AR transcriptional target, CCRK, that promotes hepatocarcinogenesis through the upregulation of β-catenin/TCF signaling... - RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinomaAlfred S L Cheng
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
Cancer Lett 253:43-52. 2007..These results suggest that RNA interference-mediated HBx suppression exerts potent anti-proliferative and chemosensitizing effects in human HCC... - Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cellsYa C Wu
School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
PLoS ONE 7:e37572. 2012..Collectively, we demonstrate that H(2)S inhibits colon epithelial cell proliferation and induces protective autophagy via the AMPK pathway... - NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptorsVivian Y Shin
Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Carcinogenesis 32:240-5. 2011..Perhaps this study may shed light on the development of anticancer drugs to improve the chemosensitivity in smokers... - Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitroJun Yu
Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Hong Kong, China
Hepatology 51:2008-19. 2010..PPARgamma suppresses tumor cell growth through reducing cell proliferation and inducing G(2)/M phase arrest, apoptosis, and up-regulating growth differentiation factor-15. Thus, PPARgamma acts as a tumor-suppressor gene in the liver... - Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancerShun X Ren
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
Cancer Res 72:6512-23. 2012..Collectively, our findings show that LL-37 activates a GPCR-p53-Bax/Bak/Bcl-2 signaling cascade that triggers AIF/EndoG-mediated apoptosis in colon cancer cells... - Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitisJun Yu
Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
Gut 56:991-9. 2007..However, it is not known whether overexpression of COX-2 in the liver is sufficient to promote activation or secretion of inflammatory factors leading to hepatitis... - Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastomaKin Mang Lau
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Acta Neuropathol 123:553-71. 2012..Importantly, the results highlight the therapeutic potential of targeting HMGA1 in MB patients... - Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2Daisy P F Tsang
Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, China
J Gastroenterol Hepatol 26:19-27. 2011..Better understanding of the molecular basis of such regulations in various cancer types will help establish EZH2-mediated epigenetic silencing as a therapeutic target... - Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrantMeiyun Fan
Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
Cancer Res 66:11954-66. 2006..Such knowledge of resistance-associated mechanisms could allow for identification of therapy targets and strategies for resensitization to these well-established antihormonal agents... - Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancerBenjamin A T Rodriguez
Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 29:1459-65. 2008..029) in cancer patients. These results suggest that hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients...