Alfred S L Cheng

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. pmc let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, People s Republic of China
    J Transl Med 12:281. 2014
  2. pmc Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development
    Wing Kit Yip
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e22888. 2011
  3. ncbi Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma
    Zhuo Yu
    Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Curr Pharm Des 19:1192-200. 2013
  4. doi Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 144:122-133.e9. 2013
  5. pmc An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
    Huaxia Qin
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    BMC Syst Biol 3:73. 2009
  6. ncbi Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
    Alfred S L Cheng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
    Int J Oncol 23:113-9. 2003
  7. ncbi Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma
    Alfred S L Cheng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Int J Oncol 24:853-60. 2004
  8. doi EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cancer Res 71:4028-39. 2011
  9. ncbi Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2
    Alfred S L Cheng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Mod Pathol 17:1169-79. 2004
  10. doi CITED2 is a novel direct effector of peroxisome proliferator-activated receptor γ in suppressing hepatocellular carcinoma cell growth
    Kin Fai Cheung
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Cancer 119:1217-26. 2013

Collaborators

Detail Information

Publications35

  1. pmc let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, People s Republic of China
    J Transl Med 12:281. 2014
    ..microRNAs have been established to be important regulators in gastric carcinogenesis. Here, we showed the functional role and putative target of let-7b and let-7g (let-7b/g) in gastric carcinogenesis...
  2. pmc Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development
    Wing Kit Yip
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e22888. 2011
    ....
  3. ncbi Epigenetic deregulation of microRNAs: new opportunities to target oncogenic signaling pathways in hepatocellular carcinoma
    Zhuo Yu
    Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Curr Pharm Des 19:1192-200. 2013
    ..Better understanding of the epigenetics-miRNA regulatory cascades in the control of the functionally significant pathways will provide new opportunities for the development of more effective therapeutic modality for HCC...
  4. doi Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Gastroenterology 144:122-133.e9. 2013
    ..Promoter hypermethylation occurs during Helicobacter pylori-induced gastritis. We investigated whether the deregulated genes contribute to gastric tumorigenesis...
  5. pmc An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
    Huaxia Qin
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    BMC Syst Biol 3:73. 2009
    ..The regulatory effect of SMAD complex likely depends on transcriptional modules, in which the SMAD binding elements and partner transcription factor binding sites (SMAD modules) are present in specific context...
  6. ncbi Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
    Alfred S L Cheng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, P R China
    Int J Oncol 23:113-9. 2003
    ..In conclusion, specific COX-2 inhibitor suppresses cell proliferation and induces apoptosis in HCC cell lines that express COX-2. Our finding suggests that COX-2 inhibition may offer a new approach for HCC chemoprevention...
  7. ncbi Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma
    Alfred S L Cheng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Int J Oncol 24:853-60. 2004
    ..Moreover, COX-2 up-regulates VEGF expression in HCC cells, possibly via PGs production. Selective inhibition of COX-2 may block HCC associated angiogenesis and thus provides a rational approach for treatment of this malignancy...
  8. doi EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis
    Alfred S L Cheng
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cancer Res 71:4028-39. 2011
    ....
  9. ncbi Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2
    Alfred S L Cheng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong
    Mod Pathol 17:1169-79. 2004
    ..In conclusion, our results strongly suggested that there was a close relationship between HBx and COX-2. COX-2 might represent an important cellular effector of HBx that contributes to hepatitis B virus-associated hepatocarcinogenesis...
  10. doi CITED2 is a novel direct effector of peroxisome proliferator-activated receptor γ in suppressing hepatocellular carcinoma cell growth
    Kin Fai Cheung
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Cancer 119:1217-26. 2013
    ..This study sought to identify the molecular target of PPARγ and characterize its antitumor effect in HCC...
  11. pmc FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells
    Shun X Ren
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 8:e63641. 2013
    ..Our study also uncovered previously unknown reciprocal regulation between these two cell death pathways...
  12. ncbi Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells
    Michael W Y Chan
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China
    Oncol Rep 18:1557-62. 2007
    ..RNA interference may be a promising alternative to specific COX-2 inhibitors in the prevention and treatment of gastric cancer...
  13. doi Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice
    Jun Yu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Biochem Biophys Res Commun 372:571-7. 2008
    ..This is the first report on the effect of COX-2 in liver fibrosis based on genetic mouse models. The results suggest that COX-2 does not appear to mediate the development of liver fibrosis...
  14. doi Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer
    Kin Fai Cheung
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong
    Cancer 118:947-59. 2012
    ..By using genome-wide methylation screening, the authors identified ring finger protein 180 (RNF180) as preferentially methylated in cancer. This study was undertaken to clarify its structure and functional role in gastric cancer...
  15. doi Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice
    Wai K Leung
    Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Carcinogenesis 29:1648-54. 2008
    ..In conclusion, both high salt and COX-2 overexpression promote chemical-induced gastric carcinogenesis, possibly related to chronic inflammation, induction of PGE(2), disruption of cell kinetics and induction of inflammatory cytokines...
  16. doi Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
    William K K Wu
    Institute of Digestive Disease, LKS Institute of Health Sciences and Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Crit Rev Oncol Hematol 86:251-77. 2013
    ..Understanding their relative importance and crosstalk will provide a rational basis for anticancer drug development...
  17. pmc Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Sir Y K Pao Center for Cancer, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e33919. 2012
    ..Our findings supported an oncogenic role of STMN1 in gastric cancer. STMN1 might serve as a prognostic marker and a potential therapeutic target for gastric cancer...
  18. doi A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
    Hai Feng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
    J Hepatol 62:1100-11. 2015
    ..Both enhancer of zeste homolog 2 (EZH2) and cell cycle-related kinase (CCRK) contribute to hepatocarcinogenesis, yet whether the two oncogenic factors have functional crosstalk is unknown...
  19. doi Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, P R China
    Oncol Rep 31:2579-86. 2014
    ..Collectively, these findings suggest that RRM2 plays a crucial role in gastric tumorigenesis and may serve as a potential prognostic marker and therapeutic target in gastric cancer. ..
  20. doi COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis
    Alfred S L Cheng
    Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    Biochem Biophys Res Commun 374:175-80. 2008
    ..Over-expression of HBx and COX-2 may provide a selective clonal advantage for preneoplastic or neoplastic hepatocytes and contribute to the initiation and progression of HCC...
  21. pmc Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis
    Hai Feng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Invest 121:3159-75. 2011
    ..Our results reveal a direct AR transcriptional target, CCRK, that promotes hepatocarcinogenesis through the upregulation of β-catenin/TCF signaling...
  22. ncbi RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
    Alfred S L Cheng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong
    Cancer Lett 253:43-52. 2007
    ..These results suggest that RNA interference-mediated HBx suppression exerts potent anti-proliferative and chemosensitizing effects in human HCC...
  23. pmc Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China
    J Transl Med 12:80. 2014
    ..The function and clinical significance of YY1 in gastric adenocarcinoma (GAC) have not been elucidated...
  24. pmc Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells
    Ya C Wu
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    PLoS ONE 7:e37572. 2012
    ..Collectively, we demonstrate that H(2)S inhibits colon epithelial cell proliferation and induces protective autophagy via the AMPK pathway...
  25. doi NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors
    Vivian Y Shin
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Carcinogenesis 32:240-5. 2011
    ..Perhaps this study may shed light on the development of anticancer drugs to improve the chemosensitivity in smokers...
  26. doi Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro
    Jun Yu
    Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Hong Kong, China
    Hepatology 51:2008-19. 2010
    ..Moreover, PPARgamma directly induced a putative tumor suppressor gene, growth differentiation factor-15...
  27. doi Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis
    Jing Shen
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
    Cancer Res 75:754-65. 2015
    ..In conclusion, hypermethylation-mediated silencing of miR-490-3p reactivates SMARCD1 to confer malignant phenotypes, mechanistically linking H. pylori, chromatin remodeling, and gastric carcinogenesis...
  28. pmc Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer
    Shun X Ren
    School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong
    Cancer Res 72:6512-23. 2012
    ..Collectively, our findings show that LL-37 activates a GPCR-p53-Bax/Bak/Bcl-2 signaling cascade that triggers AIF/EndoG-mediated apoptosis in colon cancer cells...
  29. pmc Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis
    Jun Yu
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Gut 56:991-9. 2007
    ..However, it is not known whether overexpression of COX-2 in the liver is sufficient to promote activation or secretion of inflammatory factors leading to hepatitis...
  30. doi MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, P R China
    Oncol Rep 31:2071-8. 2014
    ..All the findings supported that MCM7 might play an oncogenic role in gastric tumorigenesis. It serves as a potential prognostic marker and therapeutic target in diffuse-type GACs...
  31. doi Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma
    Kin Mang Lau
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Acta Neuropathol 123:553-71. 2012
    ..Importantly, the results highlight the therapeutic potential of targeting HMGA1 in MB patients...
  32. doi Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis
    Zhuo Yu
    Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, P R China Department of Liver Disease, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, P R China
    Gut 63:1793-804. 2014
    ..Cell cycle-related kinase (CCRK) is essential for AR-induced hepatocarcinogenesis but its molecular function in HBV-associated HCC remains obscure...
  33. doi Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2
    Daisy P F Tsang
    Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, China
    J Gastroenterol Hepatol 26:19-27. 2011
    ..Better understanding of the molecular basis of such regulations in various cancer types will help establish EZH2-mediated epigenetic silencing as a therapeutic target...
  34. ncbi Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant
    Meiyun Fan
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Cancer Res 66:11954-66. 2006
    ..Such knowledge of resistance-associated mechanisms could allow for identification of therapy targets and strategies for resensitization to these well-established antihormonal agents...
  35. pmc Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
    Benjamin A T Rodriguez
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 29:1459-65. 2008
    ..029) in cancer patients. These results suggest that hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients...