Zhen Yu Chen

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi request reprint An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula
    Emily K K Tai
    Food and Nutritional Sciences Programme, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Food Funct 4:1767-75. 2013
  2. ncbi request reprint Breast milk fatty acid composition: a comparative study between Hong Kong and Chongqing Chinese
    Z Y Chen
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, New Territories
    Lipids 32:1061-7. 1997
  3. ncbi request reprint Characterization of antioxidants present in bitter tea (Ligustrum pedunculare)
    Zhen Yu Chen
    Food and Nutritional Science Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    J Agric Food Chem 50:7530-5. 2002
  4. ncbi request reprint Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats
    Z Y Chen
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Br J Nutr 86:249-55. 2001
  5. doi request reprint Anti-hypertensive nutraceuticals and functional foods
    Zhen Yu Chen
    Department of Biochemistry, Food and Nutritional Sciences Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 57:4485-99. 2009
  6. ncbi request reprint Degradation of green tea catechins in tea drinks
    Z Chen
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People s Republic of China
    J Agric Food Chem 49:477-82. 2001
  7. doi request reprint Cholesterol-lowering nutraceuticals and functional foods
    Zhen Yu Chen
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, China
    J Agric Food Chem 56:8761-73. 2008
  8. doi request reprint DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet
    Jingnan Chen
    Department of Biology and Kwong Living Trust Food Safety and Analysis Laboratory, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Atherosclerosis 221:397-404. 2012
  9. doi request reprint Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats
    Lai Ming Yung
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Eur J Nutr 52:1145-55. 2013
  10. doi request reprint Blueberry extract prolongs lifespan of Drosophila melanogaster
    Cheng Peng
    School of Life Sciences, Chinese University of Hong Kong, Hong Kong, China
    Exp Gerontol 47:170-8. 2012

Collaborators

Detail Information

Publications89

  1. ncbi request reprint An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula
    Emily K K Tai
    Food and Nutritional Sciences Programme, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Food Funct 4:1767-75. 2013
    ..In this review, we summarize current research and scientific evidence of DHA and AA on baby development. ..
  2. ncbi request reprint Breast milk fatty acid composition: a comparative study between Hong Kong and Chongqing Chinese
    Z Y Chen
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, New Territories
    Lipids 32:1061-7. 1997
    ..The present study showed that Hong Kong and Chongqing Chinese had a different fatty acid profile in many ways, which largely reflected a different dietary habit and life-style in these two places...
  3. ncbi request reprint Characterization of antioxidants present in bitter tea (Ligustrum pedunculare)
    Zhen Yu Chen
    Food and Nutritional Science Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    J Agric Food Chem 50:7530-5. 2002
    ..The present results demonstrate that bitter tea as a beverage contains effective antioxidants that may have benefits similar to those of green tea in terms of antioxidant activity...
  4. ncbi request reprint Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats
    Z Y Chen
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Br J Nutr 86:249-55. 2001
    ....
  5. doi request reprint Anti-hypertensive nutraceuticals and functional foods
    Zhen Yu Chen
    Department of Biochemistry, Food and Nutritional Sciences Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 57:4485-99. 2009
    ....
  6. ncbi request reprint Degradation of green tea catechins in tea drinks
    Z Chen
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People s Republic of China
    J Agric Food Chem 49:477-82. 2001
    ..When canned and bottled tea drinks are produced, stored, and transported, the degradation of GTC must be taken into consideration...
  7. doi request reprint Cholesterol-lowering nutraceuticals and functional foods
    Zhen Yu Chen
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, China
    J Agric Food Chem 56:8761-73. 2008
    ..This review summarizes the findings of recent studies on the production, application, efficacy, and mechanisms of popular cholesterol-lowering nutraceuticals and functional foods...
  8. doi request reprint DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet
    Jingnan Chen
    Department of Biology and Kwong Living Trust Food Safety and Analysis Laboratory, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Atherosclerosis 221:397-404. 2012
    ..It was concluded that all three fatty acids were beneficial in improving lipoprotein profile with DPA n-3 and DHA having better effect on aortic function...
  9. doi request reprint Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats
    Lai Ming Yung
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Eur J Nutr 52:1145-55. 2013
    ..The effect of cranberry consumption on expression and activity of renin-angiotensin system in the vasculature will be determined...
  10. doi request reprint Blueberry extract prolongs lifespan of Drosophila melanogaster
    Cheng Peng
    School of Life Sciences, Chinese University of Hong Kong, Hong Kong, China
    Exp Gerontol 47:170-8. 2012
    ..It was therefore concluded that the lifespan-prolonging activity of blueberry extracts was at least partially associated with its interactions with MTH, Rpn11, and endogenous antioxidant enzymes SOD and CAT...
  11. ncbi request reprint Enhancement of contraction of rat mesenteric artery by acteoside: role of endothelial nitric oxide
    Wing Yin Tam
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    J Nat Prod 65:990-5. 2002
    ..The present results indicate that acteoside enhanced the evoked vasoconstriction, mainly through inhibition of endothelial NO production/release and inhibition of NO-mediated TEA(+)-sensitive activation of K(+) channels...
  12. doi request reprint Black rice extract extends the lifespan of fruit flies
    Yuanyuan Zuo
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Food Funct 3:1271-9. 2012
    ..It was concluded that BREs could extend the lifespan of fruit flies, most likely by regulating the genes of SOD1, SOD2, CAT, Mth and Rpn11 at the transcriptional level...
  13. ncbi request reprint Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway
    Wai San Cheang
    From Institute of Vascular Medicine, Shenzhen Research Institute, and Li Ka Shing Institute of Health Sciences W S C, X Y T, C W L, X Y, Y H, and School of Life Sciences S S T L, Z Y C, Chinese University of Hong Kong, Hong Kong, China Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX X Y T, W T W and Cardiovascular Research Center, Xi an Jiaotong University, Xi an, China N W
    Arterioscler Thromb Vasc Biol 34:830-6. 2014
    ..We aim to investigate whether PPARδ is crucial for metformin in ameliorating ER stress and endothelial dysfunction induced by high-fat diet...
  14. ncbi request reprint Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A: cholesterol acyltransferase activity
    Cheuk Kai Lam
    Food and Nutritional Sciences Programme of Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Atherosclerosis 198:85-93. 2008
    ....
  15. ncbi request reprint Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet
    Zesheng Zhang
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People s Republic of China
    J Nutr 132:5-10. 2002
    ..05). The results suggest that the mechanism by which hawthorn fruit decreases serum cholesterol involves, at least in part, the inhibition of cholesterol absorption mediated by down-regulation of intestinal ACAT activity...
  16. doi request reprint Apple polyphenols extend the mean lifespan of Drosophila melanogaster
    Cheng Peng
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China
    J Agric Food Chem 59:2097-106. 2011
    ..It was therefore concluded that the antiaging activity of AP was, at least in part, mediated by its interaction with genes SOD, CAT, MTH, and Rpn11...
  17. doi request reprint Red yeast rice increases excretion of bile acids in hamsters
    Ka Ying Ma
    Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biomed Environ Sci 22:269-77. 2009
    ..To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism...
  18. doi request reprint Sesamin extends the mean lifespan of fruit flies
    Yuanyuan Zuo
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Biogerontology 14:107-19. 2013
    ..It was concluded that sesamin extended the mean lifespan and alleviated the neurodegeneration in Drosophila melanogaster at least mediated by its interaction with genes SOD1, SOD2, CAT, and Rpn11, but not with gene Mth...
  19. doi request reprint Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet
    Yintong Liang
    School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Eur J Nutr 52:869-75. 2013
    ....
  20. ncbi request reprint Endothelium-dependent and -independent coronary relaxation induced by urocortin
    Xiaoqiang Yao
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Card Surg 17:347-9. 2002
    ..The urocortin-induced endothelium-dependent relaxation appears to be cyclic GMP-dependent...
  21. ncbi request reprint Soy leaf lowers the ratio of non-HDL to HDL cholesterol in hamsters
    Hing Man Ho
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People s Republic of China
    J Agric Food Chem 51:4554-8. 2003
    ..The present results demonstrate that not only soybean seeds but also soy leaves are cardioprotective, by favorably modulating serum lipid profile...
  22. pmc Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress in estrogen deficient rats
    Lai Ming Yung
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e17437. 2011
    ..The present study investigates whether the up-regulation of RAS and associated oxidative stress contributes to the development of endothelial dysfunction during estrogen deficiency in ovariectomized (OVX) rats...
  23. ncbi request reprint Attenuated endothelium-mediated relaxation by acteoside in rat aorta: Role of endothelial [Ca2+]i and nitric oxide/cyclic GMP pathway
    Chi Wai Lau
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Life Sci 75:1149-57. 2004
    ..This novel pharmacological action if occurring in small vessels in vivo, may contribute to the reported anti-inflammatory effect of acteoside against NO-mediated vascular permeability-related acute edema...
  24. doi request reprint Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet
    Yau Chi Chan
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
    Pharmacol Res 65:182-8. 2012
    ....
  25. doi request reprint Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick C1 like 1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG 5/8 in hamsters
    Ka Ying Ma
    Food and Nutritional Sciences Programme of Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Mol Nutr Food Res 55:247-58. 2011
    ..The present study investigated the interaction of dietary calcium with genes of transporters, receptors and enzymes involved in cholesterol metabolism...
  26. doi request reprint Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation
    Yau Chi Chan
    Institute of Vascular Medicine, Hong Kong, China
    Arterioscler Thromb Vasc Biol 30:992-9. 2010
    ..The present study aimed to examine roles of Ca(2+) influx in endothelium and endothelial nitric oxide synthase (eNOS) activation in dilatations induced by raloxifene, a second-generation SERM in myogenically active arteries...
  27. ncbi request reprint Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells
    Lai See Po
    Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Room 507C MMW Building, Shatin, N T, Hong Kong
    Cancer Lett 187:33-40. 2002
    ..Cell death assay and flow cytometry analysis demonstrated that baicalein was a stronger apoptosis inducing agent than genistein. Considering all the criteria tested, baicalein could be a better chemopreventive agent than genistein...
  28. doi request reprint Effect of phytosterols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet
    Yin Tong Liang
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Atherosclerosis 219:124-33. 2011
    ..It was concluded that Si and St not SiOP and StOP were beneficial in improving lipoprotein profile and aortic function...
  29. ncbi request reprint Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery
    Hok Sum Leung
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Vascul Pharmacol 44:299-308. 2006
    ..Thus, the eNOS-dependent H2O2 is likely to be the third mediator of acetylcholine-mediated relaxations in rat femoral arteries...
  30. ncbi request reprint Hydroxychalcones exhibit differential effects on XRE transactivation
    Huan Wang
    Food and Nutritional Sciences Programme, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Toxicology 207:303-13. 2005
    ..In summary, the present study illustrated that the inhibition of hydroxychalcone on CYP1 enzymes and XRE-transactivation was affected by the position and number of hydroxyl groups in its structure...
  31. ncbi request reprint Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats
    Suk Ying Tsang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong
    Hypertension 44:78-82. 2004
    ..Tamoxifen does not act as an estrogen antagonist; instead, it functions as an estrogen agonist during estrogen deficiency. Thus, tamoxifen may confer beneficial effects similar to estrogen in cerebrovascular vessels...
  32. doi request reprint β-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2
    Chao Yang
    School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Res 97:520-32. 2013
    ..Little is known about the impact of SOPs and β-sitosterol on the functionality of arteries. This study investigated the effects of SOPs and β-sitosterol on vasorelaxation and the possible cellular mechanisms involved...
  33. doi request reprint Black tea theaflavins extend the lifespan of fruit flies
    Cheng Peng
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Exp Gerontol 44:773-83. 2009
    ..This suggests that the lifespan-prolonging activity of BTE is mediated at least in part through SOD and CAT...
  34. doi request reprint 4-aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery
    Wai San Cheang
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Vascul Pharmacol 53:94-8. 2010
    ..Other potassium channels, Na(+)-K(+) pump or endothelium-derived relaxing factors play little role...
  35. ncbi request reprint Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters
    Lei Guan
    Li Ka Shing Institute of Health Sciences, Food and Nutritional Sciences Program of the Department of Biochemistry, and Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 54:4907-12. 2006
    ..It was concluded that both soybean and kudzu phytoestrogens could modify favorably lipoprotein profiles in ovariectomized and castrated hamsters...
  36. pmc Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels
    Yu Huang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 135:1467-76. 2002
    ..The urocortin-induced endothelium-dependent relaxation appears to be mediated by cyclic GMP-dependent mechanisms...
  37. ncbi request reprint (-)epicatechin induces and modulates endothelium-dependent relaxation in isolated rat mesenteric artery rings
    Zhen Yu Chen
    Department of Biochemistry, Chinese University of Hong Kong, China
    Acta Pharmacol Sin 23:1188-92. 2002
    ..The present study was aimed to examine the role of endothelial nitric oxide in the relaxant response to green tea (-)epicatechin and its modulation of endothelium-mediated relaxation in the isolated rat mesenteric artery rings...
  38. doi request reprint Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress
    Jinghui Dong
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Eur Heart J 33:2980-90. 2012
    ....
  39. ncbi request reprint Tamoxifen and estrogen attenuate enhanced vascular reactivity induced by estrogen deficiency in rat carotid arteries
    Suk Ying Tsang
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, PR China
    Biochem Pharmacol 73:1330-9. 2007
    ..Also, vascular effects of ovariectomy can be reversed by estrogen, tamoxifen or estrogen+tamoxifen treatment, suggesting that tamoxifen confers estrogenic effects in the vascular system...
  40. ncbi request reprint Oxidised cholesterol is more hypercholesterolaemic and atherogenic than non-oxidised cholesterol in hamsters
    Chi Ho Ng
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Br J Nutr 99:749-55. 2008
    ..1 group showed greater inhibition on acetylcholine-induced relaxation compared with that in the C-0.1 hamsters. It was concluded that OxC was much more hypercholesterolaemic and atherogenic than cholesterol...
  41. ncbi request reprint Nickel inhibits urocortin-induced relaxation in the rat pulmonary artery
    Chi Wai Lau
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin NT, China
    Eur J Pharmacol 488:169-72. 2004
    ..The present results provide indirect evidence suggesting that stimulation of Na(+)-Ca(2+) exchangers may contribute to urocortin-induced endothelium-independent pulmonary artery relaxation...
  42. ncbi request reprint Differential regulation of K+ and Ca2+ channel gene expression by chronic treatment with estrogen and tamoxifen in rat aorta
    Suk Ying Tsang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Eur J Pharmacol 483:155-62. 2004
    ....
  43. doi request reprint Capsaicinoids lower plasma cholesterol and improve endothelial function in hamsters
    Yin Tong Liang
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Eur J Nutr 52:379-88. 2013
    ....
  44. doi request reprint Frequent cholesterol intake up-regulates intestinal NPC1L1, ACAT2, and MTP
    Rui Jiao
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 58:5851-7. 2010
    ..It was concluded that the cholesterol intake frequency-induced elevation in plasma TC was associated with greater cholesterol absorption, possibly mediated by up-regulation of NPC1L1, ACAT2, and MTP...
  45. doi request reprint Hypocholesterolemic activity of onion is mediated by enhancing excretion of fecal sterols in hamsters
    Lei Guan
    Department of Biology, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Food Funct 1:84-9. 2010
    ..It was concluded that the hypocholesterolemic activity of onion powder was mediated by enhancement of fecal sterol excretion and up-regulation of LXRα and CYP7A1...
  46. ncbi request reprint Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, PR China
    Biochem Pharmacol 67:787-94. 2004
    ..Our results indicate that baicalin and baicalein attenuated NO-mediated aortic relaxation and cyclic GMP increases, likely through inhibition of NO-dependent guanylate cyclase activity...
  47. ncbi request reprint Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster
    Yuk Man Li
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Nutr Biochem 19:376-83. 2008
    ..It was concluded that GTC and BE reversed the fat-induced mortality in D. melanogaster, most likely but necessarily solely, by up-regulation of endogenous antioxidant enzymes...
  48. pmc Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i
    Hok Sum Leung
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Br J Pharmacol 147:55-63. 2006
    ..The Ca(2+) channel-independent effect suggests the usefulness of cilnidipine in the treatment of cardiovascular diseases associated with diminished NO release, such as atherosclerosis...
  49. ncbi request reprint Effect of squalene and shark liver oil on serum cholesterol level in hamsters
    Zesheng Zhang
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, The People s Republic of China
    Int J Food Sci Nutr 53:411-8. 2002
    ..The present results suggest that SQ and SLO are hypercholesterolemic at least in hamsters. Caution has to be taken when SQ or SLO are routinely consumed as health supplements...
  50. ncbi request reprint Screening of chemopreventive tea polyphenols against PAH genotoxicity in breast cancer cells by a XRE-luciferase reporter construct
    Ho Yee Chan
    Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Nutr Cancer 46:93-100. 2003
    ..It has the advantages of shorter sample processing time and producing no radioactive waste over directly measuring the CYP1A1/1B1 expressions, DNA lesion, or gel mobility shift assay...
  51. doi request reprint NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
    Pharmacol Res 65:239-46. 2012
    ....
  52. doi request reprint Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging
    Siu Ling Wong
    Institute of Vascular Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Circ Res 104:228-35. 2009
    ..The results support a critical role of COX-2 in endothelium-dependent contractions in this species with an increased importance during aging and, possibly, a similar relevance in humans...
  53. ncbi request reprint Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants
    Guihua Xu
    Department of Biochemistry, Faculty of Science, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 57:9284-92. 2009
    ..GTC, alpha-tocopherol, and quercetin were more effective than BHT in preventing the oxidation of cholesterol and beta-sitosterol...
  54. ncbi request reprint Cholesteryl ester species differently elevate plasma cholesterol in hamsters
    Rui Jiao
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    J Agric Food Chem 61:11041-7. 2013
    ....
  55. ncbi request reprint Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Cardiovasc Res 57:824-33. 2003
    ..The present study aimed to examine the role of cyclic AMP and Ca(2+)-activated K(+) channels in the relaxant response to urocortin in the isolated endothelium-denuded rat left anterior descending coronary arteries...
  56. doi request reprint Dietary calcium decreases plasma cholesterol level only in female but not in male hamster fed a high cholesterol diet
    Ka Ying Ma
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Biomed Environ Sci 25:392-8. 2012
    ..To investigate the effect of dietary calcium on plasma lipoprotein profile in castrated and ovariectomized hamsters...
  57. doi request reprint Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism
    Limei Liu
    Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Hypertension 60:833-41. 2012
    ....
  58. pmc Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China
    Antioxid Redox Signal 16:363-73. 2012
    ..Innovation: The current study, thus, suggests that drugs targeting oxidative stress-dependent COX-2-derived PGF(2α) may be useful in the prevention and management of RH. Antioxid. Redox Signal. 16, 363-373...
  59. doi request reprint Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor, and HMG-CoA reductase
    Jingnan Chen
    Kwong Living Trust Food Safety and Analysis Laboratory and Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Agric Food Chem 59:6790-7. 2011
    ..The mechanisms underlying the cholesterol-lowering activity of algae were mediated most likely by increasing the sterol excretion and decreasing the cholesterol absorption and synthesis...
  60. doi request reprint Exercise, vascular wall and cardiovascular diseases: an update (Part 1)
    Fung Ping Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Sports Med 38:1009-24. 2008
    ....
  61. ncbi request reprint Biology of ageing and role of dietary antioxidants
    Cheng Peng
    Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong
    Biomed Res Int 2014:831841. 2014
    ....
  62. ncbi request reprint Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers
    Jin Ze Xu
    Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China
    Br J Nutr 91:873-81. 2004
    ..It was concluded that the epimerisation reaction occurring in manufacturing canned and bottled tea drinks would not significantly affect antioxidant activity and bioavailability of total tea polyphenols...
  63. ncbi request reprint Genistein-induced apoptosis in MCF-7 cells involves changes in Bak and Bcl-x without evidence of anti-oestrogenic effects
    Lai See Po
    Food and Nutritional Sciences Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Br J Nutr 88:463-9. 2002
    ....
  64. ncbi request reprint Biological properties of baicalein in cardiovascular system
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Curr Drug Targets Cardiovasc Haematol Disord 5:177-84. 2005
    ..The pharmacological findings have highlighted the therapeutic potentials of using plant-derived baicalein and its analogs for the treatment of arteriosclerosis and hypertension...
  65. ncbi request reprint Reactive oxygen species in vascular wall
    Lai Ming Yung
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Cardiovasc Hematol Disord Drug Targets 6:1-19. 2006
    ....
  66. pmc PPARδ activation protects endothelial function in diabetic mice
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Diabetes 61:3285-93. 2012
    ..The current study demonstrates an endothelial-protective effect of PPARδ agonists in diabetic mice through PI3K/Akt/eNOS signaling, suggesting the therapeutic potential of PPARδ agonists for diabetic vasculopathy...
  67. ncbi request reprint Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non-HDL to HDL cholesterol
    Cheuk Kai Lam
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Mol Nutr Food Res 52:950-8. 2008
    ..A series of in vitro assays confirmed that AP inhibited CETP in a dose dependent manner. It was concluded that AP favorably improved distribution of cholesterol in lipoproteins, most likely, by its inhibition on CETP activity...
  68. ncbi request reprint Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice
    Wing Tak Wong
    Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, China
    Antioxid Redox Signal 13:757-68. 2010
    ..The present study has identified an initiative role of AT(1)R activation in mediating endothelial dysfunction of arteries from db/db mice and diabetic patients...
  69. doi request reprint Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1
    Rui Jiao
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Nutr Biochem 21:1134-9. 2010
    ..It was concluded that the hypocholesterolemic activity of GSP was most likely mediated by enhancement of bile acid excretion and up-regulation of CYP7A1...
  70. ncbi request reprint Developmental and reproductive toxicity of soybean isoflavones to immature SD rats
    Lei Guan
    Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Biomed Environ Sci 21:197-204. 2008
    ..To investigate the dose-dependent toxic effect of soybean isoflavone extracts (SIE) on reproductive development in immature rats...
  71. doi request reprint Exercise, vascular wall and cardiovascular diseases: an update (part 2)
    Lai Ming Yung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Sports Med 39:45-63. 2009
    ..Overall, more scientific evidence will undoubtedly encourage the widespread advocacy of the clinical benefits of exercise therapy in the prevention and treatment of CVD...
  72. ncbi request reprint Contribution of K+ channels to relaxation induced by 17beta-estradiol but not by progesterone in isolated rat mesenteric artery rings
    Suk Ying Tsang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Cardiovasc Pharmacol 41:4-13. 2003
    ..The present findings provide pharmacological evidence for an additional mechanism contributing to acute vasorelaxation induced by 17beta-estradiol...
  73. pmc Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery
    Suk Ying Tsang
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 138:453-60. 2003
    ..Pinacidil also induces K(+) channel-dependent but VGCCs-independent relaxation. The PKC-mediated cellular pathway may be a target site for pinacidil only in higher concentrations...
  74. doi request reprint Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels
    Bing Shen
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    J Mol Cell Cardiol 45:437-45. 2008
    ..In summary, CNG channels, CNGA2 in particular, mediate beta-adrenoceptor agonist-induced endothelial Ca(2+) influx and subsequent vascular dilation...
  75. ncbi request reprint Oestrogen receptor alpha is required for biochanin A-induced apolipoprotein A-1 mRNA expression in HepG2 cells
    Ming Yan Chan
    Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Room 507C, MMW Bldg, Shatin NT, Hong Kong
    Br J Nutr 98:534-9. 2007
    ..The present study illustrated that biochanin A might up regulate hepatic apoA-1 mRNA expression through an ER-dependent pathway...
  76. doi request reprint Differential incorporation of dietary conjugated linolenic and linoleic acids into milk lipids and liver phospholipids in lactating and suckling rats
    Ying Cao
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, China
    J Nutr Biochem 20:685-93. 2009
    ..It is concluded that maternal rats incorporate CLnA isomers into milk differently from that of CLA isomers. Most interesting is that maternal rats can metabolically convert CLnA to CLA...
  77. ncbi request reprint Baicalin-induced vascular response in rat mesenteric artery: role of endothelial nitric oxide
    Yu Huang
    Departments of Physiology and Biochemistry, Chinese University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 29:721-4. 2002
    ....
  78. ncbi request reprint Policosanol has no antioxidant activity in human low-density lipoprotein but increases excretion of bile acids in hamsters
    Chi Ho Ng
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 53:6289-93. 2005
    ....
  79. ncbi request reprint Role of endothelium in thapsigargin-induced arterial responses in rat aorta
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Eur J Pharmacol 392:51-9. 2000
    ..Activation of TPA(+)- and Ba(2+)-sensitive but not Ca(2+)-activated or ATP-sensitive K(+) channels may be also involved in thapsigargin-induced relaxation of rat isolated aortic rings...
  80. doi request reprint Stimulation of histamine H2 receptors activates TRPC3 channels through both phospholipase C and phospholipase D
    Hiu Yee Kwan
    Faculty of Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Eur J Pharmacol 602:181-7. 2009
    ..Taken together, our results showed, for the first time, that histamine could activate TRPC3 via histamine H(2) receptors, and both PLC and PLD participated in this process...
  81. ncbi request reprint Green tea catechins upregulate superoxide dismutase and catalase in fruit flies
    Yuk Man Li
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Mol Nutr Food Res 51:546-54. 2007
    ..It was concluded that prolonging lifespan by GTC in D. melanogaster was influenced, among others, by upregulation of endogenous antioxidant enzymes...
  82. doi request reprint A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density
    James F Griffith
    Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Bone 44:1092-6. 2009
    ..Other than cis-7-hexadecenoic acid [C16:1 (n=9)] and docosanoic acid [C22:0], no difference in marrow fatty acid composition was evident between subjects of varying BMD...
  83. ncbi request reprint Vascular effects of a soy leaves (Glycine max) extract and kaempferol glycosides in isolated rat carotid arteries
    Hing Man Ho
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, NT, China
    Planta Med 68:487-91. 2002
    ..Genistein and genistin also caused relaxation, however, the dose range is beyond that of the extract causing relaxation...
  84. ncbi request reprint Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens
    I Y Wong
    Departments of Biochemistry and Physiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China
    J Agric Food Chem 49:3113-9. 2001
    ..The present results suggest that the bitter tea beverage derived from LP contains effective antioxidants that may have an equal benefit as a green tea beverage...
  85. pmc Tamoxifen dilates porcine coronary arteries: roles for nitric oxide and ouabain-sensitive mechanisms
    H S Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 149:703-11. 2006
    ..Experiments were designed to determine the mechanism of the relaxation induced by tamoxifen in porcine coronary arteries at the tissue, cellular and molecular levels...
  86. ncbi request reprint Theaflavins in black tea and catechins in green tea are equally effective antioxidants
    L K Leung
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People's Republic of China
    J Nutr 131:2248-51. 2001
    ....
  87. ncbi request reprint Stimulation of chloride secretion by baicalein in isolated rat distal colon
    W H Ko
    Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Am J Physiol Gastrointest Liver Physiol 282:G508-18. 2002
    ..Baicalein may stimulate Cl(-) secretion via a cAMP-independent pathway or have a direct effect on cystic fibrosis transmembrane conductance regulator...
  88. ncbi request reprint Vasorelaxant effects of cardamonin and alpinetin from Alpinia henryi K. Schum
    Z T Wang
    Department of Pharmacognosy, China Pharmaceutical University, Nanjing
    J Cardiovasc Pharmacol 37:596-606. 2001
    ....
  89. ncbi request reprint Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle
    Z D He
    Department of Biochemistry, Chinese University of Hong Kong, Shantin, NT, China
    Planta Med 67:520-2. 2001
    ..Inhibition of smooth muscle cell proliferation by phenylethanoids indicates that these compounds may have preventative effects on arteriosclerosis...